Drug created at June 13, 2005 13:24 / Updated at June 08, 2023 10:20, Structured drug data for data science & ML, Clinical intelligence tool for your software, Search for drug interactions with our API, Get drug allergy and cross sensitivities info. Disclaimer. The 169 patients are from 23 different hemophilia treatment centers. official website and that any information you provide is encrypted de la Fuente B, Kasper C, Rickles F, Hoyer L. Response of patients with mild and moderate hemophilia A and von Willebrands disease to treatment with desmopressin. These effects probably result from increases in FVIII:C and VWF, both of which play a rate-accelerating role in these global tests of intrinsic coagulation and primary haemostasis10. Table 1.Baseline characteristics and 1-Deamino-8-D-ArgininVasoPressin (desmopressin; DDAVP) response in moderate patients. *Reason for treatment was unknown for one patient. Using DDAVP, and thereby avoiding FVIII concentrates, has two important advantages: depending on the country, DDAVP is much cheaper than FVIII concentrate, and DDAVP does not carry the risk of inhibitor development associated with the use of exogenous (allogeneic) sources of FVIII present in concentrates.31, DDAVP is a synthetic vasopressin analogue and can be administered intravenously, subcutaneously or intranasally. This activity leads to a decrease in urine volume and an increase in urine osmolality. Stoof et al. The aim of the RISE project was to assess the predictive value of clinical and genetic factors on the DDAVP response in non-severe HA patients. This activity reviews the indications, mechanism of action, contraindications, and adverse effects. Hence, patients may have already released some of their stored VWF due to stress, with with less potential for VWF to rise further with DDAVP. This leads to exocytosis of VWF and t-PA from endothelial cell Weibel-Palade bodies where VWF and t-PA are stored 11. and 17 patients from the study conducted by Stoof et al. Desmopressin shortens the prolonged activated partial thromboplastin time (APTT) and the bleeding time. 2013 Feb:14(2):203-9. doi: 10.1097/PCC.0b013e31827127b5. -, Fein S, Herschkowitz S. Low-Dose Desmopressin Nasal Spray and FDA Approval. Br J Clin Pharmacol. Eur J Pharmacol. Moreover, VWF was not studied as a potential determinant and the outcome variable which was principally studied was peak FVIII:C. In addition to the peak FVIII:C, the incremental response (proportional rise) may reveal important information on the biological mechanisms underlying DDAVP response, with possibly different predictors. Stress is known to increase endogenous FVIII:C and VWF. Vivaldi P, Savino M, Mazzon C, Rubertelli M. A hemorrhagic syndrome of the elderly patient caused by anti-factor VIII antibodies. On This Page Boxed Warning Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Accessibility National Library of Medicine sharing sensitive information, make sure youre on a federal [23] Symptoms of hyponatremia include nausea, confusion, or altered mental status. Table 5.Previous studies on 1-Deamino-8-D-ArgininVasoPressin (desmopressin; DDAVP) response in moderate hemophilia A (HA) patients. Thus, our systematic review shows that a low inhibitor titre (<5 BU) and a residual FVIII:C level greater than 5% were predictive of a clinical response to DDAVP in patients with acquired haemophilia A. Participating centers (listed in the Online Supplementary Appendix) were located in Canada, Australia and ten European countries. Genotype was known in 107 patients (63%). The use of intranasal desmopressin in bleeding dis-orders has been reported in the literature. Call 866-755-2121, Home | Privacy Policy & Terms of Use | Contact Us. Although FVIII:C levels increased by approximately 6-fold over the mean basal level, the increment was short-lived and additional infusions at 24-hour intervals failed to elicit an increase of FVIII:C because of tachyphylaxis. Groth CG, Hathaway WE, Gustafsson A. Desmopressin nasal spray for hemophilia A and type I von Willebrand disease. This team will include clinicians, specialists, mid-level practitioners, nurses, and pharmacists, coordinating their activities and sharing information to achieve the best patient outcomes. Desmopressin induces an increase in plasma levels of VWF, FVIII, and tissue plasminogen activator (t-PA) and also has a vasodilatory effect. Discovery of Potent, Selective, and Short-Acting Peptidic V2 Receptor Agonists. Franchini M, Gandini G, Di Paolantonio T, et al. High-dose DDAVP intranasal spray (Stimate) for the prevention and treatment of bleeding in patients with mild haemophilia A, mild or moderate type 1 von Willebrand disease and symptomatic carriers of haemophilia A. Gill JC, Ottum M, Schwartz B. ISSN 0390-6078 print | ISSN 1592-8721 online. -, Konkle BA, Nakaya Fletcher S. Hemophilia A. Desmopressin is contraindicated in patients at increased risk of severe hyponatremia, such as patients with excessive fluid intake, illnesses that can cause fluid or electrolyte imbalances, and in those using loop diuretics or systemic or inhaled glucocorticoids. Baseline characteristics and 1-Deamino-8-D-ArgininVasoPressin (desmopressin; DDAVP) response in moderate patients. 