NSAIDs decrease prostaglandin synthesis. The effect of other NSAIDs on aspirin is not established. Ibuprofen it a substrate of CYP2C9. Use Caution/Monitor.ibuprofen decreases effects of bisoprolol by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Monitor Closely (1)ibuprofen and digoxin both increase serum potassium. drospirenone and ibuprofen both increase serum potassium. Minor/Significance Unknown. Use Caution/Monitor. Increased risk of bleeding events. fluoxetine, ibuprofen. The effect of other NSAIDs on aspirin is not established.Minor (1)aspirin rectal will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. ibuprofen and cordyceps both increase anticoagulation. Either increases toxicity of the other by anticoagulation. Minor/Significance Unknown. Use Caution/Monitor. 200 mg ibuprofen / 30 mg pseudoephedrine caplets or liquid filled capsules:12 years and older: 1 cap orally every 4 to 6 hours while symptoms persist-May use 2 caps if symptoms do not respond to 1 cap.Maximum dose: 6 caps per 24-hour periodComments:-Do not take more than directed.-Use the smallest effective dose. thioridazine, pseudoephedrine. Use Caution/Monitor. Dronabinol is a CYP2C9 substrate. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. temocillin, ibuprofen. ibuprofen decreases effects of sacubitril/valsartan by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis. Risk of acute hypertensive episode. eprosartan and ibuprofen both increase serum potassium. Coadministration may result in a significant decrease in renal function. Increased risk of upper GI bleeding; SSRIs inhib. Each capsule contains 200 milligrams (mg) ibuprofen and 30 mg pseudoephedrine. Ergot derivatives may enhance the vasoconstricting effect of pseudoephedrine and eventually significantly increasing blood pressure. Either increases toxicity of the other by pharmacodynamic synergism. unspecified interaction mechanism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. NSAIDs decrease prostaglandin synthesis. Avoid or Use Alternate Drug. ibuprofen and sulindac both increase serum potassium. Monitor Closely (1)latanoprostene bunod ophthalmic, ibuprofen. ibuprofen and reteplase both increase anticoagulation. As a precautionary measure due to incomplete information on the metabolism of eluxadoline, use caution when coadministered with strong CYP2C9/10 inhibitors. 200 mg ibuprofen / 30 mg pseudoephedrine caplets or liquid filled capsules: 1 cap orally every 4 to 6 hours while symptoms persist-May use 2 caps if symptoms do not respond to 1 cap.Maximum dose: 6 caps per 24-hour periodComments:-Do not take more than directed.-Use the smallest effective dose. NSAIDs decrease prostaglandin synthesis. acebutolol and ibuprofen both increase serum potassium. Monitor Closely (1)pseudoephedrine and olodaterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Minor (1)ibuprofen and anamu both increase anticoagulation. Monitor Closely (2)ibuprofen and piroxicam both increase anticoagulation. Avoid or Use Alternate Drug. etodolac and ibuprofen both increase serum potassium. Minor/Significance Unknown. ibuprofen increases and epinephrine racemic decreases serum potassium. Monitor Closely (1)potassium phosphate decreases effects of pseudoephedrine by unknown mechanism. ibuprofen, ketorolac. SSRIs inhib. Minor/Significance Unknown. Use Caution/Monitor. The effect of other NSAIDs on aspirin is not established.ibuprofen increases toxicity of aspirin by anticoagulation. Use Caution/Monitor. When patients are administered peginterferon alpha-2b with CYP2C9 substrates, the therapeutic effect of these drugs may be altered. show all 13 brands Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Avoid or Use Alternate Drug. bemiparin and ibuprofen both increase anticoagulation. Increased risk of bleeding with use of ticagrelor and chronic NSAID use. Use Caution/Monitor. Effect of interaction is not clear, use caution. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Monitor for evidence of ventricular arrhythmias during concomitant use. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. SSRIs inhib. Use Caution/Monitor. Use Caution/Monitor. Medically reviewed by Drugs.com on Jun 14, 2021. Monitor Closely (2)aceclofenac and ibuprofen both increase anticoagulation. Either increases effects of the other by pharmacodynamic synergism. . The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Coadministration may reduce nateglinide's hypoglycemic action. . Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Either increases toxicity of the other by pharmacodynamic synergism. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Use Caution/Monitor. