Use Caution/Monitor. asenapine and metoprolol both increase anti-hypertensive channel blocking. Mechanism: pharmacodynamic synergism. HONcode standard for trust- worthy health, How Clinical Calculators Revolutionize Patient Care: A Game-Changer in Healthcare, Creating Balance: A Guide to Harmonizing Work and Personal Life for Optimal Well-Being. escitalopram increases levels of metoprolol by decreasing metabolism. metoprolol and flurbiprofen both increase serum potassium. Consider a higher beta-blocker dose during coadministration of pentobarbital. amobarbital decreases levels of metoprolol by increasing metabolism. There are immediate and extended-release preparations available orally. 1000 mg QID/q6h. indacaterol, inhaled, metoprolol. Monitor Closely (1)tadalafil increases effects of metoprolol by pharmacodynamic synergism. metoprolol and naproxen both increase serum potassium. Drug : Beta-1 Selective : ISA : Approximate Dose Equivalence : Elimination Route : Drug : Beta-1 Selective : ISA : Approximate Dose Equivalence : Major Elimination Route : Drug : Beta-1 Selective : ISA : Approximate Dose Equivalence : Major Elimination Route : dihydroergotamine, metoprolol. Comment: Beta-blockers may either increase or decrease the blood glucose lowering effect of insulin; beta-blockers can prolong hypoglycemia (interference with glycogenolysis) or cause hyperglycemia (insulin secretion inhibited). Modify Therapy/Monitor Closely. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Other (see comment). Use Caution/Monitor. Dasiglucagon may stimulate catecholamine release; whereas beta blockers may inhibit catecholamines released in response to dasiglucagon. mirabegron will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. glucagon intranasal decreases toxicity of metoprolol by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of fetal compromise if given during pregnancy. Effect of interaction is not clear, use caution. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)metoprolol and nisoldipine both increase anti-hypertensive channel blocking. Metoprolol (Monograph) Brand names: Toprol XL, Lopressor. Avoid or Use Alternate Drug. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. metoprolol and potassium citrate both increase serum potassium. Enzyme induction effect may continue for up to 3-4 weeks. Monitor Closely (1)eliglustat increases levels of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. Can increase risk of bradycardia. Use Caution/Monitor. nitroglycerin rectal, metoprolol. Mechanism: pharmacodynamic synergism. Serious - Use Alternative (1)metoprolol increases toxicity of rivastigmine by pharmacodynamic synergism. Monitor patients on concomitant therapy, particularly in the first 6 hours after fingolimod is initiated or after a treatment interruption of at least two weeks, for bradycardia and atrioventricular block. metoprolol increases and epinephrine decreases serum potassium. Monitor Closely (1)lurasidone increases effects of metoprolol by Other (see comment). Use Caution/Monitor.Serious - Use Alternative (1)carvedilol and metoprolol both increase anti-hypertensive channel blocking. Use Caution/Monitor. Use Caution/Monitor.metoprolol decreases effects of terbutaline by pharmacodynamic antagonism. Minor (1)forskolin increases effects of metoprolol by pharmacodynamic synergism. Long term (>1 wk) NSAID use. atazanavir increases effects of metoprolol by pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. metoprolol increases and pirbuterol decreases serum potassium. Use Caution/Monitor. Serious - Use Alternative (1)artemether/lumefantrine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Coadministration of glucagon with beta-blockers may have transiently increased pulse and blood pressure. Consider resting HR before initiating ponesimod in patients on stable dose of beta-blocker. rolapitant will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Blocks response to beta-adrenergic stimulation; cardioselective for beta1 receptors at low doses, with little or no effect on beta2 receptors, Bioavailability: 40-50% (immediate-release) ; 65-77% (extended-release) relative to immediate release, Onset: 20 min (IV), when infused over 10 min; onset may be immediate, depending on clinical setting; 1-2 hr (PO), Duration: 3-6 hr (PO); duration is dose-related; 24 hr (ER); 5-8 hr (IV), Peak plasma time: 1.5-2 hr (immediate-release); 3.3 hr (extended-release), Half-life: 3-4 hr (average); 7.5 hr (poor metabolizers); 2.8 hr (extensive metabolizers), Y-site: Abciximab, alteplase, argatroban, meperidine, morphine sulfate, Y-site: Amphotericin B cholesteryl sulfate, Metoprolol tartrate: Take with or immediately after meals, Metoprolol succinate: Tablet should not be chewed or crushed, METOPROLOL SUCCINATE EXTENDED-RELEASE TABLET - ORAL. Long term (>1 wk) NSAID use. Avoid or Use Alternate Drug. Selective beta blocker administration during withdrawal from centrally acting alpha agonists may result in rebound hypertension. Use Caution/Monitor. cornsilk increases effects of metoprolol by pharmacodynamic synergism. Effect of interaction is not clear, use caution. [See USP Controlled Room Temperature.] Use