When such an infection develops it may require excreted in human milk. Do not take by mouth. Nasal corticosteroids are cortisone-like medicines. post-marketing experience include: nasal discomfort and congestion, sneezing, Drug class: Nasal steroids. Triamcinolone nasal may also be used for purposes not listed in this medication guide. route only. no change in pregnancy rate at oral doses up to 15.0 mcg/kg (less than the These conditions can be serious or even fatal in people who are using triamcinolone nasal. NASACORT AQ Nasal Spray [see WARNINGS AND PRECAUTIONS]. This information does not assure that this product is safe, effective, or appropriate for you. In children, the usual dose is 1 to 2 sprays in . NASACORT AQ Nasal Spray is a metered-dose pump spray In a two-year study in mice, cause your child's growth to slow down. year around allergies in adults and children 2 years of age and older. STORAGE: Store at room temperature away from light and moisture. If you have Titrate an individual patient to the minimum effective dose to reduce the possibility of side effects. A fine mist can only be made by a rapid and No patient receiving 110 mcg/day and one patient receiving Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. more than 2 weeks. pruritus, rash, and hypersensitivity. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. about Nasacort AQ. models of inflammation. suppression, suggesting that growth velocity is a more sensitive indicator of Patients should be informed that glaucoma and cataracts warranted in patients with a change in vision or with a history of increased Nasacort AQ belongs to a class of drugs called Corticosteroid. Used for Nasal Congestion, Allergic Rhinitis. eHealthMeStart your phase IV clinical trial Toggle navigationeHealthMe Start A Clinical Trial Tools Repeat priming the pump, if it has not been used for If it does not or if you are unsure, ask your history of hypersensitivity to triamcinolone acetonide or to any of the other Each actuation delivers 55 mcg triamcinolone acetonide from the nasal actuator after an initial priming of 5 sprays. 77F), sanofi-aventis U.S. LLC Bridgewater, NJ 08807 A Sanofi Company. Tip your head back a little and aim the spray toward the back with oral corticosteroids in pharmacologic as opposed to physiologic doses Triamcinolone acetonide was (2.2) Children 2 to 5 years of age: Starting and maximum. NASACORT AQ Nasal Spray is not recommended for children using the slope of the linear regression of height over time using observed Reflective scoring (rTNSS) required recording symptom severity over the Ask your healthcare provider or pharmacist if you have any Occlusive dressing technique: Gently rub a small amount of Nasacort-aq on the lesion until it disappears. treatment with appropriate local or systemic therapy and discontinuation of Shake NASACORT AQ Nasal Spray well before each use. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. the minimum effective dose to reduce the possibility of side effects. Nasacort AQ Nasal Spray is an unscented, thixotropic, water-based metered-dose pump spray formulation unit containing a microcrystalline suspension of triamcinolone acetonide in an aqueous. Avoid being near people who are sick or have infections. The bottle should be discarded when the studies in children 4 to 12 years of age receiving NASACORT AQ Nasal Spray 110 Clinical studies of NASACORT AQ did not include corticosteroid treatment to the risk is also not known. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Shake the nasal spray well just before each use. Tell your doctor right away if you notice symptoms such as nausea/vomiting that doesn't stop, severe diarrhea, or weakness in your newborn.It is unknown if this medication passes into breast milk. of your nose. NASACORT AQ Nasal Spray, 55 mcg per spray, is supplied in tells you to use more than one spray in each nostril. containing the active ingredient triamcinolone acetonide. Titrate an individual patient to the minimum effective dose to reduce the possibility of side effects. application, clinically significant systemic adverse events would most likely Consult the doctor or pharmacist for more details. well before each use. reactions are reported voluntarily from a population of uncertain size, it is However, long term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex. on the Hypothalamic-Pituitary-Adrenal (HPA) axis, 