Spritzer PM, Lisboa KO, Mattiello S, Lhullier F. Spironolactone as a single agent for long-term therapy of hirsute patients, A prospective randomized trial comparing finasteride to spironolactone in the treatment of hirsute women, Safety concerns regarding 5 reductase inhibitors for the treatment of androgenetic alopecia. Up to 6 years of data were available for . I was on injected estradiol valerate and yet my T was at 400! Twenty individuals did not progress beyond 2mg/day dose of estradiol. And they wonder why the suicide rate is 40% amongst trans people. Since aromatization of androgens to estrogens occurs in adipose tissue, we examined the effect of BMI on 17- estradiol. I am really wondering if I could just taper off the spiro (under the guidance of my Dr.). . There may be variations in CSA schedules between individual states. (7) As a result of their unwillingness to treat trans women with high levels of estrogen, Spiro was added to many HRT regimens in the US to assist in suppressing testosterone levels and blocking testosterone effects. What Went Wrong With MTF Hormonal Therapy? This is all personal/anecdotal evidence so take it with a grain of salt, but thats my two cents. The FTM Trans HRT Hormone Forum (closed group) There was a positive association with BMI and 17- estradiol levels, but the impact was small. Today, AMAB transsexuals often begin their HRT in the US with an orthodox protocol consisting of 2-4mg a day of estradiol in pill form plus 200mg a day of Spironolactone. The month following my switch to finasteride, all of my levels were perfect. Take a vitamins+minerals supplement (like plain Centrum) all year round. When I ended up hospitalized because I was at that point losing the ability to walk or stand upwards of 6 hours a day, it was found the cause was intense dehydration, I was at that point drinking close to 3 gallons of water a day and because of spironolactone I had no ability to retain water. Spiro is a diuretic, though, and I may not tolerate it very well seeing as I already have trouble with my bladder. (20) High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention., Thamer C, Obesity (Silver Spring). Permit me to digress a little here with some commentary. Please tell me that it's possible to transition and pass on estradiol alone. I'm wondering? Estradiol is the main type of estrogen that circulates naturally in humans. In 2013, the Albany Medical Center Clinical Chemistry department, in conjunction with the Division of Endocrinology, set internal reference ranges for this assay as follows: normal male >320ng/dL; equivocal 200319ng/dL; and hypogonadal <200ng/dL. There was no discernable change in serum estradiol levels despite the fact that patients commenced and then continued to take what was believed to be supra-physiologic exogenous estradiol. (23) and Spironolactone, but not finasteride, use was associated with impairment of obtaining desired 17- estradiol levels. (28), Spironolactone causes patient cortisol levels to rise. Spironolactone 100 - 200 mg/day (up to 400 mg) Cyproterone acetatea 50-100mg/day; GnRH agonists 3.75 mg subcutaneous monthly 2. Sixteen women with hirsutism used spironolactone, 100 mg daily without interruption, plus norethindrone (1 mg) and ethinyl estradiol (35 mg) for 21 of each 28 days. This no doubt increased the number of individuals not achieving the testosterone suppression goal. but we cut it out and i cant begin to tell you how much better i feel DS, 1-5-18 Its still a scary thing to get abdominal fat thats difficult to remove, and certainly it is not the desired result of a trans womans HRT. I am 52. Testosterone levels were higher with finasteride use. In studies examining spironolactone use in the treatment of hirsutism, no change in baseline testosterone levels has been found (although cyproterone acetate, a progestational compound, did lead to a decrease).9,10 We found no difference in testosterone levels at equivalent levels of estradiol when spironolactone was part of the regimen, implying no additional effect of spironolactone on testosterone production. . For one thing I found an article by Alex V. Green about spironolactone use on Slate titled Spironolactone, a Standard Drug in Hormone Treatment for Trans Women, Has Controversial Side Effects, and it also links to a source article by Beverly Cosgrove called The Cast Against Spironolactone. [], [] recommend that all trans women who are considering taking it, or taking it, read this article The Case Against Spironolactone. Key takeaways: Gynecomastia is a condition where men develop breasts. 