Minor (1)atazanavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Minor (1)phenytoin will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Concomitant therapy is expected to increase the risk of immunosuppression. Monitor Closely (1)encorafenib, vinorelbine. Vinorelbine is an antineoplastic drug. Use Caution/Monitor. Use Caution/Monitor. commonly, these are generic drugs. Use Caution/Monitor. Vinorelbine is a type of drug called a vinca alkaloid. Use Caution/Monitor. Monitor Closely (1)fedratinib will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. unspecified interaction mechanism. By clicking send, you acknowledge that you have permission to email the recipient with this information. Either increases toxicity of the other by pharmacodynamic synergism. Antioxidants such as vitamin A enhance the efficacy, and reduce toxicity, of antineoplastic drugs. Minor/Significance Unknown. Minor (1)lapatinib will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Repeat cycle every 4 weeks. Avoid or Use Alternate Drug. Tecovirimat is a weak CYP3A4 inducer. vinorelbine will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Minor (1)amobarbital will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Tell your doctor right away if you develop any signs of an infection such as sore throat that doesn't go away, fever, or chills.If this medication accidentally leaks out of your vein into surrounding tissue, the skin and/or muscle may be severely damaged. Minor/Significance Unknown. Vinorelbine can also be given as an injection or short infusion (drip) into a vein in the hand or arm. Each vial contains vinorelbine tartrate equivalent to 10 mg (1 mL vial) or 50 mg (5 mL vial) vinorelbine in water for injection. Neutropenia or febrile neutropenia incidence were increased when trastuzumab was coadministered with myelosuppressive chemotherapy. Avoid or Use Alternate Drug. Avoid taking selinexor with other medications that may cause dizziness or confusion. Use Caution/Monitor. Vinorelbine is used to treat non-small cell lung cancer, sometimes used in combination with other cancer medications. Use Caution/Monitor. Minor (1)primidone will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid concurrent or sequential use to decrease risk for ototoxicity. 20022007813-overviewDiseases & Conditions, You are being redirected to Coadministration of palifermin within 24 hr of chemotherapy resulted in increased severity and duration of oral mucositis. This drug is available at a higher level co-pay. restrictions. Consult your doctor before breast-feeding. acetazolamide will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Minor (1)armodafinil will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Common side effects of Navelbine include: nausea, vomiting, fatigue, tiredness, weakness, constipation, Maitake mushroom has anti-tumor effects (animal/in vitro research). Neutropenia or febrile neutropenia incidence were increased when trastuzumab was coadministered with myelosuppressive chemotherapy. Serious - Use Alternative (1)idelalisib will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Find out more about your cancer type How does vinorelbine work? indinavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Adjust dose of drugs that are CYP3A4 substrates as necessary. Minor/Significance Unknown. trastuzumab deruxtecan, vinorelbine. Minor/Significance Unknown. Monitor Closely (1)tecovirimat will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. NAVELBINE is a vinca alkaloid indicated: In combination with cisplatin for first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) (1) As a single. This information does not assure that this product is safe, effective, or appropriate for you. Adding plans allows you to compare formulary status to other drugs in the same class. Minor/Significance Unknown. Serious - Use Alternative (1)vinorelbine decreases effects of influenza virus vaccine quadrivalent, adjuvanted by pharmacodynamic antagonism. Avoid use of deferiprone with other drugs known to be associated with neutropenia or agranulocytosis; if an alternative is not possible, monitor absolute neutrophil count more frequently. Alcohol or marijuana (cannabis) can make you more dizzy. Applies only to oral form of both agents. Minor/Significance Unknown. Monitor Closely (1)cobicistat will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Monitor Closely (1)vinorelbine will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Local tissue necrosis and/or thrombophlebitis, if extravasation occurs. tecovirimat will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Palifermin should not be administered within 24 hrbefore, during infusion of, or within 24 hr after administration of antineoplastic agents. Monitor Closely (1)carbamazepine will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. fexinidazole will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. USES: Vinorelbine is used to treat various types of cancer. Comment: Combination may increase risk of myelosuppression. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Serious - Use Alternative (1)deferiprone, vinorelbine. How to Take Vinorelbine. Monitor Closely (1)tipranavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Other (see comment). Use Caution/Monitor. Minor/Significance Unknown. Last updated on Dec 22, 2022. unspecified interaction mechanism. lumefantrine will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. posaconazole will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. voxelotor will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)butalbital will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Your doctor will follow your blood counts closely. vinorelbine, denosumab. Monitor Closely (2)vinorelbine decreases levels of phenytoin by inhibition of GI absorption. St John's Wort will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Drugs & Supplements Vinorelbine (Navelbine) Brand Names: Navelbine Reviewed: April 12, 2021 Vinorelbine is used to treat non-small cell lung cancer, sometimes used in combination with other. Your list will be saved and can be edited at any time. darifenacin will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.vinorelbine decreases levels of phenytoin by increasing metabolism. [3] This includes breast cancer and non-small cell lung cancer. Either increases effects of the other by immunosuppressive effects; risk of infection. Drug class: Mitotic inhibitors Medically reviewed by Drugs.com on Apr 3, 2023. itraconazole will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The recipient will receive more details and instructions to access this offer. Monitor Closely (1)vinorelbine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: pharmacodynamic synergism. Coadministration may increase risk for adverse effects of CYP3A4 substrates. Minor/Significance Unknown. Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Fexinidazole inhibits CYP3A4. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Specific dosage and dosing schedule depends on the person's size and the type of cancer being treated. Tell your doctor right away if you develop skin redness/tenderness/swelling/peeling/blisters or painful/difficult swallowing. Monitor Closely (1)belatacept and vinorelbine both increase immunosuppressive effects; risk of infection. Minor (1)ritonavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Even when carefully and correctly administered by trained personnel, this drug may cause a feeling of burning and pain. vinorelbine decreases levels of ethotoin by inhibition of GI absorption. Monitor Closely (1)siponimod and vinorelbine both increase immunosuppressive effects; risk of infection. Minor/Significance Unknown. Monitor Closely (1)mitomycin, vinorelbine. Monitor Closely (1)vinorelbine will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Both fish oil and Omega-3 fatty acid supplements may lower the ability of your platelets to work, which can cause bleeding. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. encorafenib, vinorelbine. Minor/Significance Unknown. nevirapine will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)vinorelbine increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Information last revised January 2023. Coadministration may increase risk of myelosuppressive effects. Maitake mushroom has anti-tumor effects (animal/in vitro research). Avoid or Use Alternate Drug. Minor/Significance Unknown. Minor/Significance Unknown. Immunosuppressive therapies may reduce immune response to H5N1 vaccine. It interferes with the growth of cancer cells, which are eventually destroyed. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. vinorelbine increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. vinorelbine decreases effects of influenza virus vaccine trivalent, adjuvanted by pharmacodynamic antagonism. vinorelbine will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. dasatinib will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)vinorelbine increases effects of fingolimod by immunosuppressive effects; risk of infection. If you or your partner becomes pregnant, talk to your doctor right away about the risks and benefits of this medication.It is unknown if this medication passes into breast milk. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. clarithromycin will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Use Caution/Monitor. Minor/Significance Unknown. Coadministration may increase risk of myelosuppressive effects. Use Caution/Monitor. metronidazole will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Fexinidazole inhibits CYP3A4. Minor (1)rifapentine will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Deaths have occurred with medications similar to vinorelbine that were injected into the spine.Vinorelbine can lower your blood cell counts (bone marrow suppression) and lower your ability to fight an infection. Lencapavir may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. Minor (1)acetazolamide will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Immunosuppressive drugs may reduce the immune response to influenza vaccine. Always ask your health care professional for complete information about this product and your specific health needs. Avoid or substitute another drug for these medications when possible. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Use Caution/Monitor. Antioxidants such as vitamin E enhance the efficacy, and reduce toxicity, of antineoplastic drugs. Use Caution/Monitor. vinorelbine, hydroxyurea. When switching from therapies with immune effects, take into account the duration and mechanism of action of these therapies when initiating ofatumumab SC. ofatumumab SC, vinorelbine. darunavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. SIDE EFFECTS: See also Warning section.Nausea, vomiting, tiredness, constipation, diarrhea, dizziness, muscle aches, joint pain, or irritation at the injection site may occur. Use Caution/Monitor. Minor/Significance Unknown. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A. Minor/Significance Unknown. prednisone will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. vinorelbine decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. 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