Metformin: (Minor) Monitor blood glucose periodically in patients on metformin for changes in glycemic control when hormone therapy is instituted or discontinued. Data regarding the association of COCs with onset of depression or exacerbation of existing depression are limited. For patients taking progestins for other indications, like hormone replacement, monitor the patient for signs and symptoms of reduced therapeutic efficacy or need for dosage adjustment. Tell your doctor when you start any new drug, and discuss if you should use additional reliable birth control. Concurrent administration may increase or decrease estrogen elimination. Dose reduction of pazopanib may be necessary when coadministration of pazopanib and ethinyl estradiol is required. Use sunscreen and wear protective clothing when outdoors. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. An alternate or additional form of contraception should be considered in patients prescribed rifampin. Another review concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines, and penicillin derivatives. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. It was previously thought that antibiotics may decrease the effectiveness of OCs containing estrogens due to stimulation of metabolism or a reduction in enterohepatic circulation via changes in GI flora. This medication does not protect you against HIV infection (AIDS) or any other sexually transmitted infections (STIs). Estrogens are CYP3A substrates and carbamazepine is a strong CYP3A inducer. Compare prices and print coupons for Desogen (Apri, Cyred, Desogestrel / Ethinyl Estradiol, Emoquette, Enskyce, Isibloom, Juleber, Reclipsen, and Solia) and other drugs at CVS, Walgreens, and other pharmacies. Empagliflozin; Metformin: (Minor) Estrogens, progestins, or oral contraceptives can decrease the hypoglycemic effects of antidiabetic agents by impairing glucose tolerance. Patients taking these hormones for other indications may need to be monitored for reduced clinical effect while on mavacamten, with dose adjustments made based on clinical efficacy. Concurrent use may increase the exposure of corticosteroids. Lesinurad may also reduce the effectiveness of other estrogens or progestins. 2005 - 2023 WebMD LLC, an Internet Brands company. Hormonal contraceptives are contraindicated in women with undiagnosed vaginal bleeding; evaluate such patients before combined hormonal contraceptive use to determine if a contraindication to use exists. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. Another review concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines, and penicillin derivatives. (Moderate) Consider the benefits and risk of administering antiretroviral regimens containing cobicistat with estrogens, such as ethinyl estradiol, or mestranol, which is converted to ethinyl estradiol. This medication may raise your blood pressure. For this reason, COCs are contraindicated in women who are over 35 years of age, and smoke. Sofosbuvir; Velpatasvir; Voxilaprevir: (Moderate) Use caution when administering velpatasvir with ethinyl estradiol. When administered as an oral 3-day regimen (125mg/80mg/80mg) in combination with ondansetron and dexamethasone, aprepitant decreased trough concentrations of ethinyl estradiol and norethindrone by up to 64% for 3 weeks post-treatment. Acetaminophen; Guaifenesin; Phenylephrine: (Moderate) Monitor for estrogen-related adverse effects during concomitant acetaminophen and ethinyl estradiol use. Patients receiving antidiabetic agents should be closely monitored for changes in diabetic control when hormone therapy is instituted or discontinued. Higher-dose hormonal regimens may also be considered. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. Patients receiving antidiabetic agents should be closely monitored for changes in diabetic control when hormone therapy is instituted or discontinued. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. Ethinyl estradiol is an inhibitor of CYP3A4. Decreased exposure of etonogestrel may be expected. Grapefruit juice: (Minor) Grapefruit juice has been reported to decrease the metabolism of some estrogens. Patients may desire to limit products that contain high amounts of caffeine to minimize caffeine-related side effects such as nausea or tremors. Data regarding progestin-only contraceptives or for newer combined contraceptive deliveries (e.g., patches, rings) are not available. Ethinyl estradiol is generally contraindicated in patients who have a history of anaphylaxis or history of angioedema to the drug. Check with your doctor immediately if any of the following side effects occur while taking desogestrel/ethinyl estradiol: Some side effects of desogestrel / ethinyl estradiol may occur that usually do not need medical attention. This interaction occurs from the inhibition of methylxanthine oxidation in the liver. Morphine: (Moderate) Combination oral contraceptives have been shown to decrease plasma concentrations of morphine, due to induction of conjugation. (Minor) Progestins can impair glucose tolerance. Acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation. This medication can make your body retain fluid, making your fingers, hands, or ankles swell. Patients receiving antidiabetic agents should be closely monitored for changes in diabetic control when hormone therapy is instituted or discontinued. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. Reduced contraceptive efficacy can occur even in the absence of breakthrough bleeding. The alternative or additional contraceptive agent may need to be continued for 1 month after discontinuation of barbiturates. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. It may be prudent for women who receive hormonal contraceptives with darunavir boosted with ritonavir or cobicistat to use an additional method of contraception to protect against unwanted pregnancy. It was previously thought that antibiotics may decrease the effectiveness of OCs containing estrogens due to stimulation of metabolism or a reduction in enterohepatic circulation via changes in GI flora. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. Acetaminophen; Hydrocodone: (Moderate) Monitor for estrogen-related adverse effects during concomitant acetaminophen and ethinyl estradiol use. (Major) Studies evaluating use of darunavir (boosted with either ritonavir or cobicistat) with ethinyl estradiol have not been conducted; therefore, an alternative (non-hormonal) method of contraception is recommended. Data regarding progestin-only contraceptives or for newer combined contraceptive deliveries (e.g., patches, rings) are not available. Data regarding progestin-only contraceptives or for newer combined contraceptive deliveries (e.g., patches, rings) are not available. Liothyronine: (Minor) The administration of estrogens can increase circulating concentrations of thyroxine-binding globulin, sex hormone-binding globulin, and cortisol-binding globulin. Roflumilast: (Moderate) Coadminister oral contraceptives containing gestodene and ethinyl estradiol and roflumilast cautiously, as the combination has resulted in increased drug exposure to roflumilast in pharmacokinetic study. Thiazolidinediones: (Minor) Patients receiving antidiabetic agents should be periodically monitored for changes in glycemic control when hormone therapy is instituted or discontinued. When the pills run out, start a new pack the following day. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. The exception is the use of levonorgestrel progestin IUDs, which have not been reported to interact and appear to maintain reliable efficacy. Concurrent administration may increase estrogen elimination. Patients taking these hormones for other indications may need to be monitored for reduced clinical effect while on omaveloxolone, with dose adjustments made based on clinical efficacy. Another review concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines, and penicillin derivatives. 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