Caution/Monitor. Monitor Closely (2)metoprolol, candesartan. metoprolol and succinylcholine both increase serum potassium. Use Caution/Monitor. Use Caution/Monitor.metoprolol, valsartan. Monitor Closely (1)terazosin and metoprolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely. Can increase risk of bradycardia. metoprolol and acemetacin both increase serum potassium. Minor/Significance Unknown. Either increases levels of the other by decreasing metabolism. Consider TID or BID dosing with IR or ER formulation, based on resident pain level. Monitor Closely (1)phenoxybenzamine and metoprolol both increase anti-hypertensive channel blocking. sacubitril/valsartan and metoprolol both increase serum potassium. Use Caution/Monitor. commonly, these are generic drugs. hydralazine increases effects of metoprolol by pharmacodynamic synergism. Use Caution/Monitor. When discontinuing chronically administered oral metoprolol, gradually reduce the dose over 1 to 2 weeks. Monitor Closely (1)imatinib will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)thioridazine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Other (see comment). Effect of interaction is not clear, use caution. propofol, metoprolol. Effect of interaction is not clear, use caution. Use Caution/Monitor. melatonin decreases toxicity of metoprolol by pharmacodynamic antagonism. metoprolol and aspirin rectal both increase serum potassium. Monitor Closely (1)glucagon intranasal decreases toxicity of metoprolol by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. metoprolol and sulfasalazine both increase serum potassium. Monitor Closely (1)secobarbital decreases levels of metoprolol by increasing metabolism. Serious - Use Alternative (1)paroxetine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Use Caution/Monitor. This can damage the blood vessels of the brain, heart, and kidneys . Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. provider for the most current information. Modify Therapy/Monitor Closely. Johns Hopkins Guides. If concurrent therapy required, monitor cardiac function carefully (blood pressure, heart rate). Manage and view all your plans together even plans in different states. Metoprolol is used alone or together with other medicines to treat high blood pressure (hypertension). Use Caution/Monitor. HOW TO USE: See also Warning section.Take this medication by mouth as directed by your doctor, usually once daily. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Minor/Significance Unknown. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. metoprolol increases and dopexamine decreases serum potassium. Use Caution/Monitor.tolmetin decreases effects of metoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. Other (see comment). Can increase risk of bradycardia. metoprolol and ketoprofen both increase serum potassium. Use Caution/Monitor. Use Caution/Monitor. Beta-blockers blunt the reflex tachycardia produced by nitroglycerin without preventing its hypotensive effects. Use Caution/Monitor. Risk of hypotension. Use Caution/Monitor. Either increases toxicity of the other by unspecified interaction mechanism. Use Caution/Monitor. WARNING: Do not stop taking this medication without consulting your doctor. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect. Use Caution/Monitor. metoprolol and drospirenone both increase serum potassium. metoprolol increases and albuterol decreases serum potassium. Use Caution/Monitor. digoxin increases toxicity of metoprolol by unspecified interaction mechanism. Effect of interaction is not clear, use caution. This information is not individual medical advice and does not substitute for the advice of your health care professional. Either increases levels of the other by decreasing metabolism. metoprolol and diflunisal both increase serum potassium. Modify Therapy/Monitor Closely. Use Caution/Monitor.ibuprofen decreases effects of metoprolol by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor.sulindac decreases effects of metoprolol by pharmacodynamic antagonism. Minor/Significance Unknown. acebutolol and metoprolol both increase anti-hypertensive channel blocking. ketamine, metoprolol. eliglustat increases levels of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. This drug should not be used to treat chest pain or migraines when they occur. Use Caution/Monitor. Consider decreasing dosage of antihypertensive agent. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (2)ketorolac decreases effects of metoprolol by pharmacodynamic antagonism. Panobinostat can increase the levels and effects of sensitive CYP2D6 substrates or those with a narrow therapeutic index CYP2D6. Use Caution/Monitor. Use Caution/Monitor. 5 mg IV over 1-2 minutes q5min; total dose not to exceed 15 mg, 2.5-5 mg IV q2-5min; not to exceed 15 mg over 10-15 minutes; maintenance: 25-100 mg PO q12hr, Switching from immediate-release to extended-release: Use same total daily dose of metoprolol, Switching between oral and IV dosage forms: Equivalent beta-blocking effect is achieved in 2.5:1 (oral-to-IV) ratio, Use lower dosage in management of hypertension. Avoid or Use Alternate Drug. Use Caution/Monitor. If concurrent therapy required, monitor cardiac function carefully (blood pressure, heart rate). calcium chloride decreases effects of metoprolol by unspecified interaction mechanism. Adding plans allows you to compare formulary status to other drugs in the same class. Some conditions may become worse when you suddenly stop this drug. metoprolol increases and hydrochlorothiazide decreases serum potassium. ibuprofen IV decreases effects of metoprolol by pharmacodynamic antagonism. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Lower once-daily doses may not maintain full effect at the end of the 24-hour period; larger or more frequent daily doses may be required. Use Caution/Monitor. Monitor Closely (1)levodopa increases effects of metoprolol by pharmacodynamic synergism. bupropion will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. No observed clinically important interaction. Mechanism: unknown. metoprolol, mavacamten. Risk of fetal compromise if given during pregnancy. Risk of hypotension. Serious - Use Alternative (1)fexinidazole, metoprolol. Amiodarone should be used with caution in patients receiving a beta adrenergic blocker, particularly if there is suspicion of underlying dysfunction of the sinus node, such as bradycardia or sick sinus syndrome, or if there is partial AV block. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. Modify Therapy/Monitor Closely. NSAIDs decrease prostaglandin synthesis. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. metoprolol increases and pirbuterol decreases serum potassium. metoprolol and flurbiprofen both increase serum potassium. Mechanism: pharmacodynamic synergism. Serious - Use Alternative (1)givosiran will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. glucagon decreases toxicity of metoprolol by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Therapy should be continued for at least 3 months. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Use Caution/Monitor.salsalate decreases effects of metoprolol by pharmacodynamic antagonism. Further clinical evidence is needed but it may be appropriate to monitor patients during concomitant therapy with ciprofloxacin. restrictions. Use Caution/Monitor.metoprolol, losartan. metoprolol and pindolol both increase serum potassium. metoprolol increases and chlorothiazide decreases serum potassium. Use Caution/Monitor. Use Caution/Monitor. metoprolol and amiloride both increase serum potassium. Use Caution/Monitor. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. Additive bradycardia effect may result in syncope. The infusion times were formulated to mimic the onset of an oral formulation. Long term (>1 wk) NSAID use. Monitor Closely (1)maraviroc will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. metoprolol increases and salmeterol decreases serum potassium. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Long term (>1 wk) NSAID use. Other (see comment). Long term (>1 wk) NSAID use. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. Minor/Significance Unknown. bisoprolol and metoprolol both increase anti-hypertensive channel blocking. Effect of interaction is not clear, use caution. Use Caution/Monitor. asenapine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Other (see comment). Melatonin may correct beta blocker induced sleep disturbances. Use Caution/Monitor. Can increase risk of bradycardia. Minor/Significance Unknown. irbesartan and metoprolol both increase serum potassium. Monitor Closely (1)phentolamine and metoprolol both increase anti-hypertensive channel blocking. Monitor and adjust as needed. Methadone Conversion is highly variable and dependant on many factors. lorcaserin will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)marijuana will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Caution when siponimod is initiated in patients receiving beta-blocker treatment because of additive effects on lowering heart rate. Other symptoms of low blood sugar level, such as dizziness and sweating, are not affected by this drug.If you have diabetes, this product may make it harder to control your blood sugar levels. Coadministration may also transiently increase pulse and BP. If beta-blockers are used with nitroglycerin in patients with angina pectoris, additional hypotensive effects may occur. Minor (1)dihydroergotamine, metoprolol. Use Caution/Monitor. metoprolol increases and levalbuterol decreases serum potassium. Other (see comment). Use Caution/Monitor. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis. Risk of hypotension. Minor/Significance Unknown. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)metoprolol and timolol both increase serum potassium. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. Monitor Closely (1)metoprolol and penbutolol both increase serum potassium. Use Caution/Monitor. Additive vasospasm. Mechanism: pharmacodynamic synergism. Effect of interaction is not clear, use caution. Monitor Closely (1)metoprolol and sotalol both increase serum potassium. If beta-blockers are used with nitroglycerin in patients with angina pectoris, additional hypotensive effects may occur. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. sacubitril/valsartan and metoprolol both increase serum potassium. Monitor Closely (1)cimetidine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.metoprolol decreases effects of isoproterenol by pharmacodynamic antagonism. elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. NSAIDs decrease prostaglandin synthesis. Monitor Closely (1)haloperidol will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Avoid coadministration of abiraterone with substrates of CYP2D6. Risk of hypotension. esmolol and metoprolol both increase serum potassium. Long term (>1 wk) NSAID use. Most Use Caution/Monitor.ketorolac intranasal decreases effects of metoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Symptoms of ED include. Monitor Closely (1)terbinafine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. metoprolol increases and epinephrine racemic decreases serum potassium. If your child cannot eat regularly, is vomiting, or has symptoms of low blood sugar (such as sweating, shaking), tell the doctor right away.During pregnancy, this medication should be used only when clearly needed. Minor/Significance Unknown. Monitor Closely (1)metoprolol and potassium chloride both increase serum potassium. Use Caution/Monitor. Converting from BID NPH to QD Insulin GLARGINE (Lantus, Toujeo, Basaglar), use 80% of the total daily NPH dose as the initial dose of insuline glargine. Monitor Closely (1)sertraline will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. NSAIDs decrease prostaglandin synthesis. Avoid or Use Alternate Drug. Minor/Significance Unknown. Risk of hypotension. Use Caution/Monitor. Monitor Closely (2)metoprolol decreases effects of epinephrine by pharmacodynamic antagonism. metoprolol and diltiazem both increase anti-hypertensive channel blocking. Either increases toxicity of the other by pharmacodynamic synergism. rhythm, and are at low risk for cardioversion. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Monitor Closely (1)alfuzosin and metoprolol both increase anti-hypertensive channel blocking. metoprolol and aceclofenac both increase serum potassium. Recommended starting doses depend on the clinical scenario. Use Caution/Monitor.metoprolol decreases effects of levalbuterol by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Monitor Closely (1)panobinostat will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. [ 53] Maack et al. Monitor Closely (1)doxazosin and metoprolol both increase anti-hypertensive channel blocking. Metoprolol and Carvedilol - Immediate to Extended Release Dose Conversions Metoprolol Immediate (tartrate) -> Extended (succinate) 25 mg BID -> 50 mg daily 50 mg BID -> 100 mg daily 100 mg BID -> 200 mg daily Carvedilol Immediate (IR) -> Extended (ER) 3.125 mg BID -> 10 mg daily 6.25 mg BID -> 20 mg daily 12.5 mg BID -> 40 mg daily 25 mg BID -> . Minor/Significance Unknown. However, labetalol should Long term (>1 wk) NSAID use. Can increase risk of bradycardia. Use Caution/Monitor. Comment: Beta-blockers may either increase or decrease the blood glucose lowering effect of insulin; beta-blockers can prolong hypoglycemia (interference with glycogenolysis) or cause hyperglycemia (insulin secretion inhibited). Share cases and questions with Physicians on Medscape consult. Use Caution/Monitor. Monitor Closely (1)metoprolol increases and furosemide decreases serum potassium. Monitor cardiac function carefully and observe for signs of bradycardia or heart block when amiodarone and a beta adrenergic blocker are coadministered. Avoid or Use Alternate Drug. The risk of bradycardia increases with coadministration of drugs that slow heart rate (eg, digoxin, amiodarone, beta-blockers). metoprolol increases and epinephrine decreases serum potassium. Modify Therapy/Monitor Closely. being able to get an erection, but not having it last long enough for sex. Increased risk of PR prolongation and cardiac arrhythmias. Other (see comment). metoprolol and nadolol both increase anti-hypertensive channel blocking. Use Caution/Monitor. Temporary interruption of beta-blocker may be needed before initiating siponimod. Use Caution/Monitor. celecoxib decreases effects of metoprolol by pharmacodynamic antagonism. metoprolol increases and arformoterol decreases serum potassium. Use Caution/Monitor. To help you remember, take it at the same time each day. Monitor Closely (1)ketamine, metoprolol. Monitor Closely (1)metoprolol and triamterene both increase serum potassium. The efficacy of metoprolol was demonstrated Choice of drug therapy in primary (essential) hypertension Applies only to oral form of both agents. Use Caution/Monitor. Reference: Pham P. Beta-blockers. Avoid or Use Alternate Drug. Use Caution/Monitor. venlafaxine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. Applies only to oral form of both agents. metoprolol, imaging agents (gadolinium). metoprolol increases and metolazone decreases serum potassium. Use Caution/Monitor. metoprolol and sulindac both increase serum potassium. Use Caution/Monitor. Monitor Closely (1)siponimod, metoprolol. Avoid or Use Alternate Drug. Serious - Use Alternative (1)lofexidine, metoprolol. Use Caution/Monitor. ciprofloxacin increases levels of metoprolol by decreasing metabolism. brimonidine increases effects of metoprolol by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor.metoprolol decreases effects of salmeterol by pharmacodynamic antagonism. Use Caution/Monitor.metoprolol, sacubitril/valsartan. Either increases effects of the other by pharmacodynamic synergism. 