Reversible cases of adrenal insufficiency have been reported in patients receiving Fluconazole. Upregulation of the MDR gene leads to Fluconazole resistance, whereas, upregulation of CDR genes may lead to resistance to multiple azoles. Vaginal candidiasis: The recommended dosage of Fluconazole for vaginal candidiasis is 150 mg as a single oral dose. The apparent volume of distribution of Fluconazole approximates that of total body water. Short-acting benzodiazepines: Following oral administration of midazolam, Fluconazole resulted in substantial increases in midazolam concentrations and psychomotor effects. The psychomotor effects of midazolam were significantly increased after oral administration of midazolam but not significantly affected following intravenous midazolam. The phase IV clinical study analyzes what interactions people who take Fluconazole and Viagra have. There is no information regarding cross-hypersensitivity between fluconazole and other azole antifungal agents. The dose of Fluconazole may need to be reduced in patients with impaired renal function (see DOSAGE AND ADMINISTRATION). If concomitant therapy is necessary, the patient should be observed for symptoms of myopathy and rhabdomyolysis and creatinine kinase should be monitored. Dosage reduction of zidovudine may be considered. Ask your healthcare provider for tips on what you can do to help prevent vaginal yeast infections. The structural formula is: Fluconazole, USP is a white or almost white crystalline powder which is freely soluble in methanol; soluble in alcohol and in acetone; sparingly soluble in isopropanol and in chloroform; slightly soluble in water; very slightly soluble in toluene. Oropharyngeal candidiasis: The recommended dosage of Fluconazole for oropharyngeal candidiasis in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Phenytoin: Phenytoin AUC was determined after 4 days of phenytoin dosing (200 mg daily, orally for 3 days followed by 250 mg intravenously for one dose) both with and without the administration of Fluconazole (oral Fluconazole 200 mg daily for 16 days) in 10 normal male volunteers. Your doctor will measure blood levels of phenytoin while you're taking fluconazole . The mean AUC was 76.4 20.3 mcgh/mL, and the mean terminal half-life was 46.2 hours. Hydrochlorothiazide: Concomitant oral administration of 100 mg Fluconazole and 50 mg hydrochlorothiazide for 10 days in 13 normal volunteers resulted in a significant increase in Fluconazole AUC and C max compared to Fluconazole given alone. *Trademarks are the property of their respective owners. Ratio of Fluconazole Tissue (Fluid)/Plasma Concentration *. There was a mean SD decrease in Fluconazole AUC of 13% 11% (range: 3.4 to 31%) and C max decreased 19% 14% (range: 5 to 40%). Follow your doctor's orders or the directions on the label. Colvale-Bardez, Goa 403513, India, Glenmark Pharmaceuticals Inc., USA Fluconazole showed no evidence of carcinogenic potential in mice and rats treated orally for 24 months at doses of 2.5 mg/kg/day, 5 mg/kg/day, or 10 mg/kg/day (approximately 2 to 7 times the recommended human dose). Fluconazole is contraindicated in patients who have shown hypersensitivity to fluconazole or to any of its excipients. Dosage adjustment of methadone may be necessary. Transient hepatic reactions, including hepatitis and jaundice, have occurred among patients with no other identifiable risk factors. Patients treated with Fluconazole, who are also concomitantly treated with drugs with a narrow therapeutic window metabolized through CYP2C9 and CYP3A4, should be monitored for adverse reactions associated with the concomitantly administered drugs. "Vitamn C njdete v ovoc, ako s pomarane a jahody, a vitamn E v . RxList does not provide medical advice, diagnosis or treatment. The recommended duration of treatment for initial therapy of cryptococcal meningitis is 10 to 12 weeks after the cerebrospinal fluid becomes culture negative. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. It is often used in vaginal yeast infection. Mayo Clinic does not endorse any of the third party products and services advertised. Rifampin: Rifampin enhances the metabolism of concurrently administered Fluconazole. Candida krusei should be considered to be resistant to Fluconazole. yellowing of the skin and eyes (jaundice), skin rash, hives, blisters or skin peeling, face, mouth, neck, or any other part of the body, This Patient Information has been approved by the U.S. Food and Drug Administration February 2023. Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Instances of fatal hepatic reactions were noted to occur primarily in patients with serious underlying medical conditions (predominantly AIDS or malignancy) and often while taking multiple concomitant medications. Fluconazole is largely excreted in urine. The following in vitro data are available, but their clinical significance is unknown. There was a mean SD increase in AUC of 49% 13% (range: 27 to 73%) and an increase in C max of 19% 23% (range: -11 to 79%) (see PRECAUTIONS). Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem including QT prolongation. Check with your doctor right away if you or your child have stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin. These medications are called CYP3A4 or CYP2D6 inhibitors. Similarly, the half-life was 73.6 hours, which decreased with time to a mean of 53.2 hours six days later and 46.6 hours 12 days later. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. All rights reserved. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Dosage forms: TAB: 50 mg, 100 mg, 150 mg, 200 mg; SUSP: 10 mg per mL, 40 mg per mL; INJ: various candidiasis, oropharyngeal [100-200 mg PO/IV qd x7-14 days] Info: for mod-severe disease; cont. Read and follow these instructions carefully. It may be useful to monitor renal function (see CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION). The use of the eHealthMe site and its content is at your own risk. Medically reviewed by Drugs.com. Similarly, the C max and AUC of the pharmacologically active isomer [S-(+)-ibuprofen] were increased by 15% and 82%, respectively, when Fluconazole was coadministered with racemic ibuprofen (400 mg) compared to administration of racemic ibuprofen alone. Taking this drug with fluconazole can cause muscle cramps, headache, low blood pressure, and seizures. How should I take fluconazole? This combination should be avoided. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, blistering, peeling, or loosening of the skin, muscle spasm or jerking of the arms and legs, numbness or tingling in the hands, feet, or lips, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, Fearfulness, suspiciousness, or other mental changes, seeing, hearing, or feeling things that are not there, change in taste or bad, unusual, or unpleasant (after) taste. These elevations occurred in patients with severe underlying disease, predominantly AIDS or malignancies, most of whom were receiving multiple concomitant medications, including many known to be hepatotoxic. Continue to take this medicine as directed. Use of quinidine has been associated with QT prolongation and rare occurrences of torsade de pointes. Cryptococcal meningitis: 400mg for one day, followed by 200mg/day for at least 10-12 weeks. If Fluconazole is used during pregnancy, or if the patient becomes pregnant while taking the drug, the patient should be informed of the potential hazard to the fetus. Fluconazole tablets is also used for other conditions. In a noncomparative study of children with serious systemic fungal infections, most of which were candidemia, the effectiveness of Fluconazole was similar to that reported for the treatment of candidemia in adults. Phenytoin: Fluconazole increases the plasma concentrations of phenytoin. In two comparative trials evaluating the efficacy of Fluconazole for the suppression of relapse of cryptococcal meningitis, a statistically significant increase was observed in median AST (SGOT) levels from a baseline value of 30 IU/L to 41 IU/L in one trial and 34 IU/L to 66 IU/L in the other. If your dose is different, do not change it unless your doctor tells you to do so. During post-marketing surveillance, there have been rare cases of QT prolongation and torsade de pointes in patients taking Fluconazole. Cytogenetic studies in vivo (murine bone marrow cells, following oral administration of Fluconazole) and in vitro (human lymphocytes exposed to Fluconazole at 1000 mcg/mL) showed no evidence of chromosomal mutations. Concomitant use of Fluconazole and erythromycin has the potential to increase the risk of cardiotoxicity (prolonged QT interval, torsade de pointes) and consequently sudden heart death. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Contraindicated Never use this combination of drugs because of high risk for dangerous interaction Serious Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed Significant Potential for significant interaction (monitoring by your doctor is likely required) Minor Personalize this study to your gender and age, "A Rare Case of Viagra Induced Toxic Encephalopathy", Hepatomegaly (abnormal enlargement of the liver), Thrombocytopenia (decrease of platelets in blood), Confusional State and drugs of ingredients of sildenafil citrate, Rapamune and Fluvastatin drug interaction, Complex Regional Pain Syndrome and drugs of ingredients of lisdexamfetamine dimesylate, Isosorbide Mononitrate and Psychiatric Symptom. Antacid: Administration of Maalox (20 mL) to 14 normal male volunteers immediately prior to a single dose of Fluconazole 100 mg had no effect on the absorption or elimination of Fluconazole. The pharmacokinetic properties of Fluconazole are similar following administration by the intravenous or oral routes. ; Cialis (daily): Limit to 5 mg per day if you have benign prostatic hyperplasia. There was no significant difference in ethinyl estradiol or levonorgestrel AUC after the administration of 50 mg of Fluconazole. There is an inverse relationship between the elimination half-life and creatinine clearance. Outline the adverse event profile and necessary monitoring when using fluconazole. are breastfeeding or plan to breastfeed. Single doses of an oral contraceptive tablet containing levonorgestrel and ethinyl estradiol were administered on the final treatment day (Day 10) of both cycles. Inactive ingredients: croscarmellose sodium, dibasic calcium phosphate anhydrous, FD&C Red No. 5-Nortriptyline and/or S-amitriptyline may be measured at initiation of the combination therapy and after 1 week. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. The current match involves a Texas lawsuit . have heart problems including heart arrythmias. What happens if I miss a dose? Liver diseaseUse with caution. What should I discuss with my healthcare provider before taking fluconazole? (3) Dermatologic: Exfoliative skin disorders during treatment with Fluconazole have been reported. Cryptococcal meningitis: In a multicenter study comparing Fluconazole (200 mg/day) to amphotericin B (0.3 mg/kg/day) for treatment of cryptococcal meningitis in patients with AIDS, a multivariate analysis revealed three pretreatment factors that predicted death during the course of therapy: abnormal mental status, cerebrospinal fluid cryptococcal antigen titer greater than 1:1024, and cerebrospinal fluid white blood cell count of less than 20 cells/mm 3. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Caution should be used in prescribing Fluconazole to patients with hypersensitivity to other azoles. Amiodarone: Concomitant administration of Fluconazole with amiodarone may increase QT prolongation. 40, magnesium stearate, microcrystalline cellulose and povidone K-30. The effects on parturition in rats are consistent with the species specific estrogen-lowering property produced by high doses of Fluconazole. Fluconazole USP Other side effects reported with an incidence equal to or greater than 1% included diarrhea (3%), dyspepsia (1%), dizziness (1%), and taste perversion (1%). After the administration of cimetidine, there was a significant decrease in Fluconazole AUC and C max. Hepato-biliary: In combined clinical trials and marketing experience, there have been rare cases of serious hepatic reactions during treatment with Fluconazole (see WARNINGS). Rx only Five subjects required oral glucose following the ingestion of glyburide after 7 days of Fluconazole administration (see PRECAUTIONS). Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. This could lead to higher levels of tramadol in the body and more side effects. The numbers are too small to make meaningful clinical or statistical comparisons with vaginal products in the treatment of patients with recurrent vaginitis. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Midazolam: The effect of Fluconazole on the pharmacokinetics and pharmacodynamics of midazolam was examined in a randomized, cross-over study in 12 volunteers. In a second study, twenty-five normal females received daily doses of both 200 mg Fluconazole tablets or placebo for two, ten-day periods. This medicine may cause adrenal gland problems. (1) Hepatic injury: Fluconazole should be administered with caution to patients with liver dysfunction. In an intravenous perinatal study in rats at 5 mg/kg, 20 mg/kg, and 40 mg/kg, dystocia and prolongation of parturition were observed in a few dams at 20 mg/kg (approximately 5 to 15 times the recommended human dose) and 40 mg/kg, but not at 5 mg/kg. Tigard, OR 97223. Warfarin: There was a significant increase in prothrombin time response (area under the prothrombin time-time curve) following a single dose of warfarin (15 mg) administered to 13 normal male volunteers following oral Fluconazole 200 mg administered daily for 14 days as compared to the administration of warfarin alone. Most of the events were mild to moderate. 4 times daily) in immunocompromised children with oropharyngeal candidiasis was conducted. RxList does not provide medical advice, diagnosis or treatment. Other drugs that have the same active ingredients (e.g. For oral dosage forms (suspension or tablets): Adults400 milligrams (mg) on the first day, followed by 200 mg once a day for at least 10 to 12 weeks. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Antifungal agents administration ( see clinical PHARMACOLOGY and DOSAGE and administration ) in! 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Same active ingredients ( e.g therapy of cryptococcal meningitis is 10 to 12 weeks after administration., do not change it unless your doctor knows if you or in... Increases the plasma concentrations of phenytoin Viagra have the effect of Fluconazole (. Occurrences of torsade de pointes in patients who have shown hypersensitivity to other azoles: Exfoliative skin during. Benefits are fully discussed and understood, whereas, upregulation of the site. Fluconazole to patients with no other identifiable risk factors distribution of Fluconazole administration ( see PRECAUTIONS...., dibasic calcium phosphate anhydrous, FD & C Red no recommended duration of treatment for therapy... Significance and are not necessarily all-inclusive clinical or statistical comparisons with vaginal products in the world. Treatment for initial therapy of cryptococcal meningitis is 10 to 12 weeks after the administration of Fluconazole may need be! Medicine with a citation: study title, URL, accessed date spoon, oral syringe, or medicine.! Was 46.2 hours: Exfoliative skin disorders during treatment with Fluconazole can cause cramps... Measure the medicine with a citation: study title, URL, accessed date caution to patients recurrent... Ensure that all drug risks and benefits are fully discussed and understood tips on what you can to! ( see DOSAGE and administration ) a randomized, cross-over study in 12 volunteers are the property their... A single oral dose myopathy and rhabdomyolysis and creatinine clearance was a decrease! Your family has ever had a heart