In surgery where the occurrence of infection may be particularly devastating (e.g., open-heart surgery and prosthetic arthroplasty), the prophylactic administration of Cefazolin for Injection may be continued for 3 to 5 days following the completion of surgery. Pediatric patients with severe renal impairment (creatinine clearance of 20 to 5 mL/min.) The serum half-life for Cefazolin for Injection is approximately 1.8 hours following IV administration and approximately 2 hours following IM administration. Predominant mechanisms of bacterial resistance to cephalosporins include the presence of extended-spectrum beta-lactamases and enzymatic hydrolysis. Cefazolin for Injection is excreted unchanged in the urine. Cefazolin for Injection is present in very low concentrations in the milk of nursing mothers. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefazolin for Injection, USP and other antibacterial drugs, Cefazolin for Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. In the first 6 hours approximately 60% of the drug is excreted in the urine and this increases to 70% to 80% within 24 hours. The sodium content is 48 mg (2 mEq sodium ion) per 1 gram of cefazolin. All dosage recommendations apply after an initial loading dose. Biliary Tract Infections: Due to E. coli , various strains of streptococci, P. mirabilis, Klebsiella species, and S. aureus. The perioperative use of Cefazolin for Injection may also be effective in surgical patients in whom infection at the operative site would present a serious risk (e.g., during open-heart surgery and prosthetic arthroplasty). Intraperitoneal administration of Cefazolin for Injection is usually well tolerated. Intermittent or continuous infusion: Dilute reconstituted Cefazolin for injection in 50 to 100 mL of 1 of the following solutions: 5% Dextrose in Lactated Ringer's Injection, USP, 5% Dextrose and 0.9% Sodium Chloride Injection, USP, 5% Dextrose and 0.45% Sodium Chloride Injection, USP, 5% Dextrose and 0.2% Sodium Chloride Injection, USP, Invert Sugar 5% or 10% in Sterile Water for Injection. Predominant mechanisms of bacterial resistance to cephalosporins include the presence of extended-spectrum beta-lactamases and enzymatic hydrolysis. Within the Prescription Medications section: Use Trial Bulletin to search for clinical trials involving this product: All MedLibrary.org resources are included in as near-original form as possible, meaning that the information from the original provider has been rendered here with only typographical or stylistic modifications and not with any substantive alterations of content, meaning or intent. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. Caution should be exercised when Cefazolin for injection is administered to a nursing woman. Package insert / product label Generic name: cefazolin sodium Dosage form: injection Drug class: First generation cephalosporins J Code (medical billing code): J0690 (Up to 500 mg, injection) Medically reviewed by Drugs.com. Cefazolin is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. It is the sodium salt of 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-methyl}-8-oxo-7-[2-(1H-tetrazol-1-yl) acetamido]-5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid. The serum half-life for Cefazolin for Injection is approximately 1.8 hours following IV administration and approximately 2 hours following IM administration. are resistant to cefazolin. Studies in patients hospitalized with infections indicate that Cefazolin for Injection, USP produces mean peak serum levels approximately equivalent to those seen in normal volunteers. Cefazolin for injection, USP is a semi-synthetic cephalosporin for parenteral administration. The Romance Retreat will see a group of single parents looking . This site is provided for educational and informational purposes only, in accordance with our Terms of Use, and is not intended as a substitute for the advice of a medical doctor, nurse, nurse practitioner or other qualified health professional. Genital Infections: (i.e., prostatitis, epididymitis) due to E. coli, P. mirabilis, Klebsiella species, and some strains of enterococci. THE INTENT OF THE PHARMACY BULK PACKAGE FOR THIS PRODUCT IS FOR PREPARATION OF SOLUTIONS FOR INTRAVENOUS INFUSION ONLY. Cefazolin for Injection, USP is excreted unchanged in the urine. Cefazolin for Injection . Urinary Tract Infections: Due to E. coli, P. mirabilis, Klebsiella species, and some strains of enterobacter and enterococci. Distributed by Hospira, Inc., Lake Forest, IL 60045 USA, Set id: fae6b455-db4f-4250-a700-794f8a699960, Morganella morganii, Providencia rettgeri, Serratia. The sodium content is approximately 24 mg (1 mEq)/500 mg of cefazolin sodium or approximately 48 mg (2.1 mEq)/1 gram of cefazolin sodium. Septicemia: Due to S. pneumoniae, S. aureus (penicillin-sensitive and penicillin-resistant), P. mirabilis, E. coli and Klebsiella species. Cefazolin for Injection, USP is indicated in the treatment of the following serious infections due to susceptible organisms: Respiratory Tract Infections: Due to S. pneumoniae, Klebsiella species, H. influenzae, S. aureus (penicillin-sensitive and penicillin-resistant), and group A beta-hemolytic streptococci. Below, check out the tour dates, as well as a weird tour . Cefazolin for Injection, USP is white to off-white crystalline powder, supplied in vials equivalent to 500 mg or 1 gram of cefazolin. Urinary Tract Infections: Due to E. coli, P. mirabilis, Klebsiella species, and some strains of enterobacter and enterococci. Directions for Proper Use of Pharmacy Bulk Package. If there are signs of infection, specimens for cultures should be obtained for the identification of the causative organism so that appropriate therapy may be instituted (see DOSAGE AND ADMINISTRATION). Cefazolin for injection is indicated in the treatment of the following serious infections due to susceptible organisms: Respiratory Tract Infections: Due to S. pneumoniae, Klebsiella species, H. influenzae, S. aureus (penicillin-sensitive and penicillin-resistant), and group A beta-hemolytic streptococci. 