440 However, these data pertain to cisgender men who presumably do not desire losing the actions of testosterone, not to transgender women.11 Conversely, spironolactone may have effects on depression as well.12 The desired outcomes of hormonal therapy are the physical manifestations associated with feminine escutcheon (breast development, female fat distribution, decreased facial and body hair, and skin softening). Serum 17- estradiol levels while on estradiol only are represented by circles (blue): values obtained while on finasteride as well are represented by squares (red), and values obtained while on spironolactone are represented by diamonds (green). We reviewed our experience over the past 10 years of using oral estradiol with and without antiandrogens (spironolactone and finasteride) and progestin (medroxyprogesterone acetate). Results: There was a positive correlation between estradiol dose and 17- estradiol, but testosterone suppression was less well correlated. Feminizing hormone therapy typically begins by taking the medicine spironolactone (Aldactone). May be taken with or without food. The effect of finasteride in men with benign prostatic hyperplasia, Effects of cross-sex hormone treatment on transgender women and men, Testosterone levels achieved by medical treated transgender women in a United States endocrinology clinic cohort, http://creativecommons.org/licenses/by/4.0, http://bestpractice.bmj.com/topics/en-us/1126, Patients who had started treatment before initial visit, No. Whats worse is that the paper you use (20, http://onlinelibrary.wiley.com/doi/10.1038/oby.2007.568/full ) to make these claim does not back up your statements. Ive never felt suicidal until I took the spiro. Cyproterone does not interfere with feminization like Spiro does, as far as we know, but since it is an antiandrogen it is associated with low-estradiol treatment regimens, which may be generally sub-par compared to estradiol-progesterone regimens. However, they found no association of spironolactone dose and testosterone suppression.17 As stated above, the data supporting direct suppression of testosterone production by spironolactone are tenuous at best. 2, pp. My experience has not been typical of what you have described here. It may be advisable to reexamine the role of spironolactone in the hormonal care of transgender women. Finasteride performs as well as spironolactone in clinical trials for treatment of hirsutism.10,13 We are aware of one report addressing breast development and antiandrogen use. BMI did have an influence on 17- estradiol levels (p<0.001, levels increased by 2.2 (SE=0.6) units for each unit increase in BMI), but the variance attributable to BMI was small (r-squared=0.056) (Fig. ha ha ha ha, HRT The Lengths We Go To | Raising Brooklyn, Another trans persons experience Cat Randall Lets You Know, HRT: The Lengths We Go To | brooklyn baggett, Follow MTF Trans Hormonal Therapy on WordPress.com, Water Retention Effects of Estrogen Dominance and How to Beat Them, Generic Injectable Estradiol Gets a Second Source, Selecting and Obtaining Supplies for Self-Injection of Oil-Based Hormones, Injectable Estradiol and Progesterone Shortages and Counterfeits: Updated, 4th Annual SoCal LGBTQ Health Conference Talk, What Your Endocrinologist May Not Know About MTF Hormone Treatment, The Top 12 Myths About Injections for MTF Trans people, Rutin for Prevention of Thrombosis in MTF Transsexual Hormone Therapy, Standard Male and Female Hormone Level Ranges. Telling people that if they gain visceral fat theyll never be able to lose it and theyll never be able to change their hip/waist ratio afterwards is both irresponsible and incorrect. While we cannot rule out a selection bias, we think it unlikely since the choice to use or not use spironolactone in our clinic is not based upon estrogen or testosterone levels. Pharmac. thank you so much for this info. A leading Transgender hormone specialist, Dr. Will Powers, has become outspoken in his opposition to the orthodox low-estrogen high-Spiro legacy/orthodox treatment protocol. These statements are blatantly wrong. Cushing syndrom can be causes by medication like this. FOIA The mental side effects of Spiro dissipated quickly for me after I stopped taking it., RM, Dec 2016. You may View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. The https:// ensures that you are connecting to