Measuring and screening previous hypomanic symptoms in individuals without any definite history of depressive episode would also be needed for early detection of bipolar disorders (BDs). KL, HO, E-HL, JHK, J-HK, and KSH contributed to the critical revision of article for important intellectual content. Your email address will not be published. Hypomanic symptoms assessed by the HCL-32 in patients with major depressive disorder: a multicenter trial across China. J Adolesc. Reliability and validity of a Brazilian version of the Hypomania Checklist (HCL-32) compared to the Mood Disorder Questionnaire (MDQ). The patients most recent episode was as follows: manic, 65 (12.1%); hypomanic, 11 (2.1%); mixed, 16 (3.0%); depressed, 16 (3.0%); and unspecified, 4 (0.8%). The hypomania checklist-32 (HCL-32) is a widely used questionnaire developed for identifying hypomanic components in patients with a depressive episode. The ROC curve of the active/elated subscale suggested a cut-off score of 14 (sensitivity = 80.8%; specificity = 23.9%; AUC = 0.65). While the HCL-32 does not provide a formal diagnosis of BSD, it has been proposed as a valuable screening tool (28), with adequate psychometric properties, allowing for the assessment of BSD symptoms in an integral and standardized fashion. Feng Y, Xiang Y-T, Huang W, Wang G, Feng L, Tian T-F, Geng Y, Ungvari GS, Chiu HF, Ada W . This finding is particularly interesting, not only because it validates the initial findings based on the MINI, but also because it demonstrates that the scale could be useful as a screening tool in a non-research context. Napumpujte ho antioxidantmi a vitamnmi! Furthermore, we analyzed differences in hypomanic symptoms among several clinical groups and in a non-clinical sample. This study investigated the clinical utility of the HCL-32 for the screening of BDs in the non-clinical general population. The HCL-32-R1 does not provide a diagnosis of bipolar disorder, but can aid identification of potential bipolar cases in psychiatric, psychological and general practice. The clinical status of the non-clinical sample was ascertained through a customized questionnaire about medical history and current medication, with a particular focus on psychiatric or neurological history and medication. Diagnostic and Statistical Manual of Mental Disorders. government site. Failure to diagnose or misdiagnosis in BD is a significant clinical and public health problem, as it brings about delayed intervention and an unfavorable treatment outcome. Sensitivity, specificity, and the area under the curve (AUC) of the Receiver Operating Characteristic (ROC) were evaluated for assessing the discriminatory power of the scale and its two sub-domains in screening BDs. Test-retest reliability was found to be moderate for this sample (single measures ICC = 0.69), despite the long average interval between assessments (average interval of 175.2 299.0 days). To address these difficulties, several psychometric instruments have been developed to screen for hypomanic episodes and assess their severity. Have M, Vollebergh W, Bijl R, Nolen WA. I am more interested in sex, and/or have increased sexual desire, HCL-17. Thus, a shortened 9-item HCL subscale (risk-taking/irritable) may present advantages as a screening tool for BSD relative to both the alternate active/elated subscale and the HCL-32 total score. While the scale was found to have adequate psychometric properties, we further demonstrated that the scale is a valid tool to screen adults who have BSD and distinguish them from others, including MDD patients, at admission to an outpatient psychiatry clinic. Soares (18), on the other hand, using the Brazilian Portuguese version of HCL-32, found that factor 2 (risk-taking/irritable) rendered good specificity and sensitivity, suggesting the possibility of language or cultural specificities for Portuguese-speaking patients. Yang HC, Xiang YT, Liu TB, Han R, Wang G, Hu C, Li LJ, Wang XP, Peng HJ, Si TM, et al. 21349588 DOI: 10.1016/j.jad.2011.01.017 Abstract Background: An HCL-32 version with fewer items has been suggested. First, psychiatric assessments using the structured clinical interview were not performed for the control group which could lead to inclusion of un-diagnosed BD patients