It is at least as effective as the older antidepressants for treating mild to severe depression. mirtazapine increases and phendimetrazine decreases sedation. acrivastine and mirtazapine both increase sedation. Effect of interaction is not clear, use caution. The use of a depression scale in everyday private practice is, however, rather troublesome and time-consuming except for the intuitive, easy-to-use CGI-I scale. The most serious side effect is agranulocytosis, which occurs in approximately one in 1,000 patients. Avoid or Use Alternate Drug. Monitor Closely (1)meprobamate and mirtazapine both increase sedation. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). Serious - Use Alternative (1)isocarboxazid and mirtazapine both increase serotonin levels. Use Caution/Monitor. ritonavir increases levels of mirtazapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.fenfluramine, mirtazapine. Use Caution/Monitor.mirtazapine and tramadol both increase serotonin levels. Enhancing neurotransmission with antidepressants induced positive behaviors within three hours even in healthy subjects. Use Caution/Monitor. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. Serious - Use Alternative (1)mirtazapine will decrease the level or effect of iobenguane I 131 by Other (see comment). efavirenz will decrease the level or effect of mirtazapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. clomipramine and mirtazapine both increase sedation. Share cases and questions with Physicians on Medscape consult. Contraindicated. Coadministration may potentiate the CNS-depressant effects of each drug. Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Use Caution/Monitor. Modify Therapy/Monitor Closely. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Use Caution/Monitor. A risk-benefit assessment of mirtazapine in the treatment of depression. Use Caution/Monitor.trimipramine and mirtazapine both increase serotonin levels. Monitor Closely (1)nefazodone and mirtazapine both increase serotonin levels. Avoid or Use Alternate Drug.buprenorphine, long-acting injection and mirtazapine both increase sedation. Avoid or Use Alternate Drug. Controlled studies in pregnant women show no evidence of fetal risk. Monitor Closely (1)amobarbital and mirtazapine both increase sedation. mirtazapine and vardenafil both increase QTc interval. Avoid or Use Alternate Drug. flurazepam and mirtazapine both increase sedation. Use Caution/Monitor.mirtazapine and lofexidine both increase QTc interval. Mirtazapine in fixed and ascending nocturnal dosing regimens was found to facilitate sleep, but it does not generally reduce daytime alertness. By clicking send, you acknowledge that you have permission to email the recipient with this information. Monitor Closely (1)clemastine and mirtazapine both increase sedation. duloxetine and mirtazapine both increase serotonin levels. Effect of interaction is not clear, use caution. Use Caution/Monitor. Synopsis: The increased release of serotonin (5-hydroxytryptamine; 5-HT) stimulates serotonin 5-HT1 receptors because mirtazapine directly blocks 5-HT2 and 5-HT3 receptors. Modify Therapy/Monitor Closely. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. Use Caution/Monitor. Mirtazapine is a moderate antagonist at muscarinic receptors, a property that may explain the relatively low incidence of anticholinergic side effects associated with its use. Avoid or Use Alternate Drug. The 50% MADRS sustained response is comparable in the severity subgroups defined by the DSM-IV severity-specifier. Serious - Use Alternative (1)mirtazapine and anagrelide both increase QTc interval. Monitor Closely (1)mirtazapine increases and dobutamine decreases sedation. Avoid or Use Alternate Drug. mirtazapine and midostaurin both increase QTc interval. dextromethorphan and mirtazapine both increase serotonin levels. papaveretum and mirtazapine both increase sedation. Monitor Closely (2)mirtazapine increases and dextroamphetamine decreases sedation. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. It is at least as effective as the older antidepressants for treating mild to severe depression.. A complete blood count and ALT measurement may be obtained if symptoms or signs suggest a need. milnacipran and mirtazapine both increase serotonin levels. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Use Caution/Monitor. Monitor Closely (1)cocaine topical and mirtazapine both increase serotonin levels. Avoid or Use Alternate Drug.clarithromycin and mirtazapine both increase QTc interval. levorphanol and mirtazapine both increase sedation. Monitor Closely (1)mirtazapine, buprenorphine subdermal implant. Use Caution/Monitor. Mirtazapine may cause a serious condition called serotonin syndrome if taken together with some medicines. Speed of changes for suicidal thoughts and best fit curves (at the different MADRS baseline scores, ranging from 1 to 6). Recent Developments in Pharmacotherapy of Depression: Bench to Bedside. loxapine and mirtazapine both increase sedation. Manage and view all your plans together even plans in different states. What Are Side Effects of Remeron? Use Caution/Monitor. Monitor Closely (1)mirtazapine increases and norepinephrine decreases sedation. Minor/Significance Unknown. Handb Exp Pharmacol. Use Caution/Monitor. Use Caution/Monitor. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. Avoid or Use Alternate Drug. brimonidine and mirtazapine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. CYP1A2 substrates may require dosage adjustment.stiripentol, mirtazapine. Serious - Use Alternative (1)mirtazapine will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Our results suggested that the efficacy of the antidepressant effect relates to a nonspecific process. fosphenytoin will decrease the level or effect of mirtazapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)hydromorphone and mirtazapine both increase sedation. Use Caution/Monitor. Loss of appetite may lead to increased morbidity or mortality. Serious - Use Alternative (1)mirtazapine, calcium/magnesium/potassium/sodium oxybates. Avoid or Use Alternate Drug. Use Caution/Monitor. Modify Therapy/Monitor Closely. Because it is unknown if mirtazapine is secreted in breast milk, it should be used with caution in breast-feeding mothers. Use Caution/Monitor. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. Monitor Closely (1)apomorphine and mirtazapine both increase sedation. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Use Caution/Monitor.mirtazapine and prochlorperazine both decrease QTc interval. meperidine and mirtazapine both increase sedation. Linezolid may increase serotonin as a result of MAO-A inhibition. Use Caution/Monitor.Serious - Use Alternative (1)mirtazapine and ziprasidone both increase QTc interval. Limit use to patients for whom alternative treatment options are inadequate, buprenorphine, long-acting injection and mirtazapine both increase QTc interval. Monitor Closely (1)mirtazapine increases and pirbuterol decreases sedation. estazolam and mirtazapine both increase sedation. Either increases toxicity of the other by sedation. Avoid or Use Alternate Drug. Owing to the potential for both CYP1A2 induction and inhibition with the coadministration of CYP1A2 substrates and cannabidiol, consider reducing dosage adjustment of CYP1A2 substrates as clinically appropriate. Mirtazapine is a tetracyclic piperazinoazepine, which has a different structure from any other currently used antidepressant. Use Caution/Monitor. Serious - Use Alternative (1)mirtazapine and midostaurin both increase QTc interval. Use Caution/Monitor. Studies in humans and animal models with spinal cord injury (SCI) have demonstrated that medications targeting serotonin receptors may decrease the susceptibility to central sleep-disordered breathing (SDB). Either increases effects of the other by serotonin levels. Difference in serotonergic and noradrenergic regulation of human social behaviours. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. PMC mirtazapine and leuprolide both increase QTc interval. Response is independent of the clinical form of depression. Either increases toxicity of the other by serotonin levels. Minor (1)larotrectinib will increase the level or effect of mirtazapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of abiraterone with substrates of CYP2D6. crofelemer increases levels of mirtazapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mirtazapine (Remeron) 15 to 45: 1.2 to 1.6: . Abbreviations: MADRS, Montgomery-Asberg Depression Rating Scale. Avoid or Use Alternate Drug. In our study, the improvement period (rate of improvement > 2%/day) lasted only 2 weeks. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.mirtazapine and pitolisant both increase QTc interval. teriflunomide decreases levels of mirtazapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. cannabidiol, mirtazapine. Contraindicated. 1999 Apr;57(4):607-31. doi: 10.2165/00003495-199957040-00010. Use Caution/Monitor. Benefits from mianserin augmentation of fluoxetine in patients with major depression non responders to fluoxetine alone. ketotifen, ophthalmic and mirtazapine both increase sedation. National Library of Medicine gemifloxacin and mirtazapine both increase QTc interval. Avoid or Use Alternate Drug. REMERON (mirtazapine) Tablets are rapidly and completely absorbed following oral administration . However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Monitor Closely (2)propofol and mirtazapine both increase sedation. tapentadol and mirtazapine both increase sedation. Serious - Use Alternative (1)mirtazapine and ciprofloxacin both increase QTc interval. The mean scores and standard deviations of single MADRS items were: apparent sadness 3.8 1.0; reported sadness 3.8 0.9; inner tension 3.5 0.9; reduced sleep 3.2 1.4; reduced appetite 2.0 1.6; concentration difficulties 3.4 1.0; lassitude 3.7 1.0; inability to feel 3.4 1.0; pessimistic thoughts 2.8 1.1; and suicidal thoughts 2.0 1.2. Use Caution/Monitor. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Avoid or Use Alternate Drug. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Either increases effects of the other by pharmacodynamic synergism. Serious - Use Alternative (1)mirtazapine and disopyramide both increase QTc interval. An official website of the United States government. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. Use Caution/Monitor. Avoid or Use Alternate Drug. Generally, when improvement is observed throughout the first week of treatment, it is very likely that the complete response will be observed within 6 weeks. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. mirtazapine increases and isoproterenol decreases sedation. tecovirimat will decrease the level or effect of mirtazapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Monitor Closely (1)fexinidazole will increase the level or effect of mirtazapine by affecting hepatic enzyme CYP1A2 metabolism. HHS Vulnerability Disclosure, Help Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. mirabegron will increase the level or effect of mirtazapine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Effect of interaction is not clear, use caution. dextromoramide and mirtazapine both increase sedation. Serious - Use Alternative (1)mirtazapine and pimavanserin both increase QTc interval. Use Caution/Monitor. morphine and mirtazapine both increase sedation. Avoid or Use Alternate Drug. Apregnancy exposure registry monitors pregnancy outcomes in women exposed to antidepressants during pregnancy; healthcare providers are encouraged to register patients by calling the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/antidepressants/. Mirtazapine is used to treat major depressive disorder in adults. Use Caution/Monitor. Avoid or Use Alternate Drug. Sorensen M, Jorgensen J, Viby-Mogensen J, et al. Use Caution/Monitor. mirtazapine and iloperidone both increase QTc interval. mirtazapine and foscarnet both increase QTc interval. and formulary information changes. Anxiety assessed with the Covi scale presented a mean score of 6.2 2 points. All Rights Reserved. Use Caution/Monitor. trimipramine and mirtazapine both increase sedation. Use Caution/Monitor. hydroxyzine and mirtazapine both increase sedation. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Increased risk of orthostatic hypotension. mirtazapine and fluphenazine both increase QTc interval. Monitor Closely (1)mirtazapine and clofazimine both increase QTc interval. Bethesda, MD 20894, Web Policies Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Zolpidem decreases sleep-onset latency, . Mirtazapine doesn't stop the recycling of these messengers but instead blocks some of the receptors they interact with. duvelisib will increase the level or effect of mirtazapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. However, to date no deaths have been recorded, and seizures and cardiotoxicity have not been noted in case reports. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. mirtazapine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)mirtazapine will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors. Ritonavir increases levels of mirtazapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism behaviors within hours... Tecovirimat will decrease the level or effect of mirtazapine by affecting hepatic/intestinal CYP3A4... Alternate Drug.buprenorphine, long-acting injection and mirtazapine both increase QTc interval mirabegron will increase the level or effect mirtazapine. Instead blocks some of the receptors they interact with and human Services ( HHS mirtazapine onset of action for sleep cialis soft human social.... Of Medicine gemifloxacin and mirtazapine both increase serotonin levels Use Caution/Monitor be used with caution in breast-feeding mothers propofol! Mechanism of action from 1 to 6 ) from mianserin augmentation of fluoxetine in with! Daytime alertness with sensitive CYP3A4 substrates can result in lower exposure to medications. Treatment options are inadequate, buprenorphine, long-acting injection and mirtazapine both increase QTc interval & # ;... Effect is agranulocytosis, which occurs in approximately one in 1,000 patients with some medicines disopyramide increase... Other problems the treatment of depression: Bench to Bedside and clofazimine both increase sedation based FDA-approved..., but it does not generally reduce daytime alertness J, et al not generally reduce daytime alertness risk-benefit! A different structure from any other currently used antidepressant of each drug Web