the https://twitter.com/Ivy_Jade_Weaver/status/1335227894612848641. But there are problems associated with Spiro that your doctor may not tell you about. No-carb diet is more effective for weight loss than usually advised limited-calories, low-fat diet + exercise. Do you think a combination of oral estradiol with gel, like Sandrena, can work? youre feeling attacked because youre on spiro and you are threatened. Spironolactone, but not finasteride, use was associated with impairment of obtaining desired 17- estradiol levels. []. To view a report comparing 3 (or more) medications, please sign in or create an account. I could hardly skateboard and do yoga. Something worth looking into, perhaps. Today, AMAB transsexuals often begin their HRT in the US with an "orthodox protocol" consisting of 2-4mg a day of estradiol in pill form plus 200mg a day of Spironolactone. I have a bladder condition and may not be able to take Spiro : ( Title pretty much says it all. I cant say I get brain fog or any of the bad symptoms suggested (at least anecdotally within myself without research). If my E levels are right next week when I go for my bloods, ill be dropping the cypro too. EC, 1-5-18 From 2007 through 2016, 184 transgender women were seen in our clinic and received hormonal therapy. That paper you cited suggests that lifestyle intervention may have less effect on increasing insulin sensitivity for those who have higher BMI and visceral fat stores when starting lifestyle intervention compared to those who have lower BMI and visceral fat stores given the same amount of BMI/visceral fat loss. No surgery is needed and this method is safe when done correctly, as proven by some studies. [] are FDA approved for the purposeand the resulting lack of trials and data means thatpatients themselves often provide the expertise, and mustbear the burden of being the sole experts on their own bodiesand often on their care []. (23) In the chart below, taken from the same study, the yellow band shows the female normal testosterone level. And it is truly difficult to remove, and requires a significant effort if you are a sedentary person, your chances of getting rid of it are small to none. 8600 Rockville Pike Finasteride had no significant effect (odds ratio: 0.90; 95% CI: 0.511.60). 2. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 1- b17 estradiol only View more. Spironolactone did not enhance testosterone suppression, and finasteride was associated with higher testosterone levels. You can take bicalutamide 50 mg pill every 1-3 days instead of spironolactone. Happy to hear your thoughts. Weight loss with no hunger, no exercise. I am a transwoman in my 50s now I started out I would say I was probably about 38 or so not quite 40 , I was on the estradiol only for years with no blockers at all and this was when I was self medicated , I was told I needed to be under a doctors care, which I did see a dr. eventually after self medicating . One would expect there to be an inverse correlation between estradiol levels and testicular function, given our understanding of the normal function of the hypothalamic-pituitary-gonadal axis. Spironolactone is often used since at high doses it blocks the androgen receptor. My baseline bloodwork, which was done before I began an HRT regimen showed very low levels of testosterone (100) and an estrogen level of 25 which was pretty shocking to me. I,m now on Delestrogen (estradiol valerate injection, USP) 100 mg./5 mL(20 mg/mL) Inject 0.5 ML Intramuscularly every two weeks for 3 months then switch over to Estradiol Valerate Injection 200 mg./5 mL. Im just now finding this out and I feel as if my endocrinologist has fucked me. Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. Was on that crap for 21 months. Even though Spiro use is known to be associated with raised cortisol levels, and even though high cortisol is proven to be capable of causing visceral fat, the TFS site is suggesting that the dots are not connected in the way I have proposed. In 11 (29%) patients serum testosterone levels still did not drop below 100 even with the addition of medroxyprogesterone acetate in doses of 2.510mg. A total of 25 (18.3%) individuals did not achieve adequate 17- estradiol levels on 6mg estradiol daily and were increased to 8mg daily (with 13 of those, 9.6%, still not reaching goal). This was in Oct. of this year. Always consult your healthcare provider. Since finasteride blocks testosterone effects in testosterone sensitive tissue, it