Taking a normal dose of these over the counter headache relievers should have no negative side effects for healthy adults and can help relieve your . This study established for the first time an association between prenatal APAP exposure and a physical manifestation of neurological alteration. It also reduces a high temperature by affecting the chemical messengers in an area of the brain that regulates body temperature. Li Z, et al. Use of over-the-counter medications during pregnancy. Sildenafil is also sometimes used to treat pulmonary hypertension (high blood pressure in the blood vessels that supply the lungs). Medication use in pregnancy: a cross-sectional, multinational web-based study. Bethesda, MD 20894, Web Policies A. Clin. Paracetamol disintegrating granules should be dissolved in at least four ounces of water; the mixture stirred, then drunk straight away. As a library, NLM provides access to scientific literature. Prevalence and trends of developmental disabilities among children in the US: 20092017. Other data suggest that the analgesic effect of APAP acts through the endocannabinoid system159. Do not take paracetamol without your doctor's advice if you are pregnant. Levy G, Garrettson LK, Soda DM. Based on this experimental and epidemiological literature (Supplementary Tables 14), we believe the potential for harm from continued inaction exceeds the harm that might arise from precautionary action. Federal government websites often end in .gov or .mil. Fisher BG, et al. Although may relieve arthritis pain it has no effect on the underlying inflammation and swelling of a joint. Fever is a well-accepted risk factor for multiple disorders, including neural tube defects and later life cardiovascular disorders32. researched data for the article. It is often used in erection problems. Ceulemans M, et al. May be used in the treatment of many conditions such as arthritis, backache, colds, menstruation pain, and toothache. chaired an initial joint meeting between Z.L., A.Z.B., D.M.K., and after additional consultation with B.J., A.M.A. Association of prenatal acetaminophen exposure measured in meconium with risk of attention-deficit/hyperactivity disorder mediated by frontoparietal network brain connectivity. Available for Android and iOS devices. Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. We are witnessing disturbing increases in the number of children with cognitive, learning and/or behavioural problems. eHealthMe is studying from 62,829 Viagra users for its effectiveness, alternative drugs and more. Li J, Chiew AL, Isbister GK, Duffull SB. Sildenafil If you've heard of Viagra, then you've also heard of sildenafil. McCarthy MM, Wright CL. https://www.chpa.org/our-issues/otc-medicines/acetaminophen, The Acetaminophen Awareness Coalition Know your dose campaign: For example, one of the ways APAP is believed to relieve pain is through inhibition of prostaglandin signalling53. Moreover, the fact that APAP is a less potent anti-androgen than other pharmaceuticals (for example, ketoconazole) probably means that only large studies would be sufficiently powered to detect effects. MedCity Influencers, Legal. Thus, a 2021 study suggested that biomarkers identified with standard methods used in biomonitoring are inadequate for human biomonitoring of a non-persistent chemical such as APAP and result in underestimation of actual exposure141. Bauer AZ, Kriebel D, Herbert MR, Bornehag C-G, Swan SH. Association between meconium acetaminophen and childhood neurocognitive development in GESTE, a Canadian cohort study. Acetaminophen/Paracetamol (Tylenol/Panadol) Used to treat minor pain and fever- Italian equivalent: Tachipirina500mg (for 1,000 mg pills, you'll need a prescription). Maternal exposure to prostaglandin E(2) modifies expression of Wnt genes in mouse brain an autism connection. All the other authors declare no competing interests. Paracetamol versus placebo for knee and hip osteoarthritis. Der Mechanismus, der dabei greift, hnelt dem, der auch die Wechselwirkungen mit Nitraten auslst: Die blutdrucksenkenden Effekte beider Wirkstoffe berlagern sich und gefhrden dadurch den Patienten. Paracetamol, aspirin and indomethacin display endocrine disrupting properties in the adult human testis in vitro. Hurtado-Gonzalez P, et al. Even everyday medications such as paracetamol, ibuprofen and codeine have to be purchased via a Farmacia. and B.J.) May cause gastrointestinal side effects at high dosages. This call to action is consistent with the 2016 Targeting Environmental Neuro-Developmental Risks (TENDR) Consensus Statement47, which we support: We as a society should be able to take protective action when scientific evidence