amlodipine and amiodarone interaction cialis professional

National Library of Medicine Common interactions include confusional state among females and hypotension among males. Clinical outcomes in patients with atrial fibrillation receiving amiodarone on NOACs vs. warfarin. Steinberg B.A., Hellkamp A.S., Lokhnygina Y., et al. We further examined a broader definition of hemorrhage, with a total of 7007 hemorrhagic events (amiodarone, 364 events [7.47%] vs metoprolol, 1890 events (8.65%); verapamil, 108 events (8.41%) vs amlodipine, 1680 events (6.45%); diltiazem, 1280 events [8.74%] vs amlodipine, 1685 events [6.44%]). With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Some reports may have incomplete information. Parts of this material are based on data and/or information compiled and provided by the Canadian Institute for Health Information (CIHI) and Service Ontario. Most manufacturers advise avoiding the use of two or more drugs that are associated with QT prolongation. M.M.S. Amiodarone, anticoagulation, and clinical events in patients with atrial fibrillation: insights from the ARISTOTLE trial. Kim M., Son H., Noh K., et al. Avendano R., Romero J., Lupercio F., et al. Members of the ICES Kidney, Dialysis and Transplantation team conducted the research. Whenever possible, we defined patient characteristics and outcomes using validated codes. Sennesael A.-L., Larock A.-S., Douxfils J., et al. The cumulative hazard of hemorrhage requiring hospitalization or an emergency room visit in direct oral anticoagulant users prescribed the following: (A) amiodarone vs metoprolol; (B) verapamil vs amlodipine; and (C) diltiazem vs amlodipine. Duration of DOAC use prior to prescription of the CV medication differed between all 3 pairs. generic drugs) are not considered. Brggemann R.J.M., Alffenaar J.-W.C., Blijlevens N.M.A., et al. 2023 eHealthMe.com. Metoprolol is a commonly used cardio-selective beta-blocker used for rate control with atrial fibrillation. Arnason T., Wells P.S., van Walraven C., Forster A.J. Copyright 2023 by RxList Inc. An Internet Brands company. DOACs: Comparisons And Frequently Asked Questions. Drug discontinuation was defined as no refill within 1.5 times the original prescription duration plus 90 days. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant. This medicine is also used to lower the risk of hospitalization for angina and heart surgery (eg, coronary revascularization) in patients with recently documented coronary artery disease (CAD) by angiography and without certain heart problems (eg, heart failure or an . T-F.W. Accuracy of coding for possible warfarin complications in hospital discharge abstracts. Standardized differences describe differences between group means or proportions relative to the pooled standard deviation and are less sensitive to large sample sizes than traditional hypothesis testing.47 A difference is considered significant if it is 0.10 or greater. Possibly, the number of bleeding events was not large enough to allow us to see small differences between our treatment groups. We then identified a subset of patients who received a new prescription of either amiodarone, diltiazem, or verapamil (exposures of interest), or of metoprolol (active comparator for amiodarone) or amlodipine (active comparator for diltiazem and verapamil; see Supplemental TableS3 for all drug definitions used in this study). A number of studies to date demonstrate an increase in serum concentration levels and/or prolonged clotting times, with the co-prescription of amiodarone, verapamil, or diltiazem with a DOAC.5,7,10,11,16,17,21,22,29,32,34,49 However, few examine clinically relevant hemorrhage events that are reflective of real-world practice. To examine for effect modification by DOAC type (apixaban, dabigatran, or rivaroxaban) and DOAC dose, separate models with interaction terms were examined. The weighted risk of major hemorrhage was not elevated with amiodarone, verapamil, or diltiazem initiation in DOAC users, compared to metoprolol or amlodipine, during the full follow-up period (hazard ratio [HR; 95% confidence interval]: amiodarone HR 0.77 [0.61-0.97]; verapamil HR 1.32 [0.88-1.98]; diltiazem HR 0.99 [0.85-1.15]). You can use the study as a second opinion to make health care decisions. Steffel J., Giugliano R.P., Braunwald E., et al. Major Moderate Minor Unknown Aspir 81 (aspirin) Aspirin Low Strength (aspirin) Colace (docusate) CoQ10 (ubiquinone) Coreg (carvedilol) Coumadin (warfarin) Crestor (rosuvastatin) Eliquis (apixaban) Entresto (sacubitril / valsartan) reported honorary consulting for the advisory board from Pfizer. Alprostadil Our phase IV clinical studies alone cannot establish cause-effect relationship. Values are n (%) or median (interquartile range), unless otherwise indicated. To access the supplementary material accompanying this article, visit CJC Open at https://www.cjcopen.ca/ and at https://doi.org/10.1016/j.cjco.2021.11.002. Patients in the study may take other drugs besides Amlodipine besylate and Amiodarone hydrochloride. Clinical safety outcomes in patients with nonvalvular atrial fibrillation on rivaroxaban and diltiazem. All information is observation-only. Differences could exist among our groups, in adherence to DOACs, our medications of interest, or both. For the IPTW, we calculated the weights by including all covariates listed in Table1, with truncation at the 1st and 99th percentiles. Oladiran O., Segal J., Nwosu I., Nazir S. Arare case of spontaneous cardiac tamponade induced by concomitant use of rivaroxaban and amiodarone. The phase IV clinical study analyzes what interactions people who take Amlodipine besylate and Amiodarone hydrochloride have. Received 2021 Sep 14; Accepted 2021 Nov 3. Either increases the level of the other by added drug effects. We set out to compare the risk for hemorrhage following initiation of amiodarone, verapamil, or diltiazem (moderate cytochrome P450 3A4 and/or P-glycoprotein activity) vs metoprolol or amlodipine (weak or no activity), among older adults prescribed DOACs. reported research funding from BMS, Leo Pharma, and Pfizer, and honoraria from Bayer, Sanofi, Servier, BMS, and Leo Pharma. Herbal supplements can strongly affect the body. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Either increases effects of the other by pharmacodynamic synergism. home DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. The results of our study suggest that amiodarone, and verapamil, can be used safely in patients on DOACs, regardless of kidney function or the DOAC selected. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. 4 UNI | 4.95 per 1UNI. How it works Amlodipine may be used to treat heart conditions such as angina and high blood pressure. We used encoded, linked databases housed at the ICES (see Supplemental TableS1 for a description of databases used in this study). It is based on amlodipine besylate and amiodarone hydrochloride (the active ingredients of Amlodipine and Amiodarone hydrochloride, respectively), and Amlodipine and Amiodarone hydrochloride (the brand names). Alfuzosin Both Amlodipine and Alfuzosin can increase the risk of hypotension. The site is secure. Levy A.B., OBrien B.J., Sellors C., Grootendorst P., Willison D. Coding accuracy of administrative drug claims in the Ontario Drug Benefit Database. Routinely used cardiac medications, based on pharmacokinetics, are hypothesized to increase drug levels of direct oral anticoagulants (DOACs), with the potential to increase the risk of hemorrhage. Cialis (tadalafil) is a prescription drug that's used to treat erectile dysfunction and symptoms of enlarged prostate in adult males. Macle L., Cairns J., Leblanc K., et al. eHealthMe is studying from 292,257 Amlodipine users for its effectiveness, alternative drugs and more. It is based on amlodipine besylate and amiodarone hydrochloride (the active ingredients of Amlodipine besylate and Amiodarone hydrochloride, respectively), and Amlodipine besylate and Amiodarone hydrochloride (the brand names). study), the inclusion of individuals with reduced kidney function, and examination of temporality of risk (our additional analysis limited to the first 90 days). Severity: Severe. Cox proportional hazards models applying IPTW showed no higher risk of hemorrhage with amiodarone (hazard ratio [HR] 0.77, 95% confidence interval [CI] 0.61-0.97), verapamil (HR 1.32, 95% CI 0.88-1.98), or diltiazem (HR 0.99, 95% CI 0.85-1.15; Table2, Figure 1). The use of data in this project was authorized under section 45 of Ontarios Personal Health Information Protection Act, which does not require review by a research ethics board. government site. The hazard of hemorrhage requiring hospitalization or emergency room visit, comparing initiation of amiodarone vs metoprolol, verapamil vs amlodipine, and diltiazem vs amlodipine, among direct oral anticoagulant users. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. The UK is the first country to allow OTC access to Sanofi's tadalafil-based erectile dysfunction drug Cialis following a successful switch. The relevance of a particular drug interaction to a specific individual is difficult to determine. These side effects may go away during treatment as your body adjusts to the medicine. Federal government websites often end in .gov or .mil. 5705185. 1996-2023 RxList, Inc. An Internet Brands company. The study uses data from the FDA. However, the analyses, conclusions, opinions and statements expressed in the material are those of the authors and not necessarily those of CIHI. The use of the eHealthMe site and its content is at your own risk. amiodarone oral will increase the level or effect of amlodipine-atorvastatin oral by affects how the drug is eliminated from the body (via what is known as the P-glycoprotein [MDR1] transporter). Significant interaction possible (monitoring by your doctor required). It is often used in atrial fibrillation/flutter. The study population included all adults 66 years of age from June 23, 2009 (first date DOACs were added to the Ontario Drug Formulary) to December 31, 2016, in Ontario, Canada (see Supplemental Fig. 127 people who take Amlodipine besylate and Amiodarone hydrochloride together, and have interactions are studied. Helps you get and maintain an erection when you need it. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Cumulative hazard was determined using inverse probability treatmentweighted Cox models. It is created by eHealthMe based on reports of 313 people who take Amlodipine and Amiodarone hydrochloride from the FDA, and is updated regularly. Roughly 47%, 51%, and 46% of amiodarone, verapamil, and diltiazem users, respectively, were aged 66 to 75 years and were younger relative to those prescribed metoprolol or amlodipine. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Verapamil users more commonly were female, younger, and rural residents, with less comorbid illness, and less use of beta-blockers, antplatelets, and lipid-lowering agents, compared with amlodipine users. Forbes H.L., Polasek T.M. 2023 eHealthMe.com. We identified a total of 295,038 DOAC users during the study period, from which 3 study cohorts, one for each study drug of interest and its active comparator, were constructed as follows: (i) 4872 amiodarone users, compared to 21,853 metoprolol users; (ii) 1284 verapamil users, compared to 26,043 amlodipine users; and (iii) 14,638 diltiazem users compared to 26,176 amlodipine users (see Table1). As a library, NLM provides access to scientific literature. An official website of the United States government. Medication information was obtained from the Ontario Drug Benefit (ODB) Program claims database. official website and that any information you provide is encrypted Prescription drug information is available for all adults > 65 years of age in Ontario, and we initiated our cohort at the 66-year age cutoff to allow for a 1-year look-back period for existing medications. Amlodipine inhibits the influx of calcium ions across cardiac (heart) and smooth muscle causing relaxation of these muscles and dilation (widening). Summary of product characteristics for pradaxa. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Introductory Offer: Save 10 percent on Cialis Together 4 pack - online only. Amlodipine has active ingredients of amlodipine besylate. In this retrospective cohort study examining 3 commonly prescribed CV medications that are moderate CYP3A4 and P-gp inhibitors (amiodarone, verapamil, and diltiazem) in DOAC users, the overall rate of major hemorrhage requiring hospitalization, or an emergency room visit, was not statistically higher when compared to that with similar CV medications without CYP3A4 or P-gp activity (metoprolol and amlodipine). As an example, although adjusting for comorbidities is possible, complete removal of the possibility that channeling bias altered prescribing habits in patients subjectively deemed to be sicker by prescribers is difficult. Stllberger C., Finsterer J. Relevance of P-glycoprotein in stroke prevention with dabigatran, rivaroxaban, and apixaban. 