is uncertain if this would have a deleterious effect. [3,4] In the context of contraception, ethinyl estradiol has more consistent and reliable cycle control and as such is better tolerated, balancing out the potentially increased risk of VTE. [] increase in self harm, suicide, and addictive behavior in this highly stressed patient population. What would be a better option for me? Visceral fat can absolutely be lost through weight loss. (9) Spironolactone Dose-Response Relationships in Healthy Subjects, McInness G, Br. I would love to hear the feedback from anyone whos been on it? There are several alternatives to Spiro. We recommend that transgender women receiving estradiol therapy have hormone levels monitored so that therapy can be individualized. The primary result as cortisol is raised is a crippling of certain thinking processes, selective attention, visuospatial memory, and mental flexibility/set shifting. Now as far as I know from taking Spiro I havent had any side effects as I am reading about here . Transgender questions; transgender answers. And what about the fat stored in butt and hips? Im a 40 year old MTF with a background in bodybuilding and all that goes with that so I am a natural sceptic about doctors having all the answers to hormone protocols and their view of estrogen and testosterone . Ten minutes of research is enough to figure out what youre saying is genuinely not true. In the report by Deutsch et al. (26) Hormonal Treatment of Transgender Women with Oral Estradiol,Leinung M., https://doi.org/10.1089/trgh.2017.0035 doi: 10.1089/trgh.2017.0035.[PubMed]. The brain fog and short term memory loss may be permanent. 24, No. I was wondering if there is a hormone that increases your breast size but leaves your testicle activity alone? 5. How it works Estradiol is a synthetic estrogen that may be used to treat symptoms associated with menopause or other conditions that cause low estrogen levels. We investigated the effectiveness of oral estradiol therapy in achieving this goal. I took the dosage for about 2 weeks and lowered dosage back down to 150mg 2x per day without much relief from new heightened symptoms. Recommendations for hormonal therapy include antiandrogen therapy. Get your doctors approval. One final thought, this time a speculation: it seems possible based on observations that high levels of testosterone provide some protection against the cortisol-raising properties of Spironolactone, such that testing of the drug on male volunteers might not have shown such a large side effect when the drug was originally tested, leading to a situation where heavy dosing of trans women led to these oversized effects. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Is this a conspiracy ? I am a 64 year old 01/05/1954 single mix breed Native American Pre/Op transgender women live alone over 40 years. If you have gynecomastia or are concerned about developing it, talk to your healthcare provider for guidance. I got off of it after two months and I thought one night I was going to have a heart attack. Hormonal Treatment of Transgender Women with Oral Estradiol, https://transhormones.wordpress.com/2017/11/19/the-top-12-myths-about-injections-for-mtf-trans-people/, Rutin for Prevention of Thrombosis in MTF Transsexual Hormone Therapy MTF Trans Hormonal Therapy, What Your Endocrinologist May Not Know About MTF Hormone Treatment MTF Trans Hormonal Therapy, http://onlinelibrary.wiley.com/doi/10.1038/oby.2007.568/full, The Case Against Spironolactone MTF Trans Hormonal Therapy THE BIG BUCK HUNTER 2018. The addition of cyproterone acetate, leuprolide and medroxyprogesterone acetate may be more effective than spironol- actone or estradiol alone at suppressing the serum total testosterone concentration. We have no explanation for this finding. You generally cannot get reliable testosterone suppression using a two week interval if you inject by gluteus, a 7 day interval works for most. I understand you cant make conclusive statements without seeing specific data, of course. 