indicates a chemical is of concern, and not wait for unequivocal proof that a chemical is causing harm to our children. If a drug's FDA approval could be overturned by any judge, anywhere, anytime the pharmaceutical industry would be . Addo KA, Palakodety N, Fry RC. Inconsistencies between studies are probably due to differences in assessment methodologies of exposure and outcomes. Engelstoft IMS, et al. Available in a range of formulations including liquid, oral tablets, oral disintegrating tablets, chewable tablets, controlled-release tablets, dispersible tablets, injectable, and rectal preparations. Lupattelli A, et al. It is available in generic and brand versions. Intrauterine exposure to paracetamol and aniline impairs female reproductive development by reducing follicle reserves and fertility. But if you routinely take other prescribed meds, tell your doctor (including your GP) that you are taking PrEP. If paracetamol does not work, there are other painkillers you can try, including: Ibuprofen and similar painkillers are available as creams or gels that you rub on to the part of your body that's painful. Skovlund E, Handal M, Selmer R, Brandlistuen RE, Skurtveit S. Language competence and communication skills in 3-year-old children after prenatal exposure to analgesic opioids. and transmitted securely. Paracetamol medication during pregnancy: insights on intake frequencies, dosages and effects on hematopoietic stem cell populations in cord blood from a longitudinal prospective pregnancy cohort. 10. Last updated on Aug 29, 2022. Batch CBD Full-Spectrum Gummies. Saragiotto BT, et al. Laue HE, et al. Perinatal exposure to paracetamol: dose and sex-dependent effects in behaviour and brains oxidative stress markers in progeny. Medically reviewed by Carmen Fookes, BPharm. Temporal trends in sperm count: a systematic review and meta-regression analysis. Some people find ibuprofen better than paracetamol for back pain. However, antigens and other medications amide does, but rather simply viagra with take to it is safe paracetamol a perhaps 1 5%. In the USA, APAP is estimated to be used by up to 65% of pregnant women18,19. Black E, et al. Amateau SK, McCarthy MM. Who can and cannot take it. Compared with no APAP, detection of APAP in meconium was associated with twice the odds of ADHD. Page last reviewed: 20 October 2022. AGD is the distance between the anus and the base of the penis, which is an indicator of the degree of masculinization of the genitals51,91,92,99. Pregnant women should minimize risk by using the lowest effective APAP dose for the shortest possible time. Evidence of neurodevelopmental toxicity of any type epidemiological or toxicological or mechanistic by itself should constitute a signal sufficient to trigger prioritization and some level of action.47. A 9.5% increase was observed in the overall rate of developmental disabilities between 20092011 and 2015201711. Endocrine insights into the pathophysiology of autism spectrum disorder. If you're on blood thinners, beware of aspirin. Only studies that investigated APAP as an independent exposure were included. Dean SL, Knutson JF, Krebs-Kraft DL, McCarthy MM. Reducing the Dose of Viagra Can Helps Reduce Headaches: If a headache has become a common symptom after taking Viagra, you should consult your doctor regarding the dose. Prenatal APAP exposure has also been associated with earlier female pubertal development. 1). Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour. Try to keep to the recommended guidelines of no more than 14 units of alcohol a week. Here we summarize this evidence and call for precautionary action through a focused research effort and by increasing awareness among health professionals and pregnant women. Reduced AGD has been found in boys following exposure to APAP during weeks 814 of gestation, which coincides with the timing of the masculinization programming window. Future studies should include evaluation of brain and behavioural effects in higher order species, from both prenatal and early life exposure, for specific indications and exposure windows153. More in Paracetamol for adults. Eating a meal before taking Viagra may slow its absorption into your bloodstream and lower its effectiveness. Doseresponse has been investigated in 19 studies112114,116122,124,127130,133,136138 and of these, 16 studies112,114,116122,124,127,129,130,133,136,137 identified a doseresponse association, whereby increased duration of exposure was associated with increased risk. Association of maternal neurodevelopmental risk alleles with early-life exposures. APAP is widely used by pregnant women as governmental agencies, including the FDA and EMA, have long considered APAP appropriate for use during pregnancy when used as directed. Leppert B, et al. Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders. Thus, these data suggest that the timing and duration of maternal APAP use are critical factors and that short-term APAP use might be of limited risk. Teratol. Smoothie. government site. Project TENDR: targeting environmental neuro-developmental risks the TENDR consensus statement. Below, check out the tour dates, as well as a weird tour . Differences and inconsistencies remain between studies that might be related to several factors, including species, strain, age, developmental stage, dose, duration, and route and schedule of administration, among others. Neurodevelopmental problems at 18 months among children exposed to paracetamol in utero: a propensity score matched cohort study. Research suggests that women are reluctant to use medications during pregnancy23,45. Karimi K, et al. FOIA Acetaminophen metabolism revisited using non-targeted analyses: implications for human biomonitoring. Experimental animal studies have suggested that perinatal APAP exposure, even at low therapeutic doses, increases the risk of brain and behavioural abnormalities in rodents51,145151, supporting the epidemiological evidence (Supplementary Table 4). Taking it with other medicines and herbal supplements. All relevant studies are summarized in Supplementary Tables 15. Long-term (5 days) fetal exposure resulted in even higher transfer rates than short-term exposure, which might lead to accumulation of APAP in the fetal brain50. Effective for the temporary relief of minor aches, pains, and headaches. At low dosages, it lacks the gastrointestinal side effects associated with NSAID pain relievers (does not cause ulcerations, bleeding or perforations). Plasma and fecal metabolite profiles in autism spectrum disorder. The https:// ensures that you are connecting to the APAP is one of the most commonly used medications globally2. Reproductive toxicity evaluation of acetaminophen in Swiss CD-1 mice using a continuous breeding protocol. APAP is an important medication and alternatives for treatment of high fever and severe pain are limited. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. Paracetamol is exactly the same as acetaminophen. In these studies, doses ranged from the maximum safe dose for a pregnant woman of 50mg/kg per day to 1,430mg/kg per day (Supplementary Tables 2, 4)81,82. All sales of APAP-containing medications, regardless of country, should be accompanied by recommendations for use in pregnancy. This method captures only part of the metabolic pathway and leaves a fairly short window to assess APAP due to its short half-life (46h)141,143,144, which can lead to underestimation of actual exposure. Prostaglandin E2 is an endogenous lipid molecule involved in normal brain development, regulating cerebellar development and inducing masculinization of the preoptic area of the brain70. Burman A, et al. American College of Obstetricians and Gynecologists. Side effects of vasodilators. Paracetamol (acetaminophen) for acute treatment of episodic tension-type headache in adults. Prenatal acetaminophen use and outcomes in children. Bennett D, et al. Be careful not to administer other products containing paracetamol or acetaminophen at the same time. The statement was developed independently of specific societies and colleges by the 13authors. Revision date: August 28, 2022. aspirin, acetaminophen, ibuprofen, tramadol, cyclobenzaprine, naproxen, Tylenol, diclofenac, oxycodone, Advil. If you're staying longer than 90 days, you may have additional medication sent to you by mail or courier. This may be confusing to some people and result in inadvertent double-ups in dosing. Copyright 1996-2023 Drugs.com. Thus, the association between prenatal acetaminophen and ADHD may be even stronger than previously estimated137. Baron-Cohen S, et al. Gonadal disorders, Endocrine system and metabolic diseases, Translational research, Neurological disorders. The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1-mediated hypothermia and is associated with prostaglandin inhibition in the brain. Timely collection of exposure information would probably minimize such exposure misclassification and recall bias. Psychiatry. The deceased was a 56-year old male found dead at home, with a past history of diabetes mellitus, hypertension, chronic alcoholism, anxio-depressive disorders, and erectile dysfunction. Hay-Schmidt A, et al. We support this statement, which is consistent with our recommendations163. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: AVIGRA (Sildenafil Citrate) Tablets Trade Name:Viagra Synonyms:Sildenafil citrate tablets Chemical Family:Mixture Intended Use:Pharmaceutical product used for male erectile dysfunction 2. You can also ask a pharmacist to check for drug interactions. Global Acetaminophen Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2026. A woman has told how she feared she'd never become a mum but gave birth to a boy at age 45 after taking Viagra to get pregnant.. Carin Rockind, 48, welcomed a "miracle" baby after trying to have a . Dreier JW, Andersen A-MN, Berg-Beckhoff G. Systematic review and meta-analyses: fever in pregnancy and health impacts in the offspring. In these cohorts exposure information was collected in a timely manner to attempt to minimize exposure misclassification and recall bias. Also, tell your doctor if you have or have had any current or past heart problems. We note that in this article, the terms women and men refer to cisgender women and cisgender men. Confounding by indication for use was controlled for in nine studies24,89,90,9395,97,101,102. Kinetics and metabolism of paracetamol and phenacetin. How and when to take it. Pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL-, induces autism spectrum disorder-like and co-morbid phenotypes in adult C57BL/J mice. Two notable studies overcame some of the important limitations of earlier studies. sharing sensitive information, make sure youre on a federal Courts Allowed to Ban Mife Today, Viagra Tomorrow? Allegaert K, van den Anker J. Dean A, et al. Once. Maternal fever during pregnancy and offspring attention deficit hyperactivity disorder. Tsai C-S, et al. Emerging clinical and molecular research has provided compelling evidence that abnormal cyclooxygenase 2 and prostaglandin E2 signalling is associated with ASD-related pathology and behaviours68,69,154,156158. Johansson HKL, et al. Thiele K, et al. In people who experience migraine headache, including women of reproductive age, studies show that migraine days can be decreased by reducing use of analgesics, including APAP43,44. Data support the contribution of environmental exposure during fetal life, including exposure to pharmaceuticals, to these increases in rates of neurological, urogenital and reproductive disorders13,14. Blecharz-Klin K, et al. Findings from the 2004 Pelotas birth cohort. Lind DV, et al. Generic Viagra, or sildenafil citrate, works the same as the brand-name version, but at a lower cost. Given the high prevalence of APAP use by pregnant women, the public health implications of use reduction might be substantial. Tipranavir Warnings Tell your doctor if you decide to take Viagra (Sildenafil). Look for a warning on the box before you attempt to crush or chew tablets, or cut capsules open. Do not exceed the recommended dosage, because this may put you at risk of liver toxicity. As with reproductive studies, inconsistencies between studies might relate to factors such as species, strain, age, dose, duration of exposure, and route and schedule of administration. Prenatal exposure to acetaminophen and risk for attention deficit hyperactivity disorder and autistic spectrum disorder: a systematic review, meta-analysis, and meta-regression analysis of cohort studies. Welsh M, et al. Koehn L, Habgood M, Huang Y, Dziegielewska K, Saunders N. Determinants of drug entry into the developing brain. Analgesic use prevalence, biomonitoring and endocrine and reproductive effects. Fan G, Wang B, Liu C, Li D. Prenatal paracetamol use and asthma in childhood: a systematic review and meta-analysis. Klein RM, et al. In a 2020 prospective cohort study conducted in Qubec, Canada, children exposed to APAP prenatally (as measured in meconium) were at increased risk of physician-diagnosed ADHD and hyperactivity, which was indicated by resting-state brain connectivity at ages 6 and 7 years137. Is it ok to take anadin or paracetamol to cure the headache pain? During pregnancy, the use of APAP is important for the treatment of high fever and severe pain that, left untreated, could potentially affect the developing fetus or the mother2631. Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants. Vhody smoothies zvisia od toho, o do nich dte. However, strong evidence from rodent studies and experiments with human cells and tissue performed in several independent laboratories shows that both acute (for example, 24h) and long-term (for example, 1 week) exposure to APAP results in a reduction in fetal androgens24,105. We here recognize our professional and social responsibility to take this action, even in the face ofuncertainty, in light of the serious consequences of inaction. The brown bottle keeps UV light out as this can also cause the drug to breakdown. Holm JB, et al. Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism. Grandjean P, Landrigan PJ. Lim H, et al. A 2019 study suggested that APAP enters the developing rat brain and cerebrospinal fluid in higher amounts than the adult brain. GUID:113FA095-0BFA-49EE-94B5-7DB1404B6426. The underestimation could be substantial, as evidenced by the far stronger associations reported in biomarker studies127,129,130,137 than in studies relying on self-report. Paracetamol is usually best for most types of pain, including headaches and stomach ache. Paracetamol is used to relieve pain. These 29 observational studies were limited by potential confounding, including by indication for APAP use, by genetic factors and by bias introduced by exposure and outcome misclassification, as well as study participant loss to follow-up139. Hence, for such studies a system of allometry (how anatomy, physiology and behaviour change based on body size) based on body surface area is normally applied, where mouse and rat dose data are divided by a factor of 12.33 and 6.2, respectively, to reach the equivalent human dose83. Paracetamol is another name for acetaminophen which is an effective mild pain reliever with a low risk of side effects. D.M.K., A.Z.B., S.H.S. "Vitamn C njdete v ovoc, ako s pomarane a jahody, a vitamn E v . Several analytical techniques have been used to control for confounding by indication, with results largely remaining unchanged3,41. Objectives: The aim of this study was to compare the rate of absorption between ordinary paracetamol tablets and effervescent paracetamol tablets. Hgesttt ED, et al. A report about an ongoing trial of the drug from Raleigh-based Sprout Pharmaceuticals for treatment of low sexual desire in women finds in interim results that the so called 'female Viagra' can . May be administered without regard to food; although food may decrease any reported stomach upset. Male urinary paracetamol and semen quality. Kristensen DM, et al. Studies of intrauterine APAP exposure have found effects on development in both mouse and rat models. During pregnancy, changes occur in APAP metabolism, which might make pregnant women and their fetus more vulnerable to toxic effects. Pietropaolo S, Bellocchio L, Bouzn-Arniz I, Yee BK. Note that this list is not all-inclusive and includes only common medications that may interact with paracetamol. Although one study that used both biomarkers and self-reported exposure suggested that the two measures of exposure were correlated127, exposure misclassification remains a concern in studies using maternal self-report24. APAP is known to readily cross the placenta and bloodbrain barrier49,50. Tovo-Rodrigues L, et al. Ask your physician, whether reducing the dose can keep you comfortable? Tassorelli C, et al. Ubiquitous presence of paracetamol in human urine: sources and implications. Acetaminophen modulates the expression of steroidogenesis-associated genes and estradiol levels in human placental JEG-3 cells. Klopcic I, Markovic T, Mlinaric-Rascan I, Sollner Dolenc M. Endocrine disrupting activities and immunomodulatory effects in lymphoblastoid cell lines of diclofenac, 4-hydroxydiclofenac and paracetamol. D.M.K., A.Z.B., D.K., Z.L., S.H.S., R.H.J. Ystrom E, et al. Paracetamol exposure in pregnancy and early childhood and development of childhood asthma: a systematic review and meta-analysis. Guides Does PrEP interact with other medications? Can you take Viagra and paracetamol together? The final statement, which takes into consideration differing international perspectives, prescribing practices and clinical considerations, was supported by 78 signees in addition to the 13 authors (Supplementary Box 1). In vivo, in vitro and ex vivo studies have shown that APAP directly perturbs hormone-dependent processes, including inhibition of androgen production and increased oestrogen production, disruption of steroidogenesis, depletion of sulfated sex hormones, perturbation of immune function, induction of oxidative stress and indirect activation of the endocannabinoid system1,2,6165. Human epidemiological studies on APAP should be designed to examine timing, dosage and duration of exposure both prenatally and postnatally. Prenatal acetaminophen affects maternal immune and endocrine adaptation to pregnancy, induces placental damage, and impairs fetal development in mice. Interrante JD, et al. R.T. Mitchell is supported by a UKRI Future Leaders Fellowship (MR/S017151/1). The published research cited in this article does not consider pregnancy that occurs in transgender men, non-binary people or intersex people. Common medications that may have a moderate interaction with paracetamol include: Alcohol may enhance the liver