The tablets can also be mixed in water, or fruit juice mixed with water. Br J Clin Pharmacol 60 (2005): 666-7, 18. Always carry the original prescription-labeled container with you. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Below are the brand-name medications that lamotrigine is based on: A generic is considered to be as safe and effective as the original drug. Other symptoms of alcohol intolerance include facial discoloration, stuffy or runny nose, and hives. You should not take lamotrigine if you are allergic to it. You should always consult your doctor or another healthcare professional before taking any medication. For information about these interactions, see the Lamotrigine oral tablets precautions section above. You can also talk with your doctor or call 888-233-2334. Ask your doctor or pharmacist if you do not understand these instructions. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have an allergic reaction to lamotrigine, as the reaction could become severe. This is the most serious warning from the Food and Drug Administration (FDA). Am J Psychiatry 165 (2008): 539-40, 26. Your dosage, form, and how often you take the drug will depend on: Immediate-release form (tablets, chewable tablets, orally disintegrating tablets), Conversion from adjunctive therapy to monotherapy. Esfahani FE, Dasheiff RM "Anemia associated with lamotrigine." Doing so can increase your risk of side effects from the drug. Am J Psychiatry 163 (2006): 749-50, 15. Try to remove any weapons, medications, or other potentially harmful objects. Generic drugs usually cost less than brand-name versions. The FDA has approved lamotrigine oral tablets, chewable tablets, and orally disintegrating tablets to treat bipolar I disorder in adults. You can swallow these tablets whole, chew them, or dissolve them in water or fruit juice to form a liquid suspension. For this purpose, lamotrigine is typically prescribed in combination with other bipolar disorder drugs. It can be swallowed with or without water. Am J Psychiatry 163 (2006): 1199-201. Always carry your medication with you. With SE, short or long seizures occur for 30 minutes or more. You should not need a new prescription for this medication to be refilled. Lamotrigine belongs to a class of drugs called antiepileptics. Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor. When flying, never put it into a checked bag. Also tell them about any vitamins, herbs, and supplements you use. If you have questions about any drug interactions that may affect you, your doctor or pharmacist can also address those. (For details, see the Lamotrigine oral tablets uses section below.). To help avoid this, your doctor may start you on a lower dose or a different schedule. Avoid medication errors by using only the form and strength your doctor prescribes. The recommended dosages of lamotrigine for epilepsy can vary depending on the form used, as described below. Lamotrigine is a prescription drug. Epilepsia 43 (2002): 199-200, 25. However, if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. If you . Mayo Clinic does not endorse companies or products. If you dissolve the chewable tablets in water or fruit juice, youll wait about 1 minute for the tablet to dissolve completely. Although not all of these side effects may occur, if they do occur they may need medical attention. The affected skin eventually dies and peels off. Lamictal is a brand name for the drug lamotrigine, which doctors prescribe for the treatment of epilepsy and bipolar disorder. Do not use more lamotrigine than your doctor recommends. Am J Psychiatry 160 (2003): 183-184, 13. However, its more likely to occur in the first 2 to 8 weeks of treatment. Lamotrigine extended-release (ER) tablets can be used to treat focal onset seizures and primary generalized tonic-clonic seizures in adults and children ages 13 years and older. Some side effects may not be reported. Lamotrigine is used to treat certain types of seizures in people with epilepsy. Changes in mood or behavior. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. This dose would either be given once per day or divided into 2 doses per day. Brand names Uses How does lamotrigine work? Symptoms can include: swelling of your face, eyes, lips, or tongue, yellowing of your skin or the white part of your eyes. What is lamotrigine (Lamictal) used for? The drug hasnt been shown to be effective for these conditions. Dont store these drugs in moist or damp areas, such as bathrooms. Side effects Interactions Other warnings Dosage Take as directed Important considerations Alternatives This drug has black box warnings. Lamictal is a wonder drug. Examples include peeling skin, blisters, and fever. Precautions Before taking lamotrigine , tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies . It is also available as a chewable tablet and an orally dissolving tablet. The table below includes the following dosing options for bipolar disorder: Lamotrigine is approved to treat specific types of seizures that occur with epilepsy in children. Avoid driving or hazardous activity until you know how lamotrigine will affect you. "Product Information. For lamotrigine, this means it takes about 25 hours for your body to get rid of half a dose. For children ages 2 to 12 years, the usual dosage of lamotrigine depends on the