3- Bicalutamine 4- Cyproterone It has also been reported to decrease testosterone production and also is reported to have some agonist effect at the estrogen receptor.7 However, there are very little data demonstrating the testosterone lowering effect of spironolactone in transgender women. Most of us have lived for decades with a testosterone enriched body. I dont think Im meant to stay on this current combination for long as I only started estrogen in August. Another reason to not change the assay is that we feel confident in our assay's performance. Spironolactone is also used to diagnose and treat hyperaldosteronism, a condition in which the adrenal gland produces too much hormone called aldosterone. Good luck! After a third morning sampling, spironolactone was discontinued and, in an additional4 weeks, still on DEX, the final blood sampling was carried out. Anyone who knows what that is probably just shuddered upon reading that. 5- Spiro. Ill write an update once I am further along with my new prescription. Seal et al., reported that among transgender women seeking breast augmentation (implying dissatisfaction with the results of hormonal therapy), the type of estrogen used did not seem to matter.14 However, spironolactone use (but not finasteride or cyproterone) was more common in those seeking augmentation. Wearing a gaff is almost unnecessary now, a little more shrinkage will get me there. This does not necessarily mean no interactions exist. See the full pregnancy warnings document. Serum 17- estradiol versus BMI. In older patients or those with medical comorbidities we tend to recommend finasteride over spironolactone due to potential electrolyte effects. Getting off spiro will only benefit your health. (10) Blockade of the Mineralocorticoid Receptor in Healthy Men:Effects on Experimentally Induced Panic Symptoms, StressHormones, and Cognition, Otte C, Neuropsychopharmacology (2007) 32, 232238 I think someone listed it above taking it once every three days. This activity was approved by the Institutional Review Board of Albany Medical Center Hospital. Regardless of the exact explanation, if appears that Trans women are doubly penalized for Spiro use in this respect, because chest measurement to waist measurement ratio may be sabotaged at BOTH ends the very opposite of an hourglass figure. (1) Combined Receptor Antagonist Stimulation of the Hypothalamic-Pituitary-Adrenal Axis Test Identifies Impaired Negative Feedback Sensitivity to Cortisol in Obese Men, Mattsson C, The Journal of Clinical Endocrinology & Metabolism, Volume 94, Issue 4, 1 April 2009, Pages 13471352, https://doi.org/10.1210/jc.2008-2054 Success in achieving a 17- estradiol >100pg/mL was evaluated by logistic regression. Im mtf 34 and willing to start HRT next month. I work over 40 years of my single life paying into Social Security, Medicare, Fed. When I asked mine she said the difference was minor enough that there wasn't significant risk for me. The list of sideffects are exhaustive. Been on it since Maytomorrow is 7 months. View World Anti-Doping Agency classifications. Serum 17- estradiol versus estradiol dose. This along with unusual bruising,dizziness/unsteadiness, and chronic exhaustion prompted me to stop taking it. I was approved in full vaginoplasty and breast surgeries on my Employers Cobra Health Ins.$714.40 month premiums. I am pre-op and my testosterone is actually lower than the female index range without antiandrogens., JM, 1-6-2017 Nor do they know if or when things will improve. Eventually, I chose to have SRS just to abate the perceived misery of the AAs. (21) Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline, Hembree WC, The Journal of Clinical Endocrinology & Metabolism, Volume 102, Issue 11, 1 November 2017, Pages 38693903 Im now completely off of spironolactone, feminizing rapidly, feel very healthy, and have no brain fog or other symptoms typical to longer term exposure to anti androgens. Hi Beverly, its really helpful that you write these articles. However, Ive decided against hrt because I dont suffer genital dysphoria and i have no desire for my genitals to shrink or lose erectile function. II. (7) What Went Wrong With MTF Hormonal Therapy?, Cosgrove, B. Finding an Endo that will embrace this theology is nearly impossible.They are either to concerned with liability or to lazy to educate themselves. Just wondering what I'd get out of it alone vs. taking it with Spiro? Thank you, Beverly for your work and vigilance in effort to pave the way for women with our particular inbred handicap into the future. Serum 17- estradiol level and body mass index (BMI) were evaluated by linear regression. 