Whether this is the optimal therapeutic range, in terms of either benefit or risk, is unclear. 2022 Oct 14;15(10):1268. doi: 10.3390/ph15101268. If a patient develops signs and symptoms of theophylline toxicity (eg, nausea or persistent, repetitive vomiting), a serum theophylline level should be measured immediately and subsequent doses withheld. FOIA In the UK, asthma is treated according to national guidelines produced by the British Thoracic Society (BTS)/Scottish Intercollegiate Guideline Network (SIGN) [2]. The effects may be increased because of slower removal of the medicine from the body. Are the admitted children in these areas more unwell? An official website of the United States government. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. First-line therapy for children who present to an acute care setting with severe exacerbations involves frequent nebulized 2 agonists and ipratropium bromide driven by high-flow oxygen, plus oral steroids. Intravenous medications, including theophyllines, are used as second-line treatments for children experiencing a life-threatening exacerbation. Monitor closely for substantially increased blood pressure or heart rate and for any evidence of myocardial ischemia with concurrent use. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. It may therefore be necessary to undertake observational dosing research using the existing clinical intravenous aminophylline dose. Black line is mean profile, grey lines are 5th and 95th percentiles, and open circles are clinical data. Vet NJ, de Winter BC, de Wildt SN, der Nagel BC, Knibbe CA, Koninckx M, et al. The systematic review also failed to show any differences in the frequency of adverse effects in children within the therapeutic range compared with those with levels>20mg/l [11]. Theophylline: Hepatic via demethylation (CYP 1A2) and hydroxylation (CYP 2E1 and 3A4); forms active metabolites (caffeine and 3-methylxanthine). Cooney L, Hawcutt D, Sinha I. sharing sensitive information, make sure youre on a federal To avoid toxicity, UK and Eire clinicians have adopted a very consistent dosing strategy: the most common loading dose is 5mg/kg over 2030min, used in>95% of pediatric patients who received it [3]. Development of a core outcome set for clinical trials in childhood asthma: a survey of clinicians, parents, and young people. UK guidance differs from international guidance. Reversal of dipyridamole- or regadenoson-induced adverse reactions (eg, angina, hypotension) during nuclear cardiac stress testing (off-label use): IV: 50 to 250 mg administered over 30 to 60 seconds, repeat as necessary. Call your doctor for medical advice about side effects. Theophylline Derivatives may enhance the hypokalemic effect of Indacaterol. Note: Since adenosine-induced side effects are short lived after discontinuation of the infusion, aminophylline administration is only very rarely required (ASNC [Henzlova 2016]). Clearance is decreased in infants <3 months with decreased renal function. However, these PK studies, whilst suggesting we under-dose for the therapeutic range we are targeting, do not provide clinical teams with any feel for the likelihood of any particular serum concentration, as the inter-individual variation was so large. the contents by NLM or the National Institutes of Health. 10 to 14.9 mcg/mL: Maintain dosage if tolerated and symptoms controlled. Nihon Kyobu Shikkan Gakkai Zasshi. However, almost all children would achieve a serum concentration of 515mg/l using this loading dose (Fig. Unauthorized use of these marks is strictly prohibited. Management: Consider avoiding erythromycin and troleandomycin in patients receiving theophylline derivatives. Aminophylline may diminish the vasodilatory effect of Regadenoson. [17]). If combined, monitor patients closely for the development of hypertension, including hypertensive crises. Frequency not defined. This was corroborated by clinical data collected in the same study [17]. In parallel with this, observational PK studies linking aminophylline serum concentrations with clinically important outcomes need to be designed. Management: Concomitant use of ozanimod with sympathomimetic agents is not recommended. What is the most important information I should know about aminophylline? Would you like email updates of new search results? There may also be a place for stratified medicine in the dosing of aminophylline, particularly during the infusion, to guide rate. In nonelective procedures, consider use of prophylactic anticonvulsants. 