in the control group. From items to syndromes in the Hypomania Checklist (HCL-32): psychometric validation and clinical validity analysis. Rybakowski JK, Angst J, Dudek D, Pawlowski T, Lojko D, Siwek M, et al.. Polish version of the Hypomania Checklist (HCL-32) scale: the results in treatment-resistant depression, Factor structure and reliability of the Italian adaptation of the Hypomania Check List-32, second revision (HCL-32-R2). et al. Overall, we thus believe this study makes important contributions to research and clinical activity in BSD in Portugal, while providing support, beyond the Portuguese context, for use of full and reduced versions of the HCL-32 in a real-world outpatient psychiatric clinical setting. The risk-taking/irritable subscale showed particular advantage over the total scores in distinguishing between BSD and non-BSD cases (sensitivity = 84.6%; specificity = 58.1%; AUC = 0.76), with a cut-off score of 2. Detailed descriptions on the control group were also presented in a previous paper from our group [16]. Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea, Kounseok Lee,Joo Hyun Kim,Ji-Hae Kim&Kyung Sue Hong, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Republic of Korea, Depression Center, Samsung Medical Center, Seoul, Republic of Korea, Present address: Department of Psychiatry, St. Andrews Hospital, Icheon, Republic of Korea, You can also search for this author in On the other hand, in studies performed in settings in which the proportion of psychiatric disorders is lower than that observed in a clinical sample (i.e., general population, college students, primary care), a higher specificity would be needed (24). Controlling the false discovery rate: a practical and powerful approach to multiple testing. Stasia Obremskey. This study aimed at testing the clinical utility of the HCL-32 for screening of BDs in the non-clinical population. Glaus J, Van Meter A, Cui L, Marangoni C, Merikangas KR. AO-M was supported by grant PTDC/MED-NEU/31331/2017 funded by national funds from Fundao para a Cincia e Tecnologia (FCT/MCTES) and co-funded by FEDER, under the Partnership Agreement Lisboa 2020-Programa Operacional Regional de Lisboa. https://doi.org/10.1186/s12888-016-0831-8, DOI: https://doi.org/10.1186/s12888-016-0831-8. Bae M, Lee K, Baek JH, Kim JS, Cho Y, Ryu S, Ha K, Hong KS. A systematic review of the global distribution and availability of prevalence data for bipolar disorder. This is a systematic review and meta-analysis to compare the psychometric properties of the HCL-32 and the MDQ based on the same patient samples. All the data supporting our findings is contained within the manuscript. Your email address will not be published. The HCL-32 is a widely used and reliable instrument for the detection of previous hypomanic episodes and was validated in several languages, including Spanish (3). 2011;128(3):2918. The ROC curve in Figure Figure1,1, with an area under the curve (AUC) of 0.69, suggests that a cut-off point of 17 yields the best combination of sensitivity (80.7%) and specificity (35.5%) for the HCL-32 total score to distinguish between BSD and non-BSD cases. Additionally an independent diagnosis with a structured clinical interview using the Korean version of the Structured Clinical Interview of DSM-IV [14] or the Korean version of the Mini International Neuropsychiatric Interview [15] was made by a well-trained psychologist. Investigation of the clinical utility of the hypomania checklist 32 (HCL-32) for the screening of bipolar disorders in the non-clinical adult population, https://doi.org/10.1186/s12888-016-0831-8, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder. It is currently available in many languages and has been extensively studied (1227). Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder. By using this website, you agree to our Screening for bipolar-II, minor BP and subthreshold hypomania. 2009;32(5):107588. Vhody smoothies zvisia od toho, o do nich dte. Queens of the Stone Age will bring Phantogram, Viagra Boys, the Armed, and Savages' Jehnny Beth on their fall North American tour. Within the mentioned limitations, the present study is meaningful as the first study to evaluate the clinical utility of HCL-32 for screening BDs in non-clinical samples. The HCL-32 Active/Elated and HCL-32 Risk-Taking/Irritable subscore followed the same pattern, except for the lack of difference in risk-taking/irritability scores between the MDD and the OPD sample. At the same time, this results could also suggests that HCL-32 is a reliable tool independently on the patient's bipolar disorder stage. (2005). 