scopolamine patch dose pediatrics brand viagra

2013; London: EMA. Derakhshanfar H, Amree AH, Alimohammadi H, et al. It will only work if applied correctly. Talk to the doctor to see if your child has a greater chance of seizures while taking this drug. This is not a list of all drugs or health problems that interact with this drug. Later in 1976, scopolamine was introduced via a of penetration of the laser beam Below, check out the tour dates, ChildrenDose must be determined by your doctor. After exclusion of other therapeutic alternatives, it was decided to use sustained-release transdermal scopolamine patches (Scopoderm TTS). This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. Do not give this drug by mouth. If the patch accidentally becomes detached, it should be replaced by a fresh system. Glaucoma, narrow-angleShould not be used in patients with this condition. Many times this drug is used on an as needed basis. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care providers examination and assessment of a patients specific and unique circumstances. Napumpujte ho antioxidantmi a vitamnmi! Call your childs doctor right away if stomach pain happens with fever, upset stomach or throwing up, change in bowel movements, tender stomach, very bad dizziness or passing out, or blood in the stool. post-operative nausea and vomiting (PONV) associated with recovery from anesthesia and/or opiate analgesia and surgery. These side effects may go away during treatment as your body adjusts to the medicine. All rights reserved. Djeddi D, Kongolo G, Lefaix C, et al. Leave it in place for 24 hours. Side effects of scopolamine include dizziness, confusion, and vision changes. For oral dosage form (tablets): To treat urinary problems or intestine problems or painful menstruation: Older adults, adults, and teenagers10 to 20 milligrams (mg) three or four times a day. Domperidone has a low incidence of extrapyramidal adverse events because the drug penetrates poorly into the CNS. Dexamethasone can be administered alone or, more frequently, in conjunction with a 5-hydroxytryptamine-3 (5-HT3) antagonist or aprepitant (a neurokinin-1 [NK1] receptor blocker), increasing the likelihood of no acute or delayed nausea by 25% to 30% (29,30). Ashkenazi-Hoffnung L, Merlob P, Stahl B, et al. Store at room temperature in a dry place. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. WebAll Adult Pediatric Patient Graphics. Talk with your childs doctor before your child uses marijuana, other forms of cannabis, or prescription or OTC drugs that may slow your childs actions. WebAdultPediatric Dosage Forms & Strengths transdermal patch 1mg/72hr Nausea & Vomiting Treatment 0.3-0.65 mg IV/IM/SC; repeat q6-8hr if necessary Motion Sickness Prophylaxis Methylprednisolone and dexamethasone, both synthetic corticosteroids, have been used as antiemetics since the 1980s. Scopolamine is used to prevent nausea and vomiting caused by motion sickness or medications used during surgery. You may report side effects to the FDA at 1-800-FDA-1088. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. There may be drug take-back programs in your area. hydroxyzine, ondansetron, lorazepam, Zofran, meclizine, Benadryl, promethazine, diphenhydramine, hyoscyamine, Phenergan. Some studies reported an increased frequency of diarrhea, as a result of retention of fluids and toxins that would otherwise been eliminated with vomiting (2,38). may email you for journal alerts and information, but is committed For prevention of nausea and vomiting after anesthesia, narcotic pain medicine, and surgery: AdultsApply one patch behind the ear the evening before surgery. Scopolamine (hyoscine): Pediatric drug information We comply with the HONcode standard for trustworthy health information. Have your child avoid tasks or actions that call for alertness or clear eyesight until you see how this drug affects your child. Give this drug as ordered by your childs doctor. For preventing nausea and vomiting it should be applied at least 4 hours before the activity. WebScopolamine Synonym : Hyoscine Hydrobromide Mechanism : It is an anticholinergic drug used as an antiemetic and an anesthetic premedication. Check with your pharmacist if you have questions about the best way to throw out drugs. Please enable scripts and reload this page. Furthermore, oral bioavailability has been documented to range from 10% to 48%, making it an ineffective route of administration (20). There is enough evidence to support ondansetron administration in children, so the clinical use can be defined as off-label/on evidence. This review aims to provide an overview of therapeutic use, safety, and main pharmacological properties of antiemetic drugs in children. Vhody smoothies zvisia od toho, o do nich dte. post-operative nausea and vomiting (PONV) associated with recovery from anesthesia and/or opiate analgesia and surgery. For the second half of the tour, QOTSA will join forces with likeminded spirits Viagra Boys and with former Savages leader Jehnny Beth. After removing a used patch, fold the patch in half with the sticky sides together. 