toxicity of paracetamol. There are 9 disease interactions with modafinil which include: cardiac disease. There are many brands of paracetamol available and it is commonly used in combination with other ingredients for cold, flu, and pain relief. R.T.M. Intrauterine exposure to acetaminophen and adverse developmental outcomes: epidemiological findings and methodological issues. Skakkebaek NE, et al. Paracetamol is what acetaminophen is called in almost every country in the world apart from the U.S., Japan, and Canada (where it is called acetaminophen). Number of Ibuprofen and Viagra reports submitted per year: Ibuprofen and Viagra drug interactions by gender *: Click here to view National Library of Medicine Prenatal exposure to acetaminophen and risk of ADHD. An additional study has suggested an association between prenatal APAP exposure and early female puberty93. As with reproductive and urogenital outcomes, exposure timing is important, as the highest risk seemed to occur from exposure during the second and third trimesters of pregnancy (with some exceptions112114). Moreover, exposure to APAP for >2 weeks increased the risk of cryptorchidism24. Albert O, et al. We suggest specific actions to implement these recommendations. Over-the-counter analgesics during pregnancy: a comprehensive review of global prevalence and offspring safety. Biol. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use paracetamol only for the indication prescribed. Early paracetamol exposure decreases brain-derived neurotrophic factor (BDNF) in striatum and affects social behaviour and exploration in rats. Critical windows of developmental vulnerability occur in utero, and during infancy and early childhood110. Complete withdrawal is the most feasible treatment for medication-overuse headache: a randomized controlled open-label trial. APAP effects on the cannabinoid and prostaglandin pathways alone or in combination might be the possible mechanisms1,62,65,69,152154. Maternal flu or fever, medication use, and neural tube defects: a population-based case-control study in Northern China. Findings from five of these studies suggest that prenatal APAP exposure is associated with male urogenital and reproductive tract abnormalities, by showing increased risk of male undescended testicles (cryptorchidism)24,89,90 and a reduced anogenital distance (AGD)91,92. Acetaminophen use during pregnancy: effects on risk for congenital abnormalities. Over-the-counter medications in pregnancy. The tour begins on Aug. 3 in Sterling Heights, Mi. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Importantly, misclassification, as mentioned above, is most likely to be non-differential and result in underestimation of the true effect, rather than to represent spurious associations104. In this Consensus Statement, we summarize the epidemiological research and animal studies that have examined neurological, urogenital and reproductive outcomes that have been associated with maternal and perinatal use of APAP (Figs1,,2).2). Zablotsky B, et al. Effects of exposure to acetaminophen and ibuprofen on fetal germ cell development in both sexes in rodent and human using multiple experimental systems. However, understanding the exact mechanisms that lead to a particular outcome in humans is complicated as APAP potentially interacts with several critical pathways during development, such as prostaglandins and steroids. Moreover, exposure of ex vivo adult testes to APAP has similarly shown a negative effect on testosterone production103. It may also be called an antipyretic because it will bring down a fever. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. A consensus protocol for the management of medication-overuse headache: evaluation in a multicentric, multinational study. Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? That's because sildenafil is simply the generic name for the brand name medication of Viagra (as well as. Furthermore, APAP inhibits serotonergic mechanisms in clinical studies54. #1. Liew Z, Bach CC, Asarnow RF, Ritz B, Olsen J. Paracetamol use during pregnancy and attention and executive function in offspring at age 5 years. Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. Prostaglandin E ( 2 ) modifies expression of Wnt genes in mouse brain an autism connection (! Day RO, Mohamudally a, Scott KF adult human testis in vitro accurate and independent information on than! Confounding by indication for use was controlled for in nine studies24,89,90,9395,97,101,102 reduces a high temperature by the! Objectives: the aim of this study was to compare the rate of developmental vulnerability occur utero... 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