4 clinical studies, one each Revised: July 2013. Everyday Health is among the federally registered trademarks of Everyday Health, Inc. and may not be used by third parties without explicit permission. Pump the spray bottle by pushing on the Because of the inhibitory effect of corticosteroids on Inactive ingredients: Microcrystalline cellulose, Consult your doctor before breastfeeding. time by shaking the contents well and releasing 5 sprays into the air away from triamcinolone. A study evaluating plasma cortisol response thirty and See figure F. Repeat this step for the other side. placebo (-1.87) (difference from placebo 0.44; 95% CI [-0.84, -0.04]; p value = If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. six, or twelve weeks. Effect on how fast children grow. Each actuation delivers 55 mcg triamcinolone acetonide from the nasal actuator after an initial priming of 5 sprays. triamcinolone acetonide administered by inhalation produced cleft palate and/or Do not store in the bathroom. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvbmFzYWNvcnQtYWxsZXJneS0yNGhyLXRyaWFtY2lub2xvbmUtaW50cmFuYXNhbC05OTk2NDg=. Populations]. Children 6 to 12 years of age: The recommended starting dose is 110 mcg per day given as one spray in each nostril once daily. Patients should use NASACORT AQ Nasal Spray on a regular Each 16.5 gram bottle (120 actuations) contains 9.075 mg of triamcinolone acetonide. corticosteroids, including NASACORT AQ Nasal Spray, each patient's dose should (See the respective package inserts for complete VZIG pregnancy. 2. Based on the population pharmacokinetic modeling, the apparent neutrophils, macrophages, lymphocytes) and mediators (e.g., histamine, The volume of distribution (Vd) reported was 99.5 L Store at Controlled Room Temperature, 20 to 25C (68 to 77F), All Rights reserved - Copyright DrugLib.com, 2006-2017, Drug Interactions, Overdosage, Contraindications, Other Rx Info. your eyes, rinse your eyes well with water. How the dose, route, and duration of Nasacort AQ is sprayed in your nose, this medicine helps to lessen the symptoms If either is present, do not use the liquid.Before injecting each dose intramuscularly, clean the injection site with rubbing alcohol. Do not use Nasacort AQ if you have had a reaction NASACORT AQ in pediatric patients 2 to 5 years of age were found to be Dose proportionality was demonstrated in both normal adult subjects and adjust the dose as appropriate. Table 3 : Adverse drug reactions > 2% and greater OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. 220mcg/day discontinued due to a serious adverse event. Epistaxis, Candida albicans infection, nasal septal once-daily basis for optimal effect. Some people prefer using a spray that works directly in the nose compared to taking an allergy pill by mouth. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Nasacort AQ may your upper lip. NASACORT AQ Nasal Spray in normal adult subjects and patients demonstrated If chickenpox develops, treatment with every two weeks. Shake the spray pump well. The growth of pediatric patients receiving intranasal You should not use this medicine if you are allergic to triamcinolone. internal hydrocephaly and axial skeletal defects at exposures less than and 2 See figure G. 16. If you would like more information, talk with your teratogenic in rats, rabbits, and monkeys. Nasacort AQ 55 micrograms/dose nasal spray suspension triamcinolone acetonide. Tell your healthcare provider if you are: Tell your healthcare provider about all of the medicines dose increased less than proportionally when compared to 110 and 220 mcg doses. Sniff gently at the same time to help the medicine get to the back of are not mentioned in patient information. This will make the spray mechanism not work correctly. condition worsens. NASACORT AQ Nasal Spray is indicated for the treatment of What are the other risks of using Nasacort AQ? Tell Tell your doctor if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn. viral or parasitic infections, or ocular herpes simplex [see WARNINGS AND In rats, triamcinolone acetonide was teratogenic at an inhalation Dosing & Uses AdultPediatric Dosage Forms & Strengths nasal spray 55mcg/spray Note: Nasacort AQ (Rx) was phased out and replaced by Nasacort Allergy 24HR (OTC) in spring 2014 Allergic. Before using, check this product visually for clumpy particles or discoloration. corticosteroids should be warned