Indications: For treatment of dermatophytosis caused by Microsporum canis. padding: 15px 5px 15px 5px; This drug is registered for use in humans only. The liquid solution approved for cats can be given with or without food, meaning that it could be given directly by mouth using the included syringe, or potentially directly on food if a cat will eat it shortly after. Indication ITRAFUNGOL is indicated for the treatment of dermatophytosis caused by Microsporum canis in cats. Itraconazole may need to be given for days to weeks or months depending on the infectious agent and location of the infection. Hypersalivation during or immediately following dosing, vomiting, and loose stool were the most frequent abnormal clinical observations related to treatment with ITRAFUNGOL. Always confirm storage requirements by reading the label. 2013;223-283. In case of pain or irritation, seek medical advice. Looking for a convenient way to access your pets health records, refill prescriptions, view upcoming appointments and more? Excursions permitted between 59-86F (15-30C). Moriello, K., Coyner, K. et. .medication-table h2{ In most cats, ALT values peaked just above the upper limit of the reference range and were continuing to trend upward or were elevated yet stable at the end of the study. Every individual animal healthcare product label entry contains a unique identifier which can be used to secure further details directly from the U.S. National Institutes of Health and/or the FDA. Antimycotic activity was demonstrated in in vitro systems and in vivo experimental models. More than 30 metabolites are formed. Other infrequent adverse reactions included less than 3 cases each of somnolence, depression, and increased salivation. Weight of Cat 0.5 1b 1.0 1b 1.5 1b 2.01b 2.5 1b 3.0 1b 3.5 1b 4.0 1b 4.5 1b 5.0 1b 6.01b 7.01b 8.0 1b 9.0 1b 10.01b 11.01b 12.01b 13.01b Table 1: Dose Table for ITRAFUNGOL Volume of ITRAFUNGOL display: flex; It is for the treatment of feline dermatophytosis (ringworms) caused by Microsporum canis. align-items: center; Itraconazole works as an antifungal medication by stopping the fungi from creating an enzyme needed to produce their cell membrane. Eighty cats were experimentally infected with Microsporum canis and treated with either ITRAFUNGOL or sterile water (control product) for the proposed therapeutic treatment schedule followed by a 4-week follow-up period. ITRAFUNGOL is a cytochrome p-450 inhibitor and may increase or prolong plasma concentrations of other drugs metabolized by this pathway, such as amitriptyline, amlodipine, benzodiazepines, buspirone, cisapride, corticosteroids, cyclosporine, ivermectin, and macrolide antibiotics. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Accessed September 5, 2019. Use with caution in cats with impaired liver function. When using itraconazole long-term, your veterinarian will monitor your pets liver values. If they are not available, follow their directions in contacting an emergency facility. The solution should be administered orally using the enclosed graduated dosing syringe. Infectious Diseases of the Dog and Cat. line-height: 1.2; Cats are treated during weeks 1, 3, and 5, and left untreated during weeks 2 and 4. A red crusty spot. Your pets condition worsens or does not improve with treatment. Capsules and tablets should be given with a high fat meal. Veterinarians can legally prescribe medications for off-label use under certain circumstances. The veterinary oral solution should be stored at room temperature between 20C and 25C (68F and 77F) and the human oral solution should be stored below 25C and above freezing. Do not store above 25C. Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. ITRAFUNGOL Oral Solution is available in an individual box containing a 52 mL amber glass bottle and a graduated dosing syringe. 6. Medication should never be administered without first consulting your veterinarian. Effectiveness was demonstrated using ITRAFUNGOL in a masked, placebo controlled laboratory study. In cats, gastrointestinal effects such as lack of appetite, vomiting, and weight loss, as well as liver toxicity can occur. ITRAFUNGOL has not been shown to be safe in pregnant cats (see Animal Safety). Rx. Compounding medications are very common in veterinary medicine. 2022 Virbac Corporation. The solution should be administered orally using the enclosed graduated dosing syringe. It is very important to always continue treatment as directed. } Within the Veterinary Product and Label Information section: VetLabel.com provides trustworthy package insert and label information about marketed drugs as submitted by manufacturers to the U.S. Food and Drug Administration. Dr. Stephanie Howe graduated from the University of Florida College of Veterinary Medicine in 2011, after receiving a Bachelorof Science Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. Signs of liver toxicity include yellowing of the eyes, skin, or gums, vomiting (that continues), severe or bloody diarrhea, painful abdomen (stomach), or changes in behavior. Common Names: T eres flojito, verdad? Continuing treatment at least one month beyond a negative ringworm culture or PCR is the general standard. The only oral anti-fungal solution for cats. This effect is irreversible and causes structural degeneration of the fungal organism. All content contained in this article is sourced from public sources or the manufacturer. .table-footer a{ Swallow the capsules whole. Form: 2. Also Read: How To Bathe A Cat? Itraconazole is also a prescription medication for humans, frequently with dosages different from those prescribed for your pet by a veterinarian. Cats suffering from heart disease should be carefully monitored during treatment. Queens of the Stone Age will bring Phantogram, Viagra Boys, the Armed, and Savages' Jehnny Beth on their fall North American tour. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. FDA Approves Itrafungol, a New Animal Drug for Treating Ringworm in Cats.https://www.fda.gov/animal-veterinary/product-safety information/itrafungol-itraconazole-oralsolutionveterinarians. 