1-Deamino-8-D-arginine vasopressin in the treatment of non-haemophilic patients with acquired factor VIII inhibitor. Nocdurna, or desmopressin acetate, was approved by the FDA on June 21st, 2018 for the treatment of nocturia due to nocturnal polyuria in adults. [1], The intranasal form of vasopressin is frequently a choice when administration occursat home. This study was conducted in accordance with the Declaration of Helsinki. ED is often a symptom of another health problem or health-related factor. Prospective multicenter study on subcutaneous concentrated desmopressin for home treatment of patients with von Willebrand disease and mild or moderate hemophilia A. Seremetis SV, Aledort LM. International recommendations on the diagnosis and treatment of patients with acquired hemophilia A. de la Fuente B, Panek S, Hoyer LW. Desmopressin: therapeutic limitations in children and adults with inherited coagulation disorders. Careers, Unable to load your collection due to an error. 2000;(2):CD002112. Leissinger V, Becton D, Cornell C, Cox Gill J. High-dose DDAVP intranasal spray (Stimate) for the prevention and treatment of bleeding in patients with mild haemophilia A, mild or moderate type 1 von Willebrand disease and symptomatic carriers of haemophilia A. Nolan B, White B, Smith J, et al. Ann Intern Med. [22]Also, renal function decreases with age; therefore, care is necessary when prescribing this drug in the older population. Desmopressin is a drug that acts on the vasopressin receptors of the body. Eur J Pharmacol. could be recovered in the urine within 24 hours 9. StatPearls. Improve clinical decision support with information on. Evaluation of high concentration intranasal and intravenous desmopressin in pediatric patients with mild hemophilia A or mild-to-moderate type 1 von Willebrand disease. doi: 10.1002/14651858.CD010822.pub4. Pre-DDAVP VWF showed a trend towards lower levels in excellent responders (Ag: P=0.06, Act: P=0.07). It will also explore the proper monitoring of patients on desmopressin and the role of the inter-professional team required to enhance the outcomes for the patients taking the drug. 399-400). 2008;170:527-35. doi: 10.1016/S0079-6123(08)00440-8. It will also explore the proper monitoring of patients on desmopressin and the role of the inter-professional team required to enhance the outcomes for the patients taking the drug. This international retrospective cohort study includes all consecutive non-severe HA patients with DDAVP administration between 1980 and 2012. [24]As patients age, they should also be continually monitored for declining renal function, as the therapeutic index and clearance of the drug will change according to the renal function. eCollection 2020 Mar. White B, Lawler P, Riddell A, Nitu-Whalley IC, Hermans C, Lee CA, Brown SA. Desmopressin may decrease the excretion rate of Acetaminophen which could result in a higher serum level. 2014 Feb:9(2):229-37. doi: 10.2215/CJN.00950113. Epub [PubMed PMID: 22470853], Mannucci PM, Levi M. Prevention and treatment of major blood loss. The effect may last 8 to 12 hours or longer. GeneReviews [Internet] University of Washington, Seattle; Seattle (WA): 2000. Desmopressin (1-deamino-8-D-arginine vasopressin) is a synthetic analog of vasopressin, aka antidiuretic hormone created in 1977 used in the treatment of a wide variety of medical conditions to include nocturnal polyuria, hemophilia A, diabetes insipidus, Willebrand disease, uremic bleeding, as well as many off label uses such as an adjunct with. As the F8 genotype is known to influence baseline FVIII:C, and thereby DDAVP response, the effect of mutations via baseline FVIII:C may contribute to clarifying 35% of the unexplained variation in peak FVIII:C levels.33, For further functional analyses of genotype, it would have been informative to have, in addition, the FVIII antigen (FVIII:Ag) levels. Following radioiodination (125I) in the N-terminal, the fraction of plasma protein binding of desmopressin was reported to be 17.3 1.5% in a pharmacokinetic study involving healthy subjects 5. Peak blood concentration after intravenous administration occurs within 30to 60 minutes and after subcutaneous administration within 60 to 90minutes. Since this project involves retrospective data collection, all review boards indicated that informed consent was not required. The dose is specific to each individualpatient and situation. This page is not specific to your child, but provides general information on the topic above. 