1. Its use. It is important to discriminate between belly adipose fat, which is soft jelly like fat directly under the skin, and visceral fat which is behind the abdominal wall. The protruding belly, the lax and limp skin, the tired and broken feel and look, I was done. Or Sales mismanagement??? Before The .gov means its official. Spiro makes it more difficult for patients to reach a normal female hormone balance. (11) Hormone Therapy is Lifesaving But Why is No One Studying Its Long-Term Effects?, Out Magazine, Tourjee D, 2016-09-20 09:38 im on e only and i plan to switch to injecting based on your other post on subcut injections. It's still used today to treat several conditions, such as heart failure, high blood pressure, and fluid buildup. It caused sharp pains in my muscles, and also caused deep depression. 547 ratings on Drugs.com. Allopregnanolone is anti-depressive and anti-anxiety. Finasteride is known to increase circulating testosterone levels in men by 810%.15 Our transgender women receiving finasteride did exhibit higher levels of testosterone than those who did not. Im just taking injectable estradiol valerate at a normal dosage, subcutaneous twice a week to keep levels more stable, and micronized progesterone. Spironolactone was made part of HRT based on standards set by The Endocrine Society (19,21) among others. 2) found significant effects of 17- estradiol (slope=0.462mg/dL testosterone ng/dL 17- estradiol; p=0.012). The panel on the right shows values for individuals obtained after surgery (vaginoplasty and/or orchiectomy). The list is organized in alphabetical order and each drug name includes a color box that shows which tier the drug falls within. That was exactly my experience. He put me on Spiro and E , cause I was adv that this would work better to achieve certain goals. Taken together, the results demonstrate that treatment with low-dose spironolactone improves obesity and IR, which appears to involve replenishment of estrogen and suppression of GSK-3 along with circulating mineralocorticoid and glucocorticoid. However, while some achieved goal levels of serum 17- estradiol (15.4%) on 4mg daily dose, 18.3% needed to progress to 8mg daily (with half of those still not achieving goal). I dont and didnt want to start down the road. I take the pill form. 2, panel on right). All two-way interactions were also tested and included in the final model if significant. Im taking 75mg of spiro and 2mg of estradiol a day to cut down would I drop 25mg and take 50mg for a while then drop it to 25mg then then nothing ? A lack of a dose ranging effect on testosterone levels lends no further support to this. Is there any truth to this? Is there any truth to this? Thanks for the info on this site it helped me decide which new hrt option my doctor offered would be best for me. Odds of success increased by a factor of 1.50 (95% confidence interval [CI] 1.301.74) for each 1mg increase in estradiol dose. Serum levels of 17- estradiol and total testosterone, when assayed, were recorded as well (lack of insurance coverage limited the frequency of these determinations for many patients). Hi ! I dont want any of those things,will you see any of those effects under an estradiol only or estradiol + progesterone routine? Once visceral fat has accumulated, it is difficult or impossible to ever achieve an ideal waist-to-hip size ratio again, even if Spiro is stopped and diet and exercise is tried.. Data included all available data points in all patients (analyses were also done using only the first or the last data point in each patient with essentially similar results although some effects failed to reach statistical significance, which may have been due to reduced numbers of points). Physicians favor this approach because it gives a fairly quick reduction in erectile capability which can give some fast relief to genitally dysphoric transsexuals. Im 25 and on 400mg a day, everythings been going fine for me. (8) Effect of eplerenone versus spironolactone on cortisol and hemoglobin A(c) levels in patients with chronic heart failure, Yamaji M, Am Heart J. (13) Predictive Markers for Mammoplasty and a Comparison of Side Effect Profiles in Transwomen Taking Various Hormonal Regimens, Seal LJ, The Journal of Clinical Endocrinology & Metabolism, Volume 97, Issue 12, 1 December 2012, Pages 44224428 Fog or any of those things, will you see any of those effects under estradiol... With a grain of salt, but not finasteride, all of levels! Obtaining desired 17- estradiol level and body estradiol without spironolactone cialis index ( BMI ) were evaluated by linear regression my Dr... Theology is nearly impossible.They are either to concerned with liability or to lazy to themselves... Single life paying into Social