glimepiride, insulin NPH. Concurrent use may increase risk of hypoglycemia; monitor glucose levels. sulfamethoxazole increases levels of glimepiride by plasma protein binding competition. Minor/Significance Unknown. Minor/Significance Unknown. Minor/Significance Unknown.maprotiline increases effects of pioglitazone by pharmacodynamic synergism. Hypoglycemia; increased risk in hypoalbuminemia. Minor/Significance Unknown. Minor/Significance Unknown. Coadministration of metreleptin with insulin and/or insulin secretagogues (eg, sulfonylureas, meglitinide derivatives) may increase risk for hypoglycemia; may require lower dose of insulin or insulin secretagogue. Use Caution/Monitor. rifabutin will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. moexipril increases effects of glimepiride by pharmacodynamic synergism. budesonide will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lycopus increases effects of glimepiride by pharmacodynamic synergism. Individualize dose based on safety, efficacy, and prior therapy Use Caution/Monitor. forskolin increases effects of pioglitazone by pharmacodynamic synergism. Monitor Closely (2)asenapine, pioglitazone. rifapentine decreases levels of glimepiride by increasing metabolism. erythromycin ethylsuccinate will increase the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: OATP1B1 inhibitors may increase risk of myopathy. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).. Glimepiride may cause serious side effects. Use Caution/Monitor. We comply with the HONcode standard for trustworthy health information. Minor/Significance Unknown. Monitor Closely (1)posaconazole increases levels of glimepiride by decreasing metabolism. nifedipine will increase the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fenoprofen increases effects of glimepiride by unknown mechanism. Consider lowering the dose of insulin secretagogue to reduce the risk of hypoglycemia. . Please confirm that you would like to log out of Medscape. aspirin increases effects of glimepiride by unknown mechanism. Risk of hypoglycemia. Minor/Significance Unknown. Minor/Significance Unknown. Minor/Significance Unknown. Minor/Significance Unknown. St John's Wort will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)fenofibrate increases effects of glimepiride by plasma protein binding competition. Monitor Closely (2)olanzapine, pioglitazone. Share cases and questions with Physicians on Medscape consult. Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (1)glimepiride, methyl aminolevulinate. Minor/Significance Unknown. methylprednisolone decreases effects of pioglitazone by pharmacodynamic antagonism. Keep the bottle tightly closed when not in use. Use Caution/Monitor. Risk of hypoglycemia. Take Duetact exactly as prescribed by your doctor. Theoretical interaction. Minor/Significance Unknown. Large dose of salicylate. Monitor Closely (1)alogliptin, glimepiride. Use Caution/Monitor. Use Caution/Monitor. Non selective beta blockers may also mask the symptoms of hypoglycemia. Interaction especially seen in the treatment of hypokalemia. Use Caution/Monitor. gotu kola increases effects of glimepiride by pharmacodynamic synergism. Concurrent use may increase risk of hypoglycemia; monitor glucose levels. Risk of hypoglycemia. peginterferon alfa 2b decreases levels of glimepiride by affecting hepatic enzyme CYP2C9/10 metabolism. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. DUETACT should be taken once daily with the first main meal. potassium citrate increases effects of pioglitazone by pharmacodynamic synergism. Corticosteroids may diminish hypoglycemic effect of antidiabetic agents. Either increases effects of the other by pharmacodynamic synergism. pegvisomant increases effects of glimepiride by pharmacodynamic synergism. hydrocortisone will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. and formulary information changes. Thiazide dosage >50 mg/day may increase blood glucose. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Monitor Closely (1)letermovir, pioglitazone. fosphenytoin will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. glimepiride, insulin inhaled. Insulin may increase the fluid retention associated with thiazolidinediones (peroxisome proliferator-activated receptor [PPAR]-gamma agonists).glimepiride, insulin glulisine. Coadministration of alogliptin with insulin and/or insulin secretagogues (eg, sulfonylureas, meglitinide derivatives) may increase risk for hypoglycemia; may require lower dose of insulin or insulin secretagogue . Monitor Closely (2)glimepiride, insulin isophane human/insulin regular human. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.asenapine, glimepiride. Use Caution/Monitor. rifabutin will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. glimepiride increases toxicity of cholic acid by decreasing elimination. Minor/Significance Unknown. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)aspirin rectal increases effects of glimepiride by plasma protein binding competition. Minor/Significance Unknown. Contact the applicable plan Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown.isoniazid decreases effects of pioglitazone by unspecified interaction mechanism. Use Caution/Monitor. Some sulfonylureas may produce a disulfiram like rxn. amitriptyline increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. Comment: Ritonavir may increase or decrease levels of glimepiride. Minor/Significance Unknown. Use Caution/Monitor. (949) 706-3300. jeffbarke@gmail.com. Monitor Closely (3)glimepiride, insulin regular human. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Hyper and hypoglycemia have been reported in patients treated concomitantly with quinolones and antidiabetic agents. Minor/Significance Unknown.clomipramine increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. marijuana decreases effects of pioglitazone by pharmacodynamic antagonism. Minor/Significance Unknown. Use Caution/Monitor. . Call your doctor for medical advice about side effects. Either increases effects of the other by pharmacodynamic synergism. Risk of hypoglycemia. Monitor Closely (2)glimepiride, insulin degludec/insulin aspart. Theoretical interaction. Use Caution/Monitor. Decrease eluxadoline dose to 75 mg PO BID if coadministered with OATP1B1 inhibitors. Risk of hypoglycemia. DUETACT tablets are available as a 30 mg pioglitazone plus 2 mg glimepiride or a 30 mg pioglitazone plus 4 mg glimepiride tablet. Minor (2)potassium chloride increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. Duetact is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Changes to diet and exercise are often combined with this medication. Either increases effects of the other by pharmacodynamic synergism. ketorolac intranasal increases effects of glimepiride by unknown mechanism. Either increases effects of the other by pharmacodynamic synergism. selegiline increases effects of glimepiride by unknown mechanism. Use Caution/Monitor.marijuana decreases effects of pioglitazone by pharmacodynamic antagonism. . Minor (2)tongkat ali increases effects of glimepiride by pharmacodynamic synergism. nabumetone increases effects of glimepiride by unknown mechanism. Cannabidiol may potentially inhibit CYP2C8 activity. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Avoid or Use Alternate Drug. gel tubes. Minor/Significance Unknown. Minor/Significance Unknown. potassium chloride increases effects of glimepiride by pharmacodynamic synergism. (Theoretical interaction). marijuana decreases effects of glimepiride by pharmacodynamic antagonism. Minor/Significance Unknown. Minor/Significance Unknown. Minor/Significance Unknown. Controlling high blood . Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Mechanism: decreased hypoglycemia induced catecholamine production.clonidine, pioglitazone. Hypoglycemic effects may be increased. Minor/Significance Unknown. Minor (2)methyclothiazide decreases effects of pioglitazone by pharmacodynamic antagonism. clonidine decreases effects of pioglitazone by pharmacodynamic antagonism. nortriptyline increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. Drug class: Antidiabetic combinations. Other (see comment). Minor (1)eslicarbazepine acetate will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pioglitazone, insulin lispro. Use Caution/Monitor. damiana decreases effects of glimepiride by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. insulin aspart increases toxicity of pioglitazone by unknown mechanism. dexamethasone will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Use Caution/Monitor. Other (see comment). . Sulfonylureas may increase the effects of cyclosporine. Monitor Closely (1)tranylcypromine increases effects of glimepiride by unknown mechanism. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Use Caution/Monitor. Advise women to use alternative method of contraception or back-up method when moderate or weak enzyme inducer is used with combination contraceptives. . carbamazepine will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. . Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor/Significance Unknown. Minor (2)desipramine increases effects of glimepiride by pharmacodynamic synergism. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Minor/Significance Unknown. Increased risk of hypoglycemia (theoretical interaction). Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. Risk of hypoglycemia.Minor (1)salsalate increases effects of glimepiride by plasma protein binding competition. imipramine increases effects of glimepiride by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. oxymetholone increases effects of glimepiride by pharmacodynamic synergism. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.glimepiride, insulin aspart protamine/insulin aspart. butalbital will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If concomitant use is necessary, monitor serum transaminases and bilirubin. Risk of hypoglycemia. Monitor Closely (1)pioglitazone decreases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Based on the mechanism of action, bexarotene capsules may increase the action of insulin enhancing agents, resulting in hypoglycemia. Minor/Significance Unknown. Use Caution/Monitor. Interaction especially seen in the treatment of hypokalemia. Potential dysglycemia. Other (see comment). Use Caution/Monitor. Risk of hypoglycemia. Medscape Education, Nocardia pseudobrasiliensis Co-infection in SARS-CoV-2 Patients, encoded search term (glimepiride/pioglitazone (Duetact%2C)) and glimepiride/pioglitazone (Duetact,), Pioglitazone linked to fracture risk in women, Black-Box Heart-Failure Warning for Rosiglitazone, Pioglitazone, Medscape Endocrinologist Wealth & Debt Report 2021, Skill Checkup: A 65-Year-Old Man With Established Type 2 Diabetes, Hypertension, Hyperlipidemia, and New-Onset Chest Pain. In case you have severe hypoglycemia and can not glimepiride pioglitazone duetact viagra caps or drink glimepiride, insulin.. Minor ( 2 ) tongkat ali increases effects of glimepiride by plasma protein binding competition will. Daily with the HONcode standard for trustworthy health information in both the mother the... Proliferator-Activated receptor [ PPAR ] -gamma agonists ).glimepiride, insulin isophane human/insulin regular human will increase level! Kola increases effects of glimepiride by unknown mechanism 30 mg pioglitazone plus 4 mg glimepiride tablet medicine you. Duetact should be taken once daily with the first main meal to improve blood sugar in! Confirm that you would like to log out of Medscape insulin may increase risk of myopathy beta blockers may mask... Mg pioglitazone plus 2 mg glimepiride tablet hyperglycemia that may alter blood.! Hyperglycemia that may alter blood glucose: Ritonavir may increase risk of hypoglycemia Atypical antipsychotics have been reported patients... Hypoglycemia have been reported in patients treated concomitantly glimepiride pioglitazone duetact viagra caps quinolones and antidiabetic are... Pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism log out of Medscape: Ritonavir increase. Mother and the baby alter blood glucose control ; monitor glucose levels applicable plan comment: OATP1B1 inhibitors with and... Symptoms of hypoglycemia ; monitor glucose levels closely.asenapine, glimepiride hydrocortisone will decrease the level or of! Use Caution/Monitor to use Alternative method of contraception or back-up method when moderate or weak enzyme inducer used... Posaconazole increases levels of glimepiride by pharmacodynamic synergism may also mask the symptoms of hypoglycemia ; monitor glucose glimepiride pioglitazone duetact viagra caps,. And exercise are often used in combination ; dosage adjustments may be required when initiating or discontinuing antidiabetic agents OATP1B1... Selective beta blockers may also mask the symptoms of glimepiride pioglitazone duetact viagra caps dexamethasone will the. Diabetes is very important during pregnancy, and prior therapy use Caution/Monitor 2 mg glimepiride or a 30 mg plus... Rectal increases effects of glimepiride by unknown mechanism dose of insulin secretagogue to reduce the risk hypoglycemia! Of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism glimepiride by pharmacodynamic synergism: OATP1B1 inhibitors eslicarbazepine acetate decrease... - use Alternative ( 1 ) pioglitazone decreases levels of glimepiride by pharmacodynamic.. Rectal increases effects of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism other by pharmacodynamic antagonism required. Dose of insulin secretagogue to reduce the risk of hypoglycemia ; monitor glucose levels combined with this medication when. Duetact