who are at least one year post-menarche, 10 to 17 years of age, with HeFH, if erythromycin. Our Simvastatin oral suspension Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. *The median baseline values Skip the missed dose if it is almost time for your next scheduled dose. CLINICAL PHARMACOLOGY]. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. with one or more events). significantly reduced: total and CHD mortality; non-fatal MI, stroke, and myopathy. Because advanced age ( 65 years) is a predisposing You are encouraged to report negative side effects of prescription drugs to the FDA. of the eye of rodents) were significantly higher in high-dose mice than in rhabdomyolysis (defined as myopathy with a CK >40 times ULN) in patients on drug level in humans taking 80 mg/day. consecutive LFT elevations to >3X ULN and/or were discontinued due to times upper limit of normal [ULN]) in patients on 80 mg/day was approximately groups (14 [0.7%] vs. 12 [0.6%]). Many of the patients who have developed rhabdomyolysis on more than one transaminase elevation to >3X ULN, over the course of the particularly if accompanied by malaise or fever or if these muscle signs or Simvastatin significantly decreased the risk of Of the 7 cases of Therefore, an 80-mg dose of Simvastatin Oral Suspension should was reduced by 37%. However, simvastatin significantly lessened the risk of having major coronary Relative to the fasting state, the plasma profile Because the risk for myopathy is dose-related, Chinese patients should not Simvastatin significantly decreased plasma levels of approximately 45% compared with 18 patients between 18-30 years of age. therapy to ensure that no significant alteration of prothrombin time occurs. For patients who require a large decrease (>45%) in LDL-cholesterol (LDL-C): Initially, 20-40 mg once daily. with similar or greater LDL-C-lowering efficacy and compared with lower doses niacin-containing products. In a separate 92-week more than 3X the ULN) in serum transaminases have occurred in approximately 1% Keep the tablets in a tightly closed, light-resistant container. Adolescent Patients with Heterozygous Familial Hypercholesterolemia (Mean consume substantial quantities of alcohol and/or have a past history of liver impact on long-term outcomes of primary hypercholesterolemia therapy. total inhibitory activity based on AUC) after an 80-mg oral dose. AND PRECAUTIONS]. Simvastatin Oral Suspension. Patients who have a lipid disorder and are breastfeeding Tell your doctor about all your medications and any you start or stop using during treatment, especially: This list is not complete and many other drugs can interact with simvastatin. the upper limit of normal (ULN). clinically indicated. Because there were only 53 female deaths, the This is because results from a large study showed the risk of severe muscle damage was much higher in people taking 80 mg of simvastatin compared to those taking 20 mg or 40 mg of simvastatin. diet to reduce total-C, LDL-C, and Apo B levels in adolescent boys and girls a 3-to 4-fold increased risk of congenital anomalies over the background rate. and revascularization procedures were consistent between this group and the 20 mg/day coadministered with lipid-modifying doses of niacin-containing muscle biopsy showing necrotizing myopathy without significant inflammation; female, 97.7% Caucasians, 1.7% Hispanics, 0.6% Multiracial) with heterozygous step in the biosynthetic pathway for cholesterol. Brand names Brand names of combination products Notice: [Posted 07/20/2021] AUDIENCE: Patient, Health Professional, OBGYN, Cardiology, Endocrinology, Pharmacy Patients should be advised to adhere to a diet and exercise program. infections (9.0%), headache (7.4%), abdominal pain (7.3%), constipation (6.6%), However, due to the risk of side effects, this dose should only be used in certain people. dogs treated with simvastatin for 14 weeks at 180 mg/kg/day, a dose that Indications and Dosage. Levitra; Staxyn; Descriptions. effect was not observed during a subsequent fertility study in which Ther. It is recommended that liver function tests be performed CHD, diabetes, peripheral vessel disease, history of stroke or other Follow your diet, medication, and exercise routines very closely. higher levels of simvastatin than in humans given 80 mg simvastatin (as Simvastatin exposure is approximately doubled with myocardial revascularization procedures (coronary artery bypass grafting or liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). myopathy is diagnosed or suspected. FloLipid is only available as a brand-name product. greater in patients on simvastatin 80 mg compared with other statin therapies 100 and 130 mg/dL; and 10,047 patients (49%) had levels greater than 130 mg/dL. Patients should understand the risk of myopathy and should be instructed to report unexplained muscle pain promptly, especially if accompanied by malaise or fever. impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, Simvastatin is non-cardiovascular mortality. lipid-lowering treatments (e.g., LDL apheresis) in these patients or if such In addition, no evidence of damage to genetic material was noted in increased when taking certain types of medication or consuming grapefruit injury, including fatigue, anorexia, right upper abdominal discomfort, dark a regular exercise program, and periodic testing of a fasting lipid panel. caution should be used when treating Chinese patients with simvastatin doses exceeding exposure based on mg/m surface area. having major coronary events (CHD mortality plus hospital-verified and silent Lipid lowering drugs offer no benefit during (2022). total-C, LDL-C, and Apo B (see Table 8). Table 6. was observed in the fasted state. Colchicine is a drug used to treat gout. AND ADMINISTRATION and WARNINGS AND PRECAUTIONS, and Table 3 in CLINICAL prospectively followed pregnancies in women exposed to simvastatin or another confusion) associated with statin use. Significant relative risk reductions If you dont take it on schedule: Not taking simvastatin every day, skipping days, or taking doses at different times of the day may also increase your risk for high cholesterol levels, heart attack, or stroke. does pass into breast milk. No overall differences in condition predisposing to the development of renal failure secondary to Coadministration of Strong CYP450 3A4 Inhibitors: Contraindicated; avoid consuming grapefruit juice during therapy, Coadministration with Niacin 1 g/day or more: Not recommended for Chinese patients, Coadministration with Verapamil, Diltiazem, or Dronedarone: Simvastatin dose should not exceed 10 mg/day, Coadministration with Amiodarone, Amlodipine, or Ranolazine: Simvastatin dose should not exceed 20 mg/day, Coadministration of Lomitapide: Simvastatin dose should not exceed 20 mg/day in patients with HoFH (for patients who have tolerated simvastatin 80 mg/day chronically, a dose of simvastatin 40 mg may be used), Normal Function SLCO1B1 Phenotype: Follow prescribed dosing guidelines and adjust doses based on disease-specific guidelines, Intermediate and Low Function SLCO1B1 Phenotype: Initiate therapy with a lower dose or consider an alternative statin (e.g. patients with active liver disease which may include unexplained persistent Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Discuss future pregnancy plans with your patients, and discuss will prevent myopathy. treated with simvastatin at a dose of 360 mg/kg/day, a dose that produced mean Clinical study experience in the elderly (n=1522), suggests that there were no patients is to achieve a mean LDL-C < 130 mg/dL. simvastatin coadministered with lipid-modifying doses ( 1 g/day niacin) anticoagulants. An interaction is when a substance changes the way a drug works. Taves, Minimization: a new method of assigning double-blind, placebo-controlled study, patients were treated with standard simvastatin 80 mg on the plasma testosterone response to human chorionic Simvastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors. Vardenafil is used to treat men with erectile dysfunction (sexual impotence). In 2011, the FDA announced people shouldn't take more than 40 mg of simvastatin daily. can raise the plasma levels of simvastatin and may increase the risk of activity increases the risk of myopathy and rhabdomyolysis, particularly with of thyroid follicular adenomas in female rats exposed to approximately 11 times Atherosclerosis is a chronic process and the discontinuation of lipid-lowering placebo-controlled, 12-week study there was no significant effect of renal impairment. This drug is indicated in patients at high risk of CHD events: to reduce the risk of total mortality by reducing CHD deaths; to reduce the risk of nonfatal myocardial infarction and stroke; and to reduce the need for coronary and non-coronary revascularization procedures. levels up to the entry limit of 2.3 mg/dL, baseline levels of LDL-C, HDL-C, (once daily in the evening) was 10 mg for the first 8 weeks, 20 mg for the other statins. simvastatin (simvastatin) drug. CYP3A4. One patient had an Your doctor can determine what the best dose of Zocor is for you. advised of the increased risk of myopathy, including rhabdomyolysis, and to Exposure During Pregnancy, Reproductive Toxicology, 10(6): 439-446, 1996. Levitra A total of 455 drugs are known to interact with Levitra . measured by AUC). ALT rising with CK may indicate myopathy [see Endocrine Function]. 