The . Running on the treadmill isnt the only way to lower your cholesterol! Dose equivalence and conversion Dose expressed as x/y mg bempedoic acid/ezetimibe. If taking a bile acid. If you have any questions, ask your doctor or pharmacist. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Before taking ezetimibe, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. All rights reserved. [, Kramer W, Girbig F, Corsiero D, Pfenninger A, Frick W, Jahne G, Rhein M, Wendler W, Lottspeich F, Hochleitner EO, Orso E, Schmitz G: Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane. wheezing. Ezetimibe and ezetimibe-glucuronide are bound 99.7 % and 88 to 92 % to human plasma proteins, respectively. Talk to your doctor about other drug options that may work for you. For this drug to work well, a certain amount needs to be in your body at all times. Yes, fatigue (tiredness) can occur with Nexlizet but it does not occur too frequently. Meaning of ezetimibe. Your doctor may monitor you more closely if you take these drugs together. Ezetimibe comes only as a tablet you take by mouth. You can take ezetimibe as a single ingredient tablet or it is also available in a tablet that contains both ezetimibe and another cholesterol lowering medication called simvastatin. Last updated on Apr 19, 2022. Active ingredients: Each film-coated tablet contains 10mg of tadalafil. You may need to have regular blood tests to see how well you are responding to the treatment, and also to check that your liver stays healthy. Ezetimibe oral tablet can cause drowsiness. These products may bind to ezetimibe, preventing your body from fully absorbing the drug. Memory loss is not a side effect of Zetia (ezetimibe) when it is used alone to treat high cholesterol. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Co-administration with food does not affect absorption. It comes with risks if you dont take it as prescribed. If you are pregnant, trying for a baby, or breastfeeding. ezetimibe monotherapy is recommended as an option for the treatment of adults with primary (heterozygous-familial or non-familial) hypercholesterolaemia who would otherwise be initiated on statin therapy but who are unable to do so because of contraindications to initial statin therapy Do not share this medication with others. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Ezetimibe is metabolised primarily in the small intestine and liver via glucuronide conjugation (a phase II reaction) with subsequent biliary excretion. Bempedoic acid and ezetimibe combination is used together with diet and other cholesterol-lowering medicines (eg, statins) to treat patients with heterozygous familial hypercholesterolemia (HeFH) and patients with heart disease who need additional lowering of their bad cholesterol (LDL) levels. It comes as an oral tablet. If you also take other cholesterol medication: Take ezetimibe 2 hours before or 4 hours after taking cholestyramine, colestipol, or colesevelam. Ezetimibe has been prescribed to help lower your cholesterol levels. Keep these considerations in mind if your doctor prescribes ezetimibe for you. This medication hasnt been studied in children younger than 10 years. For seniors: The kidneys of older adults may not work as well as they used to. This 'narrowing' reduces the blood flow through the arteries and it increases the risk of a number of heart and blood vessel diseases, such as heart attack and stroke. Taking warfarin with ezetimibe can cause warfarin to work too well or not well enough. The dosage is based on your medical condition and response to treatment. Ezetimibe oral tablet can interact with other medications, vitamins, or herbs you may be taking. Ezetimibe is used for long-term treatment. Take this medication by mouth as directed by your doctor, usually once daily with or without food. Ezetimibe (e zet' i mibe) is a synthetic azetidinone that inhibits cholesterol absorption from the intestine. 2011 Apr;89(4):524-8. doi: 10.1038/clpt.2011.4. Always speak with your doctor or pharmacist about dosages that are right for you. In the US - Call your doctor for medical advice about side effects. Ezetimibe will not help you lose weight or prevent heart disease or heart attacks. Ezetimibe oral tablet is used to reduce high cholesterol levels. dizziness or fainting. You should not do both. 2023 Healthline Media LLC. Nexlizet comes in a bottle with a child-resistant cap. Each tablet contains 180 milligrams (mg) bempedoic acid and 10 mg ezetimibe. It is not known if Nexlizet is safe and effective in people with moderate to severe liver problems. There are other drugs available to treat your condition. Medicines Complete BNF 85th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London. If you notice other effects not listed above, contact your doctor or pharmacist. You can learn more about how we ensure our content is accurate and current by reading our. While the full mechanism of action of ezetimibe in reducing the entry of cholesterol into both enterocytes and hepatocytes is not fully understood, one study proposed that ezetimibe prevents the NPC1L1/sterol complex from interacting with AP2 in clathrin coated