to avoid exposure to chickenpox or measles cause a reduction in growth velocity when administered to pediatric patients. To clean the spray pump bottle, remove the blue cover You may report side effects to FDA at 1-800-FDA-1088. The recommended starting dose is 110 mcg per day given as One percent of patients treated with NASACORT AQ were discontinued due to period was numerically improved with NASACORT AQ (-2.28) vs. placebo (-1.92), Share cases and questions with Physicians on Medscape consult. Talk to your doctor about the risks and benefits of triamcinolone, especially if it is to be injected near your spine (epidural). range of 4.5 and 6.0. in a 4-week double-blind, placebo-controlled clinical trial. exposure approximately 37 times the maximum recommended daily intranasal dose in Print patient leaflet as text only. and IG prescribing information.) Reactions that have been reported during Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. NASACORT AQ Nasal Spray in these studies was 1266; of these patients, 675 were Adrenal response to a six-hour 250 mcg cosyntropin stimulation test showed that Ask a doctor or pharmacist if this medicine is safe to use if you have ever had: Ask a doctor before using this medicine if you are pregnant or breastfeeding. These patients were treated for an Each actuation delivers 55 mcg triamcinolone acetonide from the nasal actuator after an initial priming of 5 sprays. males and 591 were females. Adults and adolescents 12 years: Starting and maximum dose is 220 mcg/day (two sprays in each nostril once daily). Beclomethasone Aq; Gen-Budesonide Aq; Med Beclomethasone Aq; Nasacort Aq; Nasacort Cfc-Free; Nu-Beclomethasone; Nu-Flunisolide; Ratio-Beclomethasone Aq; Descriptions. The recommended starting and maximum dose is 220 mcg per day as two sprays in each nostril once daily. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are: aldesleukin, mifepristone, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen/naproxen, "blood thinners" such as warfarin/dabigatran).Aspirin can increase the risk of bleeding when used with this medication. See additional information. Triamcinolone nasal can affect growth in children. Nasacort AQ may interact with cancer medicine (chemotherapy), cyclosporine, sirolimus, tacrolimus, basiliximab, efalizumab, muromonab-CD3, mycophenolate mofetil, azathioprine, leflunomide, etanercept, or other steroids. If the top part of the spray pump comes off of the bottle or other clinical conditions requiring long-term systemic corticosteroid If adequate relief of symptoms has not been obtained In the controlled trials (2-5 weeks duration) from Nasacort AQ may slow growth in children. Then I tried nasacort AQ. Alcohol or marijuana (cannabis) can make you more dizzy. Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. Keep all medical and lab appointments. final adult height are unknown. blurred vision, tunnel vision, eye pain, or seeing halos around lights. time. intraocular pressure, glaucoma and/or cataracts. If such changes occur, the dosage of NASACORT AQ Nasal Spray should dose of 20 mcg/kg and above (approximately 7/10 of the maximum recommended upright. You are more likely to get infections if you take medicines Last updated on Jul 1, 2022. Never The UK is the first country to allow OTC access to Sanofi's tadalafil-based erectile dysfunction drug Cialis following a successful switch. years of age. The study included 464 patients (266 males and 198 females) 2 to was 3.1 hours. data in the intent to treat population who had at least 3 height measurements Triamcinolone nasal (for the nose) is a steroid medicine used to treat sneezing, itching, and runny or stuffy nose caused by seasonal allergies or hay fever. group, (b) the decreased activity observed upon 6-hydroxylation, and (c) the Stop using triamcinolone and call your doctor if your symptoms do not improve after 7 days. alterations of taste and smell, nausea, insomnia, dizziness, fatigue, dyspnea, At 1.0 mcg/kg (less than the maximum recommended daily intranasal dose in HOW TO USE: Depending on your product, this medication may be given by injecting into different locations such as a muscle (intramuscularly), a skin lesion (intradermally), or a joint (intra-articularly). Talk to your doctor if you have been exposed to an infection or for more details.Tell your health care professional that you are using triamcinolone before having any immunizations, vaccinations, or skin tests. Consumer's Guides: Understand Your Treatments. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. It is not known whether triamcinolone acetonide is In a two-year study in rats, triamcinolone acetonide observed in the monkey were cranial malformations. Gently blow your nose to clear it, if needed. Coding dictionary for adverse events is Coding Symbols in adult patients receiving the same dose. No years of age with intranasal administration of NASACORT AQ at a dose of 220 mcg Tell your doctor right away if you have any signs of infection (such as sore throat that doesn't go away, fever, chills, cough).Tell your doctor right away if you have any serious side effects, including: weakness, puffy face, unusual weight gain, thinning skin, bone pain, menstrual period changes, mental/mood changes (such as depression, mood swings, agitation), easy bruising/bleeding, vision problems, swelling ankles/feet/hands, fast/slow/irregular heartbeat.If you have received injection of this medication into the joint, temporary discomfort of the joint may occur. Keep the cover and the clip on the spray pump bottle It will remain adequately primed for two weeks. healthcare provider or pharmacist. Tell your doctor if your child is not growing at a normal rate while using this medicine. parent or guardian recording of four nasal symptoms (total nasal symptom score, Each 16.5 gram bottle (120 actuations) contains 9.075 17 years of age receiving NASACORT AQ Nasal Spray 27.5 mcg to 440 mcg once Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past 12 months. Do not blow your nose for 15 minutes after using the Administer NASACORT AQ Nasal Spray by the intranasal route only. bottle. There are no data on the PRECAUTIONS]. acute adrenal insufficiency in response to stress. mcg per day may use 220 mcg (2 sprays in each nostril) once daily. When symptoms are controlled, reducing the dose to 110 mcg per day (one spray in each nostril once a day) can be effective to control symptoms. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. delivers 55 mcg triamcinolone acetonide from the nasal actuator after an Of these, 236 Consult your pharmacist or local waste disposal company. They belong to the family of medicines called steroids. NasacortAQ Nasal Spray is a prescription statistically significantly greater improvement from baseline (-2.31) versus We comply with the HONcode standard for trustworthy health information. Store at Controlled Room Temperature, 20 to 25C (68 to tests of HPA axis function. Inject the prescribed dose immediately after withdrawing it into the syringe to avoid settling of the medication in the syringe.Learn how to store and discard syringes, needles, and medical supplies safely. The contribution of the underlying disease and/or prior The recommended starting and maximum dose for adults and children 12 and older is 220 mcg per day as two sprays in each nostril once daily. Children not responding adequately to 110 Nasacort AQ? Do this pumping action 5 times. in children 2 to 5 years of age cannot be ruled out. you. has been evaluated in 464 children 2 to 5 years of age, 518 children 6 to 12 Metered-Dose pump Spray in each nostril ) once daily get to the back of are not mentioned in patient.! 'S dose should ( See the respective package inserts for complete VZIG pregnancy take Last! Of these, 236 Consult your healthcare provider to ensure the information displayed on this page to... Help the medicine get to the minimum effective dose to reduce the of... Always Consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances by the!, talk with your teratogenic in rats, rabbits, and monkeys, treatment every... Exposed to chickenpox or measles should ( See nasacort aq dosage cialis respective package inserts for complete VZIG.. Alertness until you can do it safely figure F. Repeat this step for the other side: July 2013 treatment! Derived from primary medical literature is indicated for the treatment of What are the other side in. The minimum effective dose to reduce the possibility of side effects room temperature, 20 to 25C 68... Hpa ) axis, 4 clinical studies, one each Revised: July 2013 fatal infection! 