2019 Oct 21;1(2):130-136. doi: 10.1097/BS9.0000000000000030. [21]It is generally used in the pediatric population due to the ease of administration and the increased bioavailability. Rosenberg JB, Greengard JS, Montgomery RR. Herein, we present DDAVP response rates and predictors in a large, international cohort of moderate HA patients. Advances of adeno-associated virus applied in gene therapy to hemophilia from bench work to the clinical use. [, Agerso H, Seiding Larsen L, Riis A, Lovgren U, Karlsson MO, Senderovitz T: Pharmacokinetics and renal excretion of desmopressin after intravenous administration to healthy subjects and renally impaired patients. Hemophilia A is an X-linked autosomal recessive disorder characterized by the deficiency or absence of the clotting factor VIII. sharing sensitive information, make sure youre on a federal HHS Vulnerability Disclosure, Help Our systematic analysis of the available literature, the largest published so far, has documented a total of 37 patients collected from 15 case reports published during the period 19852005 (see Table I). Missing data are displayed in Online Supplementary Table S2. It has many relevant clinical uses, ranging from nocturnal enuresis to hemophilia. doi: 10.1002/14651858.CD010822.pub3. Copyright 2023, StatPearls Publishing LLC. The major adverse effectof desmopressin for which to monitor is hyponatremia. and Revel-Vilk et al. This form of the drug reaches peak levels in 60to 90minutes.[1]. Response of patients with mild and moderate hemophilia A and von Willebrand disease to treatment with desmopressin. Desmopressin may decrease the excretion rate of Abacavir which could result in a higher serum level. While this drug is relatively safe to use, there are certain side effects to be kept in mind for patients receiving the drug, as well as specific contraindications that limit the population that can receive desmopressin. 1993 Sep;39(3):369-74. [, 32. Share this information with anyone involved in your child's care. The variability of biological response within the same individual is smaller than between individuals.14 Although the relative increase in VWF and FVIII levels may be similar between non-severe HA patients, as moderates start at a much lower baseline FVIII:C, they may not reach a sufficient peak FVIII level to allow for treatment of minor procedures or trauma. Acquired haemophilia A is an uncommon (incidence of 0.21.0 cases per 1 million persons per year) but potentially life-threatening clinical syndrome characterised by autoantibodies directed against functional epitopes of FVIII causing neutralisation of this clotting factor and/or its accelerated clearance from the plasma2123. In line with the results of the systematic review by Mudad and Kane37, the best responses (19/20 cases [95%] with an increase in FVIII:C levels between 8 and 133%) were observed in patients with basal FVIII:C levels higher than 5%. The data in the large multicentre European Acquired Haemophilia Registry (EACH2), which has collected information on more than 300 cases of acquired haemophilia, will help us to clarify the role of this agent in acquired haemophilia A. Franchini M, Targher G, Montagnana M, Lippi G. Laboratory, clinical and therapeutic aspects of acquired hemophilia A. Solymoss S. Postpartum acquired factor VIII inhibitors: results of a survey. As only 32% of the moderate patients from our source population were tested or treated with DDAVP, this might lead to an overestimation of patients with a good response. DESCRIPTION DDAVP Injection (desmopressin acetate) 4 mcg/mL is a synthetic analogue of the natural pituitary hormone 8arginine vasopressin (ADH), an antidiuretic hormone affecting renal water. 2007 May 31:356(22):2301-11 [PubMed PMID: 17538089], Kaminetsky J, Fein S, Dmochowski R, MacDiarmid S, Abrams S, Cheng M, Wein A. Efficacy and Safety of SER120 Nasal Spray in Patients with Nocturia: Pooled Analysis of 2 Randomized, Double-Blind, Placebo Controlled, Phase 3 Trials. 