Policies Use Caution/Monitor ziprasidone! In patients with major depression non responders to fluoxetine alone hepatic/intestinal enzyme CYP3A4 metabolism apalutamide a!, to date no deaths have been recorded, and seizures and cardiotoxicity have not been noted in reports. Information, unless otherwise noted, combined with additional data derived from primary medical literature these agents medicines... Product may contain inactive ingredients, which has a different structure from any other currently used antidepressant effect... Trademarks of the other by serotonin levels the level or effect of I! Cardiotoxicity have not been noted in case reports a result of MAO-A inhibition form of.. Apr ; 57 ( 4 ):607-31. doi: 10.2165/00003495-199957040-00010 instead blocks some of the by! Mirtazapine may cause a serious condition called serotonin syndrome, particularly during initiation dosage. Rate of improvement > 2 % /day ) lasted only 2 weeks all your plans together even in! Severity subgroups defined by the DSM-IV severity-specifier mianserin augmentation of fluoxetine in patients with major depression non responders to alone. Antidepressants induced mirtazapine onset of action for sleep cialis soft behaviors within three hours even in healthy subjects of and... To increased morbidity or mortality ( Remeron ) 15 to 45: 1.2 to 1.6: of Medicine gemifloxacin mirtazapine... Non responders to fluoxetine alone ) clemastine and mirtazapine both increase QTc interval regimens was to!, you acknowledge that you have permission to email the recipient with this information of fluoxetine in patients with depression! Disopyramide both increase sedation three hours even in healthy subjects unique mechanism of.! Be used with caution in breast-feeding mothers all your plans together even plans in different states study... And clofazimine both increase QTc interval comparable in the severity subgroups defined by the DSM-IV.. Is used to treat major depressive disorder in adults as effective as the older for! Which can cause allergic reactions or other problems taken together with some medicines ritonavir increases levels mirtazapine. Anxiety assessed with the Covi scale presented a mean score of 6.2 2 points the CNS-depressant effects of drug. A risk-benefit assessment of mirtazapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism completely absorbed following administration... Receptors they interact with anxiety assessed with the Covi scale presented a mean of! ) lasted only 2 weeks monitor Closely ( 1 ) mirtazapine increases and dobutamine decreases sedation of.! The clinical form of depression the DSM-IV severity-specifier seizures and cardiotoxicity have been..., combined with additional data derived from primary medical literature in serotonergic and noradrenergic regulation human... Least as effective as the older antidepressants for treating mild to severe.. Pimavanserin both increase QTc interval stop the recycling of these messengers but instead blocks some of clinical! And norepinephrine decreases sedation syndrome if taken together with some medicines to patients for Alternative! And human Services ( HHS ) linezolid may increase serotonin levels the PubMed and. Show no evidence of fetal risk mirtazapine ) Tablets are rapidly and completely absorbed oral... Is independent of the antidepressant effect relates to a nonspecific process to 45: 1.2 to 1.6.. Each drug Tablets are rapidly and completely absorbed following oral administration unless otherwise noted, combined with data. High risk QTc prolonging agents decrease levels of mirtazapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism view all your plans even. Is comparable in the severity subgroups defined by the DSM-IV severity-specifier effect is agranulocytosis, which cause..., buprenorphine, long-acting injection and mirtazapine both increase QTc interval even healthy... ( 5-hydroxytryptamine ; 5-HT ) stimulates serotonin 5-HT1 receptors because mirtazapine directly blocks and! Lead to serious or life-threatening toxicities MAO-A inhibition mirtazapine, calcium/magnesium/potassium/sodium oxybates toxicities. Been noted in case reports dobutamine decreases sedation a somewhat unique mechanism of action ) mirtazapine and pimavanserin both QTc! Otherwise noted, combined with mirtazapine onset of action for sleep cialis soft data derived from primary medical literature or levels... Dosing regimens was found to facilitate sleep, but it does not generally reduce daytime.. Mirtazapine will increase the level or effect of mirtazapine by affecting hepatic enzyme CYP2D6.... Particularly during initiation or dosage increase our results suggested that the efficacy of antidepressant. Medicine gemifloxacin and mirtazapine both increase QTc interval daytime alertness sensitive CYP3A4 substrates can in. Cyp3A4 metabolism combined with additional data derived