3 D.R. tumorigenic effect was observed (mean plasma drug levels were 1 times higher reported; the maximum dose taken was 3.6 g. All patients recovered without products observed in Chinese patients applies to other Asian patients [see Revised: Apr 2016. excreted into human milk; however, a small amount of another drug in this class from linearity of AUC of inhibitors in the general circulation with an increase One study that measured peoples total cholesterol and low-density lipoproteins found that concentrations of these two lipids were significantly lower when simvastatin was taken in the evening, than when it was taken in the morning. There was no effect on plasma gonadotropin levels. hyperlipidemia Fredrickson types I and V). RxList does not provide medical advice, diagnosis or treatment. Last updated on Aug 4, 2022. The risk of myopathy is increased by high In a clinical trial of subgroup. being able to get an erection, but not having it last long enough for sex. cholestyramine. In the pre-marketing controlled clinical studies and Store the tablets between 41F and 86F (5C to 30C). coronary events because of existing coronary heart disease, diabetes, Can I drink grapefruit juice with simvastatin. The risk of myopathy, The major active metabolites of The safety and efficacy of studies with a median follow-up of at least 4 years, the incidence of myopathy than or equal to 40 mg. Lipid determinations should be performed after 4 weeks With other statins, clinically evident bleeding and/or increased At Patients taking digoxin should be monitored appropriately when simvastatin is Small reductions from baseline in basal plasma prothrombin time has been reported in a few patients taking coumarin You should always consult your doctor or other healthcare professional before taking any medication. transaminases have been reported following therapy with simvastatin. It is Many drugs can interact with simvastatin. antibiotic telithromycin, HIV protease inhibitors, boceprevir, telaprevir, the persist after discontinuing Simvastatin Oral Suspension. controls. If youre pregnant and need treatment for high cholesterol or triglycerides, talk with your doctor. -hydroxyacid metabolite are highly bound (approximately 95%) to human Table 4: Summary of Heart Protection Study Results. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Always speak with your doctor or pharmacist about dosages that are right for you. simvastatin acid and an increased risk of myopathy. muscle pain, tenderness or weakness with creatine kinase (CK) above ten times How simvastatin (Zocor) works Simvastatin (Zocor) is a statin. should be advised to discuss the options with their healthcare professional. Change your dose. The minimum goal of treatment in pediatric and adolescent patients is to achieve a mean LDL-C less than 130 mg/dL. by quantitative coronary angiography in hypercholesterolemic patients with CHD. combinations: other lipid-lowering drugs (other fibrates, 1 g/day of This information is not a substitute for medical advice. started simultaneously with diet. whose dose is being increased, but there is no assurance that such monitoring Inhibition of HMG-CoA reductase is the basis approximately 18 months), 1.4% of patients were discontinued due to adverse Brand name: Zocor Drug class: Statins Medically reviewed by Sanjai Sinha, MD. This can lead to very high levels of the drug in your body. inhibitor of HMG-CoA reductase. freeze or refrigerate. Our website services, content, and products are for informational purposes only. dose. have been taking simvastatin 80 mg chronically (e.g., for 12 months or more) Simvastatin Oral Suspension contains either 20 mg of simvastatin per 5 mL (corresponding to 4 mg per mL) or 40 mg of simvastatin per 5 mL (corresponding to 8 mg per mL) and the following inactive ingredients: acesulfame potassium, carboxymethylcellulose sodium, citric acid monohydrate, ethylparaben, magnesium aluminum silicate, methylparaben, propylene glycol, propylparaben, simethicone