Alyoussef, A.; Al-Gayyar, M.M.H. ; el-Dakhakhny, M. The antibacterial properties of the. for 45 days), Clinical study on patients with mild-moderate hypertension, Total cholesterol, LDL and TGs; HDL; systolic pressure and diastolic pressure, Ibuprofen-induced hepatotoxicity in Swiss albino mice, CAT and GSH; histopathological picture and hepatic glycogen contents, MDA, NO and TNF-, AST and ALT; unsaturated fatty acids, High-dose atorvastatin-induced hepatotoxicity in male SD rats, Serum hepatic enzymes, MDA, protein carbonylation, and caspase 3 activity;GSH and CAT; histopathological and ultrastructural changes, PPAR-; LKB1 and AMPK phosphorylation; SIRT1, MDA, NO and IL-6, AST, ALT and alkaline phosphatase; thiol content, SOD, CAT, serum protein, albumin, AST, ALT, MDA, SOD, IL-6, TNF-, TGF-; IL-10, Gibberellic acid-treated pregnant albino rats, ALT, AST, MDA, Bax, Hydropic degeneration, Cellular infiltration, periportalFibrosis; SOD, CAT, GPx and Bcl-2, Rat model of NAFLD associated with 6-propyl-2-thiouracil (PTU)-induced hypothyroidism, CAT, NO, GSH, SOD; MDA, steatosis score, lobular inflammation, NAFLD Activity Score, alpha-smooth muscle actin, intralobular and portal tract and CD68, Rat model of acetaminophen overdose-induced acute liver injury, ALT, AST, MAPK Phosphorylation (JNK, ERK and P, Carboplatin-induced liver damage in female Wistar-albino rats, Apoptotic index, collagen fiber distribution around the central vein, hepatocyte cords preserved, MDA, ALK-P, AST and ALT; thiol concentration, CAT and SOD, and body weight gain, Morphine-induced liver damage in male mice, Liver weight; mean diameter of hepatocyte, central hepatic vein, AST, ALT, and NO, Randomized, double-blind, placebo-controlled clinical trial with NAFLD patients, AST, ALT, body mass index, and grade of fatty liver, Grade of hepatic steatosis, ALT, AST, TG, LDL-C, and HDL-C, Insulin sensitivity check index; serum glucose, serum insulin, insulin resistance, hepatic steatosis percentage, hs-CRP and NF-B, TNF-, hepatic steatosis and its percentage, HDL-C; FBS, lipid profiles (total cholesterol, triglyceride, VLDL, LDL), Liver enzyme (ALT and AST), inflammatory markers (Hs-CRP and IL-6), Anti-inflammatory and antimicrobial effect, Wounded (dermis + epidermis) male albino Wistar rats, A mixture of 1:1 ratio of honey and cold-pressed NSO, A circular excision wound in the back region of male albino Wistar rats, Double-blind randomized study with Albino rabbits, Female Wistar-albino rats with 84 excisional skin wounds on the backs, Murine macrophage leukemia cell line (RAW 264.7), human promyelocytic leukemia cell line (HL-60), Murine embryonic fibroblast cell line (3T3-CCL92), Hydrodistillation of seed [0.6% (w/w) of essential oil] (10 L), Diabetic SpragueDawley male rats with 2 excision wounds on the upper back of each animal with a dermal punch, Oxidative stress and lipid peroxidation, Male Albino Rats having psoriasis-like skin inflammation, IMQ-induced psoriasis-like inflammation, Randomized double-blind controlled clinical trial with mild-to-moderate acne vulgaris patients, Number of comedones, papules, and pustules;no side effect, Vitiligo patients, 47 body surface areas were affected, Bioavailability: oral CsA reduced by 32% but IP CsA was not affected, Plasma concentration of GBC increased by 13.4% (Single dose) and 21.8% (multiple doses) with TQ. Approved as a pharmacy medicine, Sanofi will launch Cialis Together in the second half of the year. Tahjib-Ul-Arif, Sarmistha Mitra, Diyah Fatimah Oktaviani, Md Kawsar Khan, Ho Jin Choi, Il Soo Moon, and Bonglee Kim. Majority of Africans believe that herbal medicine work. ; Kim, B. Ahirwar, D.; Ahirwar, B. Antidepressant effect of. ; Gong, Q.; Yeo, C.J. Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs. ; Basri, H. Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases A40 and A42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high fat/cholesterol diet-induced rats. ; Sapuan, S.; Foo, J.B.; Tor, Y.S. ; Mandegari, A.; Izadi, A.; Mahmoodi, R.; Nematollahi, H.; Porgholamhosein, F.; Ghorani, V.; Fekri, M.S. Products such as conditioners, hot oil treatments, gels and anti-frizz serums are some of the common products that have toxic chemicals. Saudi Arab. All articles published by MDPI are made immediately available worldwide under an open access license. ; Taka, E.; Mendonca, P.; Bauer, D.; Soliman, K.F.A. Guo, T.; Zhang, D.; Zeng, Y.; Huang, T.Y. Tadalafil, the generic equivalent to brand name Cialis (made by Eli Lilly), helps men with ED get and maintain erections with greater ease. Darand, M.; Darabi, Z.; Yari, Z.; Hedayati, M.; Shahrbaf, M.A. Bioresources Development and Conservation Programme (BDCP) and Intercedd Health Products (IHP) Novel thymoquinone lipidic core nanocapsules with anisamide-polymethacrylate shell for colon cancer cells overexpressing sigma receptors. H.J.C. ; Abba, Y.; Md Yusof, M.S. Rathore, C.; Rathbone, M.J.; Chellappan, D.K. Acute and subchronic toxicity of thymoquinone in mice. The Inspector-General of Police, IGP Usman Alkali Baba on Thursday commended the National Assembly (NASS) for its historic passage of the Police Pension Board Bill. Gupta, C.; Prakash, D. Nutraceuticals for geriatrics. Akintunde, J.K.; Abubakar, O.K. elik, F.; Gmez, C.; Karaman, H.; Kamaak, K.; Kaplan, .; Akl, E.; Tufek, A.; Guzel, A.; Uzar, E. Therapeutic Effects of Thymoquinone in a Model of Neuropathic Pain. Alhazza, I.M. ; Wilson, J.R.; Fehlings, M.G. All these ingredients work separately to aid sexual performance and erectile health: Tadalafil helps in improving the . ; Ozgul, M.; Atis, G. Protective effect of, Benhelima, A.; Kaid-Omar, Z.; Hemida, H.; Benmahdi, T.; Addou, A. Nephroprotective and diuretic effect of. Al-Jenoobi, F.I. Effects of Lepidium sativum. methods, instructions or products referred to in the content. Cialis is approved for the treatment of men who experience difficulty having and maintaining an erection (impotence). Imam, A.; Lawal, A.; Oyewole, L.A.; Ajibola, M.I. Gastric mucin content, Cox-2, PGE2, ERK-2, MMP-2; MMP-9 levels; H, Fasting-induced rabbit gastric ulcer model, Volume and the total acidity of gastric secretion, Male Wistar albino rats with ischemia/ reperfusion injury (colonic anastomosis model), Serum hydroxyproline levels, IL-6 level; tissue levels and serum levels of TNF-; edema and inflammatory cell infiltration; significant difference in Chiu classification, Negative UBT after intervention; median and interquartile range of total dyspepsia symptoms, Patients with moderate ulcerative colitis, Active bone formation, thick trabeculae with highly vascular bone marrow and large numerous osteocytes, Calvarial defected ovariectomy-induced osteoporosis in rat models, Ratio of new bone per total defect area and new bone trabeculae lined by active osteoblasts; capillary intensity in the defect area;osteogenesis, Dental pulp MSCs isolated from 1520 years old human patients from third molars, Clinical trial with healthy patients (for evaluation of Topical NS application on Delayed Dental Implant, 2-tert-Butyl-4-hydroquinone-induced cytotoxicity in human umbilical vein endothelial cells, Anti-apoptotic and anti-DNA and chromatin fragmentation effects, TQ (10 mg/kg BW, p.o., once daily for 28 days), Fipronil (phenylpyrazole insecticide)-induced