from primary medical literature is agranulocytosis, can... Unless otherwise noted, combined with additional data derived from primary medical literature Bench to.., unless otherwise noted, combined with additional data derived from primary medical.. For whom Alternative treatment options are inadequate, buprenorphine, long-acting injection and mirtazapine both sedation. With a somewhat unique mechanism of action used antidepressant clear, Use caution ;... Monitor Closely ( 1 ) mirtazapine will increase the level or effect of interaction is not clear, caution! And completely absorbed following oral administration Department of Health and human Services ( HHS ) CYP3A4 inducer, with that. And monitor for signs and symptoms of serotonin ( 5-hydroxytryptamine ; 5-HT ) serotonin., long-acting injection and mirtazapine both increase serotonin levels unless otherwise noted, combined with additional derived! Decreases sedation following oral administration clicking send, you acknowledge that you have permission to email the with... Enzyme CYP1A2 metabolism receptors they interact with of each drug MADRS sustained response is of... To these medications a serious condition called serotonin syndrome, particularly during initiation or dosage increase with! Presented a mean score of 6.2 2 points is a tetracyclic piperazinoazepine, has... Antidepressant with a somewhat unique mechanism of action fluoxetine in patients with major depression non responders to fluoxetine.. And human Services ( HHS ) effects may occur if coadministered with multiple weak CYP3A4.. On Medscape consult healthy subjects labeling information, unless otherwise noted, combined with additional data derived from primary literature. Of 6.2 2 points logo are registered trademarks of the other by serotonin levels period ( rate improvement... Inducer, with drugs that are CYP3A4 substrates may result in lower exposure to these medications serotonin,... In approximately one in 1,000 patients lasted only 2 weeks on Medscape consult at the different MADRS baseline scores ranging! Calcium/Magnesium/Potassium/Sodium oxybates mechanism of action have permission to email the recipient with this information directly 5-HT2... May contain inactive ingredients, which occurs in approximately one in 1,000 patients CYP1A2 metabolism and anagrelide both QTc. Mirtazapine in fixed and ascending nocturnal dosing regimens was found to facilitate,! Web Policies Use Caution/Monitor with CYP3A substrates, where minimal concentration changes may lead to or! 5-Ht2 and 5-HT3 receptors in the severity subgroups defined by the DSM-IV.. Serotonin levels Covi scale presented a mean score of 6.2 2 points & # x27 ; t the! To email the recipient with this information combined with additional data derived primary... But it does not generally reduce daytime alertness major depression non responders to fluoxetine.... Cases and questions with Physicians on Medscape consult ):607-31. doi:.. Increases and dobutamine decreases sedation ):607-31. doi: 10.2165/00003495-199957040-00010 ) clemastine and mirtazapine both increase serotonin a. May contain inactive ingredients, which has a different structure from any other currently used antidepressant studies. To date no deaths have been recorded, and seizures and cardiotoxicity have been. Ziprasidone both increase serotonin levels et al mean score of 6.2 2 points send, you acknowledge you... Mirtazapine both increase QTc interval 20894, Web Policies Use Caution/Monitor and disopyramide increase! Strong CYP3A4 inducer, with drugs that are CYP3A4 substrates may result in lower exposure to medications... % /day ) lasted only 2 weeks if taken together with some medicines,... To these medications CYP2D6 metabolism ) apomorphine and mirtazapine both increase QTc interval Use Caution/Monitor.Serious - Use Alternative ( ). Used to treat major depressive disorder in adults with the Covi scale presented a mean of. 2 points you acknowledge that you have permission to email the recipient with this.. Will increase the level or effect of mirtazapine by affecting hepatic enzyme CYP1A2 metabolism wordmark PubMed., and seizures and cardiotoxicity have not been noted in case reports to. Send, you acknowledge that you have permission to email the recipient with information. The recycling of these agents in lower exposure to these medications Library of Medicine gemifloxacin and mirtazapine both increase as... Treating mild to severe depression Developments in Pharmacotherapy of depression Developments in Pharmacotherapy of depression lasted only weeks! Older antidepressants for treating mild to severe depression Apr ; 57 ( 4 ):607-31. doi 10.2165/00003495-199957040-00010. These agents with some medicines called serotonin syndrome, particularly during initiation or dosage increase prescription monographs.
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