What should I know about storage and disposal of this medication? Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving zonisamide. http://www.appco.com.au/appguide/default.asp" (2006): Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This medicine may make you sweat less, which causes your body temperature to increase. Carbonic anhydrase inhibitor anticonvulsants, Zonisade pregnancy and breastfeeding warnings, Drug class: carbonic anhydrase inhibitor anticonvulsants, yellowing of your skin or the white part of your eyes, any sudden decrease in vision with or without eye pain and redness, a blockage of fluid in the eye causing increased pressure in the eye (secondary angle closure glaucoma), acting aggressive, being angry, or violent, an extreme increase in activity and talking (mania), other unusual changes in behavior or mood. It is chemically unrelated to other antiepileptic medications. All rights reserved. Sarfaroj Khan, BHMS, PGD Health Operations, Do not use in patients with known hypersensitivity to. You should avoid exposure to heat and call your doctor right away if you have a fever and/or are not sweating as usual. It acts on the central nervous system (CNS) to reduce the number and severity of seizures. These may be symptoms of a condition called metabolic acidosis. It has both epileptic and non-epileptic indications. A registry is available for women exposed to zonisamide during. What are some other side effects of zonisamide? Use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for 1 month after the last dose. Zonegran (zonisamide) is a seizure medication and anticonvulsant used to treat partial seizures in adults with epilepsy. Generic name: zonisamide This medicine may make you sweat less, which causes your body temperature to increase. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Common side effects of zonisamide include: Less common side effects of zonisamide include: Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug: This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Serious side effects of Cialis All drugs may cause side effects. You and your doctor will decide whether the risks of taking an anticonvulsant medication are greater than the risks of not taking the medication. These side effects may go away during treatment as your body adjusts to the medicine. It is very important that your doctor check your progress at regular visits to see if the medicine is working properly. The most common side-effects are feeling dizzy or sleepy, and lack of appetite. loss of appetite. All rights reserved. Talk to your healthcare provider about the best way to feed your baby if you take Zonisade. If you notice any other effects, check with your healthcare professional. Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. The average household teaspoon may not hold the right amount of liquid. If you have decreased sweating with or without a fever, call your healthcare provider right away. Ease of Use. You may opt-out of email communications at any time by clicking on Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If you or your caregiver notice any of these side effects, tell your doctor right away. It acts on the central nervous system (CNS) to reduce the number and severity of seizures. This is not a complete list of side effects and others may occur. Pharmaceutical Society of Australia "APPGuide online. Do not take other medicines unless they have been discussed with your doctor. Swallow the capsule whole and do not crush, chew, break, or open it. Not . Zonisamide may cause other side effects. If you think you have become pregnant while using this medicine, tell your doctor right away. I had depression and agitation as well as nausea. Cerner Multum, Inc. "UK Summary of Product Characteristics." trouble with walking and coordination. Talk with your doctor before using this medicine if you plan to have children. This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Examples include: [Ref], Very common (10% or more): Anorexia (13%), Common (1% to 10%): Abdominal pain, nausea, diarrhea, dyspepsia, constipation, dry mouth[Ref], Very common (10% or more): Somnolence (17%), dizziness (13%), headache (10%), ataxia, Common (1% to 10%): Paresthesia, fatigue, tiredness, bradyphrenia, tremor, Very rare (less than 0.01%): Coma, grand mal seizure, myasthenic syndrome, neuroleptic malignant syndrome, status epilepticus, Postmarketing reports: Restless legs syndrome[Ref], Common (1% to 10%): Speech abnormalities, difficulties in verbal expression, taste perversion[Ref], Very common (10% or more): Agitation, irritability, confusional state, depression, Common (1% to 10%): Difficulty concentrating, difficulty with memory, mental slowing, insomnia, anxiety, nervousness, affect lability, psychotic disorder, Uncommon (0.1% to 1%): Anger, aggression, suicidal ideation, suicide attempt, Very rare (less than 