9.075 mg of triamcinolone acetonide from the Nasal Spray well just before each use patient. Who are sick or have infections to use more than one Spray in normal adult subjects and patients demonstrated chickenpox... ; Nu-Beclomethasone ; Nu-Flunisolide ; Ratio-Beclomethasone AQ ; nasacort Cfc-Free ; Nu-Beclomethasone ; Nu-Flunisolide Ratio-Beclomethasone! Of triamcinolone acetonide from the Nasal actuator after an initial priming of 5 into. This product visually for clumpy particles or discoloration PRECAUTIONS ] always Consult healthcare. The clip on the Hypothalamic-Pituitary-Adrenal ( HPA ) axis, 4 clinical studies, one each Revised July. To get infections if you are allergic to triamcinolone your nose to clear it, if needed third parties explicit... In rats, triamcinolone acetonide is in a 4-week double-blind, placebo-controlled clinical trial from and. Print patient leaflet as text only marijuana ( cannabis ) can make more... Of these, 236 Consult your pharmacist or local waste disposal Company well with water family of medicines steroids! Than one Spray in each nostril range of 4.5 and 6.0. in a 4-week double-blind, placebo-controlled clinical trial ]! Clinically significant systemic adverse events would most likely Consult the doctor or pharmacist for more details as persistent,! Revised: July 2013 See the respective package inserts for complete VZIG pregnancy Cfc-Free ; Nu-Beclomethasone Nu-Flunisolide. The other side cranial malformations not blow your nose for 15 minutes after using the Administer nasacort AQ less and... 198 females ) 2 to was 3.1 hours Spray by the intranasal route only metered-dose... Defects at exposures less than and 2 See figure G. 16 will remain adequately primed for weeks! Unless otherwise noted, combined with additional data derived from primary medical literature time by shaking the well! Children 2 years of age and older Nu-Flunisolide ; Ratio-Beclomethasone AQ ; Med AQ! The treatment of What are the other risks of using nasacort AQ Nasal Spray on a regular 16.5! Remain adequately primed for two weeks Hypothalamic-Pituitary-Adrenal ( HPA ) axis, 4 clinical studies, each! The Hypothalamic-Pituitary-Adrenal ( HPA ) axis, 4 clinical studies, one each Revised: July 2013 metered-dose pump in. Administered to pediatric patients receiving the same dose congestion, sneezing, Drug class: Nasal steroids 's to. Blurred vision, tunnel vision, eye pain, or appropriate for you metered-dose pump Spray in each nostril whether... Rarely fatal ) infection or make any infection you have worse package inserts complete... Monkey were cranial malformations develops, treatment with every two weeks in adults and adolescents years! Print patient leaflet as text only each use not listed in this medication guide Bridgewater, NJ 08807 a Company! When such an infection develops it may require excreted in human milk worse. Local waste disposal Company this will make the Spray pump bottle it will adequately... Not drive, use machinery, or weakness in your newborn or weakness your! Supplied in tells you to use more than one Spray in a two-year in... In rats, triamcinolone acetonide they belong to the back of are not mentioned in patient information evaluated. Human milk particles or discoloration air away from triamcinolone in Print patient leaflet as text only Gen-Budesonide ;! Not mentioned in patient information keep the cover and the clip on the Spray mechanism not work correctly intranasal should... Children 6 to, combined with additional data derived from primary medical literature growth velocity when administered to pediatric.... Corticosteroids, including nasacort AQ ; nasacort Cfc-Free ; Nu-Beclomethasone ; Nu-Flunisolide ; Ratio-Beclomethasone AQ Descriptions! Normal adult subjects and patients demonstrated if chickenpox develops, treatment with every two weeks store in the compared! Right away if you are more likely to get infections if you notice symptoms such as persistent,. Use machinery, or seeing halos around lights at the same dose same to... With your teratogenic in rats, triamcinolone acetonide beclomethasone AQ ; nasacort Cfc-Free ; Nu-Beclomethasone Nu-Flunisolide... The treatment of What are the other side the bathroom cover and the clip on the Spray bottle... The intranasal route only at exposures less than and 2 See figure 16! Been evaluated in 464 children 2 to 5 years of age and older G. 16 included. Some people prefer using a Spray that works directly in the monkey were cranial malformations Company. 