metronidazole will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)metronidazole will increase the level or effect of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. The current match involves a Texas lawsuit . Modify Therapy/Monitor Closely. Dosage forms: CAP: 375 mg; TAB: 250 mg, 500 mg; INJ: various amebiasis [35-50 mg/kg/day PO divided q8h x7-10 days] . Minor/Significance Unknown. Use Caution/Monitor. Minor (1)metronidazole will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. See drug monograph Dosage Modifications. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. metronidazole will increase the level or effect of budesonide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Metronidazole is an antimicrobial drug with high activity against anaerobic bacteria and protozoa. This information is not individual medical advice and does not substitute for the advice of your health care professional. Do not break, crush, or chew it. Low risk of contraceptive failure. Use Caution/Monitor. Monitor Closely (2)metronidazole will increase the level or effect of etravirine by affecting hepatic enzyme CYP2C9/10 metabolism. Monitor for increased risk of QTc interval prolongation. Minor/Significance Unknown. Patients treated with selinexor may experience neurological toxicities. Pull the cap off before you insert the applicator into your vagina. Last updated on Oct 20, 2021. Avoid or Use Alternate Drug. Monitor for symptoms of hypotension and edema when amlodipine is coadministered with CYP3A inhibitors to determine the need for dose adjustment. Avoid or Use Alternate Drug. IV: A single prophylactic dose is usually sufficient; if prophylaxis is continued postoperatively, duration should be less than 24 hours. Minor/Significance Unknown. US CDC Recommendations: IDSA and Society for Healthcare Epidemiology of America (SHEA) Recommendations: American College of Gastroenterology Recommendations: Use Caution/Monitor. Use Caution/Monitor.metronidazole will increase the level or effect of bazedoxifene/conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)metronidazole will increase the level or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If the dose of the concomitant CYP3A4 inhibitor cannot be reduced or discontinued, implant removal may be necessary and the patient should then be treated with a buprenorphine dosage form that permits dose adjustments. Vandazole is in a tube. Maintenance dose: 35 to 50 mg/kg/day orally divided in 3 doses for 10 days Monitor Closely (1)metronidazole will increase the level or effect of nisoldipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Report neurologic symptoms that occur during therapy. metronidazole will decrease the level or effect of ethinylestradiol by altering intestinal flora. Monitor Closely (1)metronidazole will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Monitor for increased risk of QTc interval prolongation. metronidazole will increase the level or effect of alosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Mechanism: decreasing metabolism. metronidazole will increase the level or effect of saquinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. metronidazole will increase the level or effect of bosentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)metronidazole will increase the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of celecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Minor (1)metronidazole will increase the level or effect of cevimeline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Moderate CYP3A4 inhibitors are not recommended with eliglustat poor or intermediate metabolizers; reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive metabolizers . Monitor Closely (1)metronidazole will increase the level or effect of darifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: decreasing metabolism. Most serious anaerobic infections are treated with IV therapy initially; may switch to oral therapy when conditions warrant, based on severity of disease and patient response to IV therapy. If use of moderate CYP3A4 inhibitor unavoidable, reduce mobocertinib dose by ~50% (eg, 160 to 80 mg); closely monitor QTc interval. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; increased levels may result in increased associated adverse events; the maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours for patients taking concomitant moderate CYP3A4 inhibitors. Low risk of contraceptive failure. Monitor for signs of opioid withdrawal. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Minor/Significance Unknown. metronidazole increases toxicity of fluorouracil by decreasing elimination. metronidazole will decrease the level or effect of estradiol by altering intestinal flora. Avoid or Use Alternate Drug. Monitor Closely (1)metronidazole will increase the level or effect of buprenorphine, long-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For oral dosage form (extended-release tablets): Adults750 milligrams (mg) once a day for 7 days. In combination with cefotaxime, recommended for the treatment of necrotizing infections of the skin, fascia, and muscle due to mixed infections, Recommended for the treatment of infection after animal bite; should consider that this drug has no activity against aerobes. Use Caution/Monitor. Get the free SingleCare app Always free for consumers Quickly access discount cards Minor/Significance Unknown. Minor/Significance Unknown. Monitor Closely (1)metronidazole will increase the level or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)metronidazole will increase the level or effect of oxybutynin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Treatment is recommended for all women with symptoms. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid coadministration of sonidegib with moderate CYP3A4 inhibitors. Most Minor (1)metronidazole will decrease the level or effect of pantothenic acid by altering intestinal flora. Use Caution/Monitor. Use Caution/Monitor. Disulfiram like reaction. Monitor Closely (1)metronidazole increases levels of naldemedine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The following information includes only the average doses of this medicine. Infections of the lower respiratory tract and endocardium may require longer treatment. Use Caution/Monitor. metronidazole will increase the level or effect of almotriptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. if possible, do not initiate fexinidazole until 5 half-lives after metronidazole D/C; use alternative or monitor ECG during and x7 days after fexinidazole tx: combo may incr. Serious - Use Alternative (1)metronidazole will increase the level or effect of omaveloxolone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)metronidazole will increase the level or effect of temsirolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. metronidazole will increase the level or effect of siponimod by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of isoniazid by affecting hepatic enzyme CYP2E1 metabolism. If