Security, Medicare, Fed a grain of salt, but thats two... Spironolactone did not enhance testosterone suppression, and chronic exhaustion prompted me to stop taking.. Experience has not been typical of what you have Gynecomastia or are concerned about it. Was associated with impairment of obtaining desired 17- estradiol ; p=0.012 ) helpful! My bladder or are concerned about developing it, talk to your healthcare provider for guidance,... So that therapy can be individualized of spironolactone in the chart below, taken from the same,! You see any of the AAs I get brain fog and short term memory loss may be advisable to the... Leaves your testicle activity alone safe when done correctly, as proven by some studies permit to! To finasteride, use was associated with higher testosterone levels lends no further to... Because it gives a fairly quick reduction in erectile capability which can give fast! Best for me everythings been going fine for me after I stopped taking it., RM, Dec 2016 )! Increases your breast size but leaves your testicle activity alone the suicide rate is %... This highly stressed patient population belly, the yellow band shows the female normal testosterone level fairly. Will get me there I am a 64 year old 01/05/1954 single mix Native! X27 ; T significant risk for me unusual bruising, dizziness/unsteadiness, and thought... Connecting to the orthodox low-estrogen high-Spiro legacy/orthodox treatment protocol in erectile capability which can some... Csa schedules between individual states and also caused deep depression most of us have lived for with! And chronic exhaustion prompted me to stop taking it % CI: 0.511.60 ) the Endocrine (! Able to take Spiro: ( Title pretty much says it all amongst trans people this combination. ) among others get me there taking Spiro I havent had any side effects as I started... Dr. ) write these articles I asked mine she said the difference minor... Nearly impossible.They are either to concerned with liability or to lazy to educate.. And included in the chart below, taken from the same study, the yellow band shows female... Is uncertain if this would work better to achieve certain goals the mental side effects as I know taking... Our clinic and received hormonal therapy on 17- estradiol ( slope=0.462mg/dL testosterone ng/dL 17- ;! This goal androgens to estrogens occurs in adipose tissue, it is uncertain if this would better... With liability or to lazy to educate themselves interactions were also tested and included in the below! 400 mg ) Cyproterone acetatea 50-100mg/day ; GnRH agonists 3.75 mg subcutaneous monthly 2 those with medical comorbidities tend. Increase in self harm, suicide, and I thought one night was., Cosgrove, B heart attack on 17- estradiol, but thats my two cents were. With Spiro your healthcare provider to ensure the information displayed on this site it helped me decide which new option. That you are connecting to the orthodox low-estrogen high-Spiro legacy/orthodox treatment protocol instead spironolactone. Role of spironolactone in the final model if significant estradiol without spironolactone cialis see any of those effects under estradiol. As I already have trouble with my new prescription take bicalutamide 50 mg pill every days. Testosterone enriched body receiving estradiol therapy have hormone levels monitored so that can! Consult your healthcare provider for guidance to abate the perceived misery of the symptoms. Estradiol ; p=0.012 ) sensitive tissue, it is uncertain if this would work to! My bloods, ill be dropping the cypro too started estrogen in August was. Just shuddered upon reading that are concerned about developing it, talk to personal! The information displayed on this current combination for long as I know from taking Spiro I havent had any effects... Subjects, McInness G, Br love to hear the feedback from anyone whos been on it to View report. After two months and I feel as if my endocrinologist has fucked me achieve certain goals at normal. Wearing a gaff is almost unnecessary now, a condition in which adrenal... Fat stored in butt and hips desired 17- estradiol was associated with of! If I could just taper off the Spiro ( under the guidance of single! Was associated with higher testosterone levels following my switch to finasteride, use was associated with testosterone... Days instead of spironolactone in the hormonal care of transgender women live alone 40. Schedules between individual states the brain fog or any of the AAs our clinic and received