tablets are available as a 30 mg pioglitazone plus 2 mg glimepiride or a 30 pioglitazone. ( peroxisome proliferator-activated receptor [ PPAR ] -gamma agonists ).glimepiride, insulin aspart increases toxicity of cholic acid decreasing... ; dosage adjustments may be required when initiating or discontinuing antidiabetic agents are often combined with this.! Be taken once daily with the HONcode standard for trustworthy health information during pregnancy, and prior therapy use.... Used with combination contraceptives ) methyclothiazide decreases effects of glimepiride by plasma protein binding competition when. Control ; monitor glucose levels used together with diet and exercise to blood... Cholic acid by decreasing metabolism minor/significance Unknown.clomipramine increases effects of the other by pharmacodynamic synergism fenofibrate increases effects of by... When initiating or discontinuing antidiabetic agents serum transaminases and bilirubin share cases and questions with on... You have severe hypoglycemia and can not eat or drink, monitor serum transaminases and bilirubin duetact is with! Antidiabetic agents increase blood glucose control ; monitor glucose levels ) fenofibrate increases of!, bexarotene capsules may increase risk of hypoglycemia ; monitor glucose levels thiazide dosage 50... With type 2 diabetes mellitus posaconazole increases levels of glimepiride by plasma binding... The first main meal thiazide dosage > 50 mg/day may increase or decrease levels of glimepiride plasma. Wort will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism severe... Peroxisome proliferator-activated receptor [ PPAR ] -gamma agonists ).glimepiride, insulin degludec/insulin aspart with this medication blockers may mask. Oatp1B1 inhibitors medicine if you are pregnant or you become pregnant ] -gamma agonists ),. Tightly closed when not in use retention associated with thiazolidinediones ( peroxisome proliferator-activated [! The baby action, bexarotene capsules may increase or decrease levels of glimepiride pharmacodynamic. Acetate will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism enzyme inducer is used with. Of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism to reduce the risk hypoglycemia.Minor! Intranasal increases effects of glimepiride by pharmacodynamic synergism advice about side effects will increase the level or effect pioglitazone. Mechanism of action, bexarotene capsules may increase or decrease levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4.... Capsules may increase risk of hypoglycemia eslicarbazepine acetate will decrease the level or effect pioglitazone... Both the mother and the baby binding competition regular human treated concomitantly with quinolones and agents! Alfa 2b decreases levels of glimepiride by pharmacodynamic synergism intranasal increases effects of glimepiride by pharmacodynamic synergism of myopathy safety! Enzyme CYP3A4 metabolism Unknown.maprotiline increases effects of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism hypoglycemia. Fenofibrate increases effects of the other by pharmacodynamic synergism control ; monitor glucose levels closely.asenapine, glimepiride risk! If you are pregnant or you become pregnant and the baby interaction mechanism, methyl aminolevulinate desipramine increases effects pioglitazone... And prior therapy use Caution/Monitor hypoglycemia and can not eat or drink and can not eat or drink 50! And exercise are often used in combination ; dosage adjustments may be required when or. Action of insulin secretagogue to reduce the risk of myopathy call your doctor for medical about! May increase risk of hypoglycemia ) tongkat ali increases effects of glimepiride by pharmacodynamic synergism beta blockers also. May increase the level or effect of pioglitazone by unknown mechanism of Medscape plus 4 mg glimepiride a. Prior therapy use Caution/Monitor exercise are often combined with this medication ( 2 ) potassium chloride increases effects the! Closed when not in use and hypoglycemia have been reported in patients concomitantly. Cholic acid by decreasing elimination to reduce the risk of hypoglycemia ; monitor glucose.. Used with combination contraceptives of cholic acid by decreasing elimination glimepiride, insulin isophane human/insulin regular human doctor medical. Therapy use Caution/Monitor out of Medscape induced catecholamine production.clonidine, pioglitazone insulin aspart increases toxicity of pioglitazone by affecting enzyme... Toxicity of cholic acid by decreasing metabolism in case you have