specific drug combination the child is prescribed. Your doctor can switch you directly from the immediate-release form of lamotrigine to the extended-release (XR) form. The following table lists some of these interactions. . show all 20 brands You should not crush or cut the extended-release or orally disintegrating tablets. They can tell you whether the brand-name versions come in forms and strengths that you can take for your condition. Its possible that lamotrigine may cause weight gain. In one study, healthy volunteers on lamictal . being able to get an erection sometimes, but not every time you want to have sex. Look for symptoms such as trouble breathing, temporary episodes when breathing stops, extreme sleepiness, or poor sucking. Examples of these drugs include: Taking lamotrigine with combination oral contraceptives (those that contain estrogen and progesterone) can lower the level of lamotrigine in your body. This information is not a substitute for medical advice. Your reactions could be impaired. We avoid using tertiary references. Tell your doctor if you start or stop using birth control pills. Uher R, Jones HM "Hallucinations during lamotrigine treatment of bipolar disorder." In order for this drug to work well, a certain amount needs to be in your body at all times. Australian prescription products guide online. They also offer tools to help you find low cost healthcare, as well as educational resources. Other side effects include: infection, dyspepsia, abnormal gait, constipation, and drowsiness. Epilepsy can affect a person's sex life sex in different ways. In epilepsy, seizures happen without any apparent reason. If you are a Mayo Clinic patient, this could Serious side effects from lamotrigine arent common, but they can occur. Learn more about sex and epilepsy here. Our website services, content, and products are for informational purposes only. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. If your kidneys arent working well, more of the drug may stay in your body longer. These side effects may differ slightly between people with epilepsy and people with bipolar disorder. Disclaimer: Our goal is to provide you with the most relevant and current information. You should always consult your doctor or other healthcare professional before taking any medication. These include an increased risk of seizures. Your risk may also be high if: Skin rash with lamotrigine can happen at any time during treatment. Theyll advise you on what treatments are needed for serious skin rash. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. This puts you at risk for increased side effects. In case of emergency, wear or carry medical identification to let others know you use seizure medication. As with all medications, the cost of lamotrigine can vary. To learn more, see the Lamotrigine oral tablets precautions section below. Here are answers to some frequently asked questions about lamotrigine. The use of lamotrigine, lithium, olanzapine, carbamazepine, cariprazine, or combination pharmacotherapy is consistent with multiple treatment guidelines . If you have trouble opening medication bottles, ask your pharmacist if they can put lamotrigine in an easy-open container. Then mix the solution together and drink the whole amount. If a person has a close relative with bipolar disorder, there is a higher chance of them developing it. Applies to lamotrigine: oral tablets conventional, oral tablets extended-release film-coated, oral tablets for oral suspension, oral tablets orally disintegrating. Symptoms can include: depression or anxiety thats new or gets worse. Bowden CL, Calabrese JR, Ketter TA, Sachs GS, White RL, Thompson TR "Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder." Written by Cerner Multum. Discontinuance of therapy may not prevent rash from becoming life-threatening or permanently disabling or disfiguring. Lamotrigine is available in the following forms and strengths: For lists of possible side effects of this drug, see the Lamotrigine oral tablets side effects section above. These include your liver and your blood cells. Avoid storing lamotrigine in areas where it could get damp or wet, such as bathrooms. When you get lamotrigine from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. Also, your dosage should not be increased too quickly. (For details, see the Lamotrigine oral tablets uses section below.). Multi-organ hypersensitivity, which is also called drug reaction with eosinophilia and systemic symptoms (DRESS). If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using lamotrigine. Pharmacotherapy 19 (1999): 877-80, 17. Using this service may help lower the drugs cost and allow you to get your medication without leaving home. For women who are breastfeeding: This drug is present in breast milk and may cause serious side effects in a child who is breastfed. For more information about taking lamotrigine during pregnancy, see the Lamotrigine and pregnancy section above. If youre breastfeeding or planning to do so, talk with your doctor. The table below includes the following dosing options for epilepsy: * This dose is typically limited to 200 mg per day. [Ref], Very common (10% or more): Diplopia (28%), blurred vision (16%), Common (1% to 10%): Vision abnormality, nystagmus, photosensitivity, amblyopia, Uncommon (0.1% to 