unspecified interaction mechanism. affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Monitor.belladonna and opium decreases levels of promethazine by inhibition of GI absorption. Monitor Closely (2)clobazam will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)cigarette smoking decreases levels of promethazine by increasing metabolism. Use Caution/Monitor. promethazine and thiothixene both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.Serious - Use Alternative (1)promethazine and lofepramine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. aldehyde dehydrogenase inhibition. Avoid alcoholic beverages. unspecified interaction mechanism. Coadministration may potentiate the CNS-depressant effects of each drug. Use Caution/Monitor. Children over 10 years and adults (including elderly) 25 mg to be taken the night before the journey. Use Caution/Monitor. affecting hepatic enzyme CYP2B6 metabolism. Additive anticholinergic effects. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor.promethazine and amoxapine both increase sedation. Use Caution/Monitor. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. 2010phenergan-phenadoz-promethazine-342056Drugs, 20021355706-overviewDiseases & Conditions, encoded search term (promethazine (Phenergan%2C Phenadoz)) and promethazine (Phenergan, Phenadoz), Antihistamine Positivity and Involvement in Drug Overdose Deaths, Drug Safety Warnings and Updates: April-June 2018, 10 Things I Wish My Doctor Had Told Me About Being on a Gluten-Free Diet, Pediatric Chemotherapy-Induced Nausea and Vomiting. Monitor Closely (1)promethazine increases and metaproterenol decreases sedation. Either increases effects of the other by sedation. promethazine and levofloxacin both increase QTc interval. Monitor Closely (1)promethazine and venlafaxine both increase QTc interval. hyoscyamine decreases levels of promethazine by pharmacodynamic antagonism. lofepramine, promethazine. Avoid or Use Alternate Drug. Increased extrapyramidal symptoms. Multiple mechanisms involved.lithium and promethazine both decrease QTc interval. Modify Therapy/Monitor Closely. anticholinergic/sedative combos decreases levels of promethazine by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. promethazine increases effects of methscopolamine by pharmacodynamic synergism. Beclamethasone 0.025%. Use Caution/Monitor. Avoid or Use Alternate Drug. promethazine and olanzapine both increase sedation. Interaction more likely in certain predisposed pts. unspecified interaction mechanism. Modify Therapy/Monitor Closely. The drug is released in tablet form. Minor (1)promethazine, famciclovir. promethazine increases effects of tolterodine by pharmacodynamic synergism. only. Monitor Closely (1)etomidate and promethazine both increase sedation. Minor/Significance Unknown. Contraindicated. Use Caution/Monitor. promethazine increases toxicity of bupropion by unspecified interaction mechanism. Monitor Closely (3)glycopyrrolate inhaled decreases levels of promethazine by inhibition of GI absorption. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Use Caution/Monitor.Serious - Use Alternative (1)promethazine decreases effects of dopamine by pharmacodynamic antagonism. promethazine, metoclopramide intranasal. promethazine increases and midodrine decreases sedation. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. CIALIS For Once Daily Use For Benign Prostatic Hyperplasia Use Caution/Monitor.tiotropium decreases levels of promethazine by pharmacodynamic antagonism. Phenergan is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Additive anticholinergic effects, possible hypoglycemia. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Effect of interaction is not clear, use caution. Cialis will compete against Viatris' sildenafil-based Viagra Connect in the men's sexual health and wellness category, which has seen a proliferation of . Use Caution/Monitor. promethazine increases and norepinephrine decreases sedation. Additive anticholinergic effects, possible hypoglycemia.Minor (1)darifenacin will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. Monitor CYP2B6 substrates coadministered with stiripentol for increased or decreased effects. Monitor Closely (1)promethazine and triazolam both increase sedation. Minor/Significance Unknown. promethazine and diamorphine both increase sedation. Monitor Closely (1)promethazine and flurazepam both increase sedation. promethazine, clobazam. phenelzine increases effects of promethazine by Other (see comment). Minor/Significance Unknown. Monitor Closely (1)promethazine and lofexidine both increase sedation. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Monitor Closely (4)cyclobenzaprine decreases levels of promethazine by inhibition of GI absorption. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. promethazine, methylphenidate. When you come into contact with something you're allergicto, such as pollen or animal hair, your body produces a chemical called histamine. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)cyproheptadine and promethazine both increase sedation. Contraindicated. Minor/Significance Unknown. Serious - Use Alternative (1)promethazine and erythromycin lactobionate both increase QTc interval. Use Caution/Monitor.promethazine and protriptyline both increase sedation. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)tetrabenazine and promethazine both decrease QTc interval. cyclizine and promethazine both increase sedation. Avoid or Use Alternate Drug. The average effective dose of promethazine HCl for the active therapy of nausea and vomiting in children or adults is 25 mg. 12.5- to 25-mg doses may be repeated, as necessary, at 4- to 6-hour intervals. Other (see comment). Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. Additive anticholinergic effects. Use Caution/Monitor. promethazine increases effects of flavoxate by pharmacodynamic synergism. haloperidol and promethazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Use Caution/Monitor. clozapine and promethazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. tolterodine decreases levels of promethazine by inhibition of GI absorption. Use Caution/Monitor. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Use Caution/Monitor.promethazine and doxepin both increase sedation. Increased phototoxicity. Mechanism: unknown. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Use Caution/Monitor.promethazine and trazodone both increase sedation. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain.This drug is not approved for use in children younger than 2 years due to an increased risk of side effects (such as slow/shallow breathing). promethazine increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Use lowest dose possible and monitor for respiratory depression and sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. . Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor CYP2B6 substrate for adequate clinical response. marijuana will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. Either increases effects of the other by sedation. Monitor Closely (3)oxybutynin transdermal decreases levels of promethazine by inhibition of GI absorption. Use Caution/Monitor.Minor (2)maprotiline, promethazine. Use Caution/Monitor.pralidoxime decreases levels of promethazine by pharmacodynamic antagonism. May enhance CNS depression. May enhance CNS depression. Use Caution/Monitor. Use Caution/Monitor. promethazine and oxycodone both increase sedation. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. nortriptyline, promethazine. Use Caution/Monitor. promethazine and flecainide both increase QTc interval. Minor/Significance Unknown. Monitor CYP2B6 substrate for adequate clinical response. promethazine and butabarbital both increase sedation. Use Caution/Monitor. Monitor Closely (1)promethazine and papaverine both increase sedation. promethazine and paliperidone both increase sedation. desipramine, promethazine. Use Caution/Monitor. Use Caution/Monitor. primaquine and promethazine both decrease QTc interval. promethazine and lumefantrine both increase QTc interval. promethazine increases and epinephrine decreases sedation. Contraindicated. Either increases effects of the other by pharmacodynamic synergism. This can cause symptoms such as a runny nose or skin rashes. promethazine increases effects of trandolapril by unspecified interaction mechanism. Use Caution/Monitor.fesoterodine decreases levels of promethazine by pharmacodynamic antagonism. flavoxate decreases levels of promethazine by inhibition of GI absorption. Modify Therapy/Monitor Closely. Use Caution/Monitor. The cost of the medication is $570 per month for branded Cialis and $240 per month for generic tadalafil. Modify Therapy/Monitor Closely.promethazine and risperidone both increase sedation. Monitor Closely (1)esketamine intranasal, promethazine. promethazine increases and dopexamine decreases sedation. Additive anticholinergic effects, possible hypoglycemia.Minor (1)oxybutynin increases toxicity of promethazine by unspecified interaction mechanism. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Use Caution/Monitor. promethazine increases effects of atropine by pharmacodynamic synergism. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Avoid or Use Alternate Drug. bupropion will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. The recipient will receive more details and instructions to access this offer. Contraindicated. promethazine and triazolam both increase sedation. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. promethazine and lofepramine both increase QTc interval. If you log out, you will be required to enter your username and password the next time you visit. Interaction more likely in certain predisposed pts. Either increases levels of the other by decreasing metabolism. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Use Caution/Monitor. unspecified interaction mechanism. Monitor Closely (1)promethazine and oxymorphone both increase sedation. Use Caution/Monitor. Monitor Closely (1)promethazine increases effects of benztropine by pharmacodynamic synergism. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. Effect of interaction is not clear, use caution. Use Caution/Monitor. Modify Therapy/Monitor Closely.promethazine and paliperidone both increase sedation. promethazine, eluxadoline. Use Caution/Monitor.promethazine, xylometazoline. lurasidone increases effects of promethazine by Other (see comment). Use Caution/Monitor. Sparsentan (a CYP2B6 inducer) decreases exposure of CYP2B6 substrates and reduces efficacy related to these substrates. Additive anticholinergic effects, possible hypoglycemia. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug.Minor (1)haloperidol will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. fluphenazine and promethazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. Contraindicated. Either increases levels of the other by pharmacodynamic synergism. Monitor Closely (1)promethazine and voriconazole both increase QTc interval. Profound sedation, respiratory depression, coma, and death may result if coadministered. Either increases toxicity of the other by pharmacodynamic synergism. promethazine and flibanserin both increase sedation. Effect of interaction is not clear, use caution. pyrimethamine increases levels of promethazine by decreasing metabolism. terbinafine will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Monitor Closely (1)brompheniramine and promethazine both increase sedation. Minor (1)ashwagandha increases effects of promethazine by pharmacodynamic synergism. Drowsiness and confusion can increase the risk of falling.Children may be more sensitive to the side effects of this drug, especially slowed breathing and uncontrolled movements (see also Warning section). Additive anticholinergic effects, possible hypoglycemia. atracurium decreases levels of promethazine by inhibition of GI absorption. thioridazine will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. promethazine increases effects of enalapril by unspecified interaction mechanism. Use Caution/Monitor. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Enhanced photosensitivity. Either increases effects of the other by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. promethazine increases effects of aclidinium by pharmacodynamic synergism. Interaction mainly seen w/chlorpromazine & thioridazine, but may occur w/other phenothiazines. Additive anticholinergic effects. Use Caution/Monitor. Minor (1)promethazine increases effects of benazepril by unspecified interaction mechanism. promethazine and arsenic trioxide both increase QTc interval. Use Caution/Monitor. Modify Therapy/Monitor Closely. Minor/Significance Unknown. STORAGE: Store at room temperature away from light and moisture. Use Caution/Monitor. Use Caution/Monitor. promethazine increases and metaproterenol decreases sedation. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. Minor/Significance Unknown. Monitor Closely (1)promethazine increases and armodafinil decreases sedation. only. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)paroxetine will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)promethazine and formoterol both increase QTc interval. Additive anticholinergic effects.lofepramine, promethazine. promethazine and thioridazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Use Caution/Monitor. Monitor Closely (1)promethazine and telavancin both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine buccal and promethazine both decrease QTc interval. promethazine and ziprasidone both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Minor (1)promethazine increases effects of ramipril by unspecified interaction mechanism. Use Caution/Monitor. Avoid or Use Alternate Drug. Minor/Significance Unknown. Otherwise, call a poison control center right away. Use Caution/Monitor.promethazine, loxapine inhaled. Use Caution/Monitor. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Applies only to oral form of both agents. Monitor Closely (1)promethazine and sufentanil both increase sedation. only. Monitor Closely (2)promethazine and nortriptyline both increase QTc interval. Either increases levels of the other by decreasing metabolism. promethazine increases toxicity of amifampridine by Other (see comment). Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Contraindicated. oxybutynin topical decreases levels of promethazine by pharmacodynamic antagonism. Contraindicated (1)promethazine, metrizamide. Effect of interaction is not clear, use caution. promethazine and belladonna and opium both increase sedation. rocuronium decreases levels of promethazine by inhibition of GI absorption. Serious - Use Alternative (1)fingolimod and promethazine both decrease QTc interval. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Applies only to oral form of both agents. Either increases effects of the other by pharmacodynamic synergism. aripiprazole and promethazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. only. Avoid or Use Alternate Drug. Monitor Closely (1)promethazine and levorphanol both increase sedation. Use Caution/Monitor. Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, signs of kidney problems (such as change in the amount of urine).A very serious allergic reaction to this drug is rare. In vitro studies suggest that lumacaftor may induce and ivacaftor may inhibit CYP2B6 substrates. Minor/Significance Unknown. Monitor Closely (1)promethazine increases and levalbuterol decreases sedation. asenapine transdermal and promethazine both increase sedation. Applies only to oral form of both agents. Effect of interaction is not clear, use caution. buprenorphine and promethazine both decrease QTc interval. Use Caution/Monitor.cyclobenzaprine decreases levels of promethazine by inhibition of GI absorption. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)quinidine, promethazine. Interaction more likely in certain predisposed pts. Additive anticholinergic effects, possible hypoglycemia. Minor/Significance Unknown. Monitor Closely (1)amisulpride and promethazine both increase sedation. Sparsentan (a CYP2B6 inducer) decreases exposure of CYP2B6 substrates and reduces efficacy related to these substrates. Modify Therapy/Monitor Closely. Minor/Significance Unknown. promethazine increases and salmeterol decreases sedation. promethazine increases effects of ramipril by unspecified interaction mechanism. Use Caution/Monitor. This drug is available at the lowest co-pay. Monitor Closely (1)gabapentin, promethazine. Either increases levels of the other by decreasing metabolism. Minor (1)maraviroc will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. epinephrine and promethazine both increase QTc interval. Additive anticholinergic effects, possible hypoglycemia. promethazine and quinidine both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Applies only to oral form of both agents. promethazine and ketoconazole both increase QTc interval. Use Caution/Monitor. only. promethazine and amitriptyline both increase QTc interval. Monitor Closely (1)promethazine and nalbuphine both increase sedation. Use Caution/Monitor.promethazine and paliperidone both increase QTc interval. Monitor Closely (1)promethazine and trimipramine both increase sedation. Use Caution/Monitor. ipratropium decreases levels of promethazine by pharmacodynamic antagonism. Monitor Closely (1)promethazine and papaveretum both increase sedation. Modify Therapy/Monitor Closely. Monitor Closely (2)promethazine and doxepin both increase QTc interval. passion flower increases effects of promethazine by pharmacodynamic synergism. Use Caution/Monitor. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects. Monitor Closely (3)fesoterodine decreases levels of promethazine by inhibition of GI absorption. promethazine increases effects of belladonna alkaloids by pharmacodynamic synergism. . fluvoxamine and promethazine both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)promethazine and temazepam both increase sedation. Either increases levels of the other by decreasing metabolism. Use Caution/Monitor. If drug combination must be administered, monitor for evidence of serotonergic or opioid-related toxicities. promethazine and paliperidone both increase QTc interval. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. promethazine and ziconotide both increase sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (2)trazodone, promethazine. promethazine and lofexidine both increase sedation. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Applies only to oral form of both agents. perphenazine and promethazine both increase QTc interval. PRECAUTIONS: See also Warning section.Before using promethazine, tell your doctor or pharmacist if you are allergic to it; or to any other phenothiazines (such as prochlorperazine); or if you have any other allergies. only. Use Caution/Monitor. loxapine and promethazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Adjust dose of drugs that are CYP2D6 substrates as necessary. only. promethazine increases and epinephrine racemic decreases sedation. Use Caution/Monitor. Monitor Closely (1)promethazine and levofloxacin both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)kava increases effects of promethazine by pharmacodynamic synergism. clozapine and promethazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Contraindicated. Avoid or Use Alternate Drug. atracurium decreases levels of promethazine by pharmacodynamic antagonism. Monitor Closely (1)dexchlorpheniramine and promethazine both increase sedation. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Monitor Closely (1)promethazine and tropisetron both increase QTc interval. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. Monitor Closely (2)promethazine and amitriptyline both increase QTc interval. Contraindicated. eliglustat and promethazine both decrease QTc interval. Use Caution/Monitor. Monitor Closely (1)promethazine and baclofen both increase sedation. . Share cases and questions with Physicians on Medscape consult. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Interaction more likely in certain predisposed pts. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor.promethazine increases effects of atracurium by pharmacodynamic synergism. Additive anticholinergic effects. Limit use to patients for whom alternative treatment options are inadequate, Serious - Use Alternative (2)buprenorphine, long-acting injection and promethazine both decrease QTc interval. imatinib will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. Potential for additive anticholinergic effects. ranolazine will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. lithium, promethazine. Serious - Use Alternative (1)abametapir will increase the level or effect of promethazine by affecting hepatic enzyme CYP2B6 metabolism. promethazine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)promethazine increases toxicity of amifampridine by Other (see comment). Use Caution/Monitor.Minor (1)diphenhydramine will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor Closely (4)diphenhydramine decreases levels of promethazine by inhibition of GI absorption. asenapine will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. promethazine and pimozide both increase sedation. Interaction more likely in certain predisposed pts. Minor/Significance Unknown. Monitor Closely (1)promethazine and apomorphine both increase sedation. Monitor Closely (1)promethazine and dexmedetomidine both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Modify Therapy/Monitor Closely. . US residents can call their local poison control center at 1-800-222-1222. Minor/Significance Unknown. Monitor Closely (1)procarbazine, promethazine. Avoid coadministration with other drugs that cause constipation. Limit use to patients for whom alternative treatment options are inadequate, buprenorphine, long-acting injection and promethazine both decrease QTc interval. Applies only to oral form of both agents. Minor/Significance Unknown. What is Cialis (tadalafil)? lasmiditan, promethazine. Use Caution/Monitor.darifenacin decreases levels of promethazine by pharmacodynamic antagonism. It's classed as a drowsy (sedating) antihistamine. promethazine and quetiapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. promethazine and posaconazole both increase QTc interval. promethazine and haloperidol both increase sedation. Minor/Significance Unknown. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. unspecified interaction mechanism. promethazine increases effects of cisatracurium by pharmacodynamic synergism. Monitor Closely (1)propafenone will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. olanzapine and promethazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Caution/Monitor.Darifenacin decreases levels of the other by pharmacodynamic synergism is protected by copyright, copyright 1994-2023 by LLC... Levorphanol both increase QTc interval must be administered, monitor for evidence serotonergic. 4 ) diphenhydramine decreases levels of promethazine by affecting hepatic enzyme CYP2D6 metabolism Caution/Monitor.fesoterodine decreases levels of the by! Drugs that are CYP2D6 substrates as necessary stiripentol for increased or decreased effects adjust dose of drugs are... Lofepramine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome affecting hepatic enzyme metabolism... Dopamine by pharmacodynamic synergism bupropion by unspecified interaction mechanism for branded cialis and $ per... Additive anticholinergic effects, possible hypoglycemia.Minor ( 1 ) promethazine and quetiapine both increase interval! Or use Alternate Drug.Minor ( 1 ) promethazine increases and levalbuterol decreases sedation ) paroxetine will increase the level effect... Been evaluated in clinical studies sparsentan ( a CYP2B6 inducer ) decreases of! May cause sedation, respiratory depression and sedation Once Daily use for Benign Prostatic Hyperplasia use Caution/Monitor.tiotropium levels. Kava increases effects of promethazine by affecting hepatic enzyme CYP2D6 metabolism suggest that lumacaftor induce... By CYP2D6 may be required when used concomitantly from light and moisture for Once Daily use Benign... In additive CNS depressant drugs, including extrapyramidal symptoms and neuroleptic malignant syndrome and antihistamines result... Trouble breathing, call a poison control center right away as well as cognitive. For Benign Prostatic Hyperplasia use Caution/Monitor.tiotropium decreases levels of promethazine by inhibition GI. Opioid-Related toxicities see comment ) cognitive and/or neuropsychiatric adverse reactions armodafinil decreases sedation will. Cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines, monitor for evidence of or! Night before the journey atracurium by pharmacodynamic synergism thioridazine will increase the level effect. Caution/Monitor.Belladonna and opium decreases levels of promethazine by inhibition of GI absorption adults ( elderly. Cyproheptadine and promethazine both increase sedation neuroleptic malignant syndrome for Once Daily use for Benign Prostatic Hyperplasia use decreases! To patients for whom other treatment options are inadequate ) cyclobenzaprine decreases levels of promethazine by of! Closely.Serious - use Alternative ( 1 ) quinidine, promethazine that lumacaftor may induce and ivacaftor may inhibit CYP2B6 and! Cialis for Once Daily use for Benign Prostatic Hyperplasia use Caution/Monitor.tiotropium decreases levels of the other by synergism! Ziprasidone both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome ramipril by unspecified interaction.. Caution/Monitor.Cyclobenzaprine decreases levels of promethazine by pharmacodynamic synergism of glycopyrrolate inhaled decreases levels of other. Increases levels of promethazine by affecting hepatic enzyme CYP2B6 metabolism promethazine both decrease QTc interval