1). If symptoms not controlled, consider additional medications for management. Monitor therapy, Quinolones: May increase the serum concentration of Theophylline Derivatives. Solution, Intravenous, as dihydrate [preservative free]: Theophylline has two distinct actions; smooth muscle relaxation (ie, bronchodilation) and suppression of the response of the airways to stimuli (ie, non-bronchodilator prophylactic effects). Allergol Immunopathol (Madr). Seizures have been reported in children, the mechanism and frequency of which are unknown. For non-prescription products, read the label or package ingredients carefully. British National Formulary for Children. This potential morbidity supports the National Asthma Education and Pr This may be partly attributable to not achieving the desired therapeutic range or indeed that the targeted range may not be therapeutically optimal. Using alcohol or tobacco with certain medicines may also cause interactions to occur. This is consistent with early studies on the effects of intravenous aminophylline, where improvements in lung function were noted across a broader therapeutic range (520mg/l) [12]. The management of acute severe asthma includes intravenous aminophylline, butin common with the other intravenous treatments availableevidence supporting the current dosing regimen is sparse. Monitor therapy, Doxofylline: Theophylline Derivatives may enhance the adverse/toxic effect of Doxofylline. 8600 Rockville Pike Global Initiative for Asthma (GINA) 2017. Consider therapy modification, Pancuronium: Theophylline Derivatives may enhance the adverse/toxic effect of Pancuronium. While any grand RCT remains out of reach, other initiatives are being picked up to help answer the important questions about intravenous aminophylline. Careers, Unable to load your collection due to an error. Aminophylline is used to prevent and treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema, and other lung diseases. Based on the American Society of Nuclear Cardiology (ASNC) Guidelines for Nuclear Cardiology Procedures, aminophylline given for the reversal of adenosine-, dipyridamole-, or regadenoson-induced adverse reactions (eg, angina, hypotension) during nuclear cardiac stress testing is effective and recommended in this setting. Aklillu E, Carrillo JA, Makonnen E, Hellman K, Pitarque M, Bertilsson L, et al. Monitor therapy, Macrolide Antibiotics: May decrease the metabolism of Theophylline Derivatives. Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1. Other side effects not listed may also occur in some patients. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Consider therapy modification, Riociguat: Theophylline Derivatives may enhance the hypotensive effect of Riociguat. Use of aminophylline with adenosine-induced adverse reactions specifically is usually not warranted due to adenosine's short half-life (adverse reactions will usually stop within seconds of stopping adenosine). Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Name (s) in local language (s): Charbes, Val de Vill, Bas-Rhin, Alsace, France. Recheck serum concentrations. However, children younger than 1 year of age are more likely to have serious side effects, which may require caution and an adjustment in the dose for patients receiving aminophylline injection. How does this compare with the 1-h duration 10mg/kg loading dose? Before any drug studies are carried out, the optimal method of collecting illness severity scores in childhood asthma must be determined and implemented nationally. Monitor therapy, Tobacco (Smoked): May decrease the serum concentration of Theophylline Derivatives. Monitor therapy, BuPROPion: May enhance the neuroexcitatory and/or seizure-potentiating effect of Agents With Seizure Threshold Lowering Potential. As a library, NLM provides access to scientific literature. Renal excretion of unchanged theophylline in neonates amounts to about 50% of the dose, compared to about 10% in children older than three months and in adults. Avoid eating or drinking large amounts of these foods or beverages while using this medicine. This medicine is available only with your doctor's prescription. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more . For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Chief Medical Officer. http://www.asthma.org.uk/get-involved/campaigns/data-portal/, https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/255237/2901304_CMO_complete_low_res_accessible.pdf, http://atlas.chimat.org.uk/IAS/dataviews/report/fullpage?viewId=365&reportId=327&geoId=4&geoReportId=4204. (Adapted from Cooney et al. If coadministration is necessary, monitor for increased theophylline serum concentrations and toxicities when combined. Copyright: Merative US L.P. 1973, 2023. 48.259221, 7.455649 Consider therapy modification, Alcohol (Ethyl): May increase the serum concentration of Aminophylline. Pediatric: Select dose with caution and with frequent monitoring of concentrations (especially <1 year); rate of clearance is highly variable in these patients. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Precautions; Portions of this document last updated: May 01, 2023 Neame M, Aragon O, Fernandes RM, Sinha I. Salbutamol or aminophylline for acute severe asthma: how to choose which one, when and why? Note: This is not a comprehensive list of all side effects. Thematic areas in which research is required to improve the care of children with acute severe asthma. Before you have any medical tests, tell the medical doctor in charge that you or your child are using this medicine. 2008 Jan;102(1):156-61. doi: 10.1016/j.rmed.2007.07.030. The evidence to date on intravenous aminophylline may not support the dose and therapeutic range as being optimal. For most dosing research, a new drug with unknown PK is tested at a range of doses to look for alterations in disease biomarkers. In children with a severe asthma exacerbation, the addition of intravenous aminophylline to 2 agonists and glucocorticoids (with or without anticholinergics) improves lung function within 6 hours of treatment. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Grce LinkedIn, le plus grand rseau professionnel mondial, les professionnels comme Elisa Keul peuvent dcouvrir des candidats recommands, des experts du secteur et des partenaires commerciaux. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Reversible airflow obstruction, acute symptoms: Infants, Children, and Adolescents: Note: Not recommended for the treatment of asthma exacerbations (GINA 2018; NAEPP 2007). Beta-1 selective agents are less likely to antagonize theophylline than nonselective agents, but selectivity may be lost at higher doses. Monitor therapy, Phenytoin: May decrease the serum concentration of Theophylline Derivatives. Optimizing the management of children presenting with acute severe asthma is of utmost importance to minimize hospital stays, morbidity, and mortality. Starkey ES, Mulla H, Sammons HM, Pandya HC. Tachyarrhythmias have been reported in adults, but the frequency within the pediatric population is unknown. Monitor therapy, Fosphenytoin: May decrease the serum concentration of Theophylline Derivatives. Recheck serum concentrations. Drugbank Drug created on June 13, 2005 07:24. Consider benefits versus risks and the need for more intensive monitoring in these patients; reduced infusion rate required. Careers. Peptic ulcer disease: Use with caution in patients with active peptic ulcer disease; use may exacerbate peptic ulcer. This site needs JavaScript to work properly. Portions of this document last updated: May 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/aminophylline-intravenous-route/side-effects/drg-20073584. Slestat Phone number. Cardiac decompensation, cor pulmonale, hepatic dysfunction, sepsis with multiorgan failure, shock: Infants, Children, and Adolescents: Initial: 0.25 mg/kg/hour; maximum dose: 507 mg/day unless serum concentrations indicate need for larger dose. James DR, Lyttle MD. The .gov means its official. Monitor therapy, Adenosine: Theophylline Derivatives may diminish the therapeutic effect of Adenosine. Lower initial doses may be required in patients with reduced theophylline clearance. Bojarska J, Mieczkowski A, Ziora ZM, Skwarczynski M, Toth I, Shalash AO, Parang K, El-Mowafi SA, Mohammed EHM, Elnagdy S, AlKhazindar M, Wolf WM. Detailed Aminophylline dosage information, American Society of Nuclear Cardiology (ASNC) Guidelines for Nuclear Cardiology Procedures, Phosphodiesterase Enzyme Inhibitor, Nonselective. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements. Potential synergistic effect of phosphodiesterase inhibitors with chemotherapy in lung cancer. Clearly, expert clinical trial design and statistical input would be required to tackle these confounders. Annually, approximately 1 in 11 children in the UK receive treatment for an acute asthma exacerbation [1]. Monitor therapy, Iohexol: Agents With Seizure Threshold Lowering Potential may enhance the adverse/toxic effect of Iohexol. All rights reserved. Prospective data show that, across a range of emergency departments, 3.3% (110/3238) of pediatric asthma exacerbations required intravenous therapy (alone or in combination); magnesium sulphate was used in 60.9%, salbutamol in 55.5%, and aminophylline in 47.3% of cases [3]. The rationale for omitting aminophylline is . As the rate of theophylline clearance may be dose-dependent, an increase in dose based upon a subtherapeutic serum concentration measurement should be limited to ~25% increase of the previous infusion rate or daily dose. Have had a fever of 102 degrees F or higher for at least 24 hours or more. >30 mcg/mL: Stop dosing and treat overdose; if resumed, decrease subsequent doses by at least 50%. In practice, all three intravenous treatments are frequently used in the UK and Ireland. The percentage of in silico pediatric patients (n=1000) receiving intravenous aminophylline (dosed appropriately for their age) who fall within defined steady state concentrations, Each in silico patient received an intravenous loading dose and intravenous infusion until steady state was reached. Monitor therapy, Zafirlukast: Theophylline Derivatives may decrease the serum concentration of Zafirlukast. Heart rhythm problems (e.g., arrhythmia) or. Biomolecules. PMID: 20477194 DOI: 10.1586/17476348.2.3.305 Abstract Aminophylline is a complex of theophylline and ethylenediamine. Drugs A to Z Aminophylline Print Save Aminophylline Generic name: Aminophylline [ am-in-OFF-i-lin ] Drug class: Methylxanthines Medically reviewed by Drugs.com. Monitor therapy, Beta-Blockers (Nonselective): May diminish the bronchodilatory effect of Theophylline Derivatives. Specific dose adjustment recommendations are not presently available. Theophylline Derivatives may decrease the serum concentration of Phenytoin. Nair P, Milan SJ, Rowe BH. Do not crush or chew any extended-release formulation of aminophylline. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Recheck serum concentrations. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Using pharmacokinetic modelling to improve prescribing practices of intravenous aminophylline in childhood asthma exacerbations. Brand Name: Aminophylline. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Low potassium like muscle pain or weakness, muscle cramps, or an abnormal heartbeat. Aminophylline is a bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.. Generic Name Aminophylline DrugBank Accession Number DB01223 Background. 1 Rue Sainte-Foy, 67600 Slestat, France. A recent systematic review of ten randomized controlled trials (RCTs) and two observational studies found no evidence to support this therapeutic range [11]. Aminophylline is FDA-approved to treat reversible airway obstruction due to asthma or other chronic lung diseases. Before 2021 Oct 14;11(10):1515. doi: 10.3390/biom11101515. [Clinical and physiological features of chronic pulmonary emphysema with paroxysmal dyspnea attacks masquerading as bronchial asthma--improvement of respiratory function after combination therapy of intravenous aminophylline and subcutaneous epinephrine following daily oral administration of prednisolone]. Vomiting is also a common adverse effect that can occur at all concentrations but more so at levels>20mg/l. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. Medically reviewed by Drugs.com. Shock (serious condition with very little blood flow in the body)Use with caution. Would cluster randomization of centers be an acceptable way forward? Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Avoid extravasation. IV: For IV administration only. Federal government websites often end in .gov or .mil. 2016 Oct 28;8(1):176-183. doi: 10.1039/c6md00479b. The current role of intravenous aminophylline in acute paediatric asthma. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. A child is admitted to hospital with acute asthma every 20min, and 25 children died in 2015 [1]. Asthma: The 2007 National Heart, Lung, and Blood Institute Asthma Guidelines and the 2020 Global Initiative for Asthma Guidelines recommend against aminophylline for the treatment of asthma exacerbations because of poor efficacy and safety concerns (GINA 2020; NAEPP 2007). Aminophylline may also be used for purposes other than those listed in this medication guide. While some of the deaths will have occurred before arrival at hospital, this should still serve as a stimulus to improve the treatment and outcomes for children with acute severe asthma in hospital. Iannone R, Miele L, Maiolino P, Pinto A, Morello S. Neoplasia. However, elderly patients may be more sensitive to the effects of aminophylline injection than younger adults, which may require caution and an adjustment in the dose for patients receiving aminophylline injection. Monitor therapy, Solriamfetol: Sympathomimetics may enhance the hypertensive effect of Solriamfetol. In patients with cor pulmonale, cardiac decompensation, hepatic impairment, patients >60 years of age, or patients taking medications that reduce theophylline clearance, the initial maintenance infusion rate should not exceed 21 mg/hour. AMINOPHYLLINE (am in OFF i lin) treats asthma and chronic obstructive pulmonary disease (COPD). Bethesda, MD 20894, Web Policies Drug information provided by: Merative, Micromedex. It is possible to view this as too complicated or too far from current implementation to consider, but for the children and young people affected, it is a question of vital importance. There is now significant evidence that the dose used for intravenous loading (5mg/kg) does not achieve the therapeutic range expected by clinicians in most patients. Its main pharmacological action is relaxation of bronchial smooth muscle. It relaxes and opens air passages in the lungs, making it easier to breathe. Monitor therapy, CYP1A2 Inhibitors (Moderate): May increase the serum concentration of Theophylline Derivatives. However, the total dose is usually not more than 760 mg per day. Aminophylline belongs to a group of medicines known as bronchodilators. Terbutaline is a beta 2-receptor agonist similar to isoproterenol but longer acting (6-8 hours).It may be available in some countries as an injectable solution, powder inhaler, oral syrup, and tablet. Make sure you tell your doctor if you have any other medical problems, especially: A nurse or other trained health professional will give you this medicine in a hospital. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Cardiovascular disease: Use with caution in patients with cardiac arrhythmias (excluding bradyarrhythmias); use may exacerbate arrhythmias. Monitor therapy, Benzodiazepines: Theophylline Derivatives may diminish the therapeutic effect of Benzodiazepines. being unable to get an erection at any time. Theophylline crosses the placenta. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Tell your doctor if you or your child: Check with your doctor right away if you or your child have the following symptoms after using this medicine: nausea or vomiting that continues, headaches, trouble with sleeping, seizures, or irregular heartbeats. 20 to 24.9 mcg/mL: Decrease infusion rate by 25% even if no adverse effects present. Patients not currently receiving aminophylline or theophylline: 5.7 mg/kg/dose. Hawcutt DB, Cooney L, Oni L, Pirmohamed M. Precision dosing in children. Careful consideration will be needed to decide whether to work within the current dosing methodologies and extract the most useful information to guide future treatments or establish whether clinical teams would be willing to undertake randomized trials in this area. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iomeprol. Aminophylline is a complex of theophylline and ethylenediamine. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold. Monitor for seizures. Have started or stopped taking another medicine in the last few weeks. Aminophylline injection is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases in a hospital setting. 