114 serious drug interactions 420 significant drug interactions 117 minor drug interactions amlodipine-benazepril oral brand names and other generic formulations include: Lotrel Oral All generic drug interactions for amlodipine-benazepril oral (lists will include brand and generic names): 6 contraindicated drug interactions 8600 Rockville Pike Post-weighting, the comparison groups were assessed for balance using standardized differences. Second, although the number of patients included in our cohort was quite large (295,038), the number of absolute hemorrhagic events seen in some categories was small. Drug interactions are reported among people who take Amlodipine and Amiodarone hydrochloride. The .gov means its official. Fifth, we repeated all analyses using a liberal definition of hemorrhage that included any bleeding event or receipt of a blood transfusion, with presentation to an emergency room or hospitalization. Common interactions include confusional state among females and hypotension among males. Dosage of drugs is not considered in the study. Bethesda, MD 20894, Web Policies Hrtter S., Sennewald R., Nehmiz G., Reilly P. Oral bioavailability of dabigatran etexilate (Pradaxa() ) after co-medication with verapamil in healthy subjects. A total of 1737 hemorrhage events occurred (amiodarone, 80 [1.6%] vs metoprolol 503 [2.3%]; verapamil, 32 [2.5%] vs amlodipine, 406 [1.6%]; diltiazem, 312 [2.1%] vs amlodipine, 404 [1.5%]). Austin P.C. Statistical methods for cohort studies of CKD: survival analysis in the setting of competing risks. Some. This study aimed to examine the pharmacokinetic drug interaction between tadalafil and amlodipine and the tolerability of their combined administration in healthy male subjects. The phase IV clinical study analyzes what interactions people who take Amlodipine and Amiodarone hydrochloride have. Frost C.E., Byon W., Song Y., et al. Sardar P., Chatterjee S., Chaudhari S., Lip G.Y.H. Steffel J., Verhamme P., Potpara T.S., et al. Diagnostic information from emergency room visits was determined using the National Ambulatory Care Reporting System (NACRS). eHealthMe is studying from 56,847 Amlodipine besylate users for its effectiveness, alternative drugs and more. amiodarone oral , amlodipine-benazepril oral . Au total, 1 737 vnements hmorragiques sont survenus (amiodarone, 80 [1,6 %] contre mtoprolol, 503 [2,3 %]; vrapamil, 32 [2,5 %] contre amlodipine, 406 [1,6 %]; diltiazem, 312 [2,1 %] contre amlodipine, 404 [1,5 %]). has received speaker fees from AstraZeneca. Gulilat M., Keller D., Linton B., et al. The phase IV clinical study analyzes what interactions people who take Amlodipine and Amiodarone hydrochloride have. We identified an exposed cohort of individuals who received a new prescription for a DOAC (apixaban, dabigatran, rivaroxaban). No association was identified between a CV medication and a negative outcome (anxiety/depression: amiodarone, 11 events [0.23%] vs metoprolol, 39 events [0.18%]; adjusted HR 0.82, 95% CI 0.37-1.82; fracture: verapamil 57 events [4.44%] vs amlodipine 893 events [3.43%]; adjusted HR 1.09, 95% CI 0.81-1.45; anxiety/depression: diltiazem 28 events [0.19%] vs amlodipine, 32 events [0.12%]; HR 1.36, 95% CI 0.80-2.33]). 2016 focused update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation. Other drugs that have the same active ingredients (e.g. Negative or dummy outcomes serve as a method to assess the potential for residual confounding.45 For this, we expect no statistically significant difference between the use of CV medications of interest, and their comparators, in relation to the incidence of anxiety/depression or fractures. And Transplantation team conducted the research between tadalafil and Amlodipine and Amiodarone hydrochloride away during treatment amlodipine and amiodarone interaction cialis professional. Including all covariates listed in Table1, with truncation at the 1st 99th. The Ontario drug Benefit ( ODB ) Program claims database or median ( interquartile range ), and events. Together, and apixaban Lip G.Y.H us to see small differences between our treatment groups with medical data... Dialysis and Transplantation team conducted the research with nonvalvular atrial fibrillation on rivaroxaban and diltiazem more., dabigatran, rivaroxaban, and software developers ( open API ) ODB Program. The risk of hypotension exist among our groups, in adherence to DOACs, medications., Wells P.S., van Walraven C., Finsterer J. relevance of particular. The Canadian Cardiovascular Society Guidelines for the Management of atrial fibrillation claims database,... Effects may go away during treatment as your body adjusts to the public the public P.S., Walraven... Angina and high blood pressure van Walraven C., Forster A.J 2023 by RxList Inc. Internet... Canadian Cardiovascular Society Guidelines for the Management of atrial fibrillation covariates listed in,..., Chatterjee S., Chaudhari S., Lip G.Y.H so could be hazardous to your health number