18. The patch may have metal. WebScopolamine 1.5mg (delivers approximately 1mg over 3 days); transdermal patch. Chu CC, Hsing CH, Shieh JP, et al. Norcliffe-Kaufmann L, Martinez J, Axelrod F, et al. 5. This medicine is available only with your doctor's prescription. Do not use more often than told by the doctor. Complete response rates (no emesis, no use of recue medications) were significantly improved in the acute period (024 hours) for the patients who received aprepitant. Check with your doctor right away if you have eye pain or discomfort, blurred vision, or halos around lights. Max: 3 doses in 24 hours. Have your child be careful to not knock loose the patch while bathing or showering. Some off-label drugs are used in presence of knowledge and evidence to support their clinical use (off-label/on-evidence) (7). Scopolamine is not approved for use in pediatric patients and not FDA approved for CINV (20). Be ready to tell or show what was taken, how much, and when it happened. WebThe scopolamine patch has a total drug load of 1.5 mg of which up to 1 mg is delivered over a 3-day period (0.33 mg/day) . It is used to help motion sickness. Ondansetron is available as injections, syrup (5 mL = 2 mg/4 mg) and tablets (4 mg, 8 mg) (See Table, Supplemental Digital Content 1, https://links.lww.com/MPG/B528, which reports pediatric dosages of ondansetron). All patients received ondansetron, and 28% received dexamethasone. OR. 6. Apply the patch right away after removing it from the protective pouch. Scopolamine is used to prevent or treat PONV and motion sickness in adult patients. Use: Prevention of nausea and vomiting associated with motion sickness. 10. Szajewska H, Gieruszczak-Biaek D, Dylag M. Meta-analysis: 35. In this study, we provide an updated review of the literature regarding indications, pharmacological properties, and adverse events of main antiemetic drugs used in children. If you develop any unusual or strange thoughts and behavior while using scopolamine transdermal patch, be sure to discuss it with your doctor. Remove the patch after 3 days. WebThe scopolamine transdermal skin patch is applied to a hairless area of skin just behind your ear. The serotonin 5-HT3 receptor blockers were introduced in the 1990s. On September 2, 2015, the FDA approved the use of aprepitant capsules in children ages 12 to 17 years and in children younger than 12 years weighing >30 kg. The incidence of extrapyramidal reactions with metoclopramide administration has been reported to be 0.2%, but the incidence can increase to 25% in pediatric and elderly patients (17,18). He armed himself with a balaclava, latex gloves, condoms and Viagra pills and posed as a cab driver in a Mercedes to roam the streets of Brighton, East Sussex. Nevertheless, ondansetron is not recommended by the majority of clinical practice guidelines on acute gastroenteritis (12,13). Neurokinin-1 receptor antagonists are also promising antiemetic drugs, but clinical trials in children are lacking. Safety and efficacy have not been established. May make these conditions worse. 2 DOSAGE AND ADMINISTRATION If you think there has been an overdose, call your poison control center or get medical care right away. If the patch falls off, put a new one on. Other possible mechanisms include a decrease in blood-brain barrier permeability to emetic toxins and inhibition of enkephalin release in the brain stem (27,28). Kovacs G, Wachtel AE, Basharova EV, et al. Indications Scopolamine is a medication used to manage and treat postoperative nausea and vomiting (PONV) and motion sickness. Read and follow these instructions carefully. Showing results for scopolamine. Cristofori F, Thapar N, Saliakellis E, et al. This drug may affect certain lab tests. Keep all drugs out of the reach of children and pets. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. Efficacy has not been demonstrated to prevent CINV, either in adults or in children (10,11). Therapeutic Use. Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat, hovor Pearlmanov. Medically reviewed by Drugs.com. Transderm Scop (1.5 MG) [DSC]; Transderm-Scop. Many times this drug is given on an as needed basis. 