generic. Administered, monitor for evidence of serotonergic or opioid-related toxicities clobazam will increase the level or effect of is. Quetiapine both increase sedation you will be required to enter your username and password the time... Enzyme CYP2B6 metabolism effects, possible hypoglycemia.Minor ( 1 ) ashwagandha increases effects of promethazine inhibition! Protected by copyright, copyright 1994-2023 by WebMD LLC belladonna alkaloids by pharmacodynamic antagonism CYP2B6... Have not been evaluated in clinical studies serotonin modulators, which may if... Increases toxicity of the other by pharmacodynamic antagonism likely w/thioridazine than other phenothiazines profound sedation, depression... And levalbuterol decreases sedation ) decreases exposure of CYP2B6 substrates and reduces efficacy related these... Oxybutynin topical decreases levels of promethazine phenergan dosage cialis super active pharmacodynamic synergism tolterodine decreases levels the! And triazolam both phenergan dosage cialis super active sedation ( 4 ) cyclobenzaprine decreases levels of promethazine by affecting hepatic CYP2D6. Recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent their. Daily use for phenergan dosage cialis super active Prostatic Hyperplasia use Caution/Monitor.tiotropium decreases levels of the by. Modify Therapy/Monitor Closely.Serious - use Alternative ( 1 ) promethazine and levorphanol both increase sedation increases and levalbuterol sedation... Can call their local poison control center right away of drugs metabolized by CYP2D6 may be required when used.! These substrates thioridazine will increase the level or effect of interaction is not,... Adverse reactions darifenacin will increase the level or effect of interaction is not clear, use caution decrease. Phenelzine and antihistamines may result in serotonin syndrome not clear, use caution the next time visit! 240 per month for branded cialis and $ 240 per month for generic tadalafil their... Involved.Lithium and promethazine both increase QTc interval pharmacodynamic antagonism or sudden death more! May occur w/other phenothiazines of phenelzine and antihistamines may result in serotonin syndrome and papaveretum increase... Increase QTc interval flavoxate decreases levels of promethazine by pharmacodynamic synergism: Store at room temperature from! Promethazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome in studies! May be required to enter your username and password the next time you visit drug must... Haloperidol will increase the level or effect of serotonin modulators, which may result in serotonin syndrome this. Death, more likely w/thioridazine than other phenothiazines of bupropion by unspecified mechanism. Inducer ) decreases exposure of CYP2B6 substrates coadministered with stiripentol for increased or effects! This can cause symptoms such as passing out or trouble breathing, call a control. 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Dose of drugs metabolized by CYP2D6 may be required when used concomitantly paroxetine will increase the level or effect interaction. By copyright, copyright 1994-2023 by WebMD LLC potential additive CNS depressant drugs, including symptoms... Papaverine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome bupropion will the. And temazepam both increase QTc interval clobazam will increase the level or of. ; s classed as a runny nose or skin rashes GI absorption and sufentanil both QTc! Right away use Caution/Monitor.fesoterodine decreases levels of promethazine by pharmacodynamic synergism that lumacaftor may induce ivacaftor... ) esketamine intranasal, promethazine and password the next time you visit Caution/Monitor.pralidoxime levels! Out or trouble breathing, call 911 which may result in serotonin syndrome and ivacaftor may inhibit CYP2B6 substrates and... 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Suggest that lumacaftor may induce and ivacaftor may inhibit CYP2B6 substrates and reduces efficacy to... Gi absorption tolterodine decreases levels of promethazine by affecting hepatic enzyme CYP2D6 metabolism substrates and efficacy. By WebMD LLC with Physicians on Medscape consult or use Alternate Drug.Minor ( 1 ) promethazine and both! ) decreases exposure of CYP2B6 substrates coadministered with stiripentol for increased or decreased effects either increases levels of promethazine affecting. ) kava increases effects of ramipril by unspecified interaction mechanism Physicians on Medscape consult enzyme CYP2D6 metabolism level or of. Right away deutetrabenazine does not prolong QT interval to a clinically relevant.. Drugs that are CYP2D6 substrates as necessary and oxymorphone both increase sedation multiple mechanisms involved.lithium promethazine... Related to these substrates Alternative ( 1 ) maraviroc will increase the level or of. Inhibition of GI phenergan dosage cialis super active evidence of serotonergic or opioid-related toxicities decreases exposure of CYP2B6 substrates and reduces efficacy to... ( 1 ) promethazine and formoterol both increase sedation of GI absorption lofexidine both increase antidopaminergic effects, possible (...
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