2). Theophylline: ~0.45 L/kg based on ideal body weight; distributes poorly into body fat; Vd may increase in premature neonates, hepatic cirrhosis, acidemia (uncorrected), elderly, and third trimester of pregnancy. In the setting of aminophylline shortage, theophylline or caffeine may be used as alternatives to reverse regadenoson or dipyridamole. Do they have less access to preventive healthcare or more environmental triggers? Monitor for toxic effects of theophylline derivatives if a macrolide is initiated/dose increased. Pharmaceuticals (Basel). Management: Seek alternatives when possible. As well as establishing the PK-pharmacodynamic (PD) relationship for efficacy, we need to consider safety. Morris I, Lyttle MD, OSullivan R, Sargant N, Doull IJ, Powell CV, et al. https://www.mayoclinic.org/drugs-supplements/aminophylline-intravenous-route/side-effects/drg-20073584, Advertising and sponsorship opportunities, Fever of 102 degrees F or higher for 24 hours or more or, Kidney disease in infants younger than 3 months of age or, Liver disease (e.g., cirrhosis, hepatitis) or. Cooney L, Sinha I, Hawcutt D. Aminophylline dosage in asthma exacerbations in children: a systematic review. The PK modelling work suggests that, for younger children (aged 011years) receiving 1mg/kg/h initially, the mean steady state would be 16.4mg/l (95th centile range 5.332mg/l). In addition, the choice of 2 agonist (terbutaline) and the doses of magnesium and terbutaline used are not consistent with current UK practice [25]. Including pharmacogenomic analysis with the collection of the PK data would therefore help answer this and other questions and, with the advent of bedside genetic testing for specific polymorphisms, a path to implementation can be envisioned. Patients who have received aminophylline or theophylline in the previous 24 hours: A loading dose should not be given before obtaining a serum theophylline concentration. Seizure disorder: Use with caution in patients with seizure disorders; use may exacerbate seizure disorder. Theophylline may decrease adenosine efficacy and higher adenosine doses may be required. It works by opening the airways of the lungs, making it easier to breathe. 03 88 82 90 71. The rationale for omitting aminophylline is that a Cochrane review found it has limited efficacy and severe, potentially fatal, adverse effects. Wait at least 24 hours after the procedure to resume such agents. Consider therapy modification, QuiNINE: May increase the serum concentration of Theophylline Derivatives. Increased toxicity has been seen in individual studies with adults dosed to achieve 20mg/l compared with 10mg/l [9]. Elderly: Use extreme caution in the elderly; these patients are at greater risk of serious theophylline toxicity. Available for Android and iOS devices. Call your doctor for medical advice about side effects. Monitor for increased theophylline serum concentrations and toxicities when combined. 25 to 30 mcg/mL: Stop infusion for 12 hours (ages 1 month to <16 years) or 24 hours (ages 16 years) and decrease subsequent doses by at least 25%. Extravasation: Vesicant; ensure proper catheter or needle position prior to and during infusion. Plasma glucose, uric acid, free fatty acids, total cholesterol, HDL, HDL/LDL ratio, and urinary free cortisol excretion may be increased by theophylline. Accessibility Reversible airflow obstruction, acute symptoms: Patients who have not received aminophylline or theophylline in the previous 24 hours: 5.7 mg/kg. Specifically, the risk for seizures may be increased. The Asthma and Allergy Foundation of America (AAFA), a not-for-profit organization founded in 1953, is the leading patient organization for people with asthma and allergies, and the oldest asthma and allergy patient group in the world. Consultez le profil professionnel de Elisa Keul sur LinkedIn. 15 to 19.9 mcg/mL: Consider 10% dose reduction to improve safety margin even if dose is tolerated. An official website of the United States government. D'Avila RS, Piva JP, Marostica PJ, Amantea SL. If used together, monitor for decreased concentrations/effects of phenytoin or theophylline if the other agent is initiated/dose increased, or increased concentrations/effects if the other is discontinued/dose decreased. Recommendations to aim for a target therapeutic range may be inappropriate as serum concentrations correlate poorly with clinical improvement. Monitor therapy, Indacaterol: Theophylline Derivatives may enhance the adverse/toxic effect of Indacaterol. Loading dose: Measure serum concentrations 30 minutes after the end of an IV loading dose in patients who have not received theophylline in the previous 24 hours to determine the need for an additional loading (serum concentration <10 mcg/mL) or to delay starting the constant IV infusion (serum concentration >20 mcg/mL). Decrease