vesicles and induces a conformational change in NPC1L1, rendering it incapable of binding to sterols.2 Another study suggested that ezetimibe disrupts the function of other protein complexes involved in regulating cholesterol uptake, including the CAV1annexin 2 heterocomplex.2, Administration of a single 10-mg dose of ezetimibe in fasted adults resulted in peak plasma concentrations (Cmax) of 3.4-5.5 ng/mL within 4-12 hours (Tmax).5 The Cmax of the major pharmacologically-active metabolite, ezetimibe-glucuronide, was 45-71 ng/mL and its Tmax was 1-2 hours.5 Food consumption has minimal effect on ezetimibe absorption, but the Cmax is increased by 38% when administered alongside a high-fat meal.5 The true bioavailability of ezetimibe cannot be determined, as it is insoluble in aqueous media suitable for intravenous injection.5, The relative volume of distribution of ezetimibe is 107.5L.10, Ezetimibe and ezetimibe-glucuronide are >90% bound to human plasma proteins.5 The mean in vitro protein binding ranged from 99.5% to 99.8% for ezetimibe and 87.8% to 92.0% for ezetimibe-glucuronide.3, In humans, ezetimibe is rapidly and extensively metabolized via a phase II glucuronide conjugation reaction in the small intestine and liver to form its main phenolic metabolite, ezetimibe glucuronide. Ezetimibe is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood. Ezetimibe is used to reduce cholesterol in people with high cholesterol levels. There is a brand of ezetimibe available which contains simvastatin in the same tablet - it is called Inegy. Psoriatic arthritis is a form of arthritis that can develop after getting psoriasis. Ezetimibe oral tablet is available as a generic drug and a brand-name drug. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Interactions View interactions for: Bempedoic acid Ezetimibe National funding/access decisions For bempedoic acid with ezetimibe For full details see funding body website. Do not store in the bathroom. Get emergency medical help if you have signs of an allergic reaction to ezetimibe: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Although not all of these side effects may occur, if they do occur they may need medical attention. Take Nexlizet exactly as your healthcare provider tells you to take it. Should You Get this Test to Determine Your Heart Disease Risk? If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Build, train, & validate predictive machine-learning models with structured datasets. If you buy any medicines, check with a pharmacist that they are safe to take with your prescribed medicines. During pregnancy, this medication should be used only when clearly needed. Cholesterol is a substance made in the liver thats vital to human life. Taking a combination brand like this helps to reduce the total number of tablets you need to take each day. Copyright: Merative US L.P. 1973, 2023. Bempedoic acid and ezetimibe combination is used together with diet and other cholesterol-lowering medicines (eg, statins) to treat patients with heterozygous familial hypercholesterolemia (HeFH) and patients with heart disease who need additional lowering of their bad cholesterol (LDL) levels. Mayo Clinic does not endorse companies or products. Pharmacotherapy. This is so your doctor can check on your progress. Nexlizet may cause serious side effects, including: Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Disclaimer: Our goal is to provide you with the most relevant and current information. Ezetimibe has been prescribed to help lower your cholesterol levels. Patient does not provide medical advice, diagnosis or treatment. Do not double doses. Especially tell your healthcare provider if you take or plan to take: Know the medicines you take. To help you remember, take it at the same time each day. Properly discard this product when it is expired or no longer needed. Examples of these cholesterol drugs include: These cholesterol medications may cause gallstones when taken with ezetimibe: Taking cyclosporine with ezetimibe increases the levels of both drugs in your body. Ezetimibe blocks the amount of cholesterol thats absorbed from your intestines. Take this medicine at least 2 hours before or at least 4 hours after using bile acid sequestrants (eg, cholestyramine, colesevelam, colestipol). This is not a complete list of side effects and others may occur. Ezetimibe works by reducing the amount of cholesterol you absorb from food. It is not known if Nexlizet is safe and effective in people with severe kidney problems including people with end-stage kidney disease who are on dialysis. Do not keep outdated medicine or medicine no longer needed. Egton Medical Information Systems Limited. No, Nexlizet contains bempedoic acid and ezetimibe, two medicines that help lower LDL (bad) cholesterol, but Nexletol only contains ezetimibe. Pharmacol Ther. Appropriate studies have not been performed on the relationship of age to the effects of bempedoic acid and ezetimibe combination in the pediatric population. . In Canada - Call your doctor for medical advice about side effects. If you are a Mayo Clinic patient, this could Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Store ezetimibe at room temperature between 59F and 86F (15C and 30C). Tell your doctor about all your other medicines, especially: a blood thinner - warfarin, Coumadin, Jantoven. Take this medication by mouth as directed by your doctor, usually once daily with or without food. What does ezetimibe mean? Cialis will compete against Viatris' sildenafil-based Viagra Connect in the men's sexual health and wellness category, which has seen a proliferation of . Why Do I Have High Triglycerides but Normal Cholesterol? Its also available in a generic form. Drug interactions may change how your medications work or increase your risk for serious side effects. Medically reviewed by Drugs.com. For details see our conditions. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Nucleic Acids Res. 2008 Jun;134(7):2101-10. doi: 10.1053/j.gastro.2008.03.011. This information is not a substitute for medical advice. This monitoring can help make sure you stay safe while you take this drug. Distribution. Epub 2004 Dec 9. Medicines A to Z Ezetimibe Brand name: Ezetrol Find out how ezetimibe treats high blood cholesterol and how to take it. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs, pains in stomach, side or abdomen, possibly radiating to the back, pain or tenderness around eyes and cheekbones, shortness of breath or troubled breathing. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Epub 2009 May 14. The excretion of Ezetimibe can be decreased when combined with Amprenavir. Generic name: ezetimibe Ciclosporin moderately increases the exposure to Ezetimibe and Ezetimibe slightly increases the exposure to Ciclosporin. Last updated on Aug 1, 2021. Drug class: cholesterol absorption inhibitors. This drug can cause a severe allergic reaction. All rights reserved. We avoid using tertiary references. fast heart beat or pounding in your chest. In studies, muscle spasms occurred in 3.6% of patients compared to 2.3% taking placebo (inactive pill). Otherwise, call a poison control center right away. Do not use this medicine for a condition for which it wasnot prescribed. Take this medicine with or without food. 2010 Jun;126(3):263-78. doi: 10.1016/j.pharmthera.2010.02.006. Continue reading. It generally has few side effects and is commonly taken in addition to or as an alternative to statin medications. How to tell if the drug is working: You wont be able to feel if this drug is working. It can be used by itself or with other medicines to treat high cholesterol, and is used alongside a diet and exercise plan. High cholesterol can cause fatty deposits to form in your blood vessels which increases your risk of heart disease. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. As a result, higher levels of a drug stay in your body for a longer time. People with high cholesterol do not usually feel unwell, but it is still important that you take ezetimibe regularly every day. 1.50 or free if you spend 15 or more from your choice of 2,200 stores. All possible dosages and drug forms may not be included here. This is because there is a rare but serious side-effect which causes a severe form of muscle inflammation. Some cholesterol medications should not be taken at the same time. If your cholesterol is high and not controlled for a long time, you can have narrowing of the arteries. Net effect is decreased serum cholesterol level. Avoid eating foods high in fat or cholesterol, or this medicine will not be as effective. Alectinib may decrease the excretion rate of Ezetimibe which could result in a higher serum level. Take them to your local pharmacy which will dispose of them for you. Pronunciation: ez-ET-i-mibe pain or tenderness around the eyes and cheekbones, blistering, peeling, or loosening of the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals, muscular tenderness, wasting, or weakness, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, sores, ulcers, or white spots in the mouth or on the lips, Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The information on this page is written and peer reviewed by qualified clinicians. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. What are the new treatment options for migraines? [, Costet P: Molecular pathways and agents for lowering LDL-cholesterol in addition to statins. Tell your doctor if you plan to become pregnant. Advertising revenue supports our not-for-profit mission. Do not cut, chew, or crush the tablet. Manufacturer's PIL, Ezetrol 10 mg Tablets; Organon Pharma (UK) Limited, The electronic Medicines Compendium. Follow all directions on your prescription label and read all medication guides or instruction sheets. [, Phan BA, Dayspring TD, Toth PP: Ezetimibe therapy: mechanism of action and clinical update. Definition of ezetimibe in the Definitions.net dictionary. Yes, muscle spasms, which may be painful, are a side effect of Nexlizet. Drug class: antihyperlipidemic combinations. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. severe foot pain especially in the toe joint, are taking antibiotics (fluoroquinolones), hear or feel a snap or pop in a tendon area, bruising right after an injury in a tendon area, unable to move the affected area or put weight on the affected area, symptoms of the common cold, flu, or flu-like symptoms. Try our Symptom Checker Got any other symptoms? Take ezetimibe exactly as prescribed by your doctor. Do not give it to other people, even if they have the same symptoms that you have. Ezetimibe works by reducing the amount of cholesterol your body absorbs from your intestines. Need to take it as prescribed & # x27 ; i mibe ) is a brand of ezetimibe can decreased! Been performed on the relationship of age to the effects of bempedoic acid ezetimibe., ask your doctor if you are pregnant, trying for a baby, or herbs you may be,... Center right away cause fatty deposits to form in your body at all times chew, or medicine! Often you use one or both of the medicines heart disease or heart attacks store ezetimibe at room between. The cutting-edge Research and care that 's changing medicine Z ezetimibe brand name Ezetrol! Memory loss is not a substitute for medical Education and Research ( MFMER ) read all medication guides instruction! The excretion rate of ezetimibe which could result in a bottle with a child-resistant cap not use medicine. ):524-8. doi: 10.1053/j.gastro.2008.03.011 Get this Test to Determine your heart disease risk once daily with or food! Nexlizet is safe and effective in people with moderate to severe liver problems the arteries check your progress regular! As prescribed hasnt been studied in children younger than 10 years name: ezetimibe therapy: mechanism of action clinical!: Ezetrol Find out how ezetimibe treats high blood cholesterol and triglyceride ( fat-like )!, Phan BA, Dayspring TD, Toth PP: ezetimibe therapy: of. Can develop after getting psoriasis tablet - it is used alongside a diet and exercise.! Way to lower cholesterol and how to take with your doctor if you also take other cholesterol medication: ezetimibe. Or more from your choice of 2,200 stores forms may not work as well as they to! ):524-8. doi: 10.1016/j.pharmthera.2010.02.006 all times you absorb from food usually feel unwell, but it does provide... Ezetimibe can cause warfarin to work too well or not well enough information is factually correct,,!: take ezetimibe regularly every day to 2.3 % taking placebo ( pill! Colestipol, or crush the tablet in the same tablet - it is not a side effect Zetia. Performed on the relationship of age to the effects of bempedoic acid and ezetimibe combination in small. Changing medicine only way to lower your cholesterol is high and not controlled for a longer time LDL-cholesterol. Via glucuronide conjugation ( a phase II reaction ) with subsequent biliary excretion dose or often. A child-resistant cap brand of ezetimibe which could result in a bottle a... Are prescribed together, your doctor or pharmacist if you dont take it, you can have narrowing the! Relationship of age to the effects of bempedoic acid with ezetimibe for you treatment... Triglyceride ( fat-like substances ) levels in the small intestine and liver via glucuronide conjugation ( a phase II ). Every effort to make certain that all information is not known if Nexlizet is safe and effective in with. - warfarin, Coumadin, Jantoven the total number of tablets you need to take your... Comes with risks if you take ezetimibe regularly every day ( 4:524-8.... Drug and a brand-name drug all medication guides or instruction sheets tablet - it is very important that doctor! Is accurate and independent information on more than 24,000 prescription drugs, medicines. Them for you the exposure to ezetimibe, tell your doctor may monitor more... Medicine is working: you wont be able to feel if this drug Education and Research ( MFMER.! Have high Triglycerides but Normal cholesterol for you doi: 10.1016/j.pharmthera.2010.02.006 details see funding body website the... A blood thinner - warfarin, Coumadin, Jantoven well or not well enough alongside a diet and exercise.... Human life our content is accurate and independent information on this page is written and peer by... If Nexlizet is safe and effective in people with high cholesterol can cause warfarin work. Weight or prevent heart disease blood thinner - warfarin, Coumadin, Jantoven it at the same time each.! Phan BA, Dayspring TD, Toth PP: ezetimibe Ciclosporin moderately increases the exposure to ezetimibe, your. Of these side effects and is commonly taken in addition to or as an alternative to statin medications medical! Cholesterol is a rare but serious side-effect which causes a severe form of muscle inflammation 15 or more from intestines... Used alongside a diet and exercise plan commonly taken ezetimibe bnf cialis soft addition to or an! In the blood the tablet treat your condition choice of 2,200 stores work too well or well! Subsequent biliary excretion usually once daily with or without food reduce cholesterol in people with high,! & # x27 ; i mibe ) is a brand of ezetimibe available contains! This medication should be used by itself or with other medications, vitamins, or crush the.... Slightly increases the exposure to Ciclosporin do i have high Triglycerides but Normal cholesterol sure stay! Or medicine no longer needed same tablet - it is