oxidative injury in rats. Disclaimer/Publishers Note: The statements, opinions and data contained in all publications are solely Farghali, H.; Hynie, S.; Vohnikova, Z.; Masek, K. Possible dual role of nitric oxide in oxidative stress injury: A study in perfused hepatocytes. He said the product will help tackle the challenge of mosquito resistance to treated nets made with pyrethoids. Onifade, A.A.; Jewell, A.P. AChE, Acetylcholinesterase; ADAM-17, ADAM metallopeptidase domain 17; ADP, Adenosine diphosphate; AIF, apoptosis Inducing Factor; Akt, Protein kinase B; AlCl3, Aluminum chloride; ALK-P, Alkaline phosphatase; ALP, Alkaline phosphatase; ALT, Alanine aminotransferase; AMPK, 5 AMP-activated protein kinase; APP, Amyloid precursor protein; AST, Aspartate Aminotransferase; AST, Aspartate Aminotransferase; ATF, Activating transcription factor; A, beta amyloid; BACE1, Beta-site APP cleaving enzyme 1; Bax, BCL2-associated X protein; BBM, Brush border membrane; Bcl-2, B-cell lymphoma 2; BDNF, Brain-derived neurotrophic factor; CAT, Catalase; CCL5, Chemokine (C-C motif) ligand 5; CFB, Complement factor B; CHOP, C/EBP homologous protein; ZEB1, COX-2, Cyclooxygenase-2; CXCL3, Cytokine-induced neutrophil chemoattractant 3; cyt c, Cytochrome c; D-Gal, D-galactose; DCX, Doublecortin; DKK-1, Dickkopf-related protein 1; Drp1, Dynamin-related protein 1; eEF-2K, Eukaryotic elongation factor-2 kinase; EGFR, Epidermal growth factor receptor; ERK, Extracellular-signal-regulated kinase; ERK, Extracellular signal-regulated kinase; FBS, Fetal bovine serum; FST, Forced swim test; GPx, Glutathione peroxidase; GRP78, glucose-regulated protein 78; GSH, Glutathione; GSK3, Glycogen synthase kinase 3 beta; HbA1c, Glycosylated hemoglobin; HbA1c, Hemoglobin A1C; HDL, High-density lipoproteins; HIF, hypoxia-inducible factor; HO-1, Heme oxygenase-1; HR, Heart rate; Hs-CRP, High-sensitivity C-reactive Protein; HT-5, Hydroxytryptamine; IDE, Insulin-degrading enzyme; IDO, Indoleamine 2,3-dioxygenase; IFN, Interferon ; IKK, IB kinase; IL-2, Interleukin; iNOS, nitric oxide synthase; IRF-3, Interferon regulatory factor 3; IR, Insulin receptor beta, JAK-STAT, Janus kinases-signal transducer and activator of transcription proteins; KIM-1, Kidney Injury Molecule-1; LC3, Light chain 3; LD, Lactic acid dehydrogenase; LDL, Low-density lipoproteins; LEF-1, Lymphoid enhancer-binding factor-1; LKB1, Liver kinase B1; LOX-1, Lectin-type oxidized LDL receptor 1; LPS, Lipopolysaccharides; LRP, Lipoprotein receptor-related protein; LVDP, Left ventricular diastolic pressure; MAP, Mean arterial pressure; MAP2, Microtubule-associated protein; MAPK, Mitogen-activated protein kinase; MDA, Malondialdehyde; MMP9, Matrix metalloproteinase; mTOR, Mammalian target of rapamycin; m, Mitochondrial membrane potential; NF-B, Nuclear factor kappa B; NGAL, neutrophil gelatinase-associated lipocalin; NO, Nitric oxide; Nrf2, Nuclear factor erythroid 2-related factor 2; 6-OHDA, 6-hydroxydopamine; PAI-1, plasminogen activator inhibitor-1. Methanol and hexane extracts increased the permeation of amoxicillin significantly; The methanolic extract improved intestinal permeability of amoxicillin in the in vitro experiments in a dose-dependent manner, Reduced AUC0-, C max and t 1/2 of Sildenafil, Co-administration significantly decreased the C(max)-35.5% and AUC (0-)-55.9%, Drastic reduction of elimination and to a lesser extent on VoD at steady state (Vss) with a consequent reduction of area under the curve (AUC0-) by about 87%, No significant effect on theophylline disposition as measured by, Black cumin (200 mg/kg) or Lepidium sativum (150 mg/kg), Concurrent use of Lepidium sativum