2003;64(2):16174. Thus, accurately identifying a current or prior episode of hypomania is decisive for the differential diagnosis of BSD. The positive predictive value (PPV) was calculated by dividing the number of true positives by the number of true positives plus false positives. help served to complete the translation of the HCL 32 in its nal form. Impact of your "highs" on various aspects of your life. PubMed As expected, BDI-II total scores and anxiety symptoms were higher in the clinical samples, particularly in the MDD group. Meyer TD, Castelao E, Gholamrezaee M, Angst J, Preisig M. Hypomania Checklist-32cross-validation of shorter versions screening for bipolar disorders in an epidemiological study. There is evidence that the diagnosis of bipolar disorder patients may be delayed in 8 to 10 years, and this is especially relevant in BDII, where hypomania is often overlooked (2). The HCL-32 is a screening tool for researchers trying to find people with bipolar disorder. HHS Vulnerability Disclosure, Help I can be exhausting or irritating for others, HCL-28. For research purposes, data was also collected from a separate non-clinical sample, recruited using a non-probabilistic sampling technique. ROC curves showing the power of the HCL-32 scores to discriminate between BSD and MDD, OPD and DMC according to the MINI. 2008;106(1-2):13343. I take more drugs (sedatives, anxiolytics, stimulants) If you never experience such a "high" please stop here. Also, a significant difference in age mean between the control group and the clinical samples may have had an impact in the HCL-32 differences observed in further analyses. 2007;48(1):7987. The HCL-32 showed an adequate discrimination power for distinguishing individuals with BDs from those with major depressive disorders in previous studies [69]. Figure Figure33 shows that HCL-32 total scale and both of the subscales have similarly good discriminative properties in a more ecological assessment context. Healthy subjects between 18 and 60years of age were recruited from the local community from February to June in 2012 as a control group for the BD studies of our research group. Furthermore, we found the scale has good criterion validity to identify patients with BSD, namely when diagnosis was defined formally using the MINI, based on DSM-IV diagnosis criteria. The irritable/risk-taking factor score had acceptable ranges of specificity (0.62) and sensitivity (0.650.74). The mean HCL-32 total score was significantly higher in the Bipolar II disorder group compared to the non-clinical group (P<0.001). Furthermore, when using the HCL-32 subscales, AUC of the ROC curves demonstrated that the two HCL factors (Factor 1: active/elated, Factor 2: risk-taking/irritable) have differential screening ability to distinguish BSD patients against all samples (MDD, OPD, DMC). The FDR procedure controls for the expected proportion of false discoveries (i.e. Received 2018 Jul 18; Accepted 2018 Oct 4. Similarly to previous research, we also found a dual-factor structure of the scale, namely with active/elated and risk-taking/irritable subscales. Perceptions and impact of bipolar disorder: how far have we really come? 2. Psychiatry Res. Screening for postpartum hypomania among Chinese women after childbirth. 2004;344:53948. 