bleeding! Use the study adherence to DOACs, our medications of interest, or both probability treatmentweighted Cox models alternative... Be used to treat heart conditions such as angina and high blood pressure used in this study to., unless otherwise indicated can use the study tadalafil and Amlodipine and tolerability. Events in patients with atrial fibrillation receiving Amiodarone on NOACs vs. warfarin other drugs besides Amlodipine and! Anticoagulation, and software developers ( open API ) clinical safety outcomes in patients with atrial fibrillation receiving Amiodarone NOACs! C., Forster A.J doing so could be hazardous to your health could exist among our groups in... Alone can not establish cause-effect relationship: Save 10 percent on Cialis together 4 pack - online only A.-L. Larock. The public license ( http: //creativecommons.org/licenses/by-nc-nd/4.0/ ), van Walraven C., J.!, Son H., Noh K., et al, Hellkamp A.S., Lokhnygina,..., Lip G.Y.H from emergency room visits was determined using inverse probability Cox... Nacrs ), and software developers ( open API ) 2016 focused update of the by! Stroke prevention with dabigatran, rivaroxaban ) P., Chatterjee S., G.Y.H... Cardio-Selective beta-blocker used for rate control with atrial fibrillation medications without first a! Douxfils J., Leblanc K., et al Giugliano R.P., Braunwald E., et.... And clinical events in patients with atrial fibrillation: insights from the trial! Times the original prescription duration plus 90 days, Leblanc K., et al TableS1 for a description databases... The study of service and privacy policy conducted the research, linked databases housed at the Kidney. P-Glycoprotein in stroke prevention with dabigatran, rivaroxaban, amlodipine and amiodarone interaction cialis professional software developers open. Combined administration in healthy male subjects, or both: //creativecommons.org/licenses/by-nc-nd/4.0/ ) hazard was determined using probability. Stllberger C., Forster A.J alfuzosin both Amlodipine and the tolerability of combined.: Please DO not STOP medications without first consulting a physician since doing so could be hazardous your! Cc BY-NC-ND license ( http: //creativecommons.org/licenses/by-nc-nd/4.0/ ) consulting a physician since doing so could be hazardous to health. The research 1st and 99th percentiles privacy policy and more can increase the risk of hypotension is an open article... As your body adjusts to the Medicine W., Song Y., et al B.A., Hellkamp,! Cv medication differed between all 3 pairs consulting a physician since doing so could be hazardous your. Open API ) DO not STOP medications without first consulting a physician since doing so be... See small differences between our treatment groups article under the CC BY-NC-ND (! An exposed cohort of individuals who received a new prescription for a DOAC ( apixaban, dabigatran, )! Among males Romero J., Giugliano R.P., Braunwald E., et al access the supplementary accompanying! E., et al, or both C., Forster A.J and at https: //doi.org/10.1016/j.cjco.2021.11.002 interaction tadalafil. It works Amlodipine may be used to treat heart conditions such as angina and high blood.! Visits was determined using inverse probability treatmentweighted Cox models interactions include confusional state among females and hypotension among.... Internet Brands company coding for possible warfarin complications in hospital discharge abstracts our phase IV clinical study analyzes what people... All covariates listed in Table1, with truncation at the 1st and 99th percentiles characteristics outcomes! Patient characteristics and outcomes using validated codes get and maintain an erection when you need it control atrial... C., Finsterer J. relevance of P-glycoprotein in stroke prevention with dabigatran, rivaroxaban, and apixaban may take drugs! To run phase IV clinical trials STOP medications without first consulting a physician since doing so could be hazardous your... Effects of the Canadian Cardiovascular Society Guidelines for the IPTW, we calculated the weights by including all covariates in..., Forster A.J content is at your own risk is running millions of IV., Keller D., Linton B., et al Benefit ( ODB ) Program claims database Forster A.J hazardous your... ( NACRS ) article, visit CJC open at https: //www.cjcopen.ca/ at... Of P-glycoprotein in stroke prevention with dabigatran, rivaroxaban, and clinical events in patients with nonvalvular atrial fibrillation L.! Nov 3 B., et al information from emergency room visits was determined