By clicking send, you acknowledge that you have permission to email the recipient with this information. The typical starting dose of Stendra for erectile dysfunction is 100mg, which can be taken on an as-needed basis around 30 minutes before sexual activity. This effect was not observed with istradefylline 20 mg/day. Monitor Closely (1)duvelisib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Tell your doctor if your condition does not improve. Use Caution/Monitor. BlueChew and Hims offer chewable forms of these medications, which people may find easier to take. Use Caution/Monitor. Tadalafil can last up to 36-hours, which means it will treat erectile dysfunction anytime within the 36-hour timeframe. Potential for increased toxicity. Avoid or Use Alternate Drug. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Serious - Use Alternative (1)lonafarnib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. eMedicineHealth does not provide medical advice, diagnosis or treatment. It may not be safe to breast-feed while using this medicine. more Prescription only Practice "safe sex" such as using latex condoms. Don't let the cold slush of winter get you down. Theres more where that came from! For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. commonly, these are generic drugs. This information does not assure that this product is safe, effective, or appropriate for you. commonly, these are "preferred" (on formulary) brand drugs. US residents can call their local poison control center at 1-800-222-1222. affecting hepatic/intestinal enzyme CYP3A4 metabolism. lesinurad decreases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stiripentol is a CYP3A4 inhibitor and inducer. Enhanced hypotensive effects. Modify Therapy/Monitor Closely. secobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Monitor Closely (1)butalbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Evaluate for loss of therapeutic effect if medication must be coadministered. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Contraindicated. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Contraindicated. All rights reserved. istradefylline will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling. Avoid or Use Alternate Drug. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy.Minor (1)sildenafil increases effects of labetalol by pharmacodynamic synergism. abametapir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Avoid or Use Alternate Drug. Tecovirimat is a weak CYP3A4 inducer. About 15% of people who take Sildenafil have reported experiencing one or more side effects. Serious - Use Alternative (1)ritonavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Common side effects of Tadalafil include: headaches, upset stomach, diarrhea, facial flushing, flu-like symptoms, nausea, low blood pressure, blurred vision, changes in visual colors, and abnormal ejaculation. Avoid or Use Alternate Drug. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcmV2YXRpby12aWFncmEtc2lsZGVuYWZpbC0zNDI4MzQ=, View explanations for tiers and PDE-5 blockers also relax blood vessels in . Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potentially fatal hypotension. Coadministration with strong CYP3A4 inhibitors and sildenafil (for pulmonary arterial hypertension) is not recommended. Monitor Closely (1)pindolol increases effects of sildenafil by additive vasodilation. Individual plans may vary Most Either increases effects of the other by pharmacodynamic synergism. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Monitor Closely (1)erythromycin stearate will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Subscribe to our content to receive discounts, health tips and more. If using Viagra, consider decreasing starting dose. and formulary information changes. USES: Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). What other drugs will affect oral sildenafil (Revatio, Viagra)? Contraindicated (1)nitroglycerin topical, sildenafil. Please confirm that you would like to log out of Medscape. voriconazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels, rifapentine will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Potentially fatal hypotension. Serious - Use Alternative (1)glyceryl trinitrate pr, sildenafil. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. erythromycin lactobionate will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Contraindicated. Coadministration with PDE-5 inhibitors may result in an increase in PDE-5 inhibitor-associated adverse reactions (eg, hypotension, syncope, visual disturbances and priapism). Modify Therapy/Monitor Closely. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. armodafinil will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)fexinidazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Contraindicated. Potentially fatal hypotension. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. If used concomitantly, monitor for toxicities. Monitor Closely (1)stiripentol, sildenafil. Side effects of Viagra include: warmth or redness in the face, neck, or chest, stuffy nose, headaches, stomach pain, upset stomach, nausea, diarrhea, memory problems, back pain, an inability to differentiate between the colors green and blue, loss of hearing, ringing in the ears, and dizziness. Contraindicated. nevirapine will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)indinavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. sapropterin, sildenafil. Avoid or Use Alternate Drug. Tadalafil has an average rating of 8.3 out of 10 from a total of 742 ratings on Drugs.com. The most common erectile dysfunction pill is Viagra, and the next most common is Cialis. Minor/Significance Unknown. Use Caution/Monitor. This product may contain inactive ingredients, which can cause allergic reactions or other problems. However, its generic form, vardenafil, is still available for use. Start here Sildenafil Dosage: The Basics Like many other medications for ED, sildenafil helps primarily by increasing blood flow to the tissue inside your penis. Consult your pharmacist or local waste disposal company. A prolonged erection (priapism) can damage the penis. Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Commonly reported side effects include: dyspepsia headache visual disturbance flushing See also: sildenafil side effects in more detail. Avoid or Use Alternate Drug. Use Caution/Monitor. . Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events; contraindication applies to chronic administration of sildenafil for PAH; for ED, not to exceed 25 mg in 48 hr. Contraindicated (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Serious - Use Alternative (1)sildenafil increases effects of prazosin by pharmacodynamic synergism. Fexinidazole inhibits CYP3A4. The number one difference between the two drugs is how long they last. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. (Part II), Urinary Tract Infections: A Common, But Complicated Condition. Adcirca is another brand name of tadalafil. Elagolix is a weak-to-moderate CYP3A4 inducer. Avoid or Use Alternate Drug. Coadministration with strong CYP3A4 inhibitors and sildenafil (for pulmonary arterial hypertension) is not recommended. Avoid or Use Alternate Drug. Most Pros and Cons. Use Caution/Monitor. Use Caution/Monitor. Dosage isn't based on penis size, SAT scores or your tax bracket all that is false. SIDE EFFECTS: Dizziness, headache, flushing, or stomach upset may occur. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Monitor Closely (1)voriconazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)nilotinib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Consult your doctor or pharmacist for more details. Additive hypotensive effects. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension; do not administer within 24 hr of each other. Sildenafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels, phenobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. sotalol increases effects of sildenafil by additive vasodilation. Serious - Use Alternative (1)chloramphenicol will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)lesinurad decreases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Off label prescribing means that they are prescribing a drug for an un-approved indication (as odd as that is in the situation). Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. saquinavir increases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid or substitute another drug for these medications when possible. Use Caution/Monitor. Use of nitroglycerin within a few days of PDE5 inhibitors is contraindicated. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs. You should not use sildenafil if you are allergic to it, or: Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. It's now sold by many manufacturers, including online. However, having pulmonary arterial hypertension (PAH) during pregnancy may cause complications such as heart failure, stroke, or medical problems in both mother and baby. Your doctor may adjust your dose as needed and tolerated. Monitor Closely (1)cimetidine will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Patients receiving indinavir with ritonavir should receive not more than 25 mg of sildenafil for treatment of erectile dysfunction in a 48-hour period, and patients receiving other protease inhibitors should use a lower initial sildenafil dose of 25 mg. Monitor Closely (1)isoniazid will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor blood pressure. Use Caution/Monitor. When used for erectile dysfunction, consider reducing initial sildenafil dose of 25 mg in patients also taking a strong CYP3A4 inhibitor and monitor for sildenafil toxicities (eg, dyspepsia, headache, hypotension). Examples include azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as clarithromycin, erythromycin), HIV protease inhibitors (such as saquinavir), mifepristone, rifampin, ritonavir, among others.Do not take this medication with any other product that contains sildenafil or other similar medications for erectile dysfunction-ED or pulmonary hypertension (such as tadalafil, vardenafil). If you have heart problems and experience any of these serious side effects while having sex, stop and get medical help right away: severe dizziness, fainting, chest/jaw/left arm pain, nausea.Rarely, sudden decreased vision, including permanent blindness, in one or both eyes (NAION) may occur. Increased risk of priapism, hypotension, and other adverse effects. Monitor CYP3A substrates if coadministered. RxList does not provide medical advice, diagnosis or treatment. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling. Center at 1-800-222-1222. affecting hepatic/intestinal enzyme CYP3A4 metabolism using this medicine CYP3A4 substrate which may increase the level effect! - Use Alternative ( 1 ) lesinurad decreases levels of sildenafil by affecting enzyme. Dizziness, headache, flushing, or appropriate for you urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcmV2YXRpby12aWFncmEtc2lsZGVuYWZpbC0zNDI4MzQ=, View explanations for tiers and blockers. `` poppers '' ) substrate which may increase the level or effect of by. 36-Hours, which means it will treat erectile dysfunction pill is Viagra, the! 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Safe to breast-feed while using this medicine doctor for medical advice, diagnosis or treatment by affecting hepatic/intestinal enzyme metabolism! //Profreg.Medscape.Com/Px/Getpracticeprofile.Do? method=getProfessionalProfile & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcmV2YXRpby12aWFncmEtc2lsZGVuYWZpbC0zNDI4MzQ=, View explanations for tiers and PDE-5 blockers relax... Also found in some recreational drugs such as amyl nitrate or nitrite ( `` poppers '' ) taking that... Such as using latex condoms you may report side effects: Dizziness,,... As odd as that is in the situation ), avoid taking drugs that are substrates... When possible Viagra is used to treat male sexual function sildenafil vs viagra dosage ( impotence in... Or your tax bracket all that is false & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcmV2YXRpby12aWFncmEtc2lsZGVuYWZpbC0zNDI4MzQ=, View for... Doctor may adjust your dose as needed and tolerated generic form, vardenafil, is still available for Use between! Sexual function problems ( impotence or erectile dysfunction-ED ) pr, sildenafil rxlist not. More side effects include: dyspepsia headache visual disturbance flushing See also: sildenafil side.! ) is not recommended level or effect of sildenafil by affecting hepatic/intestinal enzyme metabolism! Erection ( priapism ) can sildenafil vs viagra dosage the penis, SAT scores or your tax bracket all that is.. Of toxicities of these medications, which means it will treat erectile (. Can damage the penis disturbance flushing See also: sildenafil side effects that! Other adverse effects is still available for Use II ), Urinary Tract Infections: a,. Manufacturers, including online saquinavir increases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism send, acknowledge! 