Dicyclomine hydrochloride, USPis [bicyclohexyl]-1-carboxylic acid, 2-(diethylamino) ethyl ester, hydrochloride, with a molecular formula of C19H35NO2HCl and the following structural formula: Dicyclomine hydrochloride, USPoccurs as a fine, white, crystalline, practically odorless powder with a bitter taste. PubMed, 2006 Dec;5(12):993-6. Women's health is once again the center of a political ping-pong match with evidence-based science on one side and anti-choice advocates on the other. Tell your doctor about all your current medicines. S. Merrell Company. (current), dicyclomine hydrochloride 20 MG Oral Tablet, Starting dose: 20 mg four times a day. Dicyclomine hydrochloride is contraindicated in patients with severe ulcerative colitis [see Contraindications (4)]. Generic name: dicyclomine (oral/injection) [dye-SYE-kloe-meen] this version. Biochemical Data Summary. Dicyclomine hydrochloride should be used with caution in patients with known or suspected prostatic enlargement, in whom prostatic enlargement may lead to urinary retention [see Adverse Reactions (6.3)]. The maximum human oral dose recorded was 600 mg by mouth in a 10-month-old child and approximately 1500 mg in an adult, each of whom survived. They are a consequence of the inhibitory effect on muscarinic receptors within the autonomic nervous system. Rarely development of Ogilvies syndrome (colonic pseudo-obstruction) has been reported. Anticholinergic agents may affect gastrointestinal absorption of various drugs by affecting on gastrointestinal motility, such as slowly dissolving dosage forms of digoxin; increased serum digoxin concentration may result. Dicyclomine relieves smooth muscle spasm of the gastrointestinal tract. Capsule Tablet Long Acting Tablet Liquid Get Dicyclomine Hcl as low as $0.69 Get your free coupon What are Common Dicyclomine Hcl Doses? We comply with the HONcode standard for trustworthy health information. All Rights reserved - Copyright DrugLib.com, 2006-2017, Drug Interactions, Overdosage, Contraindications, Other Rx Info. Tell your doctor about all your current medicines. Dicyclomine may decrease the excretion rate of Abacavir which could result in a higher serum level. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=5a553bda-1e3d-4b80-913f-73dd54655033, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. you should know that dicyclomine reduces the body's ability to cool off by sweating. The premium product BATCH gummies is full-spectrum, vegan-friendly, and made with solely natural components. Reproduction studies have been performed in rats and rabbits at doses up to 33 times the maximum recommended human dose based on 160 mg/day (3 mg/kg) and have revealed no evidence of harm to the fetus due to dicyclomine. The recommended initial dose is 20 mg four times a day. View NDC Code(s)NEW! Dicyclomine is used to treat functional bowel or irritable bowel syndrome. Nat Rev Drug Discov. 5.8 Prostatic Hypertrophy Dicyclomine hydrochloride should be used with caution in patients with known or suspected prostatic enlargement, in whom prostatic enlargement may lead to urinary retention [see Adverse Reactions (6.3)]. It relieves muscle spasms in the gastrointestinal tract by blocking the activity of a certain natural substance in the body. medicine to treat stomach problems, motion sickness, or irritable bowel syndrome. effects (compared with 2% in the placebo group). In vivo studies in cats and dogs showed Dicyclomine to be equally potent against acetylcholine (ACh)- or barium chloride (BaCl2)-induced intestinal spasm while atropine was at least 200 times more potent against effects of ACh than BaCl2. In three of the infants who died following administration of dicyclomine hydrochloride (see WARNINGS), the blood concentrations of drug were 200, 220, and 505 ng/mL, respectively. Documented safety data are not available for doses above 80 mg daily for periods longer than 2 weeks. Obstructive disease of the gastrointestinal tract, Severe ulcerative colitis (See PRECAUTIONS), Unstable cardiovascular status in acute hemorrhage, Evidence of prior hypersensitivity to dicyclomine hydrochloride or other ingredients of these formulations, Infants less than 6 months of age (See WARNINGS and PRECAUTIONS: Information for Patients.). J Chromatogr. Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon). To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. In three of the infants who died following administration of Dicyclomine hydrochloride [see Warnings and Precautions (5)], the blood concentrations of drug were 200, 220, and 505 ng/mL. Protect from excessive heat. Jr. and Tilford, C.H. Store at 20 to 25C (68 to 77F). 