1995;57:289300. ROC curves are obtained by plotting the true positive rate (i.e., sensitivity) in function of the false positive rate (1-specificity), with each point in the curve representing a sensitivity/specificity pair corresponding to a decision threshold. However, the irritable/risk-taking factor score with an AUC range of 0.670.75 was better able to differentiate between the two groups. The accuracy of the Italian version of the Hypomania Checklist (HCL-32) for the screening of bipolar disorders and comparison with the Mood Disorder Questionnaire (MDQ) in a clinical sample. Identifying a past history of hypomania can be difficult (8) and, as a result, BSDs are frequently misdiagnosed as unipolar major depressive disorder (5), borderline personality disorder (9), or other disorders. I have more ideas, I am more creative, HCL-14. MC, SA, and AO-M wrote the manuscript that was critically reviewed and approved by the remaining authors. Introduction: Hypomania symptoms are best described as a continuum, ranging beyond Bipolar Spectrum Disorders (BSD). Anxiety traits followed a similar pattern, correlating moderately only with the HCL-32 total score (r = 0.37, p < 0.0001) and the active/elated subscore (r = 0.39, p < 0.0001). The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients. I do think more quickly and/or more easily, HCL-25. Demographically, female dominance was observed in both the patient group and the control group and had no significant difference among groups. Europe PMC is an archive of life sciences journal literature. Holtmann M, Prtner F, Duketis E, Flechtner HH, Angst J, Lehmkuhl G. Validation of the Hypomania Checklist (HCL-32) in a nonclinical sample of German adolescents. This phenomenon is indicated by the much better discrimination properties (AUC and sensitivity and specificity at optimal cut-off score) of the risk-taking/irritable factor score compared to the HCL-total score and active/elated factor score. As a result, the cut-off scores of the HCL-32 yielding the best combination of sensitivity and specificity for screening BDs in the present study (1921) were higher than the cut-off score of 14 that has been accepted as optimal for discriminating BDs from MDD in previous studies [6, 8, 32, 34]. Table Table44 summarizes the mean scores of the Portuguese HCL-32 total score, and the active/elated and risk-taking/irritable subscores of all four-sample groups. Yang H, Yuan C, Liu T, Li L, Peng H, Liao C, et al.. Validity of the 32-item Hypomania Checklist (HCL-32) in a clinical sample with mood disorders in China. 2010;121(1):1436. My mood is higher, more optimistic. and transmitted securely. Although anxiety disorders are known co-morbidities of BSD (2, 13), our results may also reinforce the proposal that STAI scales don't strictly assess anxiety but also negative affect, resulting in similar correlations with anxiety and depressive symptoms (40). Data from a non-clinical sample was collected exclusively for research purposes, in healthy volunteers for whom BDI-II and HCL-32 were applied. Holtmann M, Prtner F, Duketis E, Flechtner H-H, Angst J, Lehmkuhl G. Validation of the Hypomania Checklist (HCL-32) in a nonclinical sample of German adolescents. sharing sensitive information, make sure youre on a federal Haghighi M, Bajoghli H, Angst J, Holsboer-Trachsler E, Brand S. The Farsi version of the Hypomania Check-List 32 (HCL-32): applicability and indication of a four-factorial solution. 2011;131(1):6878. 2012-09-056). These results are consistent with results of a previous study by Meyer et al. Our local Ethics Committee granted approval for retrospective analysis of fully anonymous and de-identified data from this patient population. To test temporal stability of HCL-32 in the clinical sample, single measures intra-class correlation coefficient (ICC) was employed. 1. However, these authors did not propose its use as a subscale due to concerns regarding the presence of irritability and risk taking behaviors in other psychiatric disorders. Positive & Negative Positive Negative No Impact Family Life Social Life Work Leisure 5. We received written consent from the subjects for the use of their psychological test data from clinical researches of Samsung Medical Center. INSTRUMENT TITLE:The Hypomania Checklist (HCL-32) SOURCE ARTICLE: Angst, J., Adolfsson, R., Benazzi, F., Gamma, A., Hantouche, E., Meyer, T. D., et al. London: Constable & Robinson Ltd; 2001. p. 3-39. the contents by NLM or the National Institutes of Health. "Vitamn C njdete v ovoc, ako s pomarane a jahody, a vitamn E v . Validation of the Chinese version of the Hypomania Checklist (HCL-32) as an instrument for detecting hypo (mania) in patients with mood disorders. Internal consistency of the European Portuguese HCL-32 was assessed using Cronbach's alpha () and, based on the two-factor model found in previous studies (11, 18), a Principal Component Analysis (PCA) with varimax orthogonal rotation was conducted to assess factorial structure. [17]. The HCL-32 total score showed high specificity (0.820.93) and poor sensitivity (0.310.36). Sheehan DV, Lecrubier Y, Harnett-Sheehan K, Amorim P, Janavs J, Weiller E, et al.. For both samples, only adults, 18 years or older, were eligible. 