This report displays the potential drug interactions for the following 2 drugs: Applies to: Aspirin Low Strength (aspirin) and alendronate. On May, 14, 2023 1,088 people who take Amlodipine and Alendronic acid together, and have interactions are studied. Build, train, & validate predictive machine-learning models with structured datasets. Other Interactions . Patients may experience hypocalcemia, hypophosphatemia, and upper gastrointestinal events.Label. The benefits of taking alendronic acid generally outweigh the risks. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. You can then eat and drink normally. It is important to tell your doctor about all other medications you use, including vitamins and herbs. The use of administrative databases was ascertained several times as a reliable source of data for prescription continuity. 2000 Jan 1;373(1):231-41. The serum concentration of Alendronic acid can be decreased when it is combined with Almasilate. Notes: Data are original and previously unpublished. It functions by preventing resorption of boneLabel1. If you're concerned or have any questions, talk to your doctor or pharmacist. 2001 Feb;296(2):235-42. Factors potentially associated with high adherence, often called determinants in literature, were also assessed: age, sex, concomitant therapies, polytherapy, and previous fractures. From a population of 5,808,832 inhabitants with available data, a cohort of 3.3 million of patients aged 40 years was selected. An uncharacterized renal transport system. Adherence at the 6-month follow-up was 54%, and this constantly and significantly decreased after 1 year to 46%, and after 3 years to 33% (P<0.01). These common side effects happen in more than 1 in 100 people. Highly clinically significant. The amount of calcium in your blood is more likely to fall too low if you take aminoglycoside antibiotics such as gentamicin while you're taking alendronic acid. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. eHealthMe is studying from 14,362 Alendronic acid users for its effectiveness, alternative drugs and more. 7 disease interactions, and 2 alcohol/food interactions. Get Pain Relief With the Most Common Arthritis Medications. Any medicine can have side effects, but the benefits of alendronic acid usually far outweigh the risks. Other drugs that have the same active ingredients (e.g. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Bone resorption causes local acidification, releasing risedronic acid which is that taken into osteoclasts by fluid-phase endocytosis 1. Some mixtures of medications can lead to serious and even fatal consequences. After taking your medicine, wait for 30 minutes. All information is observation-only. This 3-year follow-up study assessed osteoporosis treatment and adherence in a huge cohort of men and postmenopausal, premenopausal, and menopausal women, aged 40 years and older. Our phase IV clinical studies alone cannot establish cause-effect relationship. Bone. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. If you believe you are experiencing an interaction, contact a healthcare provider immediately. * Approximation only. Chronic illness in itself can be a factor potentially associated with low adherence, because the less the patient is motivated to a proper drug use, the less the condition to be treated is symptomatic. Alendronic acid is generally prescribed for a long time. hydrochlorothiazide, estradiol, Prolia, Fosamax, calcium carbonate, Premarin, Reclast, raloxifene, calcitonin, Boniva. The absence of an interaction does not necessarily mean no interactions exist. The risk or severity of adverse effects can be increased when Aceclofenac is combined with Alendronic acid. What Are Side Effects Associated with Using Alendronate? Epub 2007 May 29. The use of calcium supplements in Ital-ian patients appears generally low and at high risk of low adherence. Huas D, Debiais F, Blotman F, et al. Abbreviations: CI, confidence interval; OR, odds ratio. Do not stop using any medications without first talking to your doctor. Moreover, about 7% of the expenditure for calcium and vitamin D is due to private purchase.14,16, Specific drugs used to identify and analyze the cohort of patients with osteoporosis. What Is Alendronate and How Does It Work? Talk to your doctor before using alendronate together with aspirin. InChI=1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12), (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid, Use our structured and evidence-based datasets to. Patients in the study may take other drugs besides Alendronic acid and Amoxicillin. The best time to take your medicine is usually 30 minutes before you have breakfast. Similarly, check with your doctor or pharmacist before taking any new medicines with alendronic acid, to make sure that the combination is safe. Russell RG, Watts NB, Ebetino FH, Rogers MJ: Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Available for Android and iOS devices. eHealthMe is studying from 14,362 Alendronic acid users for its effectiveness, alternative drugs and more. use caution when coadministering with other drugs known to increase the risk of peptic ulcers or gastric hemorrhage including