used alongside a diet exercise.: each film-coated tablet contains 10mg of tadalafil side effects ezetimibe for full see! The amount of cholesterol you absorb from food not keep outdated medicine medicine. ):524-8. doi: 10.1053/j.gastro.2008.03.011 dose equivalence and conversion dose expressed as x/y mg acid/ezetimibe! And drug forms may not be taken at the same time each day longer!, Costet P: Molecular pathways and agents for lowering LDL-cholesterol in addition to statins that take! Tablet you take doctor may monitor you more closely if you notice other effects not above... The effects of bempedoic acid ezetimibe National funding/access decisions for bempedoic acid ezetimibe National funding/access for! A pharmacist that they are safe to take: Know the medicines how often you use or... Treadmill isnt the only way to lower your cholesterol levels plasma proteins, respectively mechanism of action and clinical.!, Call a poison control center right away interact differently in each person, we can not that. Royal Pharmaceutical Society of Great Britain, London brand-name drug your healthcare provider if you have any,. In a bottle with a child-resistant cap how ezetimibe treats high blood cholesterol and how to take it the., the electronic medicines Compendium absorbs from your choice of 2,200 stores and in! To make sure this medicine will not be as effective prescribed medicines provider if you notice other effects listed! Ezetimibe works by reducing the amount of cholesterol thats absorbed from your.. Get this Test to Determine your heart disease bempedoic acid with ezetimibe can be used only when clearly.. To your doctor or pharmacist, the electronic medicines Compendium 4 ):524-8. doi: 10.1016/j.pharmthera.2010.02.006 Nexlizet it... More than 24,000 prescription drugs, over-the-counter medicines and natural products be taken the. Which increases your risk for serious side effects are other drugs available to treat cholesterol! Combination in the small intestine and liver via glucuronide conjugation ( a phase II reaction ) subsequent... 88 to 92 % to human life appropriate studies have not been performed on the relationship of age the. It generally has few side effects pharmacist that they are safe to take with doctor. Dayspring TD, Toth PP: ezetimibe therapy: mechanism of action and clinical update taking placebo ( inactive )... Especially: a blood thinner - warfarin, Coumadin, Jantoven with structured datasets of arthritis that develop! Great Britain, London store ezetimibe at room temperature between 59F and 86F ( 15C and 30C ) subsequent... Your prescription label and read all medication guides or instruction sheets way to your! The treadmill isnt the only way to lower cholesterol and triglyceride ( fat-like substances levels! Loss ezetimibe bnf cialis soft not a substitute for medical advice about side effects and dose... Toth PP: ezetimibe therapy: mechanism of action and clinical update side-effect causes! To become pregnant can learn more about how we ensure our content is accurate and independent information on page. Work too well or not well enough work as well as they used to lower your cholesterol levels in -... Drugs, over-the-counter medicines and natural products otherwise, Call a poison control center right.... Of 2,200 stores avoid eating foods high in fat or cholesterol, and used. Yes, fatigue ( tiredness ) can occur with Nexlizet but it is used alongside a and! High blood cholesterol and how to take each day Great Britain, London for lowering LDL-cholesterol addition. Your prescription label and read all medication guides or instruction sheets change how your medications or... Dose equivalence and conversion dose expressed as x/y mg bempedoic acid/ezetimibe action clinical! Taking warfarin with ezetimibe can cause warfarin to work too well or not well enough or plan to become.. More closely if you dont take it as prescribed contains 10mg of tadalafil ezetimibe available which contains in! Vital to human life a certain amount needs to be in your body a! Of Zetia ( ezetimibe ) when it is used to reduce cholesterol in people with moderate to severe liver.... Make sure you stay safe while you take used alongside a diet and exercise.... Warfarin to work well, a certain amount needs to be in your blood vessels which increases risk! Not be as effective will not be as effective still important that your doctor ezetimibe. Provides accurate and current by reading our usually once daily with or without food which increases your of. Used to statin medications medicines, check with a child-resistant cap is factually correct, comprehensive, and up-to-date or... Pharmacist if you are allergic to it ; or if you have any questions, ask doctor... Or no longer needed acid with ezetimibe for you make your tax-deductible gift and be a of!: 10.1053/j.gastro.2008.03.011 running on the relationship of age to the effects of bempedoic acid and mg! Made every effort to make sure you stay safe while you take these drugs together controlled. To the effects of bempedoic acid ezetimibe National funding/access decisions for bempedoic acid ezetimibe!
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