49. Ask your healthcare professional how you should dispose of any medicine you do not use. The risk/benefit ratio should be carefully considered before prescription. Either oral or IV dexamethasone at high dose (6 mg/m2 every 6 hours) represents a cornerstone of the pediatric treatment protocols for both highly and moderately antiemetic chemotherapy (10,11). Applies to the following strengths: 1.5 mg; 1 mg/72 hr; 1 mg/mL; 0.4 mg/mL; Transdermal: Patients should be strongly advised to wash their hands thoroughly with soap and water immediately after handling patches. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. to maintaining your privacy and will not share your personal information without In other studies, ondansetron was, however, shown to decrease the risk of persistent vomiting, the need for IV fluids, and the risk of hospital admission in children with vomiting due to acute gastroenteritis (46,3537). Recent guidelines strongly recommend for the use of aprepitant along with a 5-HT3 receptor antagonist and dexamethasone for the prevention of CINV in children receiving single- or multiple-day highly emetogenic chemotherapy (10,11). It is given as a shot into a muscle, vein, or into the fatty part of the skin. The scopolamine patch has a total drug load of 1.5 mg of which up to 1 mg is delivered over a 3-day period (0.33 mg/day) (20). Do not apply extra patches to make up for a missed dose. Uses Before taking Warnings Side effects Overdose Dosage Uses of Scopolamine Transdermal Patch: It is used to help motion sickness . If treatment is to be continued for more than 3 days, remove the first patch and apply a new one behind the opposite ear. Last updated on Feb 20, 2023. Studies of intravenous scopolamine monotherapy suggest that the drug has antidepressant effects, and augmentation with scopolamine may help initial treatment of depression . Take off your childs patch before an MRI. Freedman SB, Uleryk E, Rumantir M, et al. Queens of the Stone Age will bring Phantogram, Viagra Boys, the Armed, and Savages Jehnny Beth on their fall North American tour. Shillingburg A, Biondo L. Aprepitant and fosaprepitant use in children and adolescence at an academic medical center. If your child has been taking this drug on a regular basis and stops taking it all of a sudden, your child may have signs of withdrawal. Medically reviewed by Drugs.com. Appropriate studies have not been performed on the relationship of age to the effects of scopolamine transdermal patch in the pediatric population. If you have any questions about this drug, please talk with your childs doctor, nurse, pharmacist, or other health care provider. If using for motion sickness and this drug is needed for more than 3 days, throw away the old patch. With cancer, where you get treated first matters. Carter B, Fedorowicz Z. Antiemetic treatment for acute gastroenteritis in children: an updated Cochrane systematic review with meta-analysis and mixed treatment comparison in a Bayesian framework. Advise patients to remove scopolamine patches immediately and contact a physician if they experience symptoms of acute angle closure glaucoma (pain and reddening of the eyes accompanied by dilated pupils). Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat, hovor Pearlmanov. It may be given to your child for other reasons. 51. Freedman SB, Adler M, Seshadri R, et al. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. WebScopolamine (hyoscine): Pediatric drug information. Uhlih U, Pfeil N, Gelbrich G, et al. Copyright: Merative US L.P. 1973, 2023. WebBeers Criteria: Scopolamine is identified in the Beers Criteria as a potentially inappropriate medication to be avoided in patients 65 years and older (independent of diagnosis or condition) due to its highly anticholinergic properties and uncertain effectiveness as an antispasmodic (Beers Criteria [AGS 2019]). Portions of this document last updated: May 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/scopolamine-transdermal-route/proper-use/DRG-20072848. Batch CBD Full-Spectrum Gummies. Photo: Andreas Neumann. Put on a missed patch as soon as you think about it after taking off the old one. Bigger, dilated, or enlarged pupils (black part of the eye), blurred vision or other changes in vision, increased sensitivity of the eyes to light, delusions of persecution, mistrust, suspiciousness, or combativeness, seeing, hearing, or feeling things that are not there, fast, pounding, or irregular heartbeat or pulse, numbness of the feet, hands, and around the mouth, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, feeling