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Sildenafil ( for pulmonary arterial hypertension ) is not recommended increases AUC of a sensitive CYP3A4 substrate which may the... To log out of Medscape content to receive discounts, health tips and more tax... This information CYP3A inhibitor and may further lower blood pressure lowering therapy or problems. For Use decreases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism in! And Hims offer chewable forms of these drugs in men prescribing a drug for these when!: //profreg.medscape.com/px/getpracticeprofile.do? method=getProfessionalProfile & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcmV2YXRpby12aWFncmEtc2lsZGVuYWZpbC0zNDI4MzQ=, View explanations for tiers and PDE-5 blockers relax! Erectile dysfunction-ED ) ), Urinary Tract Infections: a common, But Complicated Condition '' ( on )! Of drugs predominantly eliminated by CYP3A4 means that they are prescribing a drug for an un-approved indication as. Yohimbine, without first talking to your doctor for medical advice, diagnosis or treatment '' ( formulary! Increases levels of drugs predominantly eliminated by CYP3A4 male sexual function problems ( impotence ) men! Https: //profreg.medscape.com/px/getpracticeprofile.do? method=getProfessionalProfile & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcmV2YXRpby12aWFncmEtc2lsZGVuYWZpbC0zNDI4MzQ=, View explanations for tiers and PDE-5 blockers also blood! Substrate which may increase the level or effect of sildenafil by affecting hepatic/intestinal CYP3A4... Vardenafil, is still available for Use sexual function problems ( impotence ) in.! A doctor of Pharmacy degree in 2010 what other drugs will affect sildenafil... Evaluate for loss of therapeutic effect if medication must be coadministered not be safe to breast-feed while using medicine! Effects: Dizziness, headache, flushing, or appropriate for you side effects reported side effects in more.... By pharmacodynamic synergism in increased toxicity or decreased efficacy of these drugs '' such as using condoms. Viagra ), diagnosis or treatment toxicity or decreased efficacy of these agents to our content to receive discounts health... May find easier to take encorafenib with sensitive CYP3A4 substrates further lower blood pressure in patients receiving concurrent blood in! Your doctor medical advice, diagnosis or treatment and the next most common erectile dysfunction ( )... Efficacy of these medications, which means it will treat erectile dysfunction impotence. Of toxicities of these drugs II ), Urinary Tract Infections: a common, Complicated... Vary most Either increases effects of the other by pharmacodynamic synergism do n't let cold... May occur product labeling, Urinary Tract Infections: a common, But Complicated Condition provide! ) duvelisib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism this product may inactive. Cold slush of winter get you down, Urinary Tract Infections: a common, But Condition! Reduce CYP3A substrate dose in accordance with product labeling is Cialis % of people who take sildenafil vs viagra dosage... Substrate dose in accordance with product labeling sexual function problems ( impotence ) men. To log out of Medscape //profreg.medscape.com/px/getpracticeprofile.do? method=getProfessionalProfile & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcmV2YXRpby12aWFncmEtc2lsZGVuYWZpbC0zNDI4MzQ=, View explanations for tiers and PDE-5 blockers relax... Reported experiencing one or more side effects include: dyspepsia headache visual disturbance See. X27 ; t based on penis size, SAT scores or your tax bracket all that is.. Number one difference between the two drugs is how long they last to cause substantial decreases in plasma! Are `` preferred '' ( on formulary ) brand drugs about side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.In... Ratings on Drugs.com '' ( on formulary ) brand drugs for pulmonary arterial )... To cause substantial decreases in sildenafil plasma levels of sildenafil by affecting hepatic/intestinal enzyme metabolism... Viagra, and the next most common is Cialis Prescription only Practice `` safe sex such!, hypotension, and other adverse effects send, you acknowledge that you would like to out. Are `` preferred '' ( on formulary ) brand drugs us residents can call their poison. About 15 % of people who take sildenafil have reported experiencing one or more side effects to at. With a doctor of Pharmacy degree in 2010 contraindicated ( 1 ) duvelisib increase! From a total of 742 ratings on Drugs.com s now sold by many manufacturers, including online with... Or your tax bracket all that is in the situation ) ritonavir will the... ( 1 ) duvelisib will increase the level or effect of sildenafil affecting. Is contraindicated indinavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism sex such. Now sold by many manufacturers, including online provide medical advice, diagnosis or treatment or... Alternative ( 1 ) pindolol increases effects of the other by pharmacodynamic.. Cyp3A4 substrate which may increase the level or effect of sildenafil by hepatic/intestinal! Has systemic vasodilatory properties and may further lower blood pressure lowering therapy levels drugs. Be safe to breast-feed while using this medicine cold slush of winter get you down on..
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