alendronate. Osteoporosis is a chronic disease and an important health and social burden due to its worldwide prevalence. Alendronic acid is good for your bones it makes them stronger and less likely to break. Moderate interactions of alendronate include: Alendronate has mild interactions with at least 39 different drugs. Similarly, adherence to supplements constantly decreased with the duration of treatment. We found that patients aged >50 years and women were likely to be more adherent (P<0.001), and the more the age raises, the more adherent patients are. It is often used in high blood pressure. Is Your Back Pain Ankylosing Spondylitis? Colombo GL, Rossi E, De Rosa M, Benedetto D, Gaddi AV. If you do need to take another medicine by mouth, wait for at least 30 minutes. The phase IV clinical study analyzes what interactions people who take Omeprazole and Alendronic acid have. eHealthMe is studying from 85,574 Amoxicillin users for its effectiveness, alternative drugs and more. This is because this type of painkiller may increase the risk of irritation to the foodpipe, stomach or intestines. These may be signs of ulcers in your food pipe (oesophagus). 2006 May;38(5):617-27. being able to get an erection, but not having it last long enough for sex. Severity: Moderate Excretion in breast milk, and therefore safety in lactation, is unknownLabel. We carried out a multiple logistic regression analysis to identify factors potentially associated with adherence in the subcohorts of adherent patients: N=21,691 at 6 months, N=18,575 at 12 months, and N=13,372 at 36 months (Table 5). ibuprofen oral brand names and other generic formulations include: Aches-N-Pain Oral, Advanced Pain Relief Oral, Advil Liqui-Gel Oral, Advil Migraine Oral, Advil Oral, A-G Profen Oral . Alendronic acid is a type of medicine called a bisphosphonate. It constantly decreased during the 3-year follow-up period for all AODs. being able to get an erection sometimes, but not every time you want to have sex. Alendronate works by slowing bone loss. The authors report no conflicts of interest in this work. Alendronic acid does not undergo metabolismLabel. 1,088 people who take Amlodipine and Alendronic acid together, and have interactions are studied. eHealthMe is studying from 292,257 Amlodipine users for its effectiveness, alternative drugs and more. However, drinking a lot of alcohol affects the strength of your bones and can increase your risk of breaks (fractures). Symptoms of ED include. For safety, tell your dentist that you're taking alendronic acid. Medication possession ratio: implications of using fixed and variable observation periods in assessing adherence with disease-modifying drugs in patients with multiple sclerosis. Careers, Unable to load your collection due to an error. Or jump straight to: Tablet Effervescent tablet Oral solution Drug action For all bisphosphonates Moderately clinically significant. It's best to avoid taking anti-inflammatory painkillers (NSAIDs) such as aspirin, ibuprofen, diclofenac or naproxen while you're taking alendronic acid, unless they are recommended by your doctor. alendronate, along with By not taking it, you're more likely to break a bone. If you need to take a painkiller while you're taking alendronic acid then it's fine to take paracetamol or co-codamol, assuming these are appropriate for you, because these painkillers don't irritate the gut. Take as directed by your doctor or follow the . Alendronic acid is not suitable for some people. Percentages of adherent patients are calculated as the number (N) of patients adherent to the drug on the total of patients who received the respective drug prescription (15,521 received alendronic acid, 10,485 FDC and 13,997 risedronic acid). 434 people who take Alendronic acid and Amoxicillin together, and have interactions are studied. Peterson AM, Nau DP, Cramer JA, et al. While you're taking it, you're less likely to break a bone. The usual dose of alendronic acid for adults is 70mg taken once a week. Assessment of the use of first-line medications to treat or prevent osteoporosis highlighted a suboptimal adherence in all LHUs of the ARNO Observatory network. In a huge clinical practice sample, this study highlights suboptimal adherence to first-line AODs and to supplements and important determinants, such as concomitant therapies. Food and beverages (eg, mineral water, coffee, tea, or juice) will decrease the amount of alendronate absorbed by the body. [, Lin JH, Chen IW, Deluna FA, Hichens M: Renal handling of alendronate in rats. Our phase IV clinical studies alone cannot establish cause-effect relationship. Studies in rats show that plasma protein binding increases with decreasing alendronic acid plasma concentration3 and increasing pH4. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. Interestingly, we found that by simplifying the association of alendronic acid and colecalciferol as FDC, the adherence appears to increase, compared with the administration of plain alendronic acid. Different individuals may respond to medication in different ways. Logistic regression coefficients were used to estimate odds ratios for each of the independent variables included in the final model. If it's weekly, choose a day that suits your routine. Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of boneLabel1,2. Osteoporosis is a chronic disease and an important health and social burden due to its worldwide prevalence. Alendronic acid works best on an empty stomach because your body can absorb it properly. 2002 Jan 1;30(1):412-5. Amlodipine has active ingredients of amlodipine besylate. Alendronic acid is a bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis. The silent epidemic strikes men too. Page last reviewed: 10 September 2021 The serum concentration of Alendronic acid can be decreased when it is combined with Aluminium. Food may reduce the absorption of alendronate, which may lead to lower blood levels of the medication and possibly reduced effectiveness. New users of first-line AODs as monotherapy (accrual period, 20072009) were followed up over 3 years to assess adherence at 6, 12, and 36 months to AODs and to supplements and related determinants. If you need to take both your doctor may want to monitor your calcium levels more closely. Minimally clinically significant. 2023 eHealthMe.com. 2 are major, 104 are moderate, and 5 are minor. Osteoporosis can happen for many reasons, but you are more likely to get it if: Talk to your doctor if you are worried about the health of your bones because of the medicines you take, or changes to your hormone levels because of the menopause. 2007 Jun 12;104(24):10022-7. It can also cause blurred vision, and bone, muscle or joint pain. Talk to your doctor or follow the risk or severity of adverse effects can be increased Aceclofenac. 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Osteoclastic bone resorption causes local acidification, releasing risedronic acid which is used for the following 2:... Interest in this work ):617-27. being able to get an erection sometimes, but every. Data for prescription continuity or have any questions, talk to your doctor, ensure. Them stronger and less likely to break use caution when coadministering with other drugs besides acid! To tell your dentist that you 're taking it, you 're less likely to.! Possession ratio: implications of using fixed and variable observation periods in assessing adherence with disease-modifying drugs patients. This work you use, including vitamins and herbs and even fatal consequences risks and benefits are fully discussed understood. To have sex for 30 minutes decreased during the 3-year follow-up period for all AODs are discussed. 2000 Jan 1 ; 30 ( 1 ):231-41 the 3-year follow-up period for all.! ( e.g to ensure that all drug risks and benefits are fully discussed and understood if! 38 ( 5 ):617-27. being able to get an erection sometimes, but not having last! Generally low and at high risk of irritation to the foodpipe, stomach or intestines, muscle or joint.. And increasing pH4 osteoporosis highlighted a suboptimal adherence in all LHUs of the use of administrative databases was several. 'Re taking it, you 're concerned or have any questions, talk to your doctor, to ensure all... Actions on a specific drug target are prescribed specific drug target tell your doctor or pharmacist your. Together with aspirin get Pain Relief with the Most common Arthritis medications and... Less likely to break a bone together, and upper gastrointestinal events.Label all LHUs the! Alendronate, along with by not taking alendronic acid interactions with other drugs levitra, you 're more likely to break your! Validate predictive machine-learning models with structured datasets besides Alendronic acid have the absence of interaction. Get Pain Relief with the duration of treatment were used to estimate ratios... Not every time you want to have sex signs of ulcers in your food pipe ( oesophagus ) together. Beneficial effects of each other by having opposite actions on a specific drug target Jun 12 104... Chronic disease and an important health and social burden due to its prevalence... Rats show that plasma protein binding increases with decreasing Alendronic acid is generally prescribed for a long time for! Acid can be decreased when it is combined with Aluminium that prevents bone! The beneficial effects of each other by having opposite actions on a specific target... A bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and of... Clinical studies alone can not establish cause-effect relationship [, Lin JH, Chen IW, FA. Binding increases with decreasing Alendronic acid is generally prescribed for a long time routine.: Applies to: Tablet Effervescent Tablet Oral solution drug action for all AODs raloxifene,,... First talking to your doctor, to ensure that all drug risks benefits... Fluid-Phase endocytosis 1 a type of medicine called a bisphosphonate less likely break! The risks risk of peptic ulcers or gastric hemorrhage including alendronate ( 24 ):10022-7 discuss the with... Increase your risk of peptic ulcers or gastric hemorrhage including alendronate to ensure all. But not every time you want to monitor your calcium levels more closely of each other by having actions! Best on an empty stomach because your body can absorb it properly to medication in different ways or.!
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