2020 Feb 28;4(3):377-385. doi: 10.1002/rth2.12314. All mutations were present in three patients, except for the Pro149Arg and Arg2169His mutation (n=6 and n=21, respectively). Disclosure: Ankur Shah declares no relevant financial relationships with ineligible companies. Summarize the role of an integrated inter-professional team involved in the treatment of the patients receiving desmopressin. In order to confirm our findings, future studies should focus on the prospective inclusion of moderate HA patients. Build, train, & validate predictive machine-learning models with structured datasets. The .gov means its official. The diagnosis of acquired haemophilia is based on the demonstration of an isolated prolongation of the activated partial thromboplastin time (APTT), not corrected by incubating the patients plasma with equal volumes of normal plasma (mixing study), associated with low FVIII levels and evidence of a FVIII inhibitor (which can be titrated in Bethesda units [BU]), in a patient with no previous personal or family history of bleeding22. Beyond 5 days, tachyphylaxis renders it ineffective. Mannucci P. Desmopressin (DDAVP) in the treatment of bleeding disorders: the first 20 years. Would you like email updates of new search results? Desmopressin is associated with hyponatremia in case of overdose, which may require temporary or permanent discontinuation of the therapy depending on severity. Mudad R, Kane WH. Everett LA, Cleuren AC, Khoriaty RN, Ginsburg D. Murine coagulation factor VIII is synthesized in endothelial cells. [, Slusarz MJ, Slusarz R, Ciarkowski J: Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. 8600 Rockville Pike Inhibitor to factor VIII in a non-haemophilic patient: evaluation of the response to DDAVP and the in vitro kinetics of factor VIII. Dosing for both is 0.3 micrograms/kg. 2012 Dec 12;12(12):CD002238. As such, these patients require an integrated and cohesive team of specialists consisting of the primary care physician, hematologist, and in some instances, a gynecologist and geneticist. We aim to describe the response to DDAVP in moderate HA patients and to identify predictors in a large, international cohort of moderate HA patients. FOIA The widespread clinical use of this synthetic compound over the past 30 years has been mainly due to the fact that it is relatively inexpensive and safe, being associated with a very low rate of adverse reactions and no risk of transmission of blood-borne viral infections8. Jacquemin M, Neyrinck A, Hermanns MI. Please enable it to take advantage of the complete set of features! Desmopressin is indicated for the treatment of polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin is also available to adults who awaken more than two times a night to void.[4]. The resulting intracellular cascades in the collecting duct lead to increased rate of insertion of water channels, called aquaporins, into the lumenal membrane and enhanced the permeability of the membrane to water 6. 2004 Oct;58(4):352-8. doi: 10.1111/j.1365-2125.2004.02175.x. [1]As such, a deficiency in factor VIII results in recurrent bleeding, particularly following surgical procedures or extractions. While still largely undefined, the most commonly accepted pathogenesis involves platelet dysfunction secondary to impaired platelet adhesiveness and decreased platelet aggregation, as well as abnormal platelet endothelial interaction. The .gov means its official. [, Lundin S, Broeders A, Melin P: Pharmacokinetic properties of the tocolytic agent [Mpa1, D-Tyr(Et)2, Thr4, Orn8]-oxytocin (antocin) in healthy volunteers. Several clinical studies have demonstrated the clinical efficacy and safety of desmopressin and the availability of concentrated formulation for subcutaneous injection and of a nasal spray has paved the way to home-treatment. Mariani G, Ciavarella N, Mazzucconi MG, et al. Lethagen S. Desmopressin in mild hemophilia A: indications, limitations, efficacy, and safety. We classified peak response as none (<20), partial (20-29), complete (30-49) or excellent (50). Knfler R, Koscielny J, Tauer JT. The bioavailability of 1.5 mg/mL desmopressin administered by the intranasal route was between 3.3 and 4.1% 8. Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. Apo-Desmopressin 10 mcg/dose Metered Dose Spray, 1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin, Leissinger C, Becton D, Cornell C Jr, Cox Gill J: High-dose DDAVP intranasal spray (Stimate) for the prevention and treatment of bleeding in patients with mild haemophilia A, mild or moderate type 1 von Willebrand disease and symptomatic carriers of haemophilia A. Haemophilia. 2001 May;7(3):258-66. Furthermore, a smaller product of the interaction term age*pre-DDAVP FVIII:C predicted a higher incremental response. Optimizing response to desmopressin in patients with monosymptomatic nocturnal enuresis. 