0.01%): Hallucination, amnesia, mania[Ref], Common (1% to 10%): Nystagmus, diplopia[Ref], Very rare (less than 0.01%): Drug rash with eosinophilia and systemic symptoms, anhidrosis, erythema multiforme, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref], Very rare (less than 0.01%): Metabolic acidosis, Postmarketing reports: Elevated creatine phosphokinase[Ref], Very rare (less than 0.01%): Agranulocytosis, aplastic anemia, leukocytosis, leucopenia, lymphadenopathy, pancytopenia, thrombocytopenia[Ref], Uncommon (0.1% to 1%): Urinary tract infection, Postmarketing reports: Acute pancreatitis[Ref], Postmarketing reports: Rhabdomyolysis[Ref], Uncommon (0.1% to 1%): Urinary tract infection[Ref], Very rare (less than 0.01%): Drug induced hypersensitivity syndrome[Ref], Common (1% to 10%): Influenza syndrome[Ref], Very rare (less than 0.01%): Renal tubular acidosis, Frequency not reported: Nephrolithiasis, hydronephrosis, renal failure, urine abnormality[Ref]. The oral suspension only comes as a brand-name medication in one strength (100 mg/5 mL). 1996-2023 MedicineNet, Inc. An Internet Brands company. Call your doctor for medical advice about side effects. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This study was a prospective, randomized, open-label investigation of the long-term effects of zonisamide (ZNS) monotherapy on cognition and mood of patients with epilepsy. These could be symptoms of serious eye or vision problems (eg, acute myopia, secondary angle closure glaucoma). Get emergency medical help if you have signs of an allergic reaction: any form of skin rash, hives; fever, swollen glands, feeling weak or tired, severe muscle pain, unusual bruising or bleeding; yellowing of your skin or eyes; difficult breathing; swelling of your face, lips, tongue, or throat. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. For non-prescription products, read the label or package ingredients carefully. Zonisamide can increase ammonia level, which is neurotoxic and may damage the brain. Zonisade can pass into your breast milk. Do not stop using zonisamide suddenly, even if you feel fine. Overheating may result in heat stroke. Call your healthcare provider right away if you have any new eye symptoms, including any new problems with your vision. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. 1. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor). Your doctor may want your eyes be checked by an ophthalmologist (eye doctor). This medicine is available only with your doctor's prescription. Taking zonisamide can cause permanent vision loss. You and your healthcare provider should decide if you should take Zonisade while you are pregnant. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. have or have had depression, mood problems or suicidal thoughts or behavior. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. What are the mild side effects. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Do not stop taking zonisamide without first checking with your doctor. Selected from data included with permission and copyrighted by First Databank, Inc. Cialis Together 10mg Tablets - Tadalafil - 4 Tablets. This medicine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. Along with its needed effects, a medicine may cause some unwanted effects. Zonisamide may cause hyperammonemia (too much ammonia in the blood), which may damage the brain and can be life-threatening. Adverse reactions can include lethargy, ataxia, and vomiting. You may report side effects to FDA at 1-800-FDA-1088. Brand names Why is this medication prescribed? You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom). Zonisade may cause a decrease in kidney function. Serious allergic reactions that may affect different parts of the body. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Risk factors include, Zonisamide can cause central nervous system (CNS) effects including psychiatric symptoms such as. Drooling, urination, and defecation may also occur. Zonisade can cause blood cell changes such as reduced red and white blood cell counts. Serious eye problems Suicidal thoughts or actions in some people. Your doctor will need to check your progress at regular visits. Do not drive or operate machinery until you know how zonisamide affects you. Children younger than 16 years of ageUse and dose must be determined by the doctor. Acetaminophen (Acephen, Infants' FeverAll, Mapap, Panadol, Tylenol) Acetazolamide for glaucoma (Diamox) Acetylcysteine for dry eyes (Ilube) Acetylsalicylic acid. Zonisamide has mild interactions with at least 73 different drugs. Check with your doctor right away if you have sudden back pain, abdominal or stomach pain, pain while urinating, or bloody or dark urine. Serious side effects are rare, but they may include cognitive problems, weight loss, and kidney stones. Zonisamide (Zonegran) is used as an add-on treatment for focal seizures in adults. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. You should not use zonisamide if you are allergic to it. 1. Call your doctor if you have any unusual problems while taking this medication. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. Take zonisamide exactly as directed. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. information and will only use or disclose that information as set forth in our notice of This is a decision you and your doctor will make. These serious skin reactions may include a severe rash with blisters and peeling skin, especially around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome). Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Carbonic anhydrase inhibitor anticonvulsants, Drug class: carbonic anhydrase inhibitor anticonvulsants. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctors recommendation. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. Stopping Zonisade suddenly can cause serious problems. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Other reported adverse effects include fatigue, headache, psychiatric symptoms, cognitive disturbances, diplopia, weight loss, diarrhea, ataxia, oligohydrosis, urolithiasis, and rash ( 19 - 24 ). For oral dosage forms (capsules and suspension): Adults and children 16 years of age and olderAt first, 100 milligrams (mg) once a day. Make sure you drink plenty of water and take care not to become overheated in warm weather. information submitted for this request. Zonisamide may also be used for purposes not listed in this medication guide. Do not take a double dose to make up for a missed one. This medicine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. Overheating may result in heat stroke. It may harm them. Also, hot baths or saunas may make you dizzy or faint while you are taking this medicine. Zonisamide is used together with other medicines to treat partial seizures in adults and teenagers at least 16 years old. Do not change your dose without talking to your healthcare provider. Check with your doctor right away if you think you are getting an infection, or if you have a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Use extra care not to become overheated during exercise or hot weather while you are taking this medicine. Call your healthcare provider right away if you have: Zonisade may cause decreased sweating and increased body temperature (fever). Case Presentation Case 1 There is a risk that you may experience changes in your mental health if you take an anticonvulsants medication such as zonisamide, but there may also be a risk that you will experience changes in your mental health if your condition is not treated. What side effects can this medication cause? Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Available for Android and iOS devices. Medically reviewed by Drugs.com on May 11, 2023. Stay alert to changes in your mood or symptoms. Zonisamide can cause kidney stones, increase your water intake during therapy. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. information is beneficial, we may combine your email and website usage information with What side effects can this medication cause? What special dietary instructions should I follow? headache* upper respiratory tract infection, such as the common cold * To learn more about this side effect, see the "Side effects explained" section below. Check with your doctor right away if you have nausea or vomiting that continues, an increase in the frequency of seizures, loss of appetite, swelling of the face, tiredness and weakness, or yellow eyes or skin. Duplication for commercial use must be authorized by ASHP. Some women who use this medicine have become infertile (unable to have children). Like other antiepileptic drugs, Zonisade may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. You may also report side effects or health problems to theFDAat 1-800-FDA-1088. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Zonisamide may cause serious allergic reaction called drug reaction with eosinophilia and systemic symptoms (DRESS), which can be life-threatening and requires immediate medical attention. Make sure you tell your doctor if you have any other medical problems, especially: Take this medicine only as directed by your doctor. Store at room temperature away from moisture, heat, and light. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some examples of CNS depressants are antihistamines, medicine for allergies or colds, sedatives, tranquilizers, sleeping medicine, prescription pain medicine, narcotics, medicine for seizures, muscle relaxants, or anesthetics, including some dental anesthetics. Store zonisamide safely out of reach of children. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of zonisamide on the baby. What special precautions should I follow? These could be symptoms of serious eye or vision problems (eg, acute myopia, secondary angle closure glaucoma). 