"Linezolid-associated toxic optic neuropathy: a report of 2 cases." It works by stopping the growth of bacteria. In the community setting, many antibiotic-resistant bacteria have emerged (Table 1).5 The prevalence of drug-resistant Streptococcus pneumoniae has increased 60-fold since 1980 with 51 percent and 8 percent of isolates demonstrating intermediate- or high-level resistance to penicillin or third-generation cephalosporins, respectively.9 Thus, pneumococcal pneumonia is becoming more difficult to treat with first-line agents. "Product Information. Applies to linezolid: oral powder for suspension, oral tablet. Linezolid disrupts bacterial growth by inhibiting the initiation. In case of overdose, call the poison control helpline at 1-800-222-1222. Many people using this medication do not have serious side effects. In addition, the every 12 hours dosing schedule improves compliance. However, you should not flush this medication down the toilet. Ferry T, Ponceau B, Simon M, et al. Do not shake. Faguer S, Kamar N, Fillola G, Guitard J, Rostaing L "Linezolid-related pancytopenia in organ-transplant patients: report of two cases." This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. Convulsions have also been reported during postmarketing experience.[Ref]. Do not use linezolid if you have used an MAO inhibitor in the past 14 days. infections (October)." More frequently reported side effects include: anemia, decreased hemoglobin, and thrombocytopenia. Portions of this document last updated: May 01, 2023. Clin Infect Dis 38 (2004): 767-8, 8. The patient restarted linezolid 5 months later and again showed symptoms on day 21 of therapy. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Linezolid is a synthetic antibiotic belonging to a new class of antimicrobials called the oxazolidinones. J Antimicrob Chemother 56 (2005): 440-1, 49. What should I know regarding pregnancy, nursing and administering Linezolid to children or the elderly? Many other medications may also interact with linezolid, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Intravenous linezolid at twice daily dosages of 600 mg produced a clinical cure rate of 88.6 percent compared with 73.7 percent in the patients with vancomycin-resistant enterococcus infections who received 200 mg daily.16. J Antimicrob Chemother 50 (2002): 1017-26, 6. Other dosage forms: Along with its needed effects, linezolid may cause some unwanted effects. Mayo Clinic does not endorse companies or products. For this medicine, the following should be considered: Allergies J Antimicrob Chemother 61 (2008): 421-4, 57. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. As emphasized earlier, linezolid should be reserved for the treatment of patients with infections caused by multidrug-resistant bacteria that are proved by laboratory testing, and to life-threatening or complicated infections associated with multiple resistances to first-line treatments. Linezolid tablets or liquid can be taken with or without food. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Do not use two doses at one time. Selected from data included with permission and copyrighted by First Databank, Inc. if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability), you should know that the oral suspension contains aspartame that forms phenylalanine. Absorption. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Linezolid is not affected by the cytochrome P450 system and does not require dose modification in patients with liver dysfunction or kidney failure. Keep all medical and lab appointments. Tedizolid is a newer drug in the same class with comparable spectrum of activity but with limited US Food and Drug Administration-approved indications. Meyer B, Thalhammer F "Linezolid and continuous venovenous hemofiltration." Tell your doctor or pharmacist if you take anything in the list of products that may interact with this drug, or any of the products that increase serotonin, within 2 weeks before or after taking linezolid. You may report side effects to the FDA at 1-800-FDA-1088. The dosage is based on your medical condition and response to treatment. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to linezolid: intravenous solution, oral powder for reconstitution, oral tablet. For the best effect, take this antibiotic at evenly spaced times. This document does not contain all possible drug interactions. Narita M, Tsuji BT, Yu VL "Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome." Arellano FM "Linezolid and reversible myelosuppression." This condition may occur during treatment or weeks to months after treatment has stopped. Do not shake. Stopping the medication too early may result in a return of the infection. Stein GE "Safety of newer parenteral antibiotics." Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Diarrhea may be a sign of a new infection. Check with your doctor immediately if any of the following side effects occur: More common Chills confusion diarrhea dizziness fainting fast heartbeat fever lightheadedness pale skin rapid, shallow breathing rash trouble breathing unusual bleeding or bruising unusual tiredness or weakness Less common Black, tarry stools bleeding gums No serotonin syndrome effects (confusion, delirium, tremors, restlessness, hyperpyrexia, or diaphoresis) were observed with this combination.14 No effects of serotonin syndrome were observed during a phase III study of 52 patients comparing fluoxetine, paroxetine and sertraline with linezolid.18 Nevertheless, caution is therefore recommended when using linezolid with agents such as citalopram (Celexa), fluvoxamine (Luvox), fluoxetine (Prozac), paroxetine (Paxil), or sertraline (Zoloft) until clinical safety is demonstrated.14,15. Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Wiener M, Guo Y, Patel G, Fries BC "Lactic Acidosis after Treatment with Linezolid." Do not share this medication with others. tell your doctor if you have a chronic (long-lasting) infection, or if you have or have ever had carcinoid syndrome (a condition in which a tumor secretes serotonin). Special instructions for linezolid. Steinberg M, Morin AK "Mild serotonin syndrome associated with concurrent linezolid and fluoxetine." Get the FREE SingleCare app (9,650) Make saving on Rx even easier. Phlebitis, arthralgias/myalgias, hyperbilirubinemia (25 percent). You should be very familiar with the list of foods you must avoid while you are using linezolid. Take your next dose at the regular time. Senneville E, Legout L, Valette M, et al. Talk to your pharmacist for more details. To help you remember, take this medication at the same time(s) every day. Linezolid will not treat a viral infection (flu or a common cold). Diarrhea, headache, nausea, vomiting, or dizziness may occur. Measure a dose with the supplied syringe or a dose-measuring device (not a kitchen spoon). Drug information provided by: Merative, Micromedex. This survey is being conducted by the WebMD marketing sciences department. . Information is also available online at https://www.poisonhelp.org/help. Some products that may interact with this drug include: diet pills/appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine, methylphenidate), apraclonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, deutetrabenazine, a certain combination product (dextromethorphan/quinidine), levodopa, maprotiline, methyldopa, metoclopramide, certain opioid pain relievers (such as fentanyl, meperidine, methadone, tapentadol), certain drugs for Parkinson's disease (such as entacapone, tolcapone), certain supplements (such as tryptophan, tyramine), tetrabenazine, tricyclic antidepressants (such as amitriptyline, doxepin), valbenazine. Taking other MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Nasraway SA, Shorr AF, Kuter DJ, O'Grady N, Le VH, Cammarata SK "Linezolid does not increase the risk of thrombocytopenia in patients with nosocomial pneumonia: comparative analysis of linezolid and vancomycin use." Joshi L, Taylor SR, Large O, Yacoub S, Lightman S "A case of optic neuropathy after short-term linezolid use in a patient with acute lymphocytic leukemia." Follow diet instructions closely. Youssef S, Hachem R, Chemaly RF, et al. The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Shneker BF, Baylin PD, Nakhla ME "Linezolid inducing complex partial status epilepticus in a patient with epilepsy." J Clin Psychopharmacol 26 (2006): 681-683, 18. Canada residents can call a provincial poison control center. This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. If myelosuppression occurs, then discontinuation of therapy should be considered. Tell your doctor right away if you have symptoms of low blood sugar such as sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Wu VC, Wang YT, Wang CY, et al. Das PK, Warkentin DI, Hewko R, Forrest DL "Serotonin syndrome after concomitant treatment with linezolid and meperidine." The time from the onset of therapy to the first sign of lactic acidosis ranged from 1 to 16 weeks. It is well absorbed with high bioavailability that allows conversion to oral therapy as soon as the patient is clinically stable. Continue reading for a comprehensive list of adverse effects. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. 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