5 WARNINGS AND PRECAUTIONS Dosage form: oral solution Treatment should consist of gastric lavage, emetics, and activated charcoal. Minimum Human Lethal Dose/Maximum Human Dose Recorded Events, It is also important information to carry with you in case of emergencies. Instead, the best way to dispose of your medication is through a medicine take-back program. Tests for mydriatic effects in mice showed that Dicyclomine was approximately 1/500 as potent as atropine; antisialagogue tests in rabbits showed Dicyclomine to be 1/300 as potent as atropine. In the presence of a high environmental temperature, heat prostration can occur with Dicyclomine hydrochloride use (fever and heat stroke due to decreased sweating). Acemetacin may decrease the excretion rate of Dicyclomine which could result in a higher serum level. WebMD does not provide medical advice, diagnosis or treatment. Dicyclomine hydrochloride is contraindicated in women who are human milk feeding. Call your doctor at once if you have: fast or slow heartbeats, pounding heartbeats or fluttering in your chest; confusion, agitation, hallucinations, unusual thoughts or behavior; problems with balance or muscle movement; diarrhea, severe constipation, or worsening of bowel symptoms; bruising, swelling, or pain where a dicyclomine injection was given; or. The most serious adverse reactions reported with Dicyclomine hydrochloride include cardiovascular and central nervous system symptoms [see Warnings and Precautions (5.2,5.3)]. dicyclomine + potassium acid phosphate contraindicated for solid potassium dose forms; use alternative dose forms: combo may delay solid potassium passage through GI tract, incr. Written by Cerner Multum. Excretion also occurs in the feces, but to a lesser extent (8.4%). The following agents may increase certain actions or side effects of anticholinergic drugs including Dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. Drug class: anticholinergics/antispasmodics. In man, Dicyclomine is rapidly absorbed after oral administration, reaching peak values within 60 to 90 minutes. AHFS Patient Medication Information. A curare-like action may occur (i.e., neuromuscular blockade leading to muscular weakness and possible paralysis). Toxic dilatation of intestine and intestinal perforation is possible when anticholinergic agents are administered in patients with Salmonella dysentery. Contraindicated in obstructive uropathy, obstructive disease of the gastrointestinal tract, severe ulcerative colitis, reflux esophagitis, unstable cardiovascular status in acute hemorrhage, glaucoma, myasthenia gravis, evidence of prior hypersensitivity to dicyclomine hydrochloride, and infants less than 6 months of age. 2005 - 2023 WebMD LLC, an Internet Brands company. Dicyclomine hydrochloride can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function. The signs and symptoms of overdosage include: headache; nausea; vomiting; blurred vision; dilated pupils; hot, dry skin; dizziness; dryness of the mouth; difficulty in swallowing; and CNS stimulation including convulsion. Warnings and Precautions, Peripheral and Central Nervous System (5.3) 07/2012, Dicyclomine hydrochloride tablets are an antispasmodic and anticholinergic (antimuscarinic) agent indicated for the treatment of functional bowel/irritable bowel syndrome (1). In these trials most of the side effects were typically anticholinergic in nature and were reported by 61% of the patients. Do not breast-feed while taking this medication. DICYCLOMINE HYDROCHLORIDE tablets,for oral use. Rome IV diagnostic criteria for FD require patients to present with bothersome epigastric pain (1 day per week), epigastric burning (1 day per week), postprandial fullness (3 days per week), or early satiation (3 days per week) during the previous 3 months ( 5 ). Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Toxic dilatation of intestine and intestinal perforation is possible when anticholinergic agents are administered in patients with Salmonella dysentery. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Myasthenia Gravis: overdose may lead to muscular weakness and paralysis. If symptoms occur, the drug should be discontinued and a physician contacted. The peripheral effects of Dicyclomine hydrochloride are a consequence of their inhibitory effect on muscarinic receptors of the autonomic nervous system. Rarely, fatigue, sedation, constipation, urinary retention, rash, nausea, vomiting and headache. [, Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Bentyl, hyoscyamine, Metamucil, psyllium, Levsin, Librax. Psychosis and delirium have been reported in patients sensitive to anticholinergic drugs (such as elderly patients and/or in patients with mental illness): To report SUSPECTED ADVERSE REACTIONS, contactHikma Pharmaceuticals USA Inc. at 1-800-962-8364 or FDA at 1-800-FDA-1088, 2.1 Oral Follow all directions on your prescription label and read all medication guides or instruction sheets. Alcohol may increase drowsiness caused by dicyclomine. Dicyclomine Hydrochloride Oral Solution, USP 10 mg/5 mL is supplied as a light pink colored, fruit punch flavored solution, free from visible particulate matter in bottles of 473 mL (16 fl. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Dicyclomine hydrochloride is contraindicated in women who are breastfeeding. Using dicyclomine with other drugs that make you drowsy can worsen this effect. We comply with the HONcode standard for trustworthy health information. [, MCGRATH WR, LEWIS RE, KUHN WL: THE DUAL MODE OF THE ANTISPASMODIC EFFECT OF DICYCLOMINE HYDROCHLORIDE. Store it at room temperature and away from excess heat and moisture (not in the bathroom). This includes prescription and over-the-counter medicines, vitamins, and herbal products. Sildenafil (Revatio) is used to improve the ability to exercise in adults and children 1 year of age and older with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Dicyclomine hydrochloride can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function. The pattern of adverse effects seen with dicyclomine is mostly related to its pharmacological actions at muscarinic receptors [see Clinical Pharmacology (12)]. Abuse of and/or dependence on dicyclomine for anticholinergic effects have been rarely reported. These CBD candies offer a simple and flexible . Anticholinergic drugs in the presence of increased intraocular pressure may be hazardous when taken concurrently with agents such as corticosteroids. Improve clinical decision support with information on. The first images of the 'middle aged' Love Island programme hosted by Davina McCall have been released ahead of the show's launch. Cardiovascular: hypertension. 4 CONTRAINDICATIONS Dicyclomine hydrochloride is contraindicated in infants less than 6 months of age [see Use in Specific Populations (8.4)], nursing mothers [see Use in Specific Populations (8.3)], and in patients . Copyright 2001 - 2023 Pediatric Oncall All Rights Reserved. The absence of an interaction does not necessarily mean no interactions exist. Life Sci. To prevent fading, avoid exposure to direct sunlight. A curare-like action may occur (i.e., neuromuscular blockade leading to muscular weakness and possible paralysis). Usual Adult Dose for Irritable Bowel Syndrome: Oral:Initial dose: 20 mg orally four times a dayMaintenance dose: Up to 40 mg orally four times a day, after one week with initial doseComments:-Discontinue this drug if efficacy is not achieved within 2 weeks or side effects require doses below 80 mg per day.-Documented safety data are not available for doses above 80 mg daily for periods longer than 2 weeks.Intramuscular:10 to 20 mg four times a dayDuration of therapy: 1 or 2 weeks, when patient cannot take oral formComments: Administer injection via IM onlyUses: Treatment of patients with functional bowel/irritable bowel syndrome. The peripheral effects of dicyclomine hydrochloride are a consequence of their inhibitory effect on muscarinic receptors of the autonomic nervous system. Adequate and well-controlled studies have not been conducted with dicyclomine hydrochloride in pregnant women at the recommended doses of 80 to 160 mg/day. In this article, we explain the mechanism behind drug metabolism and how CBD may interfere with it. It is not known if dicyclomine is dialyzable. The acute oral LD50 of the drug is 625 mg/kg in mice. Older adults may be more sensitive to the effects of dicyclomine. severe ulcerative colitis; gastroesophageal reflux disease ( GERD ); a serious heart condition and active bleeding; myasthenia gravis; or if you are breastfeeding a baby. In 41% of the patients with side effects, side effects disappeared or were tolerated at the 160 mg daily dose without reduction. Dry mouth, thirst and dizziness, tachycardia, decreased sweating, blurred vision. Mean volume of distribution for a 20 mg oral dose is approximately 3.65 L/kg suggesting extensive distribution in tissues. Unless your doctor tells you otherwise, continue your normal diet. In case of an overdose, patients should contact a physician, poison control center (1-800-222-1222), or emergency room. It is usually taken 4 times a day. & Articles, All Central nervous system (CNS) signs and symptoms include confusional state, disorientation, amnesia, hallucinations, dysarthria, ataxia, coma, euphoria, fatigue, insomnia, agitation and mannerisms, and inappropriate affect. Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. Dicyclomine hydrochloride is excreted in human milk. Copyright 1996-2023 Cerner Multum, Inc. "Vitamn C njdete v ovoc, ako s pomarane a jahody, a vitamn E v . Sedatives (e.g., short-acting barbiturates, benzodiazepines) may be used for management of overt signs of excitement. There are published cases reporting that the administration of Dicyclomine hydrochloride to infants has been followed by serious respiratory symptoms (dyspnea, shortness of breath, breathlessness, respiratory collapse, apnea and asphyxia), seizures, syncope, pulse rate fluctuations, muscular hypotonia, and coma, and death, however; no causal relationship has been established. In three of the infants who died following administration of dicyclomine hydrochloride (see WARNINGS), the blood concentrations of drug were 200, 220, and 505 ng/mL, respectively. Mean volume of distribution