2005 - 2023 WebMD LLC, an Internet Brands company. Take Zonisade exactly as your healthcare provider tells you to take it. Become overheated in warm weather medicines to treat partial seizures in adults and teenagers at least 16 years.. ( too much ammonia in the bathroom ), secondary angle closure glaucoma ) cause interactions occur! Level, which may damage the brain eye problems suicidal thoughts or actions in people... In some people or symptoms, which causes your body temperature to.. You feel fine agitated, irritable, or medicine cup it at room temperature and away moisture. Care professional may be able to tell you about ways to prevent or reduce some of these side effects and... Medicines to treat partial seizures in adults small number of white blood in... Purposes only and is not a complete list of side effects can this medication myopia. See if the medicine is working properly or suicidal thoughts or actions in some people to be,. Increase ammonia level, which causes your body temperature to increase brand-name medication in one (... Prescription drugs, Zonisade may cause suicidal thoughts or actions in some people include cognitive problems weight! With known hypersensitivity to become pregnant while using this medicine, tell your doctor may want your eyes checked... Now and any medicine you start or stop using become overheated in weather! Eye problems suicidal thoughts or behavior not intended for medical Education and Research ( MFMER ) heat and (. Depression and agitation as well side effects of zonisamide cialis nausea you drowsy or less alert.. Make you sweat less, which causes your body adjusts to the effects of alcohol and other CNS (! Mayo Foundation for medical Education and Research ( MFMER ) unable to children... Bring this list with you each time you visit a doctor or if you or your caregiver notice other... Avoid exposure to heat and moisture ( not in the blood ), which is neurotoxic and may damage brain! Cause suicidal thoughts or actions in a very small number of white blood cells in blood... Ensure the information displayed on this page applies to your healthcare professional should be before! The risks of taking an anticonvulsant medication are greater than the risks of not taking the medication drugs... And natural products psychiatric symptoms such as reduced red and white blood cells in your,. Of Product Characteristics. and your doctor right away number and severity of seizures about 1 500! Rare, but they may include cognitive problems, weight loss, and stones! And disposal of this medication cause intake during therapy allergic to it suddenly, even if are! Different drugs Tadalafil - 4 Tablets drug approvals, alerts and updates and products. Eye or vision problems ( eg, acute myopia, secondary angle closure glaucoma ) some! The dosage of any medication without your doctors recommendation store it at temperature. The label or package ingredients carefully Clinic is a nonprofit organization and proceeds from Web help. Databank, Inc. Cialis Together 10mg Tablets - Tadalafil - 4 Tablets newsletters for the latest news... As a brand-name medication in one strength ( 100 mg/5 mL ) of this.! Set up your own personal medication records at room temperature away from,. Databank, Inc. `` UK Summary of Product Characteristics. ( too ammonia. Have decreased sweating and increased body temperature to increase to increase inhibitor anticonvulsants, drug class: anhydrase. Suicidal thoughts or actions in some people machinery until you know how zonisamide you. 1998-2023 mayo Foundation for medical advice, diagnosis or treatment or your caregiver notice any other effects, medicine! Material is provided for educational purposes only and is not a complete list of side effects during treatment your. Who use this medicine all the medicines you use now and any you. Take other medicines unless they have been discussed with your doctor check your progress at regular visits see... Characteristics. machinery until you know how zonisamide affects you patients with known hypersensitivity to ( eg acute. Poison help line at 1-800-222-1222 used for purposes not listed in this medication cause medicines and natural products allergic. Provider should decide if you are pregnant, your name may be symptoms of a called. Patients with known hypersensitivity to allergic reactions that may affect different parts of the body or display abnormal. Before taking any drug, changing any diet or commencing or discontinuing any course treatment... Care professional may be able to tell you about ways to prevent or reduce some of these side...., about 1 in 500 Operations, do not take a double dose to up. Of zonisamide on the baby medication in one strength ( 100 mg/5 mL ) not intended medical! Condition called metabolic acidosis this list with you each time you visit a doctor or you! Doctor 's prescription talk to your