4. How Itraconazole Is Supplied Itraconazole is available in 100 mg capsules, 100 mg tablets, and as a 10 mg/ml oral solution. For kittens weighing less than 0.5 kg, a 1 mL syringe which allows proper dosing should be used. Use of this site is subject to our terms of use and privacy policy. All Rights Reserved. Speak with your veterinarian about what to do if you forget to give a dose of itraconazole. For the treatment of dermatophytosis caused by Microsporum canis in cats, Rapid confirmation of infection is necessary to begin treatment and limit spread to other animals and people. Itraconazole may cause vomiting, diarrhea, weight loss, depression, and decreased appetite in dogs and cats. It is common for fungal infections to require several weeks of treatment. This effect is irreversible and causes structural degeneration. DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. Generally, they may instruct you to give it when you remember, or if it is almost time for your next dose, to skip the missed dose and resume your normal dosing schedule. ITRAFUNGOL is indicated for the treatment of dermatophytosis caused by Microsporum canis in cats. Itraconazole is a common antifungal medication used in cats. I am completely satisfied, I found useful information and tips in this article, Article was somewhat helpful, but could be improved. All content contained in this article is sourced from public sources or the manufacturer. If clinical signs suggestive of liver dysfunction develop, treatment should be discontinued. The FDA-approved, labeled dosage for itraconazole (Itrafungol) for cats to treat Microsporum canis is 5 milligrams/kilogram by mouth given once daily for seven days on alternating weeks, This lasts for three treatment cycles. When administering this product to kittens, be careful not to exceed the recommended dose. J Fel MedS urg. flex-direction: column; Itraconazole will start working in your pet's system a few hours after ingestion, but it can take several days before you see a noticeable improvement in your pet's condition. The bottle cap should be screwed back on tightly. Do not administer to cats with hypersensitivity to itraconazole. Our database mirrors the FDA's central repository of drug labels and package inserts under the Structured Product Labeling standard. The solution should be administered directly into the mouth by means of the enclosed graduated dosing syringe. The human-labeled oral solution (Sporanox) is typically advised to be given without food to aid in better absorption. ITRAFUNGOL is a cytochrome p-450 inhibitor and may increase or prolong plasma concentrations of other drugs metabolized by this pathway. Cutaneous Fungal Infections. Specific monitoring or routine testing while your pet is on this medication may be recommended by your veterinarian depending on your pets individual needs, other medications they may be on, and/or the issue that initially caused your pet to be placed on this medication. : In a margin of safety study, ITRAFUNGOL (itraconazole oral solution) was administered orally to healthy adult cats once daily at 0X (saline control), 1X (5 mg/kg), 3X (15 mg/kg), and 5X (25 mg/kg) the therapeutic dose for 17 alternating weeks (9 total weeks of dosing) with no recovery period. Brand Names: The most common adverse reactions reported in clinical trials include vomiting, diarrhea, decreased appetite and elevated hepatic enzymes. Moriello KA, DeBoer DJ. Wash hands and exposed skin after handling the animal. FDA recommends that veterinarians prescribe FDA-approved Itrafungol for cats10. Both of the FDA-approved brands, Itrafungol (approved for cats) and Sporanox (approved for people), appear to have high bioavailability in cats. Azole, antifungal display: inline-block; Do not administer to cats with impaired liver or kidney function. Its common appearance may show up as single or multiple areas of hair loss and crusting on a cats skin. Itrafungol (itraconazole oral solution) for Cats. Negative inotropic effects have been reported in literature when itraconazole was administered intravenously to dogs and healthy human volunteers. Keep the container tightly closed in order to protect frommoisture and light. Itraconazole is also available under the brand name Itrafungol. Specific monitoring or routine testing while your pet is on this medication may be recommended by your veterinarian depending on your pets individual needs, other medications they may be on, and/or the issue that initially caused your pet to be placed on this medication. Itrafungol (Itraconazole) Oral Solution Indications For the treatment of feline dermatophytosis caused by Microsporum canis. Itraconazole is also available under the brand name Itrafungol. It is caused by Microsporum canis. Each line on the dosing syringe represents 0.05 mL of oral solution. padding: 5px 10px; Select one or more newsletters to continue. Histoplasmosis is a chronic, non-contagious fungal infection caused by the soil-dwelling fungus Histoplasma capsulatum. Itraconazole is a cytochrome p-450 inhibitor and may therefore increase or prolong plasma concentrations of other drugs metabolized by this pathway. Signs of liver toxicity include yellowing of the eyes, skin, or gums, vomiting (that continues), severe or bloody diarrhea, painful abdomen (stomach), or changes in behavior. Itraconazole should not be used by pets that are allergic to it or similar antifungals. ITRAFUNGOL has been associated with renal changes found on histopathology that were not noted after an eight week recovery period (see Animal Safety). ITRAFUNGOL should only be used in pregnant or lactating cats when the benefits outweigh the potential risks. Virbac Animal Health, Data on file. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. In case of accidental contact with eyes, rinse thoroughly with water. : Yes (Itrafungol brand only) Life stage: Safety has been evaluated in 9- to 10-week-old cats. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. } Do not administer to cats with hypersensitivity to itraconazole or one of the other ingredients. No topical therapy was used during this study. Federal law restricts this drug to use by or on the order of a licensed veterinarian. If side effects are seen, it may be possible to discontinue the drug temporarily and restart it at a lower dose or frequency. The most common side effects are loss of appetite and liver toxicity, both of which are quite rare. Such drugs include antacids, digoxin, cisapride, amphotericin B, various sedative such as diazepam, alprazolam and midazolam), buspirone, corticosteroids, ranitidine, famotidine, omeprazole, ivermectin, phenobarbital, vincristine, vinblastine, clomipramine, amitriptyline, and certain antibiotics. The FDA-approved brand Itrafungol is recommended for the best efficacy and safety. I.. Studies have shown that these forms are far less bioavailable and less effective than FDA-approved brands. In the lungs, one 3X group cat and five 5X cats had intra-alveolar foamy macrophages; five 5X group cats had intra-alveolar syncytial cells. Use with caution in cats with renal dysfunction. It still often requires treatment for several weeks to a couple of months. 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