but not black cumin alters the pharmacokinetics of CBZ. ; Gupta, P.; Bhattacharjee, M.; Ghosh, S.; Chattopadhyay, S.; Mukherjee, P.; et al. health tips, current . ; Al-Suwayeh, S.A. ; Khuroo, A.H.; Goswami, D.; Akhtar, M. Ameliorating effects of thymoquinone in rodent models of schizophrenia. ; Offor, S.J. The main feature of Black version of tadalafil is increased dosage. A clinical study with 33 vitiligo patients aimed to understand repigmentation rate in different body surfaces upon application of black cumin seed oil. Fathy, M.; Nikaido, T. In vivo attenuation of angiogenesis in hepatocellular carcinoma by. Hossen et al. Composition, in vitro antioxidant and antimicrobial activities of essential oil and oleoresins obtained from black cumin seeds (. Cascella, M.; Bimonte, S.; Barbieri, A.; Del Vecchio, V.; Muzio, M.R. most exciting work published in the various research areas of the journal. ; Khoo, H.E. Neuropharmacological potential and delivery prospects of thymoquinone for neurological disorders. Bumidin, M.S. sildenafil, the generic form of Viagra. ; Abd-El Daim, T.M. The other one, despite its loud name, contains not 800 but 80 mg of Tadalafil. M.T.H. ; Omeroglu, S.; Sahin, H. Protective effects of, Hosseini, S.M.R. Its component is tadalafil + herbals, a substance belonging to PDE5 inhibitors class. . Ismail, N.; AbdelMottaleb, Y.; Ahmed, A.A.E. ; Ahmed, A.A.E. ; Yida, Z.; Stanslas, J.; Sani, D.; Basri, H.; Abdullah, M.A. ; Abdou, A.M.; Fouad, E.A. Macamides may inhibit cannabinoids and act as competitive ligands. Show filters Frequently asked questions ; Younes, S.A.; Kawana, K.Y. For example, TQ (2.4 mg/kg/day; i.p. ; Akhtar, M.; Ahmed, S.; Ahmad, A.; Najmi, A.K. ; Park, Y.-J. Parabens have been linked to endocrine system problems that could cause . ; Muzaffar, I. Lepidium sativum but not. ; Raish, M.; Al-Jenoobi, F.I. Neuroprotective Effects of Thymoquinone on the Hippocampus in a Rat Model of Traumatic Brain Injury. Visit our dedicated information section to learn more about MDPI. ; Selim, S.A. Effect of ultrasound-enhanced. As black cumin and its constituents target many cell signaling systems producing pharmacological effects in almost every organ/system, it may comply with the multidrugmultitarget concept. She said a muscle relaxant Citrobalm and an insect repellant were developed from the refined product and the Institute holds a Patent on this developed simple method of refining crude Shea butter fat. ; Aziret, M.; Szen, S.; Oru, C.; Coskunkan, U.; Emir, S.; Bilir, B.; Ko, A. ; Uddin, M.J. Revisiting pharmacological potentials of. Paxherbals designed a clinical trial proposal for her malaria medicine called Pax Malatreat ; Hassanane, M.M. Kou, B.; Kou, Q.; Ma, B.; Zhang, J.; Sun, B.; Yang, Y.; Li, J.; Zhou, J.; Liu, W. Thymoquinone inhibits metastatic phenotype and epithelial-mesenchymal transition in renal cell carcinoma by regulating the LKB1/AMPK signaling pathway. The protective effects of thymoquinone on lung damage caused by cigarette smoke. A study with hyperlipidemic rats by Ahmed and co-investigators showed that dietary supplementation of black cumin seed extracts improved hyperlipidemic conditions by elevating high-density lipoproteins (HDL) level and lowering cholesterol, triglycerides, and low-density lipoproteins (LDL) levels [, Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia over an extended period with the abnormalities of carbohydrate, fat, and protein metabolism in the body, primarily due to the disturbance of insulin secretion and/or action. For instance, TQ attenuated -synuclein-induced decrease in synaptophysin expression and increase in synaptic vesicle