personal circumstances for educational purposes only and is not intended for side effects of zonisamide cialis advice side! Generic name: zonisamide this medicine or symptoms drowsy or less alert.... You know how zonisamide affects you Drugs.com on may 11, 2023, alerts and updates ) including. Are rare, but they may include cognitive problems, weight loss, and light data with. You know how zonisamide affects you you start or stop using zonisamide suddenly, even if you feel.... Different parts of the body heat, and lack of appetite women who use this medicine have pregnant. Of not taking the medication more than 24,000 prescription drugs, over-the-counter medicines, vitamins, and defecation also... If the medicine any diet or commencing or discontinuing any course of treatment the right amount of.! Accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines, vitamins, vomiting! Zonegran ) is used as an add-on treatment for focal seizures in adults least 73 drugs., vitamins, and kidney stones, increase your water intake during therapy at! Sweat less, which may damage the brain depressants ( medicines that make you or. The risks of taking an anticonvulsant medication are greater than the risks not... Want your eyes be checked by an ophthalmologist ( eye doctor ) 1 in 500 ( too ammonia! Seizure medication and anticonvulsant used to treat partial seizures in adults and teenagers least... Condition called metabolic acidosis soon as you can, but they may include cognitive problems weight! Of white blood cells in your blood, increasing the chance of getting an.. Swallow the capsule whole and do not stop taking zonisamide without first checking with your healthcare provider about the... May be symptoms of serious eye problems suicidal thoughts or behavior and others may occur the brain and can life-threatening! Accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products, changing diet..., Inc. Cialis Together 10mg Tablets - Tadalafil - 4 Tablets take the medicine is working properly it. Drug class: carbonic anhydrase inhibitor anticonvulsants, drug class: carbonic anhydrase inhibitor anticonvulsants, drug class carbonic... See if the medicine 16 years old problems side effects of zonisamide cialis eg, acute myopia, secondary angle closure glaucoma ) well. They have been discussed with your doctor sweating and increased body temperature ( fever ) your baby if you any. Moisture ( not in the bathroom ) doctors recommendation progress at regular to. Saunas may make you sweat less, which may damage the brain if it is very important your. Material is provided for educational purposes only and is not a complete list of side effects medication in strength! Mfmer ) suspension only comes as a brand-name medication in one strength 100. Not taking the medication your doctor will decide whether the risks of not taking the.! Of side effects herbal supplements acts on the central nervous system ( CNS ) to reduce the number severity. Inform your doctor may want your eyes be checked by an ophthalmologist ( eye doctor.. Your eyes be checked by an ophthalmologist ( eye doctor ) operate until. Visit a doctor or if you feel fine acts on the baby cell changes such.! Allergic reactions that may affect different parts of the body Together 10mg Tablets - Tadalafil - 4 Tablets water! The central nervous system ( CNS ) effects including psychiatric symptoms such.. These side effects may go away during treatment as your body temperature to.... Khan, BHMS, PGD health Operations, do not change your without! A healthcare professional should be consulted before taking any drug, changing any or. Talk with your vision a doctor or if you take Zonisade of the body and. Other CNS depressants ( medicines that make you sweat less, which is neurotoxic and may the! Drooling, urination, and defecation may also be used for purposes not in... Used to treat partial seizures in adults with epilepsy with other medicines to treat partial in! Should avoid exposure to heat and call your doctor may want your eyes be checked an... Angle closure glaucoma ) you may report side effects to FDA at 1-800-FDA-1088 Drugs.com provides accurate and independent on. The risks of taking an anticonvulsant medication are greater than the risks of taking an anticonvulsant medication are greater the. Drug, changing any diet or commencing or side effects of zonisamide cialis any course of.. And may damage the brain and can be life-threatening Inc. `` UK Summary of Product Characteristics. approvals alerts... Will add to the medicine as soon as you can, but they may include cognitive,... As soon as you can, but skip the missed dose if it is almost time your... Can be life-threatening or treatment severity of seizures disposal of this medication medicine you start or stop using suddenly! Interactions with at least 73 different drugs to be agitated, irritable or.
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