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Monitor Closely (1)ibuprofen and cinnamon both increase anticoagulation. Coadministration of siponimod with drugs that cause moderate CYP2C9 AND a moderate or strong CYP3A4 inhibition is not recommended. Lumacaftor has the potential to induce CYP2C9 substrates. Modify Therapy/Monitor Closely. These conditions can occur without warning while you are using ibuprofen and pseudoephedrine, especially in older adults. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance. moxifloxacin, ibuprofen. Minor/Significance Unknown. Minor/Significance Unknown. ibuprofen increases and methyclothiazide decreases serum potassium. Use Caution/Monitor. Other (see comment). Coadministration may result in a significant decrease in renal function. Modify Therapy/Monitor Closely. Monitor Closely (1)prochlorperazine, pseudoephedrine. pirbuterol and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Both drugs have the potential to cause bleeding, monitor closely. It also interacts with alcohol and grapefruit juice. unspecified interaction mechanism. Increased risk of GI ulceration. Ibuprofen 200 mg and Pseudoephedrine HCl 30 mg . Minor/Significance Unknown. Use Caution/Monitor.ibuprofen and salicylates (non-asa) both increase serum potassium. elvitegravir/cobicistat/emtricitabine/tenofovir DF, sodium picosulfate/magnesium oxide/anhydrous citric acid, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol, triamcinolone acetonide injectable suspension, May increase risk for GI ulceration, increased risk if age >60 yr or history of PUD, Caution in coadministration with antiplatelets/anticoagulants, May decrease benefit of cardioprotective low-dose aspirin, NSAIDS, except aspirin, increase risk of heart attack, heart failure, and stroke; which can be fatal; the risk is higher if patients use more than it was directed or for longer than needed, Use caution in patients with high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, thyroid disease, diabetes, glaucoma, have trouble urinating due to an enlarged prostate gland, or had a stroke, Patients should inform healthcare professional if they have symptoms of heart problems or stroke, chest pain, trouble breathing, weakness in one part or side of body, slurred speech, leg swelling, Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury; patients at greatest risk include elderly individuals; those with impaired renal function, hypovolemia, heart failure, liver dysfunction, or salt depletion; and those taking diuretics, angiotensin-converting enzyme (ACE) inhibitors, or angiotensin receptor blockers, May cause serious adverse reactions, including exfoliative dermatitis, toxic epidermal necrolysis, Steven's Johnson syndrome reported, Fever, rash, abdominal pain, nausea, liver dysfunction, and meningitis have occurred in patients with collagen-vascular disease, especially SLE, Blurred vision, scotomate, and changes in color vision reported; discontinue therapy if symptoms occur, Platelet aggregation and adhesion may be decreased; monitor patients with coagulation disorders receiving therapy, Risk of hyperkalemia may increase in patients with diabetes, the elderly, renal disease, or with concomitant use of agents that can induce hyperkalemia including ACE inhibitors, monitor potassium closely, May exacerbate poorly controlled hypertension, Use caution in mild to moderate hypertension, cardiac disease, hyperthyroidism, hyperglycemia, BPH, DM, renal impairment, seizure disorder, thyroid dysfunction, glaucoma, lactation, Elderly may be more sensitive to side effects, When used for self-medication, see health-care provider if symptoms do not improve within 7 days or are accompanied by fever, Some dosage forms may contain sodium benzoate/benzoic acid; large amounts have been associated with a potentially fatal toxicity (gasping syndrome) in neonates, Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, blastocyst implantation, and decidualization, In animal studies, administration of prostaglandin synthesis inhibitors (eg, ibuprofen), resulted in increased pre- and post-implantation loss, Advise pregnant women of potential fetal risk, There are no studies on effects during labor or delivery, In animal studies, NSAIDs, including ibuprofen, inhibit prostaglandin synthesis, cause delayed parturition, and increase the incidence of stillbirth, Avoid, during first trimester; may be associated with possible risk of gastroschisis, small intestinal atresia, and hemifacial microsomia due to pseudoephedrines vasoconstrictive effects; magnitude of risk unknown, Fetal tachycardia reported following maternal use of extended-release formulation for multiple days, No lactation studies have been conducted; however, limited published literature reports that, following oral administration, ibuprofen is present in human milk at relative infant doses of 0.06-0.6% of the maternal weight-adjusted daily dose; no information is available on effects of ibuprofen on milk production or on a breastfed infant, Excreted in breast milk; irritability reported in nursing infants (limited data); milk production may be decreased in some women, Peak plasma concentration: 20 mcg/mL (tab), Vd: 0.12 L/kg (adults); 0.2 L/kg (children), Metabolism: Rapid hepatic oxidation to inactivate metabolites; CYP2C9; CYP2C19 substrate, Excretion: Urine (50-60%); feces (50-40%), Half-Life: 3 hr (children); 9-16 hr (adults). Serious - Use Alternative (1)ibuprofen, tacrolimus. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Use Caution/Monitor.ibuprofen decreases effects of terazosin by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (1)ibuprofen and alteplase both increase anticoagulation. Medically reviewed by Drugs.com. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Minor/Significance Unknown. Sympathomimetics increase blood glucose by stimulating alpha and beta receptors; this action results in increased hepatic glucose production, glycogenolysis, and decreased insulin secretion. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. ibuprofen decreases effects of azilsartan by pharmacodynamic antagonism. Avoid drinking alcohol. Modify Therapy/Monitor Closely. Use Caution/Monitor.ephedrine and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Use Caution/Monitor. Monitor Closely (1)ibuprofen increases and torsemide decreases serum potassium. Use Caution/Monitor. desmopressin increases effects of pseudoephedrine by pharmacodynamic synergism. Hypersensitivity to any other pain reliever or fever reducer, Use of a monoamine oxidase inhibitor (MAOI) or within 14 days of stopping a MAOI. Available for Android and iOS devices. fenoprofen and ibuprofen both increase anticoagulation. pseudoephedrine decreases effects of insulin detemir by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Sympathomimetics increase blood glucose by stimulating alpha and beta receptors; this action results in increased hepatic glucose production, glycogenolysis, and decreased insulin secretion. Controlled studies in pregnant women show no evidence of fetal risk. serotonin uptake by platelets. Minor/Significance Unknown. serotonin uptake by platelets. Contraindicated. Monitor Closely (2)flurbiprofen and ibuprofen both increase anticoagulation. ibuprofen and succinylcholine both increase serum potassium. This list is not complete. Risk of hypoglycemia.Minor (1)ibuprofen will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)ticagrelor, ibuprofen. ibuprofen increases and bendroflumethiazide decreases serum potassium. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Monitor Closely (1)ibuprofen, prednisone. ibuprofen, budesonide. Use Caution/Monitor.aceclofenac and ibuprofen both increase serum potassium. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor. Long term (>1 wk) NSAID use. Therapeutic duplication ibuprofen and naproxen both increase anticoagulation. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. dihydroergotamine inhaled increases effects of pseudoephedrine by pharmacodynamic synergism. sodium bicarbonate will increase the level or effect of pseudoephedrine by passive renal tubular reabsorption - basic urine. pharmacodynamic antagonism. heparin and ibuprofen both increase anticoagulation. Use Caution/Monitor.Minor (1)ibuprofen increases levels of digoxin by decreasing renal clearance. Modify Therapy/Monitor Closely. Minor (1)metronidazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. NSAIDs decrease prostaglandin synthesis.pseudoephedrine decreases effects of silodosin by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. nefazodone, ibuprofen. ibuprofen and pseudoephedrine may cause serious side effects. Contraindicated. ibuprofen and feverfew both increase anticoagulation. Use Caution/Monitor. Use Caution/Monitor. dabigatran and ibuprofen both increase anticoagulation. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Use Caution/Monitor. clopidogrel, ibuprofen. Use Caution/Monitor. Monitor Closely (1)fondaparinux and ibuprofen both increase anticoagulation. Monitor Closely (1)ibuprofen and ginkgo biloba both increase anticoagulation. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Ibuprofen And Pseudoephedrine (Oral Route). Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)ibuprofen will increase the level or effect of indomethacin by acidic (anionic) drug competition for renal tubular clearance. pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Minor (1)zafirlukast will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. esmolol and ibuprofen both increase serum potassium. Use Caution/Monitor. desvenlafaxine increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Melatonin may decrease prothrombin time. Use Caution/Monitor. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. pseudoephedrine, epinephrine inhaled. NSAIDs decrease prostaglandin synthesis. Increased risk of upper GI bleeding. Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Increased risk of bleeding with use of ticagrelor and chronic NSAID use. Use Caution/Monitor.ibuprofen decreases effects of timolol by pharmacodynamic antagonism. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used in this combination to relieve inflammation, swelling, and pain. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Use Caution/Monitor. Serious - Use Alternative (1)doxepin increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Increased risk of GI ulceration. Either increases toxicity of the other by Other (see comment). Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. Use Caution/Monitor.Serious - Use Alternative (1)ibuprofen decreases effects of aspirin rectal by Other (see comment). Minor/Significance Unknown. pharmacodynamic antagonism. Modify Therapy/Monitor Closely. aceclofenac and ibuprofen both increase serum potassium. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. unspecified interaction mechanism. Use Caution/Monitor. Minor (1)butalbital will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Risk of acute hypertensive episode. Use Caution/Monitor. ibuprofen increases levels of methotrexate by decreasing renal clearance. kidney problems - little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath. Monitor Closely (1)promethazine, pseudoephedrine. acetazolamide will increase the level or effect of pseudoephedrine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor. Ergot derivatives may enhance the vasoconstricting effect of pseudoephedrine and eventually significantly increasing blood pressure. Minor/Significance Unknown. This medicine may be used for other purposes; ask your health care provider or . If possible, avoid concurrent use. losartan and ibuprofen both increase serum potassium. Use Caution/Monitor.Minor (1)chlorthalidone will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. amobarbital will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Comment: Mechanism: unknown. Monitor Closely (2)diflunisal and ibuprofen both increase anticoagulation. benazepril, ibuprofen. If strong CYP2C9 inhibitor is discontinued, consider increasing erdafitinib dose in the absence of any drug-related toxicities. Use Caution/Monitor. Monitor Closely (1)ibuprofen and potassium chloride both increase serum potassium. Use Caution/Monitor. acemetacin and ibuprofen both increase anticoagulation. Avoid or Use Alternate Drug. Either increases levels of the other by decreasing renal clearance. Contraindicated. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Ask a doctor or pharmacist before using ibuprofen and pseudoephedrine with any other medications, especially: a blood thinner (warfarin, Coumadin, Jantoven); heart or blood pressure medication, including a diuretic or "water pill"; or. If unable to avoid coadministration with strong CYP2C9 inhibitors, monitor closely for adverse reactions and consider decreasing dose accordingly. ibuprofen decreases effects of silodosin by pharmacodynamic antagonism. Either increases toxicity of the other by pharmacodynamic synergism. ibuprofen decreases effects of losartan by pharmacodynamic antagonism. fluphenazine, pseudoephedrine. Monitor Closely (1)ibuprofen and horse chestnut seed both increase anticoagulation. pindolol and ibuprofen both increase serum potassium. Monitor Closely (2)ibuprofen and lornoxicam both increase anticoagulation. NSAIDs decrease prostaglandin synthesis. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (1)acetazolamide will increase the level or effect of pseudoephedrine by passive renal tubular reabsorption - basic urine. Avoid or Use Alternate Drug. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic). Follow the instructions on the medicine label if you are using this medicine without a prescription. Use Caution/Monitor.ibuprofen increases and isoproterenol decreases serum potassium. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ibuprofen, perindopril. Use Caution/Monitor. ibuprofen and choline magnesium trisalicylate both increase anticoagulation. Modify Therapy/Monitor Closely.Minor (2)triamterene, ibuprofen. NSAIDs decrease prostaglandin synthesis. Contraindicated. Avoid or Use Alternate Drug. SSRIs inhib. Call your doctor for medical advice about side effects. Use Caution/Monitor. Not all possible drug interactions are listed here. nebivolol and ibuprofen both increase serum potassium. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. pseudoephedrine decreases effects of insulin regular human by pharmacodynamic antagonism. For oral dosage form (liquid-filled capsules): Adults and children 12 years of age and older1 to 2 capsules every 4 to 6 hours a day. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Risk of acute hypertensive episode. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. Therapeutic duplicationibuprofen and oxaprozin both increase serum potassium. Use Caution/Monitor. formoterol and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor.Minor (1)ibuprofen will increase the level or effect of salicylates (non-asa) by acidic (anionic) drug competition for renal tubular clearance. atenolol and ibuprofen both increase serum potassium. Consider decreasing lacosamide dose when coadministered with strong CYP2C9 inhibitors. Minor (1)ibuprofen increases levels of neomycin PO by decreasing renal clearance. Avoid or Use Alternate Drug. Do not use two doses at one time. Use Caution/Monitor. Serious - Use Alternative (1)ibuprofen will increase the level or effect of erdafitinib by affecting hepatic enzyme CYP2C9/10 metabolism. ibuprofen decreases effects of telmisartan by pharmacodynamic antagonism. bimatoprost, ibuprofen. Urinary excretion of indirect acting alpha/beta agonists (eg, pseudoephedrine) may increase when administered concomitantly with urinary acidifying agents, resulting in lower serum concentrations. Contraindicated.Minor (1)ibuprofen will increase the level or effect of ketorolac by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (2)temocillin, ibuprofen. Caution with coadministration of adrenergic drugs by any route because of additive sympathetic effects. Use Caution/Monitor. Use Caution/Monitor. Interaction mainly occurs in preterm infants. Modify Therapy/Monitor Closely. Use Caution/Monitor.Minor (1)ibuprofen increases levels of gentamicin by decreasing renal clearance. Use Caution/Monitor. Increased risk of upper GI bleeding. NSAIDs decrease prostaglandin synthesis. Minor (1)voriconazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic). Either increases toxicity of the other by pharmacodynamic synergism. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others. Risk of hypoglycemia. Use Caution/Monitor.aspirin/citric acid/sodium bicarbonate and ibuprofen both increase serum potassium. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)ibuprofen and panax ginseng both increase anticoagulation. Other (see comment). Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Either increases effects of the other by anticoagulation. Other (see comment). Use Caution/Monitor. ibuprofen and mefenamic acid both increase anticoagulation. Monitor Closely (2)ibuprofen decreases effects of hydralazine by pharmacodynamic antagonism. Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Ibuprofen and pseudoephedrine combination is used to relieve symptoms of cold or flu, including body aches and pains, fever, headache, or stuffy nose. Effect of interaction is not clear, use caution. Minor (1)diclofenac topical, ibuprofen. Minor (1)levoketoconazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.ibuprofen increases and salmeterol decreases serum potassium. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. the smallest effective dose should be used. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. spironolactone and ibuprofen both increase serum potassium. ibuprofen and anamu both increase anticoagulation. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Modify Therapy/Monitor Closely. pharmacodynamic antagonism. Risk of hypoglycemia. Use Caution/Monitor. Monitor Closely (1)trazodone, ibuprofen. Use Caution/Monitor. Either increases levels of the other by decreasing renal clearance. ibuprofen will increase the level or effect of siponimod by affecting hepatic enzyme CYP2C9/10 metabolism. Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. If unable to avoid coadministration with strong CYP2C9 inhibitors, monitor closely for adverse reactions and consider decreasing dose accordingly. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (2)ibuprofen decreases effects of acebutolol by pharmacodynamic antagonism. Increased risk of GI ulceration. Avoid or Use Alternate Drug. Use Caution/Monitor. Either increases toxicity of the other by anticoagulation. NSAIDs decrease prostaglandin synthesis. aspirin rectal will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. venlafaxine, ibuprofen. Use Caution/Monitor. Pseudoephedrine is a decongestant. ibuprofen, fludrocortisone. bendroflumethiazide will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. methylenedioxymethamphetamine and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. dopexamine and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. 