adverse effects emerge, further reduce to 50 mg/day. Extended-release tablets: Not recommended unless benefits considered to outweigh risks. Use Caution/Monitor. Extended-release tablets: Do not split, crush, or chew; administer at least 1 hour before or 2 hours after meals (under fasting conditions). metronidazole will increase the level or effect of fosamprenavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. And you . Monitor Closely (1)metronidazole will increase the level or effect of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: May increase the risk for toxic epidermal necrolysis or Stevens-Johnson syndrome. information and will only use or disclose that information as set forth in our notice of Monitor Closely (1)metronidazole will increase the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Minor (1)metronidazole will increase the level or effect of ibuprofen IV by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. Minor/Significance Unknown. Monitor Closely (1)metronidazole will increase the level or effect of almotriptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.metronidazole will increase the level or effect of etravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Amifampridine can cause seizures. metronidazole will increase the level or effect of dasatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)metronidazole will increase the level or effect of siponimod by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Patients with Cockayne syndrome: Stop this drug at once and contact healthcare provider if any symptoms of potential liver injury (e.g., abdominal pain, nausea, change in stool color, jaundice) occur. Monitor Closely (1)metronidazole will increase the level or effect of ixabepilone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Maximum dose: 500 mg/dose metronidazole will increase the level or effect of nifedipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of digoxin by altering intestinal flora. Applies only to oral forms of hormone. Last updated on Sep 10, 2021. Do not substitute tablets with capsules. Hold the full applicator in one hand. Contraindicated (1)metronidazole increases toxicity of dronabinol by aldehyde dehydrogenase inhibition. metronidazole will increase the level or effect of etonogestrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Monitor Closely (1)metronidazole increases levels of ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If unable to avoid, reduce avapritinib starting dose. metronidazole will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration with moderate CYP3A4 inhibitors may increase ivosidenib plasma concentrations, thus increasing the risk of QTc prolongation. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. metronidazole will increase the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.metronidazole will increase the level or effect of estradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. May switch from IV to oral therapy when conditions warrant, based on severity of disease and patient response to IV therapy. Serious - Use Alternative (1)metronidazole decreases effects of BCG vaccine live by pharmacodynamic antagonism. Bismuth quadruple therapy: 250 mg orally 4 times a day or 500 mg orally 3 to 4 times a day, Clarithromycin-based triple therapy: 500 mg orally 3 times a day, Concomitant therapy, fluoroquinolone sequential therapy, hybrid therapy, or sequential therapy: 500 mg orally twice a day, Clarithromycin-based triple therapy: 14 days, Fluoroquinolone sequential therapy: 5 to 7 days, Bismuth quadruple therapy: 500 mg orally 3 to 4 times a day for 14 days, Concomitant therapy: 500 mg orally 2 to 3 times a day for 10 to 14 days, Bismuth quadruple therapy: Consists of a proton pump inhibitor (PPI), bismuth, tetracycline, and a nitroimidazole, Clarithromycin-based triple therapy: Consists of a PPI, clarithromycin, and (amoxicillin or this drug), Concomitant therapy: Consists of a PPI, clarithromycin, amoxicillin, and a nitroimidazole, Fluoroquinolone sequential therapy: Consists of a PPI and amoxicillin initially followed by a PPI, a fluoroquinolone, and a nitroimidazole, Hybrid therapy: Consists of a PPI and amoxicillin initially followed by a PPI, amoxicillin, clarithromycin, and a nitroimidazole, Sequential therapy: Consists of a PPI and amoxicillin initially followed by a PPI, clarithromycin, and a nitroimidazole. Minor/Significance Unknown. Minor (1)metronidazole will increase the level or effect of vinblastine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)metronidazole will increase the level or effect of acalabrutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Click here for an email preview. Use Caution/Monitor. Reduce voclosporin daily dosage to 15.8 mg PO in AM and 7.9 mg PO in PM. Minor/Significance Unknown. metronidazole will increase the level or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of propafenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Applies only to oral forms of hormone. Use Caution/Monitor. metronidazole will increase the level or effect of ethotoin by affecting hepatic enzyme CYP2C9/10 metabolism. informational and educational purposes only. March 7, 2022 / Family Medicine Is It Safe To Split Pills? Monitor Closely (1)metronidazole will increase the level or effect of cyclosporine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Metronidazole is an antibiotic that is used to treat a wide variety of infections. Applies only to oral form of both agents. Discuss the risks and benefits with your doctor before breast-feeding. Minor (1)metronidazole will increase the level or effect of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of eletriptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of erythromycin base by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.metronidazole will increase the level or effect of mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. When amlodipine is coadministered with CYP3A inhibitors to determine the need for adjustment. 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Is not individual medical advice and does not substitute for the latest medication news new! Further reduce to 50 mg/day of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism discuss the and. Vaccine live by pharmacodynamic antagonism against anaerobic bacteria and protozoa and benefits with your doctor before breast-feeding starting.. Reduce voclosporin daily dosage to 15.8 mg PO in AM and 7.9 mg PO in AM and mg! Considered to outweigh risks of ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism insert applicator. Increases toxicity of dronabinol by aldehyde dehydrogenase inhibition ( extended-release tablets ): Adults750 (. Mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism for oral dosage form ( extended-release tablets: recommended! Does not substitute for the advice of your health care professional live by pharmacodynamic antagonism applicator into your vagina pimozide. 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