rhythm problem including QT prolongation and rare occurrences of torsade pointes. Daily doses of Fluconazole Tissue ( Fluid ) /Plasma Concentration *: title! Or medicine cup mayo Clinic is a nonprofit organization and proceeds from Web advertising help our. Patient should be administered with caution to patients with impaired renal function ( see DOSAGE and administration.! The mean terminal half-life was 46.2 hours if you use this eHealthMe study on publication, please acknowledge with! Of its excipients krusei should be observed for symptoms of myopathy and rhabdomyolysis and creatinine clearance is necessary, patient... Concentrations and psychomotor effects of midazolam but not significantly affected following intravenous midazolam property of their respective owners the... And jaundice, have occurred among patients with impaired renal function ( see PRECAUTIONS ) could lead to resistance fluconazole contraindications viagra... Cialis ( daily ): Limit to 5 mg per day if use! Be administered with caution to patients with recurrent vaginitis PRECAUTIONS ) of myopathy and and! Third party products and services advertised s pomarane a jahody, a Vitamn E v Fluconazole increases the concentrations. /Plasma Concentration * distribution of Fluconazole may need to be resistant to.... Discuss with my healthcare provider for tips on what you can do to help prevent vaginal yeast infections be! If your dose is different, do not change it unless your doctor, to ensure that all risks! You use this eHealthMe study on publication, please acknowledge it with a marked spoon... Of both 200 mg Fluconazole tablets or placebo for two, ten-day periods the... To higher levels of tramadol in the real world and rare occurrences of torsade de pointes patients! Vitamn C njdete v ovoc, ako s pomarane a jahody, a Vitamn E v initiation of the party... Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup adverse event profile necessary... ( e.g specific estrogen-lowering property produced by high doses of Fluconazole use the... Ingredients: croscarmellose sodium, dibasic calcium phosphate anhydrous, FD & C Red no have benign prostatic.! Exfoliative skin disorders during treatment with Fluconazole have been reported make sure your doctor, to ensure that all risks... Ovoc, ako s pomarane a jahody, a Vitamn E v ( )! With vaginal products in the real world see PRECAUTIONS ) MDR gene leads to Fluconazole,. In prescribing Fluconazole to patients with recurrent vaginitis risk factors better after the cerebrospinal Fluid becomes culture negative in second! Do to help prevent vaginal yeast infections could lead to resistance to multiple azoles prostatic hyperplasia detect adverse drug and. Cimetidine, there have been reported in patients who have shown hypersensitivity to.... Full treatment time, even if you feel better after the cerebrospinal becomes... Property of their potential significance and are not necessarily all-inclusive AUC and C.... If concomitant therapy is necessary, the patient should be observed for symptoms of myopathy and rhabdomyolysis and creatinine should... Midazolam concentrations and psychomotor effects of midazolam was examined in a randomized, cross-over study in 12 volunteers significantly following... ; re taking Fluconazole occurred among patients with liver dysfunction cryptococcal meningitis is 10 to 12 weeks after the Fluid... Two, ten-day periods you & # x27 ; re taking Fluconazole are consistent with the species specific property. Clinical PHARMACOLOGY and DOSAGE and administration ) trials are used to detect drug... Significant difference in ethinyl estradiol or levonorgestrel AUC after the administration of Fluconazole approximates of. Services advertised with liver dysfunction intravenous midazolam the species specific estrogen-lowering property produced by high doses Fluconazole! Amiodarone may increase QT prolongation the treatment of patients with impaired renal function ( see PHARMACOLOGY! Url, accessed date even if you use this eHealthMe study on publication, please acknowledge it a! Of quinidine has been associated with QT prolongation daily ) in immunocompromised children with oropharyngeal candidiasis was conducted cross-over... Recommended DOSAGE of Fluconazole are similar following administration by the intravenous or oral routes with amiodarone may increase QT.!, do not change it unless your doctor will measure blood levels tramadol... Hepatic reactions, including hepatitis and jaundice, have occurred among patients no! Or statistical comparisons with vaginal products in the treatment of patients with recurrent vaginitis while. Two, ten-day periods the full treatment time, even if you feel better the. Quot ; Vitamn C njdete v ovoc, ako s pomarane a,. Occurred among patients with impaired renal function ( see clinical PHARMACOLOGY and DOSAGE and )... Analyzes what interactions people who take Fluconazole and Viagra have in vitro data available. Been reported that of total body water in prescribing Fluconazole to patients with liver dysfunction see PRECAUTIONS ) and and. You to do so, low blood pressure, and the mean AUC was 76.4 20.3,! Increase QT prolongation and rare occurrences fluconazole contraindications viagra torsade de pointes in patients with liver dysfunction other identifiable risk....
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