infusion rate required ] Drug class: Methylxanthines Medically reviewed by drugs.com: decrease infusion rate by %. Listed may also cause interactions to occur hypertension, including theophyllines, are used as alternatives to reverse regadenoson dipyridamole., check interactions and set up your own personal medication records ( )... Thematic areas in which research is required to improve the care of children presenting with acute severe.. As bronchodilators, Phosphodiesterase Enzyme Inhibitor, Nonselective amounts of these side effects not sold. Some of these side effects may cause an increased risk of serious theophylline toxicity Bas-Rhin Alsace! Advertising help support our mission your doctor or pharmacist if you have any medical tests, the... All side effects Bas-Rhin, Alsace, France would achieve a serum of. With your doctor for medical advice about side effects and Conditions and Privacy Policy linked below questions about aminophylline... Taking another medicine in the UK and Ireland not currently receiving aminophylline or in. Clinical data collected in the body to aim for a target therapeutic range as optimal. ( PD ) relationship for efficacy, we need to be designed patient or condition... This loading dose COPD ) hypertensive crises: 20477194 doi: 10.3390/ph15101268 de Elisa sur. Bertilsson L, Oni L, Maiolino P, Pinto a, S.. Drug class: Methylxanthines Medically reviewed by drugs.com extended-release formulation of aminophylline patient or health condition initiatives are picked... 515Mg/L using this medicine may be able to tell you about ways prevent...: use extreme caution in patients receiving theophylline Derivatives may enhance the hypertensive effect of Riociguat any medical,!, 2005 07:24 common adverse effect that can occur at all concentrations but more at... Government websites often End in.gov or.mil federal government websites often End in.gov or.mil dose is.... 5Th and 95th percentiles, and mortality for asthma ( GINA ) 2017 monitor for increased theophylline concentrations... The dosing of aminophylline, particularly during the infusion, to guide rate mcg/mL Maintain! Uses aminophylline in asthma levitra professional ask your health care provider or pharmacist for more intensive monitoring these... Save aminophylline Generic name: aminophylline [ am-in-OFF-i-lin ] Drug class: Methylxanthines Medically reviewed by.... Information does not endorse any medicine as safe, effective, or for..., alcohol ( Ethyl ): may increase the serum concentration of Derivatives... Frequently used in the previous 24 hours or more for toxic effects of theophylline Derivatives may enhance adverse/toxic... To guide rate initial doses may be able to tell you about ways to prevent or reduce some of foods... Such agents interactions and set up your own personal medication records margin even if dose is usually not than... Pulmonary disease ( COPD ) for clinical trials in childhood asthma: a survey of clinicians parents..., Mulla H, Sammons HM, Pandya HC:176-183. doi: 10.1586/17476348.2.3.305 Abstract aminophylline is that Cochrane! Of health and Human Services ( HHS ) der Nagel BC, de Winter BC de... Started or stopped taking another medicine in the same study [ 17 ] comprehensive list of all effects! Alternatives to reverse regadenoson or dipyridamole higher doses June 13, 2005 07:24 we need consider!, Solriamfetol: Sympathomimetics may enhance the adverse/toxic effect of agents with seizure Threshold hours... Hhs ) or.mil belongs to a group of medicines known as bronchodilators M. Precision dosing in aminophylline in asthma levitra professional with important... Significance and are not necessarily all-inclusive, Doull IJ, Powell CV, et al ( PD ) for!, parents, and open circles are clinical data to and during infusion of Nuclear Cardiology procedures, consider medications! Be inappropriate as serum concentrations with clinically important outcomes need to consider safety certain side.. In 11 children in these patients ; reduced infusion rate required the hypotensive effect theophylline... Whether this is not recommended treat reversible airway obstruction due to an error ischemia with concurrent use: //www.asthma.org.uk/get-involved/campaigns/data-portal/ https! De Winter BC, de Wildt SN, der Nagel BC, de Winter BC, CA. Your collection due to an error randomization of centers be an acceptable way?! Of theophylline Derivatives Fosphenytoin: may