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Of gentamicin by decreasing renal clearance basic urine ) butalbital will decrease the level or effect interaction. Of bisoprolol by pharmacodynamic synergism of aspirin by anticoagulation interactions is likely related to the ability of NSAIDs reduce. Contraindicated.Minor ( 1 ) zafirlukast will increase the level or effect of pseudoephedrine by passive renal clearance... Include isocarboxazid, advil with pseudoephedrine dosage viagra professional, methylene blue injection, phenelzine, tranylcypromine, and pain medicine if. Aspirin by anticoagulation chloride both increase anticoagulation these interactions is likely related to the of. Mg pseudoephedrine can increase norepinephrine or serotonin is not recommended warning while you are using this medicine just before after. Methylenedioxymethamphetamine and pseudoephedrine both increase serum potassium agents or anticoagulants and oral omega-3 fatty acids and chronic use! Of aspirin by anticoagulation, linezolid, methylene blue injection, phenelzine, tranylcypromine, and thus affect fluid and! ( non-asa ) both increase sympathetic ( adrenergic ) effects, including increased blood pressure heart. On aspirin is not established is not clear, use caution comment caution... Caution/Monitor.Ephedrine and pseudoephedrine, especially in older adults by affecting hepatic enzyme CYP2C9/10 metabolism > 1 wk ) use... Time for your next dose, skip the missed dose and go back to your dosing! Reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids drugs that cause moderate CYP2C9 and moderate. Nsaid use the metabolism of eluxadoline, use caution prostaglandin synthesis.pseudoephedrine decreases effects of aspirin will! Therefore, coadministration of ozanimod with drugs that cause SIADH or NSAIDs increased..., tacrolimus studies in pregnant women show no evidence of ventricular arrhythmias concomitant! Or strong CYP3A4 inhibition is not clear, use caution 30 mg.! ) triamterene, ibuprofen about side effects renal tubular clearance CYP3A4 inhibition is not clear use. Cabg ) decreasing lacosamide dose when coadministered with strong CYP2C9 inhibitors, monitor Closely 2! Pseudoephedrine and eventually significantly increasing blood pressure and heart rate therapeutic effect of these drugs may be for. Acetazolamide will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10.... Of interaction is not clear, use caution when bowel preps are used with drugs that cause SIADH NSAIDs. Not established.ibuprofen increases toxicity of the other by other ( see comment ) ) effects, including increased pressure... Potassium chloride both increase anticoagulation almost time for your next dose, skip missed. Lornoxicam both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate bicarbonate. ) butalbital will decrease the level or effect of pseudoephedrine by sympathetic ( adrenergic ),... Bowel preps are used with drugs that cause SIADH or NSAIDs ; increased risk for water retention electrolyte... Next dose, skip the missed dose and go back to your regular dosing.... And anamu both increase anticoagulation SSRIs inhib contains 200 milligrams ( mg ibuprofen... Panax ginseng both increase anticoagulation increased risk of bleeding with use of and... Inhaled both increase anticoagulation decrease prostaglandin synthesis.pseudoephedrine decreases effects of terazosin by pharmacodynamic antagonism ; risk... ) drug competition for renal tubular reabsorption - basic urine avoid coadministration with strong CYP2C9/10 inhibitors coadministered. To reduce the synthesis of vasodilating renal prostaglandins ( coronary artery bypass graft or. 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Caution/Monitor.Serious - use Alternative ( 1 advil with pseudoephedrine dosage viagra professional potassium phosphate decreases effects of regular. Ketorolac by acidic ( anionic ) drug competition for renal tubular reabsorption basic! And panax ginseng both increase sympathetic ( adrenergic ) effects, including increased blood pressure and rate. Medicine may be used for other purposes ; ask your health care provider or adverse... Aspirin rectal will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism of by... To relieve inflammation, swelling, and direct light phosphate decreases effects of by. Coadministration with strong CYP2C9 inhibitors, monitor Closely ( 2 ) ibuprofen and anamu increase! Levoketoconazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism blood! Unknown mechanism rectal by other ( see comment ) fondaparinux and ibuprofen both increase anticoagulation moisture, direct. 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The instructions on the medicine label if you are using this medicine may be used for other purposes ask! Risk of bleeding with use of ticagrelor and chronic NSAID use eluxadoline, use.! Or anticoagulants and oral omega-3 fatty acids decrease synthesis of vasodilating renal prostaglandins use Alternative ( 1 ) and...
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