Additive anticholinergic effects, possible hypoglycemia. Avoid or Use Alternate Drug. chlorpromazine and glasdegib both increase QTc interval. Contraindicated. Either increases levels of the other by decreasing metabolism. Applies only to oral form of both agents. Serious - Use Alternative (1)propranolol, chlorpromazine. Monitor Closely (1)chlorpromazine and protriptyline both increase sedation. Ask your pharmacist any questions you have about refilling your prescription. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)desflurane and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor.chlorpromazine, yohimbine. Use Caution/Monitor. donepezil transdermal, chlorpromazine. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Monitor Closely (2)chlorpromazine, phentermine. chlorpromazine and gemtuzumab both increase QTc interval. chlorpromazine and shepherd's purse both increase sedation. osimertinib and chlorpromazine both increase QTc interval. Mechanism: unknown. mobocertinib and chlorpromazine both increase QTc interval. Use Caution/Monitor. Drugs used to treat long-term hiccups include baclofen, chlorpromazine and metoclopramide. Before taking chlorpromazine Interaction more likely in certain predisposed pts. Monitor Closely (1)buprenorphine and chlorpromazine both increase sedation. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. chlorpromazine and thiothixene both increase sedation. Additive anticholinergic effects, possible hypoglycemia. clomipramine, chlorpromazine. Avoid taking selinexor with other medications that may cause dizziness or confusion. chlorpromazine increases and formoterol decreases sedation. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects. Use Caution/Monitor.chlorpromazine decreases effects of epinephrine racemic by pharmacodynamic antagonism. Limit dosages and durations to the minimum required. Use Caution/Monitor. Interaction more likely in certain predisposed pts. only. Chlorpromazine may interfere with the results of home pregnancy tests. Use Caution/Monitor. Monitor Closely (1)chloral hydrate and chlorpromazine both increase sedation. Chlorpromazine comes as a tablet to take by mouth. amisulpride, chlorpromazine. Minor/Significance Unknown. Monitor for evidence of ventricular arrhythmias during concomitant use. Use Caution/Monitor.chlorpromazine increases effects of tolterodine by pharmacodynamic synergism. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and droperidol both increase QTc interval. Avoid or Use Alternate Drug. Sickness (nausea) associated with advanced or terminal illnesses. Minor/Significance Unknown. Monitor Closely (1)chlorpromazine and citalopram both increase QTc interval. Use Caution/Monitor. restrictions. Use Caution/Monitor. Use Caution/Monitor. Not all beta blockers share this interaction (e.g., atenolol, nadolol, sotalol do not interact). Monitor Closely (1)clonazepam and chlorpromazine both increase sedation. Monitor Closely (2)clobazam will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Minor/Significance Unknown. diphenhydramine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Coadministration of photosensitizing drugs may enhance the phototoxic reaction to photodynamic therapy with aminolevulinic acid. chlorpromazine and trifluoperazine both increase QTc interval. Monitor Closely (1)methoxsalen, chlorpromazine. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor.chlorpromazine increases effects of anticholinergic/sedative combos by pharmacodynamic synergism. Either increases effects of the other by QTc interval. Either increases effects of the other by pharmacodynamic synergism. chlorpromazine and fluoxetine both increase QTc interval. chlorpromazine and risperidone both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. chlorpromazine and maprotiline both increase QTc interval. Monitor Closely (1)chlorpromazine and moxonidine both increase sedation. Monitor closely for signs of respiratory depression and sedation. Monitor Closely (1)chlorpromazine and papaverine both increase sedation. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended. chlorpromazine and haloperidol both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Use Caution/Monitor. Minor/Significance Unknown. Serious - Use Alternative (1)vemurafenib and chlorpromazine both increase QTc interval. Use Caution/Monitor. Effect of interaction is not clear, use caution. Mechanism: unknown. For the past 6 hours his hiccups have persisted; because you are the doctor on call, you are contacted by the ward nurse. Minor/Significance Unknown. D/C phenothiazine 24h before admin. Persistent hiccups are a frustrating experience for palliative care patients, and can have a profound impact on their quality of life. #81 Management of Hiccups Chad Farmer MD Download PDF Background Hiccups (singultus) are an involuntary reflex involving the respiratory muscles of the chest and diaphragm, mediated by the phrenic and vagus nerves and a central (brainstem) reflex center. Effect of interaction is not clear, use caution. chlorpromazine and ziconotide both increase sedation. Use Caution/Monitor. Use Caution/Monitor.chlorpromazine and prochlorperazine both increase sedation. Use Caution/Monitor. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. Modify Therapy/Monitor Closely.methadone and chlorpromazine both increase sedation. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. Monitor Closely (2)chlorpromazine, diethylpropion. Avoid or Use Alternate Drug. This medication is given in a hospital or clinic or doctor's office and will not be stored at home. and formulary information changes. Mechanism: unknown. Monitor Closely (1)chlorpromazine and topiramate both increase sedation. Comment: Phenothiazines may increase blood glucose concentrations. only. Use Caution/Monitor. Monitor Closely (2)chlorpromazine and thiothixene both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Either increases levels of the other by decreasing metabolism. Use Caution/Monitor. Make sure lab personnel and all your doctors know you use this drug. Use Caution/Monitor.diphenhydramine decreases levels of chlorpromazine by inhibition of GI absorption. For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. Modify Therapy/Monitor Closely. Your doctor will probably tell you not to take chlorpromazine for 2 days before the myelogram and for one day after the myelogram. Interaction more likely in certain predisposed pts. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine buccal and chlorpromazine both increase QTc interval. Minor/Significance Unknown. Monitor Closely (3)pancuronium decreases levels of chlorpromazine by inhibition of GI absorption. Use Caution/Monitor. Monitor Closely (3)chlorpromazine increases effects of atropine IV/IM by pharmacodynamic synergism. unspecified interaction mechanism. Avoid or Use Alternate Drug. Mechanism: unknown. carisoprodol and chlorpromazine both increase sedation. You may report side effects to Health Canada at 1-866-234-2345. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug.Minor (1)amiodarone will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. chlorpromazine decreases effects of levodopa inhaled by pharmacodynamic antagonism. Mechanism: unknown. Either increases effects of the other by sedation. chlorpromazine decreases effects of apomorphine by pharmacodynamic antagonism. Applies only to oral form of both agents. Use Caution/Monitor. chlorpromazine, serdexmethylphenidate/dexmethylphenidate. azelastine and chlorpromazine both increase sedation. Use Caution/Monitor. Monitor Closely (1)difenoxin hcl and chlorpromazine both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. capecitabine and chlorpromazine both increase QTc interval. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Effect of interaction is not clear, use caution. Consider dose reduction of either or both agents to avoid serious adverse effects. Use Caution/Monitor. Minor/Significance Unknown. chlorpromazine increases and propylhexedrine decreases sedation. Monitor Closely (1)chlorpromazine and trimethoprim both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)asenapine and chlorpromazine both increase QTc interval. Comment: Phenothiazines may increase blood glucose concentrations. primaquine and chlorpromazine both increase QTc interval. Effect of interaction is not clear, use caution. Monitor Closely (1)saquinavir, chlorpromazine. Monitor Closely (1)ketamine and chlorpromazine both increase sedation. Mechanism: unknown. ribociclib increases toxicity of chlorpromazine by QTc interval. Use Caution/Monitor. Take at least 2 hours before and not less than 6 hours after administration of sodium picosulfate, magnesium oxide and anhydrous citric acid to avoid magnesium chelation. Your doctor may decrease your dose once your condition is controlled. sorafenib and chlorpromazine both increase QTc interval. Use Caution/Monitor.Minor (1)chlorpromazine increases toxicity of atropine IV/IM by unknown mechanism. Potential for additive anticholinergic effects. chlorpromazine and lofexidine both increase sedation. Mechanism: unknown. nilotinib will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. A quick Internet search of treating hiccups yields more than 70 000 sites. Use Caution/Monitor. Minor/Significance Unknown. Serious - Use Alternative (1)chlorpromazine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Use Caution/Monitor. chlorpromazine increases effects of pralidoxime by pharmacodynamic synergism. 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