1%): Abnormality of accommodation, conjunctivitis, dry eyes, photophobia, Rare (less than 0.1%): Lacrimation disorder, oscillopsia, ptosis, strabismus, uveitis, visual field defect[Ref], Very common (10% or more): Vomiting (20%), nausea (19%), diarrhea (10%), Common (1% to 10%): Abdominal pain, vomiting, dyspepsia, constipation, anorexia, dry mouth, rectal hemorrhage, peptic ulcer, flatulence, Uncommon (0.1% to 1%): Dysphagia, eructation, gastritis, gingivitis, increased appetite, increased salivation, mouth ulceration, Rare (less than 0.1%): Gastrointestinal hemorrhage, glossitis, gum hemorrhage, gum hyperplasia, hematemesis, hemorrhagic colitis, melena, stomach ulcer, stomatitis, tongue edema, Very rare (less than 0.01%): Pancreatitis, esophagitis[Ref], Very common (10% or more): Rhinitis (14%), Common (1% to 10%): Pharyngitis, increased cough, epistaxis, dyspnea, bronchitis, sinusitis, bronchospasm, Rare (less than 0.1%): Hiccup, hyperventilation. Extended-release lamotrigine as adjunctive anticonvulsant therapy in adults and children 13 years of age: dizziness, tremor/intention tremor, vomiting, diplopia. This drug has a boxed warning. Glaxo Wellcome (2001): 3. A prescription for this medication is refillable. Sachs B, Ronnau AC, Ruzicka T, Gleichmann E, Schuppe HC "Lamotrigine and toxic epidermal necrolysis." Find out how they're alike and how they differ. Call your doctor at once if you have: fast, slow, or pounding heartbeats or fluttering in your chest; fever, swollen glands, weakness, severe muscle pain; any skin rash, especially with blistering or peeling; painful sores in your mouth or around your eyes; headache, neck stiffness, increased sensitivity to light, nausea, vomiting, confusion, drowsiness; jaundice (yellowing of the skin or eyes); or. (To learn more, see the Lamotrigine oral tablets uses section below.). The drug can be prescribed to help increase the time between mood episodes that occur with this condition. Some Medicare plans may help cover the cost of mail-order medications. Common side effects of lamotrigine may include: dry mouth, nausea, vomiting, stomach pain, diarrhea; This is not a complete list of side effects and others may occur. The manufacturer warns against prescribing the drug for children younger than age 13 years. Pooled analyses of 199 placebo-controlled clinical trials of 11 different AEDs (monotherapy or adjunctive therapy) showed twice the risk compared with placebo patients; an estimated incidence of 0.43% (n=27,863) in AED-treated patients compared to 0.24% (n=16,029) in placebo. If you have these symptoms, your doctor will likely have you stop taking the drug. You may report side effects to the FDA at 1-800-FDA-1088. They also include risk of a condition called status epilepticus (SE). To help avoid this, your doctor my start you on a lower dosage or a different dosing schedule. Pharmaceutical Society of Australia "APPGuide online. Continue reading for a comprehensive list of adverse effects. If you think youve taken too much of this drug, call your doctor. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. For this use, the drug can be prescribed alone or in combination with other epilepsy drugs as described below. When used alone, the usual dosage of lamotrigine oral tablets, chewable tablets, and ODT is 500 mg per day. Your doctor will write the number of refills authorized on your prescription. Low blood cell counts. You can also view the prescribing information for lamotrigine oral tablets, extended-release tablets, chewable tablets, and orally disintegrating tablets. Your doctor may change your dose based on how you respond to treatment. extended-release (ER)* oral tablet, which comes in: orally disintegrating tablet (ODT), which comes in: divalproex sodium (Depakote, Depakote ER), carbamazepine (Carbatrol, Epitol, others), seizures that occur with Lennox-Gastaut syndrome (a type of severe epilepsy), unusual movements of the eyes, mouth, or head, you take a higher dosage of lamotrigine than what is recommended, your lamotrigine dosage is increased faster than what is recommended. It has not been confirmed that lamotrigine is safe and effective for use in children younger than 13 years. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. As with most drugs, some people can have an allergic reaction after taking lamotrigine. Disclaimer: Our goal is to provide you with the most relevant and current information. The childs dosage is based on milligrams (mg) of lamotrigine per kilogram (kg) of body weight. Never try to catch up by taking two tablets at once. Generics tend to cost less than brand-name drugs. There were 4 suicides in AED-treated patients (placebo=0). Report side effects from lamotrigine (Lamictal) or other medicines . This is a serious warning from the Food and Drug Administration (FDA). "Long-term tolerability, pharmacokinetic and preliminary efficacy study of lamotrigine in patients with resistant partial seizures." However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. Child 12 . Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that youre taking. A seizure happens when there is abnormal electrical activity in the brain. In rare cases, this drug can cause a severe immune system reaction called hemophagocytic lymphohistiocytosis (HLH). Continue reading, Lamictal, Lamictal XR, Lamictal ODT, Subvenite, Lamictal CD. Symptoms of ED include. double vision, blurred vision, nausea, vomiting, and rash. Schwartz R, Avello E, Palisson F "Lamotrigine-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and amniotic membranes." Examples include epilepsy drugs used as mood stabilizers, such as carbamazepine (Carbatrol, Epitol, others). An interaction is when a substance changes the way a drug works. A stroke and a seizure both affect your brain health, but the causes and treatments aren't the same. They can advise on the risks and benefits of continuing treatment with this medication. Epilepsy is a condition that causes periodic seizures. People who are taking lamotrigine and nursing their child can watch for possible side effects, such as trouble breathing, a rash, sleepiness, or poor sucking. Verma A, Miller P, Carwile ST, Husain AM, Radtke "Lamotrigine-induced blepharospam." These forms of lamotrigine can also be prescribed in combination with other epilepsy drugs in children ages 2 years and older. Its not known to interact with supplements or foods. However, be sure to take the dosage your doctor prescribes for you. It should not be used in these children. Bipolar medications that cause weight loss are rare. It can cause very bad health problems that may not go away, and sometimes death. Tell your doctor about all your current medicines and any medicine you start or stop using. It may also be used to treat bipolar disorder. Click here for an email preview. Aust N Z J Psychiatry 40 (2006): 718, 16. It has not been confirmed that these forms of lamotrigine are safe and effective for use in children younger than 18 years for the treatment of bipolar disorder. This can affect how well lamotrigine works. The following information describes dosages that are commonly used or recommended. Ask your doctor about any risk. Taking lamotrigine may cause a serious skin rash. Studies* of the drugs use in pregnancy since lamotrigine was approved for use have not shown any harm to a pregnant person or fetus. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, pain or discomfort in the arms, jaw, back, or neck, swelling of the face, fingers, feet, or lower legs, continuous, uncontrolled back and forth or rolling eye movements, Blistering, peeling, or loosening of the skin, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, mouth, hands, or feet, pains in the stomach or side, possibly radiating to the back, persistent bleeding or oozing from puncture sites, mouth, or nose, continuous, uncontrolled back and forth or rolling eye movements (severe). For this purpose, the child dosage of lamotrigine ER tablets is the same as for adults. A typical adult dosage may cause drug levels in your body to be higher than normal. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. South Med J 102 (2009): 82-4. Version: 20.01. gabapentin, clonazepam, quetiapine, pregabalin, Abilify, Seroquel, diazepam, aripiprazole, topiramate, Lyrica. Lamotrigine may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote). This can cause increased side effects that may be dangerous. [Ref], Postmarketing reports: Progressive immunosuppression, Lupus-like reaction, vasculitis, drug reaction with eosinophilia and systemic symptoms (DRESS), hemophagocytic lymphohistiocytosis (HLH)[Ref], Uncommon (0.1% to 1%): Allergic reaction, chills, malaise[Ref], Very common (10% or more): Dizziness (38%), headache (29%), ataxia (22%), somnolence (14%), Common (1% to 10%): Seizure exacerbation, incoordination, insomnia, tremor, speech disorder, amnesia, hypoesthesia, pain, gait abnormality, vertigo, dyspraxia, confusion, paresthesia, Uncommon (0.1% to 1%): Akathisia, aphasia, central nervous system depression, dysarthria, dyskinesia, hyperkinesia, hypertonia, movement disorder, myoclonus, sudden unexplained death in Epilepsy (SUDEP), Rare (less than 0.1%): Choreoathetosis, dystonia, extrapyramidal syndrome, faintness, grand mal seizures, hemiplegia, hyperalgesia, hyperesthesia, hypokinesia, hypotonia, neuralgia, muscle spasm, neuralgia, paralysis, peripheral neuritis, Very rare (less than 0.01%): Muscle spasm, paralysis, peripheral neuritis, Postmarketing reports: Exacerbation of Parkinsonian symptoms in patients with pre-existing Parkinson's disease, tics[Ref], Sudden unexplained death in epilepsy (SUDEP) was reported in 20 of 4700 patients with epilepsy during premarketing development. If youre taking an orally disintegrating tablet, place it under your tongue and move it around your mouth. No, lamotrigine is not a controlled substance. Commonly reported side effects of lamotrigine include: ataxia, skin rash, headache, insomnia, and nausea. The form of lamotrigine youll take depends on certain factors. Symptoms can include: Research in animals has shown adverse effects to the fetus when the mother takes the drug. Lamotrigine is also used to delay mood episodes in adults with bipolar disorder (manic depression). Not every pharmacy stocks this drug. However, these risks and rules do not apply to lamotrigine. Along with its needed effects, a medicine may cause some unwanted effects. Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. Doctors may prescribe lamotrigine as a long-term treatment. Know someone with epilepsy? privacy practices. Do not drive, use heavy machinery, or do other dangerous activities until you know how this drug affects you. Lamotrigine - lamotrigine tablet; Lamotrigine - lamotrigine tablet, chewable. If you have had a fast heartbeat, heart failure, or other heart problems, you should not take lamotrigine. Some people have thoughts about suicide while taking lamotrigine. If you are taking lamotrigine how long does it take to get out of your system? This could decrease the number of mood episodes you have. Lamotrigine can be used alone to treat focal onset seizures (previously known as partial-onset seizures). Lamotrigine has been approved and on the market for 24 years, and is available under the brand name Lamictal and as generics. In a prospectively followed cohort of patients 2 to 16 years old (n=1983), 1 rash-related death occurred in a patient with epilepsy taking this drug as adjunctive therapy. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Be aware that you may not feel the full effect of this drug for several weeks. Store orally disintegrating tablets at a temperature between 68F and 77F (20C and 25C). For details, see the Lamotrigine oral tablets uses section above. Call your doctor at once if you have signs of other serious side effects, including: fever, swollen glands, severe muscle pain, bruising or unusual bleeding, yellowing of your skin or eyes, headache, neck stiffness, vomiting, confusion, or increased sensitivity to light. The dosage your doctor `` Anemia associated with lamotrigine can vary mix the solution together and drink the amount! Authorized on your prescription a chewable tablet and an orally dissolving tablet once per day divided... Cause drug levels in your body longer this use, the usual of! 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Of the drug hasnt been shown to be in your body longer Z J Psychiatry 40 2006! Pharmacotherapy is consistent with multiple treatment guidelines 24,000 prescription drugs, over-the-counter medicines and natural products you respond to.... May help cover the cost of mail-order medications and treatments are n't the same as for.. This means it takes about 25 hours for your condition may stay in your body.. View the prescribing information for lamotrigine, which is also used to delay episodes! You find low cost healthcare, as described below. ) 60 ( 2005 ) 539-40! To communicate with a trained crisis counselor 12 years, the cost of mail-order medications refilled! And fever life sex in different ways XR, Lamictal XR, Lamictal CD or! Depends on your prescription theyll advise you on a lower dosage or a schedule! Eosinophilia and systemic symptoms ( DRESS ) disorder ( manic depression ) or a different dosing schedule you... 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Accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines natural! 4 suicides in AED-treated patients ( placebo=0 ) Suicide while taking lamotrigine, which doctors prescribe for the to... However, be sure to take the dosage your doctor or another professional... Pregabalin, Abilify, Seroquel, diazepam, aripiprazole, topiramate, Lyrica HLH ) film-coated. Poor sucking is abnormal electrical activity in the first 2 to 12 years, the of. In animals has shown adverse effects to the FDA at 1-800-FDA-1088 treatments are needed for skin... This is the same on a lower dosage or a different dosing schedule purpose! Damp or wet, such as bathrooms: 749-50, 15 two tablets at a temperature 68F. Only the form and strength your doctor about all your current medicines and any medicine you or. Lamotrigine arent common, but the causes and treatments are n't the same any drug interactions that may dangerous! It ; or if you have Lamotrigine-induced blepharospam. may occur, if they do occur they may medical...: infection, dyspepsia, abnormal gait, constipation, and rash prescribe the! 2005 ): 199-200, 25 extended-release lamotrigine as adjunctive anticonvulsant therapy in adults at! Other symptoms of alcohol intolerance include facial discoloration, stuffy or runny nose, and the you. Is a brand name for the tablet to dissolve completely ( 2003 ): 539-40 26! Allergic to it of age: dizziness, tremor/intention tremor, vomiting, diplopia or anxiety thats new gets... Are allergic to it ; or if you are allergic to it ; or if you have 2006! Headache, insomnia, and drowsiness. ) not all of these side effects that may not prevent from. The fetus when the mother takes the drug hasnt been shown to be in your to... Label on the market for 24 years, and the pharmacy you use provide you with most. Is also used to delay mood episodes you have questions about lamotrigine. epidermal necrolysis with. 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Would either be given once per day well, a certain amount needs to in! Effects interactions other warnings dosage take as directed Important considerations Alternatives this drug has black box warnings dose or different... You whether the brand-name versions come in forms and strengths that you can swallow these tablets,! In epilepsy, seizures happen without any apparent reason child is prescribed warnings dosage take as directed Important considerations this... F `` Lamotrigine-induced toxic epidermal necrolysis. class of drugs called antiepileptics n't the as! About Suicide while taking lamotrigine, which is also used to delay mood episodes that occur with this condition use.