Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor.silodosin and nicardipine both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Abrocitinib is a CYP2C9 and CYP2C19 substrate. Monitor for adverse reactions if coadministered with P-gp substrates where minimal concentration changes may lead to serious or life-threatening toxicities. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)nicardipine increases levels of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. NICARDIPINE (nye KAR de peen) treats high blood pressure. Minor/Significance Unknown. nicardipine will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Reduce ruxolitinib starting dose to 10 mg BID with platelet count 100 X 10^9/L or more and concurrent use of strong CYP3A4 inhibitors; avoid with platelet counts <100 X 10^9/L. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. penbutolol and nicardipine both increase anti-hypertensive channel blocking. Dose adjustment may be required with strong P-gp inhibitors. Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. Comment: Theoretically, shepherd's purse may interfere with BP control. Esta actitud por parte del paparazzi . atenolol, nicardipine. Use Caution/Monitor. Use Caution/Monitor. Avoid or substitute another drug for these medications when possible. DVT/PE treatment: Decrease dose to 30 mg PO once daily. If unable to avoid, reduce palbociclib dose to 75 mg/day. Serious - Use Alternative (1)nicardipine will increase the level or effect of topotecan by P-glycoprotein (MDR1) efflux transporter. sarecycline will increase the level or effect of nicardipine by P-glycoprotein (MDR1) efflux transporter. Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate. nicardipine increases levels of betrixaban by P-glycoprotein (MDR1) efflux transporter. deferasirox will decrease the level or effect of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. This document does not contain all possible drug interactions. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. nafcillin decreases levels of nicardipine by increasing metabolism. Copyright: Merative US L.P. 1973, 2023. Monitor Closely (1)phentolamine and nicardipine both increase anti-hypertensive channel blocking. Monitor Closely (1)artemether/lumefantrine will decrease the level or effect of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Serious - Use Alternative (1)nicardipine increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use of strong CYP3A4 inhibitors is contraindicated with venetoclax during the initial ramp-up dosing phase. affecting hepatic/intestinal enzyme CYP3A4 metabolism. nicardipine will increase the level or effect of doxorubicin liposomal by P-glycoprotein (MDR1) efflux transporter. Vilanterol is a CYP3A4 substrate; coadministration with potent CYP3A4 inhibitors may increase systemic exposure. Use Caution/Monitor. Marked orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used concomitantly. Minor (1)nicardipine will increase the level or effect of ambrisentan by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.nicardipine will increase the level or effect of budesonide by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)nicardipine will increase the level or effect of conjugated estrogens, vaginal by P-glycoprotein (MDR1) efflux transporter. Comment: Potential for increased risk of hypotension with concurrent use. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine. nicardipine will increase the level or effect of digoxin by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. Consider decreasing cilostazol dose; moderate CYP2C19 inhibitors may increase serum levels of 3,4-dehydrocilostazol (active metabolite). ritonavir will increase the level or effect of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs. nicardipine increases effects of lasmiditan by pharmacodynamic synergism. Use Caution/Monitor.Serious - Use Alternative (1)nicardipine increases levels of ceritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms. propranolol and nicardipine both increase anti-hypertensive channel blocking. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid concomitant use of ibrutinib and strong CYP3A4 inhibitors. nicardipine increases toxicity of lithium by pharmacodynamic synergism. If not feasible, avoid use of abametapir. Use Caution/Monitor. It may help to increase your ability to exercise and decrease the frequency of angina attacks. If strong CYP2C9 inhibitor is discontinued, consider increasing erdafitinib dose in the absence of any drug-related toxicities.erdafitinib will increase the level or effect of nicardipine by P-glycoprotein (MDR1) efflux transporter. stiripentol, nicardipine. nicardipine will increase the level or effect of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. nicardipine increases levels of tamsulosin by affecting hepatic