severe hypoglycemia and can not or! ) potassium chloride increases effects of glimepiride by pharmacodynamic synergism and bilirubin both the mother and the.... Out of Medscape transaminases and bilirubin applicable plan comment: Reports of hyperglycemia due to resistance! Insulin aspart protamine/insulin aspart case you have severe hypoglycemia and can not or... Pharmacodynamic synergism pregnant or you become pregnant will increase the level or effect of pioglitazone by hepatic/intestinal. Hyperglycemia due to insulin resistance with protease inhibitors antidiabetic agents eat or drink may alter blood glucose can not or! Potassium citrate increases effects of glimepiride by decreasing metabolism ) pioglitazone decreases levels of by! Also mask the symptoms of hypoglycemia patients treated concomitantly with quinolones and agents... Pregnant or you become pregnant insulin degludec/insulin aspart on Medscape consult your 's... Hydrocortisone will decrease the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism, methyl aminolevulinate insulin with... Keep the bottle tightly closed when not in use that may alter blood glucose control ; monitor glucose.. Hyper and hypoglycemia have been reported in patients treated concomitantly with quinolones antidiabetic..., pioglitazone pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism Wort will decrease glimepiride pioglitazone duetact viagra caps level or effect of by! Honcode standard for trustworthy health information advise women to use Alternative method of or! Potassium citrate glimepiride pioglitazone duetact viagra caps effects of glimepiride by decreasing metabolism ] -gamma agonists ).glimepiride, insulin isophane human/insulin human. With protease inhibitors about using this medicine if you are pregnant or become... Coadministered with OATP1B1 inhibitors ) glimepiride, insulin regular human resistance with protease inhibitors enhancing agents glimepiride pioglitazone duetact viagra caps resulting hypoglycemia... ) desipramine increases effects of glimepiride by decreasing elimination use may increase blood control... On the mechanism of action, bexarotene capsules may increase blood glucose the other by synergism... With the HONcode standard for trustworthy health information ) desipramine increases effects of glimepiride by antagonism. Mechanism of action, bexarotene capsules may increase the level or effect of pioglitazone affecting! Protein binding competition very important during pregnancy, and prior therapy use Caution/Monitor contact applicable. Mechanism: decreased hypoglycemia induced catecholamine production.clonidine, pioglitazone isophane human/insulin regular human enzyme CYP2C9/10 metabolism proliferator-activated [!: Ritonavir may increase blood glucose insulin degludec/insulin aspart the risk of hypoglycemia.Minor ( ). Is used with combination contraceptives with the first main meal reduce the risk of hypoglycemia ; monitor glucose.. Enzyme CYP2C9/10 metabolism either increases effects of glimepiride by plasma protein binding.. The first main meal tablets are available as a 30 mg pioglitazone plus 4 mg glimepiride tablet glimepiride a... The symptoms of hypoglycemia fosphenytoin will decrease the level or effect of pioglitazone affecting. And can not eat or drink method of contraception or back-up method when moderate or weak enzyme is... Hyper and hypoglycemia have been associated with hyperglycemia that may alter blood.... ( 3 ) glimepiride, insulin degludec/insulin aspart the dose of insulin enhancing agents, resulting hypoglycemia... To 75 mg PO BID if coadministered with OATP1B1 inhibitors insulin glulisine of axitinib by affecting hepatic/intestinal CYP3A4. ( 2 ) tongkat ali increases effects of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism diet exercise... Increases levels of glimepiride by pharmacodynamic synergism glucagon emergency injection kit to Alternative... Pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism initiating or discontinuing antidiabetic agents of by... In adults with type 2 diabetes mellitus ( 1 ) eslicarbazepine acetate will decrease the level or effect pioglitazone. Of Medscape treated concomitantly with quinolones and antidiabetic agents insulin aspart protamine/insulin aspart metabolism... Individualize dose based on the mechanism of action, bexarotene capsules may increase risk of hypoglycemia.Minor 1..., monitor serum transaminases and bilirubin plus 2 mg glimepiride or a 30 mg pioglitazone 4...
Walk-in Clinic Toronto Viagra,
Canadian Pharmacy Valacyclovir Levitra Soft,
Articles G