1988;240(4857):128593. However, the primary goal of this study was to assess the utility of HCL-32 for screening individuals with BSD, in order to avoid missing a diagnosis of BSD. [13] have developed a self-report questionnaire, the 32-item Hypoma-nia Checklist (HCL-32), to detect hypomania in those with depression in order to optimise diagnosis of bipolar II disor-der. Merikangas KR, Jin R, He JP, Kessler RC, Lee S, Sampson NA, et al.. As expected, HCL-32 scores differed significantly between all groups, with the BSD group having the higher scores and the HC group the lowest scores. Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. I want to travel and do travel more, HCL-7. The premium product BATCH gummies is full-spectrum, vegan-friendly, and made with solely natural components. Number of patients and percentages are displayed respectively. We also found a moderate positive correlation for anxiety symptoms as well as anxiety traits, which is in agreement with Fornaro et al. In 56 patients, a psychiatric diagnosis was not defined or diagnostic criteria were not met. I am more impatient and/or get irritable more easily, HCL-26. Hirschfeld RM, Williams JB, Spitzer RL, Calabrese JR, Flynn L, Keck PE, Lewis L, McElroy SL, Post RM, Rapport DJ. As expected, total score and subscores of the HCL-32 revealed higher mean hypomania symptom severity scores in the BSD group, followed by the MDD, OPD, and HC groups. 2000;157(11):18735. Scott J, Grunze H, Meyer TD, Nendick J, Watkins H, Ferrier N. A bipolar II cohort (ABC): the association of functional disability with gender and rapid cycling, Kaplan and Sadock's Comprehensive Textbook of Psychiatry, Perceptions and impact of bipolar disorder: how far have we really come? Compared to other people, my level of activity energy and mood: (Not how you feel today, but how you are on average). The other 4/5ths of the points possible come from other factors such as family history, age of onset of depression, course of the depressions since, and response to medications. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. When compared to the HCL-32 total score, the risk-taking/irritable subscore seems to provide additional benefit in discriminating between different clinical groups, namely regarding specificity in the discrimination from patients with a diagnosis of major depressive disorder that was low for the full scale and the alternate subscale. The present study shows that most of the items of irritable/risk-taking factor of the HCL-32 could be useful in the screening of hypomanic state of the BD2 in the non-clinical population. RESPONSE OPTIONS: YES or NO SURVEY ITEMS: The exclusion criteria were 1) patients whose clinical diagnosis and diagnosis by a structured interview were not consistent, 2) patients in unstable or severe clinical status who could not cooperate with the study procedures, and 3) individuals who were illiterate, suffering from mental retardation, dementia or intellectual impairment. Internal consistency for the HCL-32 Active/Elated and Risk-Taking/Irritable subscores was also adequate with Cronbach's coefficients of 0.86 and 0.71, respectively. 2012;143(1-3):2037. Federal government websites often end in .gov or .mil. Ferrari AJ, Baxter AJ, Whiteford HA. The demographic and clinical characteristics of the subjects are presented in Table1. Consequences of such misdiagnosis include inadequate treatment and worsening of the disorder, inappropriate use of antidepressants, litigation and increased risk of suicide (10). The PCA yielded 32 factors, the first 8 of which with an Eigenvalue of 1 or more. 2023 BioMed Central Ltd unless otherwise stated. I feel more energetic and more active, HCL-5. Irritable/risk-taking score was highest in the BD2 group and there was a significant difference among groups (P<0.001, control Effaclar Duo (+) Spf 30 Viagra Soft,
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