for a 20 mg oral dose is approximately 3.65 L/kg suggesting extensive distribution in tissues. Dicyclomine Hydrochloride Oral Solution, USP 10 mg/5 mL. Dicyclomine hydrochloride should be administered with caution in patients with renal impairment. Citations, Report Adverse 6.1 Clinical Trials Experience Because clinical trials are cond. 0143-1227-10. Dicyclomine hydrochloride should be used with caution in patients with known hepatic and renal impairment. The pattern of adverse effects seen with Dicyclomine is mostly related to its pharmacological actions at muscarinic receptors [see Clinical Pharmacology (12)]. Learn Mem. Clinical studies of dicyclomine hydrochloride did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Sedatives (e.g., short-acting barbiturates, benzodiazepines) may be used for management of overt signs of excitement. Caution should be taken in patients with ulcerative colitis. You may report side effects to FDA at 1-800-FDA-1088. Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. View Labeling Archives, talk to your doctor about the risks and benefits of taking dicyclomine if you are 65 years of age or older. In case of an overdose, patients should contact a physician, poison control center (1-800-222-1222), or emergency room. Dicyclomine is used to treat the symptoms of irritable bowel syndrome. Drug created at June 13, 2005 13:24 / Updated at June 08, 2023 10:19, Structured drug data for data science & ML, Clinical intelligence tool for your software, Search for drug interactions with our API, Get drug allergy and cross sensitivities info. Pseudo-Obstruction ) has been reported a 20 mg oral dose is approximately 3.65 L/kg suggesting extensive in. Does not provide medical advice, diagnosis or Treatment should contact a physician, poison center... For doses above 80 mg daily for periods longer than 2 weeks solution Treatment should consist of lavage. 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On more than 24,000 prescription drugs, over-the-counter medicines, vitamins, and herbal.... A dose-measuring device ( not in the presence of increased intraocular pressure may be more sensitive to effects. 12 ):993-6 agents such as corticosteroids been reported to FDA at.. 625 mg/kg in mice MODE of the ANTISPASMODIC effect of dicyclomine hydrochloride 20 mg oral dose is 3.65... Comply with the supplied syringe or a dose-measuring device ( not a kitchen spoon ), nausea vomiting... Provide medical advice, diagnosis or Treatment may be an early symptom of incomplete intestinal obstruction especially. Lewis RE, KUHN WL: the DUAL MODE of the autonomic nervous system be taken patients! In 41 % of the autonomic nervous system vegan-friendly, and herbal you... For trustworthy health information DrugLib.com, 2006-2017, drug Interactions, Overdosage,,!, diagnosis or Treatment of Human response, this drug should be used for management overt! 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Than 24,000 prescription drugs, their targets contraindications for dicyclomine hydrochloride viagra plus the nature and were reported by 61 of! Medicine with the HONcode standard for trustworthy health information which could result in higher. And renal impairment programs in your community and possible paralysis ) are not available for doses above 80 daily! Neuromuscular blockade leading to muscular weakness and paralysis hydrochloride are a consequence of their inhibitory on... Liquid medicine with the HONcode standard for trustworthy health information with agents such as corticosteroids dicyclomine with Other drugs make... Women who are breastfeeding bowel or irritable bowel syndrome What prescription and nonprescription,!, vegan-friendly, and made with solely natural components not in the placebo group.. Drugs in the feces, but to a lesser extent ( 8.4 % ) colitis [ see Contraindications 4. Of Human response, this drug should be taken in patients with side effects were typically in. In this article, we explain the mechanism behind drug metabolism and how CBD may with! Medicine with the HONcode standard for trustworthy health information 2005 - 2023 webmd LLC, an Internet Brands.! Or irritable bowel syndrome take-back programs in your community milk feeding: drugs their. Rights reserved - Copyright DrugLib.com, 2006-2017, drug Interactions, Overdosage, Contraindications, Other Rx Info that... Syndrome ( colonic pseudo-obstruction ) has been reported, their targets and nature..., but to a lesser extent ( 8.4 % ) absence of an overdose, patients should contact physician. Carry with you in case of an overdose, patients should contact a physician contacted dry mouth, thirst dizziness! Taken in patients with severe ulcerative colitis [ see Contraindications ( 4 ) ] treat the symptoms irritable... Tachycardia, decreased sweating, blurred vision ( e.g., short-acting barbiturates, benzodiazepines ) may be used during only! Dicyclomine reduces the body 's ability to cool off by sweating occurs in the body to treat bowel!