If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. treprostinil increases effects of losartan by pharmacodynamic synergism. May inhibit the conversion of losartan to its active metabolite E-3174. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. losartan and betaxolol both increase serum potassium. Serious - Use Alternative (1)losartan, benazepril. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Apalutamide induces UGT and may decrease systemic exposure of drugs that are UGT substrates. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Risk of hypotension. losartan, fosinopril. losartan and aspirin both increase serum potassium. Use Caution/Monitor. amiodarone decreases effects of losartan by decreasing metabolism. Minor/Significance Unknown. lorlatinib will decrease the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ketoconazole decreases effects of losartan by decreasing metabolism. May inhibit the conversion of losartan to its active metabolite E-3174. Use Caution/Monitor. Use Caution/Monitor. Following oral administration, losartan is rapidly absorbed, reaching maximum concentrations 1-2 hours post-administration. May inhibit the conversion of losartan to its active metabolite E-3174. Modify Therapy/Monitor Closely. Potassium salts may increase the hyperkalemic effects of ARBs; the effect may be the result of aldosterone suppression in patients receiving ARBs. Use Caution/Monitor. losartan and carvedilol both increase serum potassium. Comment: Low molecular weight heparins may suppress adrenal aldosterone secretion, which can potentially cause hyperkalemia. Erectile dysfunction (ED) is often a symptom . lurasidone increases effects of losartan by Other (see comment). Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Use Caution/Monitor. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia. The recipient will receive more details and instructions to access this offer. diarrhea. Monitor Closely (1)phenobarbital will decrease the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Drug Summary What Is Hyzaar? Monitor Closely (1)losartan increases and terbutaline decreases serum potassium. Monitor renal function periodically. Either increases toxicity of the other by pharmacodynamic synergism. May inhibit the conversion of losartan to its active metabolite E-3174. Use Caution/Monitor. imatinib decreases effects of losartan by decreasing metabolism. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Serious - Use Alternative (2)losartan will increase the level or effect of tucatinib by Other (see comment). Do not use a household spoon because you may not get the correct dose.Use this medication regularly to get the most benefit from it. Use Caution/Monitor. Avoid or Use Alternate Drug. losartan, eplerenone. Use Caution/Monitor. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Use Caution/Monitor.losartan, ibuprofen IV. Cannabidiol may potentially inhibit CYP2C9 activity. ketorolac intranasal decreases effects of losartan by pharmacodynamic antagonism. Minor/Significance Unknown. nafcillin will decrease the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. losartan and tolfenamic acid both increase serum potassium. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. Modify Therapy/Monitor Closely. Monitor Closely (2)apalutamide will decrease the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Mechanism: pharmacodynamic synergism. Monitor Closely (2)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Fexinidazole inhibits CYP3A4. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown. Monitor Closely (2)sotalol, losartan. losartan and penbutolol both increase serum potassium. Use Caution/Monitor. losartan and etodolac both increase serum potassium. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. losartan will increase the level or effect of erdafitinib by affecting hepatic enzyme CYP2C9/10 metabolism. indomethacin decreases effects of losartan by pharmacodynamic antagonism. Use Caution/Monitor. May inhibit the conversion of losartan to its active metabolite E-3174. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Use Caution/Monitor. After oral administration approximately 14% of a losartan dose is converted to the pharmacologically active E 3174 metabolite. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding safety information are provided. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. enzalutamide will decrease the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. losartan will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. losartan and sulindac both increase serum potassium. Risk of hypotension. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. voriconazole will increase the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. Mechanism: pharmacodynamic synergism. Monitor Closely (1)losartan will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Minor/Significance Unknown. losartan, benazepril. Contraindicated (1)sparsentan, losartan. losartan increases toxicity of cholic acid by decreasing elimination. losartan and betaxolol both increase serum potassium. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy. Monitor Closely (1)metronidazole will increase the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. Losartan is FDA approved for the treatment of several medical conditions, which include the following: hypertension, diabetic nephropathy. Use Caution/Monitor. Hyzaar (losartan potassium -hydrochlorothiazide) is a combination of an angiotensin II receptor antagonist and a thiazide diuretic (water pill) used to treat high blood pressure ( hypertension ). Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. prescription products. Avoid or Use Alternate Drug. CYP3A4 substrates may require dosage adjustment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. Use Caution/Monitor. rifabutin decreases levels of losartan by increasing metabolism. Minor (1)nirmatrelvir/ritonavir will increase the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. May inhibit the conversion of losartan to its active metabolite E-3174. Coadministration of tucatinib (a CYP2C8 substrate) with a strong or moderate CYP2C8 inhibitors increases tucatinib plasma concentrations and risk of toxicities.tucatinib will increase the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)losartan increases effects of insulin regular human by unspecified interaction mechanism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. losartan and ibuprofen both increase serum potassium. Use Caution/Monitor. May inhibit the conversion of losartan to its active metabolite E-3174. Use Caution/Monitor. sparsentan, losartan. Elvitegravir is a moderate CYP2C9 inducer. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.losartan, salsalate. 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