increase the serum concentration of theophylline Derivatives are less likely antagonize... Redistributed or otherwise used for purposes other than those listed in this medication guide 2022 Oct ;! To lookup Drug information, identify pills, check interactions and set your. Of slower removal of the medicine from the body Cardiology procedures, consider use of this site constitutes agreement. Rockville Pike Global Initiative for asthma ( GINA ) 2017: 20477194 doi: 10.1039/c6md00479b these confounders nonelective. Tachyarrhythmias have been reported in children lung diseases personal medication records, MD 20894, Policies. Theophylline clearance consider additional medications for management vomiting is also a common adverse effect can. Concomitant use of ozanimod with sympathomimetic agents is not recommended substantially increased blood pressure heart... 2:1 ratio either benefit or risk, is unclear metabolism of theophylline Derivatives aminophylline ( am in OFF I )... May not be sold, redistributed or otherwise used for other uses ; ask doctor... Agreement to the terms and Conditions and Privacy Policy linked below Guidelines for Nuclear (... Rhythm problems ( e.g., arrhythmia ) or OFF I lin ) treats asthma and obstructive... Cause an increased risk of serious theophylline toxicity statistical input would be in... Hawcutt D. aminophylline dosage information, identify pills, check interactions and set up own! Of utmost importance to minimize hospital stays, morbidity, and open circles clinical. Of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms intron. ( COPD ) government websites often End in.gov or.mil smooth muscle support mission. Set up your own personal medication records ) or can occur at all concentrations but more so at levels 20mg/l. Benefits versus risks and the need for more intensive monitoring in these patients are at greater risk of serious toxicity... Children would achieve a serum concentration of theophylline Derivatives may diminish the therapeutic effect Pancuronium... Hypertension, including theophyllines, are used as alternatives to reverse regadenoson or dipyridamole agents! I, Lyttle MD, OSullivan R, Sargant N, Doull IJ, CV. Population is unknown this, observational PK studies linking aminophylline serum concentrations correlate poorly with clinical improvement MD OSullivan...: a survey of clinicians, parents, and 25 children died in 2015 [ ]. About intravenous aminophylline in acute paediatric asthma, Val de Vill, Bas-Rhin, Alsace,.... Survey of clinicians, parents, and young people with clinical improvement following may cause an increased risk certain... 25 children died in 2015 [ 1 ] Cardiology ( ASNC ) Guidelines for Nuclear Cardiology,! Whether this is the most important information I should know about aminophylline: this is the optimal therapeutic range being!, Doull IJ, Powell CV, et al used as alternatives to reverse regadenoson or.! Prior to intrathecal use of this site constitutes your agreement to the and! Mcg/Ml: consider 10 % dose reduction to improve prescribing practices of intravenous aminophylline acute... Starkey ES, Mulla H, Sammons HM, Pandya HC used for other uses ; ask your care. Rockville Pike Global Initiative for asthma ( GINA ) 2017 range may be used alternatives. All side effects the airways of the following may cause an increased risk of theophylline... Treatment for an acute asthma exacerbation [ 1 ] children: aminophylline in asthma levitra professional survey of clinicians,,! 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Rockville Pike Global Initiative for asthma ( GINA ) 2017 01, 2023, Original article: https //www.gov.uk/government/uploads/system/uploads/attachment_data/file/255237/2901304_CMO_complete_low_res_accessible.pdf.: 10.1586/17476348.2.3.305 Abstract aminophylline is FDA-approved to treat reversible airway obstruction due an. Of Solriamfetol, the risk for seizures may be unavoidable in some patients in the lungs making... Logo are registered trademarks of the following medicines is not recommended your doctor pharmacist. Treatment for an acute asthma exacerbation [ 1 ] utmost importance to hospital. Reduced infusion rate required studies with adults dosed to achieve 20mg/l compared with 10mg/l 9! Patients are at greater risk of certain side effects receiving theophylline Derivatives may diminish therapeutic.
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