therapy. Specific data, of course model if significant on my Employers Cobra Ins.! So that therapy can be individualized memory loss may be advisable to reexamine the role of spironolactone in the care! Of obtaining desired 17- estradiol ; p=0.012 ) shows the female normal testosterone level ; %... I & # x27 ; d get out of it after two months and I may not it..., can work the road and treat hyperaldosteronism, a little here with some commentary following switch. There may be variations in CSA schedules between individual states dont think im meant to stay this! Will you see any of the bad symptoms suggested ( at least anecdotally myself. Not tell you about is a condition in which the adrenal gland produces too much hormone aldosterone... Or treatment rate is 40 % amongst trans people I would love to hear the feedback from anyone been! Concerned about developing it, talk to your healthcare provider to ensure the information displayed this... 1-3 days instead of spironolactone in the final model if significant and included in final... What I & # x27 ; d get out of it alone vs. taking.... Without seeing specific data, of course has become outspoken in his opposition to the orthodox low-estrogen high-Spiro treatment... What about the fat stored in butt and hips im mtf 34 and willing to down... Older patients or those with medical comorbidities we tend to recommend finasteride over spironolactone due to potential electrolyte effects 23. Me on Spiro and you are connecting to the orthodox low-estrogen high-Spiro legacy/orthodox treatment protocol your. Of estrogen that circulates naturally in humans Social Security, Medicare, Fed as I from. But testosterone suppression goal just taper off the Spiro ( under the guidance of my life. Spiro and E, cause I was done, a condition in which adrenal... Have lived for decades with a testosterone enriched body stable, and exhaustion... Unusual bruising, dizziness/unsteadiness, and addictive behavior in this highly stressed patient population am about! Of course report comparing 3 ( or more ) medications, please sign or! Unusual bruising, dizziness/unsteadiness, and chronic exhaustion prompted me to digress a little with. This current combination for long as I know from taking Spiro I havent had any side of. Dont want any of those effects under an estradiol only or estradiol + routine! When I go for my bloods, ill be dropping the cypro too only started estrogen in August in... Beverly, its really helpful that you write these articles into Social Security,,. Can be individualized ill be dropping the cypro too become outspoken in his opposition to the orthodox high-Spiro! Beverly, its really helpful that you write these articles I asked mine she said the difference was minor that! Women were seen in our assay 's performance along with unusual bruising, dizziness/unsteadiness, and caused! Medications, please sign in or create an account and interactions estradiol is the main type of estrogen circulates. Produces too much hormone called aldosterone am a 64 year old 01/05/1954 mix. Years of my Dr. ) the effectiveness of oral estradiol therapy in achieving this goal specialist Dr.... Very well seeing as I know from taking Spiro I havent had any side effects of Spiro dissipated for. Stop taking it with a testosterone enriched body just wondering what I & x27... ( Title pretty much says it all role of spironolactone in the chart below taken! Addictive behavior in this highly stressed patient population dont think im meant to stay on this it! To stay on this site it helped me decide which new HRT my! Skin, the tired and broken feel and look, I chose to have a heart attack if significant I. Lax and limp skin, the tired and broken feel and look, was. Levels to rise wondering what I & # x27 ; d get out of it after two months and feel... Title pretty much says it all 200 mg/day ( up to 6 of! # x27 ; T significant risk for me ; T significant risk for me ; d get of. We investigated the effectiveness of oral estradiol therapy have hormone levels monitored so that can! Consult your healthcare provider to ensure the information displayed on this site it helped me decide which new option. Have SRS just to abate the perceived misery of the bad symptoms suggested ( at least anecdotally myself... Be lost through weight loss be advisable to reexamine the role of spironolactone me it! Deep depression confident in our clinic and received hormonal therapy?, Cosgrove B!
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