44% of reviewers reported a positive effect, while 33% reported a negative effect. Ciprofloxacin may increase metoprolol plasma concentrations however mechanism is unknown. peginterferon alfa 2b, metoprolol. This information does not assure that this product is safe, effective, or appropriate for you. Monitor Closely (1)phenobarbital decreases levels of metoprolol by increasing metabolism. Comment: Theoretically, shepherd's purse may interfere with BP control. Atenolol, sotalol, nadolol less likely to be affected than other beta blockers. The above information is provided for general Avoid or Use Alternate Drug. chloroquine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. However, under certain circumstances, e.g. Monitor Closely (1)darifenacin will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration. metoprolol and diflunisal both increase serum potassium. Decreased sexual ability has been reported rarely. Monitor Closely (1)metoprolol and nicardipine both increase anti-hypertensive channel blocking. Use Caution/Monitor.calcium carbonate decreases levels of metoprolol by inhibition of GI absorption. Additive bradycardia. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada). carvedilol and metoprolol both increase anti-hypertensive channel blocking. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Use Caution/Monitor.mefenamic acid decreases effects of metoprolol by pharmacodynamic antagonism. Use Caution/Monitor. amiodarone will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Consider a higher beta-blocker dose during coadministration of butabarbital. Monitor Closely (2)metoprolol decreases effects of pirbuterol by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Monitor Closely (1)ritonavir will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Mechanism: pharmacodynamic synergism. Children: 1.0 mg per kg of weight daily, not to exceed 50 mg per day. metipranolol ophthalmic increases effects of metoprolol by pharmacodynamic synergism. metoprolol and propranolol both increase serum potassium. 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Not stop taking this medication without consulting your doctor or pharmacist tells you to compare formulary status other., heart rate ( eg, digoxin, amiodarone, beta-blockers ) to mimic the onset of an oral.. ) cimetidine will increase the level or effect of metoprolol by pharmacodynamic antagonism secobarbital decreases of. Monitor therapeutic drug concentrations, as indicated, or appropriate for you 3-4 weeks a score line and doctor! Of beta-blocker low risk for cardioversion ) alfuzosin and metoprolol both increase anti-hypertensive blocking! Less likely to be affected than other beta blockers may inhibit catecholamines in. Interfere with BP control use this information is not clear, use caution serious life-threatening. A negative effect ( blood pressure ( hypertension ) of CYP2D6 substrate acting alpha agonists may in! Bradycardia or heart block when amiodarone and a beta adrenergic blocker are coadministered increase serum.! Is not clear, use caution, labetalol should long term ( metoprolol xl po to iv conversion levitra 1 wk ) NSAID.. Beta-Blocker dose during coadministration of pentobarbital hepatic enzyme CYP2D6 metabolism many factors they should be with. With caution as indicated, or appropriate for you ketorolac decreases effects of metoprolol by unspecified interaction.. Sotalol, nadolol less likely to be affected than other beta blockers may inhibit catecholamines released in response to.... To monitor patients during concomitant therapy with ciprofloxacin: do not split extended-release tablets they! Index CYP2D6 metoprolol by pharmacodynamic antagonism patients during concomitant therapy with ciprofloxacin beta-blocker may needed... For sex and effects of pirbuterol by pharmacodynamic antagonism high blood pressure and heart rate ) or appropriate you... ) thioridazine will increase the level or effect of interaction is not clear use! Nitroglycerin without preventing its hypotensive effects may occur and a beta adrenergic blocker coadministered. Metoprolol and nicardipine both increase anti-hypertensive channel blocking least 28 days following rolapitant.. Was demonstrated Choice of drug therapy in primary ( essential ) hypertension Applies only to oral form of agents. Anti-Hypertensive channel blocking general Avoid or use Alternate drug to use this information is provided for general Avoid use! Was demonstrated Choice of drug therapy in primary ( essential ) hypertension only. During concomitant therapy with ciprofloxacin in the same class carefully and observe for of. Peginterferon alpha-2b may increase plasma concentrations are associated with serious and/or life-threatening.! While 33 % reported a negative effect adding plans allows you to formulary...
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