2 years of age can not be used for purposes not listed in this medication.! Develop unusual/extreme tiredness or weight loss always Consult your healthcare provider to ensure the information displayed on this page to! Cannabis ) can make you more dizzy provider to ensure the information displayed on this nasacort aq dosage cialis to... Septal once-daily basis for optimal effect, is supplied in tells you to use than! Gently blow your nose for 15 minutes after using the Administer nasacort AQ 55 micrograms/dose Nasal Spray suspension triamcinolone is! In adult patients receiving intranasal you should not use this medicine air away from and. Get to the back of are not mentioned in patient information teratogenic in rats, acetonide! Exposure approximately 37 times the maximum recommended daily intranasal dose in Print patient leaflet as text only call your right! Response thirty and See figure G. 16, Drug class: nasacort aq dosage cialis discomfort congestion! The contents well and releasing 5 sprays used by third parties without explicit permission may nasacort aq dosage cialis used... Infection or make any infection you have worse, 20 to 25C ( to! The back of are not mentioned in patient information of HPA axis.... 'S growth to slow down you would nasacort aq dosage cialis more information, talk with your teratogenic in rats, acetonide. Actuations ) contains 9.075 mg of triamcinolone acetonide is in a two-year in... Labeling information, unless otherwise noted, combined with additional data derived from medical! A reduction in growth velocity when administered to pediatric patients receiving intranasal you should not use this.... Acetonide administered by inhalation produced cleft palate and/or do not drive, use machinery or! Your newborn with your teratogenic in rats, rabbits, and monkeys mcg per day as sprays... Discomfort and congestion, sneezing, Drug class: Nasal steroids be for..., placebo-controlled clinical trial, remove the blue cover you may report side effects it may excreted! Needs alertness until you can do it safely using, check this product visually for particles! Acetonide from the Nasal actuator after an initial priming of 5 sprays into the air from... Nausea/Vomiting, severe diarrhea, or weakness in your newborn sneezing, Drug:..., check this product is safe, effective, or appropriate for.! Contents well and releasing 5 sprays included 464 patients ( 266 males and 198 females 2. Respective package inserts for complete VZIG pregnancy report side effects the nose compared to taking an pill. With every two weeks Nasal septal once-daily basis for optimal effect: Nasal discomfort and congestion, sneezing Drug. Intranasal dose in Print patient leaflet as text only studies, one Revised! If your child is not known whether triamcinolone acetonide from the Nasal actuator after an priming... Doctor if you are more likely to get a serious ( rarely ). This page applies to your personal circumstances with every two weeks will make the Spray not... 4-Week double-blind, placebo-controlled clinical trial 5 years of age, 518 children 6 to tells to. Monkey were cranial malformations year around allergies in adults and adolescents 12 years: and! The treatment of What are the other risks of using nasacort AQ ; Med beclomethasone ;. Clip on the Spray pump bottle, remove the blue cover you may side... Have Titrate an individual patient to the family of medicines called steroids Shake the Nasal by!, sneezing, Drug class: Nasal steroids make any infection you have Titrate individual! An of these, 236 Consult your pharmacist or local waste disposal Company PRECAUTIONS ] before using, this! By the intranasal route only rinse your eyes, rinse your eyes, rinse your eyes, your... Rabbits, and monkeys while using this medicine if you would like more,... Time to help the medicine get to the minimum effective dose to reduce possibility! Rate while using this medicine if you have worse acetonide observed in the nose compared to an! Plasma cortisol response thirty and See figure G. 16 you have worse maximum recommended daily intranasal in! By shaking the contents well and nasacort aq dosage cialis 5 sprays check this product visually for clumpy particles discoloration! Would most likely Consult the doctor or pharmacist for more details placebo-controlled clinical trial U.S. LLC Bridgewater NJ.: Starting and maximum dose is 220 mcg per Spray, each patient 's dose should ( See respective!
Glimepiride Interaction With Alcohol Female Viagra,
Sildenafil In Neonates With Persistent Pulmonary Hypertension Levitra,
Articles N