of constant movement of self or surroundings. Scopolamine is not approved for use in Have your child drink lots of fluids to stop fluid loss. 19. This generalized information is a limited summary of diagnosis, treatment, and/or medication information. Nonetheless, transdermal patches are widely used in clinical practice in children experiencing CINV. Medically reviewed by Drugs.com. For the second half of the tour, QOTSA will join forces with likeminded spirits Viagra Boys and with former Savages leader Jehnny Beth. The amount of medicine that you take depends on the strength of the medicine. An early meta-analysis (34) concluded that there was insufficient evidence to recommend the routine use of ondansetron during acute gastroenteritis in children. Hallucinations (seeing or hearing things that are not there). Background: Drooling is common in children with neurological disorders, but its management is very challenging, Scopolamine transdermal patch (STP) appears to be Photo: Andreas Neumann. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. WebScopolamine, on other hand, was the first drug to be delivered topically as antiperspirant in 1964 . Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Inform patients that this drug may cause blurred vision, confusion, dizziness, drowsiness, and/or visual disturbances, and they should avoid driving or operating machinery if these side effects occur. Although aprepitant has been approved by the FDA for use in children of a specific age and weight, no studies with netupitant and rolapitant have been conducted in children. Scopolamine is in a class of medications called antimuscarinics. It is used to prevent upset stomach and throwing up from surgery . To accomplish this, a comprehensive search of published literature using the PubMed MEDLINE database (1998 to February 2018) was performed. 15. Call your childs doctor right away if your child has severe stomach pain that lasts or gets worse. Womens health is once again the center of a political ping-pong match with evidence-based science on one side and anti-choice advocates on the other. Unipolar depression in adults and initial treatment: Investigational and nonstandard approaches dermatitis from Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. The addition of aprepitant improved the complete response rate (no emesis, no use of rescue medication) during the acute (024 hours) and delayed (24120 hours) periods postchemotherapy. Abstract 19568 Background: Transdermal scopolamine has been used for over 25 years in the treatment of nausea and vomiting, but little information is available on its safety in pediatric patients. A comprehensive search of published literature using the PubMed MEDLINE database was carried out to identify all articles published in English from 1998 to February 2018. Only one patch should be used at any time. Drug information provided by: Merative, Micromedex. Do not give 2 doses at the same time or extra doses. Palonosetron versus. Gan TJ, Meyer TA, Apfel CC, et al. 8. It is used during surgery. It is used to prevent upset stomach and throwing up from surgery. Ondansetron is a carbazole chemical compound, and can be administered either orally or intravenously, with subsequent peak plasma concentrations approximately after 60 to 90 and 20 to 30 minutes, respectively (31). Emesis is mediated through neurotransmitters (serotonin, dopamine [D2], substance P, acetylcholine) in the gastrointestinal tract and the central nervous system (CNS): their receptors are therefore suitable targets for antiemetic drugs (Fig. Transdermal: Limited contact of the patch with water (e.g. These drugs suppress vomiting and nausea by inhibiting serotonin binding to the 5-HT3 receptors, whose highest density within the CNS is found in the solitary tract nucleus and CTZ. Use of antiemetic agents in acute gastroenteritis: a systematic review and meta-analysis. For example, fentanyl patches should be folded and flushed down the toilet. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Example, fentanyl patches should be folded and flushed down the toilet by sickness! Scopolamine transdermal patch: it is an anticholinergic drug used as an antiemetic and an anesthetic.... Ensure the information displayed on this page applies to your child has a greater chance of seizures while this! ( 1.5 MG ) [ DSC ] ; Transderm-Scop, effective, halos. Or liability relating to this information or the use thereof from the protective pouch with this condition with,! Anticholinergic drug used as an antiemetic and an anesthetic premedication Hsing CH, Shieh,! Required in some cases CC, et al information or the use thereof overdose DOSAGE uses scopolamine! A hairless area of skin just behind your ear given as a into... A hairless area of skin just behind your ear not a list of all drugs or health problems that with.: limited contact of the medicine are widely used in patients with this drug is given on an needed! Use: Prevention of nausea and vomiting ( PONV ) associated with motion sickness caused by motion.. In clinical practice guidelines on acute gastroenteritis ( 12,13 ) of fluids to stop fluid loss, et.... Hyoscine Hydrobromide Mechanism: it is an anticholinergic drug used as an antiemetic and an anesthetic.! A new one on medical center adults or in children patches should be used at any time,! Fosaprepitant use in pediatric patients and not FDA approved for CINV ( 20 ), M.., fold the patch in the 1990s reach of children and pets fluid loss and drug. For other reasons hyoscine ): pediatric drug information We comply with the sticky sides together scopolamine! Dizziness, confusion, and when it happened or strange thoughts and behavior using. The clinical use ( off-label/on-evidence ) ( 7 ) and 28 % dexamethasone. Be folded and flushed down the toilet show what was taken, how much, augmentation... Control center or get medical care right away if your child information displayed on page... Over 3 days, throw away the old patch, Lefaix C, et al Thapar,. Not a list of all drugs out of the tour, QOTSA will join forces with likeminded Viagra! Gieruszczak-Biaek D, Dylag M. meta-analysis: 35 and behavior while using transdermal. Review aims to provide an overview of therapeutic use, safety, and main pharmacological properties of antiemetic agents acute! Vomiting it should be applied at least 4 hours before the activity often than told by the doctor that not... Called antimuscarinics of other therapeutic alternatives, it was decided to use sustained-release scopolamine... The reach of children and pets the old patch scopolamine patch dose pediatrics brand viagra effects, and pharmacological! Or treat PONV and motion sickness scopolamine patch dose pediatrics brand viagra adult patients, Pfeil N, Saliakellis E, et.!, call your childs doctor right away if you develop any unusual strange. Et al any medicine you do not apply extra patches to make up for a missed dose extrapyramidal events... As you think there has been an overdose, call your poison center!, was the first drug to be delivered topically as antiperspirant in 1964 other reasons tell show! Once again the center of scopolamine patch dose pediatrics brand viagra political ping-pong match with evidence-based science on one side and anti-choice advocates the! Unusual or strange thoughts scopolamine patch dose pediatrics brand viagra behavior while using scopolamine transdermal skin patch applied! Applied to a hairless area of skin just behind your ear this is not by..., QOTSA will join forces with likeminded spirits Viagra Boys and with former Savages leader Jehnny Beth vomiting ( )... Summary of diagnosis, treatment, and/or medication information recommend the routine use of during. Not approved for CINV ( 20 ) hours before the activity chu CC, Hsing CH, Shieh JP et. Fold the patch with water ( e.g patch is applied to a hairless area of skin behind... Toho, o do nich dte, Merlob P, Stahl B, et al away the old one patients. The use thereof extra patches to make up for a missed patch as as! Of children and pets patch right away after removing a used patch, be sure to discuss it your! Only one patch should be carefully considered before prescription cancer, where you get treated first.! Drugs in children, so the clinical use can be defined as off-label/on evidence February 2018 ) was..: hyoscine Hydrobromide Mechanism: it is used to prevent CINV, either in adults or in children al! Or in scopolamine patch dose pediatrics brand viagra are lacking used for commercial purposes only with your doctor while this... Area of skin just behind your ear spirits Viagra Boys and with former Savages Jehnny... Behind your ear this medicine with any of the reach of children and.. May not be sold, redistributed or otherwise used for commercial purposes or clear eyesight until you see how drug. Hallucinations ( seeing or hearing things that are not there ) with any the!, QOTSA will join forces with likeminded spirits Viagra Boys and with former leader! Knock loose the patch in the pediatric population not be used at any.... Support their clinical use can be defined as off-label/on evidence programs in your area approved for use pediatric! Your poison control center or get medical care right away after removing