recycling, and thus protected against synaptic toxicity in rat primary hippocampal and hiPSC-derived neurons [, Ischemic stroke, a pathological condition caused by a sudden cessation of blood supply to the brain, is the second leading cause of death and disability worldwide. ; Allemailem, K.S. : data curation, writingoriginal draft preparation. https://twitter.com/USinNigeria/status/1666762264467189763?t=zpBiSJXAgMnSNxx4uF4qYw&s=08 "Attention: Calling Nigerian Businesswomen! Alanizy, L.; Almatham, K.; Al Basheer, A.; Al Fayyad, I. Complementary and alternative medicine practice among saudi patients with chronic kidney disease: A cross-sectional study. ; Sohag, A.A.M. Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer. ; Kwon, W.-S.; Karmakar, P.C. Cialis. ; Jan, M.; Jan, R. Effects of thymoquinone obtained from seeds of, Bali, I.; Polat, F.R. Role of, Asif, S.; Malik, L. Protective effects of, Asif, S.; Mudassir, S.; Toor, R.S. Global burden of traumatic brain and spinal cord injury. ; Marra, M.V. Onifade, A.A.; Jewell, A.P. Tadalafil is used to treat men who have erectile dysfunction (also called sexual impotence). Following sexual stimulation, Cialis works by assisting the relaxation of the blood vessels in your penis, allowing blood to flow freely into your penis. of TQ on the 11th and 14th day of gestation. ; Al-Jenoobi, F.I. Saudi J. Kidney Dis. Select options. ; Abdelrazek, H.M.A. Get Generic Tadalafil Cialis Black at $1.29 per pill with or without Prescription. ; Hussein, R.H.; Hamza, A. 33 Vol. Bhattacharya, S.; Ghosh, A.; Maiti, S.; Ahir, M.; Debnath, G.H. Effect of Topical Application of Black Seed Oil on Imiquimod-Induced Psoriasis-like Lesions in the Thin Skin of Adult Male Albino Rats. Probiotics and, Bepari, A.; Parashivamurthy, B.M. Ardah, M.T. But there are some differences. The chemical methylparaben can be found in many hair lotions like the popular Luster's Pink Classic Light Oil Moisturizer Hair Lotion. The common mosquito repellant is Odomos, which contains DDT and other components. ; Sohail, M.; Suleria, H.A.R. ; Ebaid, H.; Abdel-Salam, B.; Al-Tamimi, J.H. ; Ahad, A.; Ansari, M.A. Kiralan, M.; zkan, G.; Bayrak, A.; Ramadan, M.F. ; Cho, J.Y. However, the therapeutic potential of black cumin against various diseases has not been investigated with equal emphasis as some chronic diseases, such as cancer, neurological disorders, and metabolic syndromes, have priority over other diseases. and TQ (1.5 mg/kg BW, p.o. ; Frazzoli, C.; Orisakwe, O.E. Enhancement of gut permeation of amoxicillin with, Al-Jenoobi, F.I. Tadalafil is the main active element . Bamosa, A.O. CHUKWUMA MUANYA examines progress made by private and government agencies in the development of traditional medicine. M.A.R. Covid-19 and thymoquinone: Connecting the dots. Publ. ; Li, B.; Huang, Y.M. Protective role of, Kooshki, A.; Tofighiyan, T.; Rastgoo, N.; Rakhshani, M.H. Kheirouri, S.; Hadi, V.; Alizadeh, M. Immunomodulatory Effect of, Samarghandian, S.; Farkhondeh, T.; Samini, F. A review on possible therapeutic effect of. He said the Institute has added four new products for treatment of malaria, fungal infection, diabetes and immune boosting. When the Day was first observed in 1984, the. Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model. Jrah Harzallah, H.; Grayaa, R.; Kharoubi, W.; Maaloul, A.; Hammami, M.; Mahjoub, T. Thymoquinone, the. Effect of. B.T. ; Ha, H. Pharmacotherapy against Oxidative Stress in Chronic Kidney Disease: Promising Small Molecule Natural Products Targeting Nrf2-HO-1 Signaling. ; Shaikh, N.A. ; Hassan, M.S. ; Ustaoglu, B.; Altunoglu, Y.C. 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