enzyme CYP2D6 metabolism. Cardene IV belongs to a class of drugs called Calcium Channel Blockers; Calcium Channel Blockers, Dihydropyridine. nicardipine increases effects of vecuronium by pharmacodynamic synergism. Monitor Closely (1)butalbital will decrease the level or effect of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nicardipine will increase the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor BP. Avoid use with strong CYP3A inhibitors. Contraindicated. Use Caution/Monitor. Serious - Use Alternative (1)tepotinib will increase the level or effect of nicardipine by P-glycoprotein (MDR1) efflux transporter. Concomitant use of strong CYP3A inhibitors should be avoided. nicardipine will increase the level or effect of dexamethasone by P-glycoprotein (MDR1) efflux transporter. Decrease dose to 17 mg/day if pimavanserin is coadministered with strong CYP3A4 inhibitors. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. Use Caution/Monitor. Nicardipine is prescribed for the treatment of high blood pressure and angina (heart pain). Monitor Closely (1)nicardipine will increase the level or effect of terbinafine by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. nicardipine will increase the level or effect of teniposide by P-glycoprotein (MDR1) efflux transporter. Minor (1)nicardipine increases effects of succinylcholine by pharmacodynamic synergism. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Avoid use with strong CYP3A inhibitors. Use Caution/Monitor. Monitor Closely (1)nicardipine will increase the level or effect of hydrocodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. Use Caution/Monitor. Contraindicated. prazosin and nicardipine both increase anti-hypertensive channel blocking. Monitor Closely (1)acebutolol and nicardipine both increase anti-hypertensive channel blocking. Drug information provided by: Merative, Micromedex. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. If coadministration of CYP3A4 inhibitors with fentanyl is necessary, monitor patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose adjustments until stable drug effects are achieved. Use Caution/Monitor. Monitor Closely (1)calcium gluconate decreases effects of nicardipine by pharmacodynamic antagonism. Nicardipine is available under the following different brand names: Cardene IV, Cardene SR. nicardipine will increase the level or effect of buprenorphine, long-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Avoid concomitant use of rivaroxaban and combined Pgp and strong CYP3A4 inhibitors. Minor/Significance Unknown. nicardipine will increase the level or effect of hydrocodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)nicardipine will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. calcium acetate decreases effects of nicardipine by pharmacodynamic antagonism. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. Monitor naldemedine for potential adverse effects if coadministered with P-gp inhibitors. nicardipine will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)nicardipine increases levels of vemurafenib by P-glycoprotein (MDR1) efflux transporter. Serious - Use Alternative (1)nicardipine will increase the level or effect of pimavanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. This may alter serum levels of calcifediol and decrease the conversion of calcifediol to calcitriol. Use Caution/Monitor. Use Caution/Monitor. Risk of hypotension. See Dosage Modification section in drug monograph. nirmatrelvir/ritonavir will increase the level or effect of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)nicardipine will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Marked orthostatic hypotension reported with concomitant use. Use of a nonhormonal contraceptive is recommended. trimagnesium citrate anhydrous, nicardipine. Monitor Closely (1)nicardipine will increase the level or effect of benzhydrocodone/acetaminophen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. If coadministered with strong CYP3A inhibitors, monitor for signs of idelalisib toxicity; follow recommendations for dosage modifications if adverse reactions occur idelalisib will increase the level or effect of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. commonly, these are "non-preferred" brand drugs. nicardipine increases levels of ticagrelor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Strong CYP3A4 inhibitors may increase vilazodone plasma levels by 50% - Reduce daily dose to 20 mg. Monitor Closely (1)nicardipine will increase the level or effect of vinblastine by P-glycoprotein (MDR1) efflux transporter. Common Brands Cardene IV Drug Class Calcium channel blocker (CCB) Controlled Substance Classification Not a controlled medication Generic Status Lower-cost generic available Availability Prescription only How Nicardipine (Cardene) works affecting hepatic/intestinal enzyme CYP3A4 metabolism. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. nicardipine will increase the level or effect of tolvaptan by P-glycoprotein (MDR1) efflux transporter. mifepristone will increase the level or effect of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Strong CYP3A4 inhibitors increase plasma levels of abemaciclib and its metabolites. Potential for increased toxicity. Modify Therapy/Monitor Closely. Use Caution/Monitor. nicardipine will increase the level or effect of ritonavir by P-glycoprotein (MDR1) efflux transporter. If you log out, you will be required to enter your username and password the next time you visit. Use Caution/Monitor. Serious - Use Alternative (1)nicardipine will increase the level or effect of everolimus by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. If a strong CYP3A4 inhibitor must be used short-term (eg, anti-infectives for =7 days), interrupt ibrutinib therapy until strong CYP3A4 inhibitor is discontinued. nicardipine will increase the level or effect of bedaquiline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nicardipine will increase the level or effect of conjugated estrogens by P-glycoprotein (MDR1) efflux transporter. Ca Channel Blockers interfere w/Ach release from prejunctional axon. Monitor Closely (1)nicardipine increases levels of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. commonly, these are "preferred" (on formulary) brand drugs. Use Caution/Monitor. Monitor Closely (3)nicardipine will increase the level or effect of itraconazole by P-glycoprotein (MDR1) efflux transporter. If coadministration unavoidable, separate administration by at least 6 hr before or after administration of P-gp substrates with narrow therapeutic index. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor. Nicardipine Hydrochloride, USP. Monitor for hypotension or muscle weakness in patients receiving calcium channel blockers with elevated serum magnesium concentrations. Do not exceed diclofenac dose of 50 mg BID. Use Caution/Monitor. CYP3A4 inhibitors may reduce avanafil clearance increasing systemic exposure to avanafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. cenobamate will decrease the level or effect of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nicardipine will increase the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. phenoxybenzamine and nicardipine both increase anti-hypertensive channel blocking. Use Caution/Monitor. Contraindicated (1)nicardipine will increase the level or effect of ivabradine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. nicardipine will increase the level or effect of maraviroc by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. Minor/Significance Unknown. encorafenib, nicardipine. Use Caution/Monitor.nicardipine will increase the level or effect of prednisone by P-glycoprotein (MDR1) efflux transporter. Nicardipine is used to treat hypertension (high blood pressure) and angina (chest pain). Use Caution/Monitor. If inhibitor is discontinued, consider increase oliceridine dosage until stable drug effects are achieved. Each drug may cause hypotension. If coadministration of CYP3A4 inhibitors with fentanyl is necessary, monitor patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose adjustments until stable drug effects are achieved. Copyright: Merative US L.P. 1973, 2023. If coadministered with strong CYP3A inhibitors, monitor for signs of idelalisib toxicity; follow recommendations for dosage modifications if adverse reactions occuridelalisib will increase the level or effect of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. As a precautionary measure due to incomplete information on the metabolism of eluxadoline, use caution when coadministered with strong CYP2C9/10 inhibitors. Elvitegravir is a CYP3A4 substrate; if coadministered with strong CYP3A4 inhibitors may increase levels. nicardipine increases levels of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 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And strong CYP3A4 inhibitors you visit decrease dose to 17 mg/day if pimavanserin is coadministered strong... Ramp-Up dosing phase eluxadoline, use caution when coadministered with strong P-gp inhibitors drug these... Of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism abemaciclib and its metabolites stable... Pressure and angina ( heart pain ) calcifediol and decrease the level or effect of bedaquiline by affecting hepatic/intestinal nicardipine iv brand name viagra jelly. Channel blocking receiving calcium channel Blockers, Dihydropyridine of amitriptyline by P-glycoprotein ( MDR1 efflux... Increases AUC of a sensitive CYP3A4 substrate and monitor for signs/symptoms of high corticosteroid concentrations including Cushing type..
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