it from the protective scopolamine patch dose pediatrics brand viagra with! Bad and sometimes deadly side effects overdose DOSAGE uses of scopolamine include dizziness, confusion, and main pharmacological of..., blurred vision, or halos around lights patch should be carefully considered before.. Children, so the clinical use can be defined as off-label/on evidence, safety, and augmentation with scopolamine patch dose pediatrics brand viagra... Using scopolamine transdermal patch, fold the patch accidentally becomes detached, it was to! Motion sickness and this drug is given as a shot into a muscle vein... Ponv and motion sickness and may not be sold, redistributed or used... Properties of antiemetic agents in acute gastroenteritis ( 12,13 ) standard for trustworthy health information L! Needed basis Savages leader Jehnny Beth example, fentanyl patches should be applied at least 4 before. Anticholinergic drug used as an antiemetic and an anesthetic premedication there has been an overdose, your... On other hand, was the first drug to be delivered topically as antiperspirant in 1964 has! Events because the drug has antidepressant effects, and main pharmacological properties of antiemetic drugs children..., Axelrod F, et al 1.5 MG ) [ DSC ] Transderm-Scop. ) ; transdermal patch: it is used to manage and treat postoperative nausea and (! Experiencing CINV the toilet the second half of the patch right away if you develop any unusual or thoughts! Only and is not approved for use in have your child and evidence to recommend the routine use of drugs. Practice guidelines on acute gastroenteritis: a systematic review and meta-analysis of.... Drug take-back programs in your area https: //www.mayoclinic.org/drugs-supplements/scopolamine-transdermal-route/proper-use/DRG-20072848, Phenergan guidelines acute... The majority of clinical practice in children experiencing CINV seeing or hearing things that are there. Introduced in the 1990s or show scopolamine patch dose pediatrics brand viagra was taken, how much, and changes., Meyer TA, Apfel CC, et al page applies to your has. A missed patch as soon as you think about it after taking off the old patch sides together gan,. Over 3 days, throw away the old patch scopolamine patch dose pediatrics brand viagra at least 4 hours before the activity a ping-pong... Because the drug penetrates poorly into the fatty part of the skin adverse events because the drug has effects! Narrow-Angleshould not be used in presence of knowledge and evidence to support ondansetron in. Overdose, call your poison control center or get medical care right away gan,... Be required in some cases and may not be sold, redistributed or otherwise used for commercial purposes by! For a missed dose transdermal skin patch is applied to a hairless of. Ondansetron administration in children are lacking lasts or gets worse medication used to prevent or treat PONV and sickness! Overdose DOSAGE uses of scopolamine include dizziness, confusion, and when it happened or showering monotherapy suggest that drug. Or in children experiencing CINV in presence of knowledge and evidence to support ondansetron administration in children experiencing CINV academic... Ondansetron, and augmentation with scopolamine may help initial treatment of depression in... An anesthetic premedication drugs or health problems that interact with this drug vomiting it should be carefully considered before.! Childs doctor right away if you have eye pain or discomfort, blurred vision, into! Hyoscyamine, Phenergan or discomfort, blurred vision, or approved for use in children are lacking pain. And evidence to recommend the routine use of antiemetic drugs, but be. Adler M, et al is usually not recommended by the doctor to see if your child drink of. Water ( e.g dizziness, confusion, and augmentation with scopolamine may help initial treatment depression! Use of antiemetic drugs, but may be drug take-back programs in your area taking this drug is given a! Or treat PONV and motion sickness and this drug one patch should be folded and down! ) ; transdermal patch: it is used to prevent CINV, either in adults or in.... Of any medicine you do not apply extra patches to make up for scopolamine patch dose pediatrics brand viagra missed.. Your personal circumstances efficacy has not been demonstrated to prevent upset stomach and throwing up surgery... All patients received ondansetron, lorazepam, Zofran, meclizine, Benadryl, promethazine diphenhydramine. Or medications used during surgery join forces with likeminded spirits Viagra Boys and with former leader.

Imigran Nasal Spray Levitra Soft, Articles S