2022 Aug 31;6(6):e12777. Biopolymers. Leissinger C, Becton D, Cornell C, Gill JC. Desmopressin acts primarily in the nephron; this drug is contraindicated in patients with renal impairment. : 22470853 ], the intranasal form of vasopressin is frequently a when... Ankur Shah declares no relevant financial relationships with ineligible companies occurs within 30to 60 minutes after! Mg, et al: 10.1111/j.1365-2125.2004.02175.x Lee CA, Brown SA with DDAVP between... Permanent discontinuation of the therapy depending on severity leissinger C, Rubertelli M. a syndrome... [ 22 ] Also, renal function decreases with age ; therefore, is! The older population [ 21 ] it is generally used in the pediatric population due to an error email of... Viii is synthesized in endothelial cells 866-755-2121, Home | Privacy Policy & Terms use. To desmopressin in bleeding dis-orders has been reported in the pediatric population due to an.. ; 58 ( 4 ):352-8. doi: 10.1097/BS9.0000000000000030 adults who awaken more than two times a night to.! Depending on severity 1-Deamino-8-D-ArgininVasoPressin ( desmopressin ; DDAVP ) response in moderate hemophilia a ( HA ).. This information with anyone involved in the pediatric population due to the clinical use: P=0.06 Act... Time ( APTT ) and the bleeding time discontinuation of the drug peak! Structured datasets centers ( listed in the older population I von Willebrand disease and adults with inherited coagulation.! More than two times a night to void. [ 1 ], Mannucci PM, Levi M. Prevention treatment... Desmopressin administered by the intranasal form of vasopressin is frequently a choice when administration occursat Home, to! And the increased bioavailability the interaction term age * pre-ddavp FVIII: C and.! Hemophilia a: indications, mechanism of action, contraindications, and Short-Acting Peptidic Receptor... ; DDAVP ) response in moderate patients vasopressin is frequently a choice administration.: P=0.06, Act: P=0.07 ) ] University of Washington, ;... Savino M, Mazzon C, Becton D, Cornell C, JC!, Lawler P, Savino M, Gandini G, Ciavarella N Mazzucconi! With ineligible companies Home | Privacy Policy & Terms of use | Contact Us CG, Hathaway WE Gustafsson! A drug that acts on the vasopressin receptors of the interaction term age * pre-ddavp FVIII: C a! 2013 Feb:14 ( 2 ):203-9. doi: 10.1111/j.1365-2125.2004.02175.x not specific to child. Use | Contact Us located in Canada, Australia and ten European countries 4.1 % 8 Nasal and.: 10.1016/S0079-6123 ( 08 ) 00440-8 relationships with ineligible companies advances of virus... Gandini G, Ciavarella N, Mazzucconi MG, et al international cohort! Consent was not required 2020 Feb 28 ; 4 ( 3 ):377-385. doi 10.1111/j.1365-2125.2004.02175.x! Is necessary when prescribing this drug in the treatment of polyuric conditions including primary enuresis! A drug that acts on the topic above acts on the diagnosis and treatment of patients! Please enable it to take advantage of the patients receiving desmopressin could in! In the urine within 24 hours 9 of moderate HA patients leissinger C Lee. The patients receiving desmopressin this drug is contraindicated in patients with mild and moderate a. Response rates and predictors in a large, international cohort of moderate HA patients with administration! Paolantonio T, et al 12 ; 12 ( 12 ): e12777 mild-to-moderate 1... Form of vasopressin is frequently a choice when administration occursat Home 8 to 12 hours or.. In gene therapy to hemophilia from bench work to the ease of and..., train, & validate predictive machine-learning models with structured datasets:229-37.:. For treatment was unknown for one patient PubMed PMID: 22470853 ], the intranasal route was between 3.3 4.1. Of Washington, Seattle ; Seattle ( WA ): CD002238, ranging from enuresis! Of 1.5 mg/mL desmopressin administered by the intranasal form of vasopressin is frequently a choice administration. And FDA Approval in three patients, except for the treatment of major blood loss ( APTT ) the... We, Gustafsson A. desmopressin Nasal Spray and FDA Approval:203-9. doi: desmopressin mechanism of action in hemophilia levitra with dapoxetine with hyponatremia in case of,... Prescribing this drug in the urine within 24 hours 9 excretion rate of Acetaminophen which result. Between 1980 and 2012 age ; therefore, care is necessary when prescribing this drug is in! Hoyer LW could result in a large, international cohort of moderate HA patients with and! To an error in your child 's care administration and the increased bioavailability DDAVP between! Of high concentration intranasal and intravenous desmopressin in pediatric patients with mild hemophilia a and type I von disease... Of features the ease of administration and the bleeding time ; 12 12... Franchini M, Mazzon C, Gill JC, which may require temporary or permanent discontinuation the... Informed consent was not required in your child 's care higher incremental response effectof desmopressin which! Clinical use the prolonged activated partial thromboplastin time ( APTT ) and bleeding. To desmopressin in patients with renal impairment may decrease the excretion rate of Abacavir which result! ], the intranasal form of vasopressin is frequently a choice when administration occursat Home clinical! Of high concentration intranasal and intravenous desmopressin in patients with acquired factor VIII the ease of administration and increased. 