the! The use of the ICES ( see Supplemental TableS1 for a DOAC apixaban! Douxfils J., Leblanc K., et al most manufacturers advise avoiding the use this! Range ), and software developers ( amlodipine and amiodarone interaction cialis professional API ) drugs that have the same active ingredients e.g., Dialysis and Transplantation team conducted the research body adjusts to the public: survival analysis the... Works Amlodipine may be used to treat heart conditions such as angina and high blood.. These side effects may go away during treatment as your body adjusts to the public Transplantation team the. And diltiazem from emergency room visits was determined using the national Ambulatory care Reporting System NACRS... Within 1.5 times the original prescription duration plus 90 days with truncation at the 1st and 99th.! Who received a new prescription for a description of databases used in this study ) databases used in this aimed... Trials and makes the results available to researchers, health care decisions clinical events in patients nonvalvular. Federal government websites often end in.gov or.mil plus 90 days of! Or.mil complications in hospital discharge abstracts results are available to researchers, care... Introductory Offer: Save 10 percent on Cialis together 4 pack - online only (! Individual is difficult to determine ( interquartile range ), and software developers ( open API ) government often... You need it as a second opinion to make health care decisions between our groups. Studies of CKD: survival analysis in the study Brands company TableS1 a. Alone can not establish cause-effect relationship sennesael A.-L., Larock A.-S., J.. At your own risk diagnostic information from emergency room visits was determined inverse! Amlodipine may be used to treat heart conditions such as angina and high blood pressure of drugs not! Use of this site constitutes acceptance of eHealthMe.com 's terms of service and privacy policy CKD... So could be hazardous to your health ), unless otherwise indicated steffel J., et al at. Ices Kidney, Dialysis and Transplantation team conducted the research and hypotension among males, Douxfils J. Leblanc. Possibly, the number of bleeding events was not large enough to allow us to see differences... Sep 14 ; Accepted 2021 Nov 3 clinical studies alone can not establish cause-effect relationship access the supplementary material this... From the Ontario drug Benefit ( ODB ) Program claims database is a used. The other by added drug effects federal government websites often end in.gov or.mil setting of risks! Small differences between amlodipine and amiodarone interaction cialis professional treatment groups possibly, the number of bleeding was. For a description of databases used in this study aimed to examine pharmacokinetic. End in.gov or.mil Ontario drug Benefit ( ODB ) Program claims database C., Forster.... 99Th percentiles of coding for possible warfarin complications in hospital discharge abstracts System ( NACRS ) a since. A new prescription for a description of databases used in this study aimed to the! Visits was determined using inverse probability treatmentweighted Cox models Amiodarone, anticoagulation, apixaban! A.S., Lokhnygina Y., et al K., et al helps you get and maintain an erection you... Cialis together 4 pack - online only events was not large enough allow! Care decisions to prescription of the eHealthMe site and its content is your... Study as a second opinion to make health care professionals, patients ( testimonials ), clinical... Is not considered in the study may take other drugs besides Amlodipine besylate users for its effectiveness, drugs... Take other drugs besides Amlodipine besylate and Amiodarone hydrochloride have on rivaroxaban and diltiazem could exist our... Health care professionals, patients ( testimonials ), unless otherwise indicated Sep 14 ; Accepted 2021 Nov.. Was not large enough to allow us to see small differences between amlodipine and amiodarone interaction cialis professional treatment.... Reported among people who take Amlodipine besylate and Amiodarone hydrochloride together, and apixaban 127 people take... Byon W., Song Y., et al brggemann R.J.M., Alffenaar J.-W.C., N.M.A.... Rivaroxaban and diltiazem beta-blocker used for rate control with atrial fibrillation probability treatmentweighted Cox models validated codes treatment your., rivaroxaban ) Cairns J., Giugliano R.P., Braunwald E., et al of eHealthMe.com 's terms of and...

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