24 Hazardous Material : No Product Resources : Prescribing Information (422 KB) not to scale Studies in patients hospitalized with infections indicate that cefazolin produces mean peak serum levels approximately equivalent to those seen in normal volunteers. The molecular formula is C14H13N8NaO4S3and molecular weight is 476.49. The drug appears to have no adverse effect on the fetus. Urinary Tract Infections: Due to E. coli, P. mirabilis, Klebsiella species, and some strains of enterobacter and enterococci. The sodium content is 48 mg (2.1 mEq) per 1 gram of cefazolin sodium. CLINICAL PHARMACOLOGY Gram-Negative Bacteria:Escherichia coli Proteus mirabilis. All Rights Reserved. Studies in patients hospitalized with infections indicate that Cefazolin for Injection produces mean peak serum levels approximately equivalent to those seen in normal volunteers. Cefazolin for injection, USP is a sterile, white to yellowish powder. Within the Prescription Medications section: Use Trial Bulletin to search for clinical trials involving this product: All MedLibrary.org resources are included in as near-original form as possible, meaning that the information from the original provider has been rendered here with only typographical or stylistic modifications and not with any substantive alterations of content, meaning or intent. In synovial fluid, the level of Cefazolin for Injection becomes comparable to that reached in serum at about 4 hours after drug administration. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function (see PRECAUTIONS, General and DOSAGE AND ADMINISTRATION). Cefazolin for Injection, USP achieves peak urine concentrations of approximately 2,400 mcg/mL and 4,000 mcg/mL respectively following 500-mg and 1-gram intramuscular doses. Store dry powder at 20 to 25C (68 to 77F) [see USP Controlled Room Temperature]. This package code is originally configured in a 5-4-1 segment 10-digit format and by adding a zero within the original NDC package code we can obtain the converted 11-digit format in a 5-4-2 segment configuration. Written by ASHP. Additional medications in the Prescription Medications section by. Intraperitoneal administration of Cefazolin is usually well tolerated. Methicillin-resistant staphylococci are uniformly resistant to cefazolin. The prophylactic administration of Cefazolin for Injection should usually be discontinued within a 24 hour period after the surgical procedure. Anaphylaxis, eosinophilia, itching, drug fever, skin rash, Stevens-Johnson syndrome. Predominant mechanisms of bacterial resistance to cephalosporins include the presence of extended-spectrum beta-lactamases and enzymatic hydrolysis. Patients with creatinine clearance rates of 11 to 34 mL/min. Intramuscular, Intravenous . For specific information regarding susceptibility test interpretive criteria and associated test methods and quality control standards recognized by FDA for this drug, please see: https://www.fda.gov/STIC. Bone and Joint Infections: Due to S. aureus. Pseudomembranous colitis has been reported with nearly all antibacterial agents, including cefazolin, and may range in severity from mild to life-threatening. Each Pharmacy Bulk Package contains cefazolin sodium equivalent to 10 grams of cefazolin. Reconstituted solutions may range in color from pale yellow to yellow without a change in potency. In surgery where the occurrence of infection may be particularly devastating (e.g., open-heart surgery and prosthetic arthroplasty), the prophylactic administration of Cefazolin for Injection may be continued for 3 to 5 days following the completion of surgery. Each Pharmacy Bulk Package contains, cefazolin sodium equivalent to 10 grams of cefazolin. Women's health is once again the center of a political ping-pong match with evidence-based science on one side and anti-choice advocates on the other. Each ADD-Vantage vial contains, cefazolin sodium equivalent to 1 gram of cefazolin. For the second half of the tour, QOTSA will join forces with likeminded spirits Viagra Boys and with former Savages leader Jehnny Beth. Mean peak levels were 29 mcg/mL (range 13 to 44 mcg/mL) with 50 mg/L (3 patients), and 72 mcg/mL (range 26 to 142 mcg/mL) with 150 mg/L (6 patients). FURTHER DILUTION IS REQUIRED. In surgery where the occurrence of infection may be particularly devastating (e.g., open-heart surgery and prosthetic arthroplasty), the prophylactic administration of cefazolin for injection may be continued for 3 to 5 days following the completion of surgery. This site complies with the HONcode standard for trustworthy health information: verify here. Studies have shown that following intravenous administration of Cefazolin for Injection, USP to normal volunteers, mean serum concentrations peaked at approximately 185 mcg/mL and were approximately 4 mcg/mL at 8 hours for a 1-gram dose. After intramuscular administration of cefazolin for injection to normal volunteers, the mean serum concentrations were 37 mcg/mL at 1 hour and 3 mcg/mL at 8 hours following a 500-mg dose, and 64 mcg/mL at 1 hour and 7 mcg/mL at 8 hours following a 1-gram dose. The sodium content is 24 mg (1.05 mEq) per 500 mg of cefazolin sodium and 48 mg (2.1 mEq) per 1 gram of cefazolin sodium. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefazolin for injection, USP and other antibacterial drugs, Cefazolin for injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Cefazolin for injection, USP is white to off-white crystalline powder. Within the Prescription Medications section: Use Trial Bulletin to search for clinical trials involving this product: All MedLibrary.org resources are included in as near-original form as possible, meaning that the information from the original provider has been rendered here with only typographical or stylistic modifications and not with any substantive alterations of content, meaning or intent. ), Cefazolin for Injection produced mean serum levels of approximately 10 and 30 mcg/mL after 24 hours instillation of a dialyzing solution containing 50 mg/L and 150 mg/L, respectively. CEFAZOLIN- cefazolin sodium injection, powder, for solutionApotex Corp. Cefazolin for Injection, USP is a semi-synthetic cephalosporin for parenteral administration. The INTENT of the tour, QOTSA will join forces with likeminded spirits Viagra Boys with... 1 gram of cefazolin sodium Injection, powder, for solutionApotex Corp. cefazolin for,... 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