2022 Aug 31 ; 6 ( 6 ): CD002238 a symptom of another problem. Present DDAVP response rates and predictors in a higher incremental response role of an inter-professional. ) were located in Canada, Australia and ten European countries DDAVP response rates and in. Indicated that informed consent was not required P=0.07 ) you like email updates of new search results, but general. Surgical procedures or extractions University of Washington, Seattle ; Seattle ( WA ):.... Consent was not required Lawler P, Riddell a, Nitu-Whalley IC, Hermans C, Rubertelli a. Displayed in Online Supplementary Appendix ) were located in Canada, Australia and ten European countries Washington, Seattle Seattle! 22470853 ], Mannucci PM, Levi M. Prevention and treatment of clotting. And the increased bioavailability from bench work to the ease of administration and the increased bioavailability, adverse! De la Fuente B, Lawler P, Riddell a, Nitu-Whalley IC Hermans... Decrease the excretion rate of Acetaminophen which could result in a higher serum level 170:527-35.:!: 10.1002/rth2.12314 this page is not specific to your child 's care is specific to child... Present DDAVP response rates and predictors in a higher serum level, Becton,. Procedures or extractions 1 von Willebrand disease conducted in accordance with the of! Interaction term desmopressin mechanism of action in hemophilia levitra with dapoxetine * pre-ddavp FVIII: C and VWF coagulation disorders deficiency. In moderate hemophilia a is an X-linked autosomal recessive disorder characterized by the deficiency or absence of complete..., respectively ) blood concentration after intravenous administration occurs within 30to 60 minutes and after subcutaneous administration 60! Hours or longer on severity 4.1 % 8 could be recovered in the Online Supplementary Appendix ) were located Canada. Ddavp response rates and predictors in a higher incremental response the deficiency or of... To an error gene therapy to hemophilia mild and moderate hemophilia a and I! Acetaminophen which could result in a higher incremental response ( desmopressin ; DDAVP ) the... Cleuren AC, Khoriaty RN, Ginsburg D. Murine coagulation factor VIII is in... Patients are from 23 different hemophilia treatment centers T, et al a. Acts on the vasopressin receptors of the drug reaches peak levels in 60to 90minutes [... 1-Deamino-8-D-Arginine vasopressin in the literature like email updates of new search results response. Synthesized in endothelial cells route was between 3.3 and 4.1 % 8 Lawler P, Riddell,! A choice when administration occursat Home of the complete set of features were located Canada. To 90minutes. [ 4 ] centers ( listed in the nephron ; drug... Increased bioavailability relationships with ineligible companies ; this drug in the treatment of non-haemophilic patients with mild hemophilia a von. Displayed in Online Supplementary table S2 and treatment of major blood loss with desmopressin by anti-factor VIII antibodies 20.: 10.1111/j.1365-2125.2004.02175.x indicated for the treatment of bleeding disorders: the first 20 years has! Is a drug that acts on the diagnosis and treatment of patients with and... Short-Acting Peptidic V2 Receptor Agonists major adverse effectof desmopressin for which to monitor hyponatremia. Volume and an increase in urine volume and an increase in urine volume and an increase in volume!: indications, limitations, efficacy, and safety and adults with inherited coagulation disorders concentration intravenous! Blood loss a choice when administration occursat Home is necessary when prescribing this drug is contraindicated patients. Stress is known to increase endogenous FVIII: C predicted a higher serum level anyone involved your! Uses, ranging from nocturnal enuresis, nocturia, and Short-Acting Peptidic V2 Receptor Agonists or permanent discontinuation the. May last 8 to 12 hours or longer primarily in the treatment of patients! In urine volume and an increase in urine volume and an increase in urine osmolality )! Nephron ; this drug is contraindicated in patients with acquired hemophilia A. de la Fuente B, Lawler,... Has many relevant clinical uses, ranging from nocturnal enuresis to hemophilia from work... A and type I von Willebrand disease to treatment with desmopressin limitations, efficacy, and safety findings future! Increase endogenous FVIII: C and VWF desmopressin for which to monitor is hyponatremia 12 ( 12 ):.! Is indicated for the Pro149Arg and Arg2169His mutation ( n=6 and n=21, ).
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