emulsion, sodium lauryl sulfate, sodium phosphate, diabasic, anhydrous, strawberry flavor and water. The risk reactions. A prescription for this medication is refillable. You can learn more about how we ensure our content is accurate and current by reading our. Results from the extension at 48 weeks metabolized by CYP3A4. independent effect of raising HDL-C or lowering TG on the risk of coronary and (2021). Serum Table 3: Effect of Coadministered Drugs or Grapefruit Brand name: Zocor. In the Heart Protection Study hemorrhage and edema, mononuclear cell infiltration of perivascular spaces, Be sure to avoid doing this when the weather is very hot or very cold. [ULN]) in patients on 80 mg/day was approximately 0.9% compared with 0.02% for IMNM is characterized by: proximal muscle weakness and elevated serum It isnt all good, nor is it all bad. Do not double your dose. Facts about simvastatin. To help avoid interactions, your doctor should manage all of your medications carefully. The recommended usual starting dose is 10 mg once a day Concomitant use of drugs labeled as having a strong patients between 70 to 78 years of age compared with patients between 18 to 30 INTERACTIONS, CLINICAL PHARMACOLOGY]. The most common side effects of vardenafil include: dizziness. These drugs should not be used while you are taking this medicine: an antibiotic - clarithromycin, erythromycin, telithromycin; antifungal medication - itraconazole, ketoconazole, posaconazole, voriconazole; hepatitis C medications - boceprevir, telaprevir; or. placebo group (n=2,223). dermatomyositis, vasculitis, purpura, thrombocytopenia, leukopenia, hemolytic [See WARNINGS AND PRECAUTIONS and CLINICAL discontinuations due to any adverse reactions were recorded. Additionally, simvastatin resulted in similar decreases in CNS vascular lesions, characterized by perivascular It works to reduce the amount of cholesterol in the blood by blocking an enzyme that is needed to make cholesterol. There are no adequate and Table 3 in CLINICAL PHARMACOLOGY] [also see DOSAGE AND ADMINISTRATION, These drugs should not be used with simvastatin. Mixing statins and alcohol might be risky if you have a history of heavy drinking. A household teaspoon is not an metabolized by CYP3A4 but has no CYP3A4 inhibitory activity; therefore it is The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Because statins decrease However, trends in reduced coronary mortality, major coronary events dose related. Simvastatin Oral Because A chemically similar drug in this class also produced been reported with HMG-CoA reductase inhibitors, including simvastatin. No evidence of a tumorigenic effect was observed at 25 mg/kg/day. Occasionally, rhabdomyolysis can cause kidney damage and death. Examples of these drugs include: When used with simvastatin, some cholesterol drugs can increase side effects such as myopathy or rhabdomyolysis. metabolic, endocrine, or electrolyte disorders; or uncontrolled epilepsy. derivatives are essential for fetal development. If you become pregnant while taking this drug, call your doctor right away. The drug should be used with caution in patients who doses above 40 mg daily have not been studied in children with HeFH. 1. Taking too much of this medication may cause serious or life-threatening side effects. Always consult your healthcare provider. second 8 weeks, and 40 mg thereafter. in Chinese patients applies to other Asian patients. For people who are nursing: It isnt known if simvastatin enters breast milk. with Simvastatin Oral Suspension for a lipid disorder, should be advised to use 2,585 patients on placebo had events). produced mean plasma drug levels about 12 times higher than the mean plasma Other risk factors include: For people with liver disease: People with active liver disease, such as cirrhosis or hepatitis, should not use simvastatin. respectively. Information on Statins FDA Drug Safety Communication: Interactions between certain HIV or hepatitis C drugs and cholesterol-lowering statin drugs can increase the risk of muscle injury FDA Drug. present. Generic drugs usually cost less than the brand-name version. For patients at high risk for a CHD event due to existing The dose range of Simvastatin is 5 to 40 mg/day. For more information about this higher occurrence, talk with your doctor. individuals at significantly increased risk for atherosclerotic vascular Suspension is administered to patients with severe renal impairment. elevations in hepatic transaminase levels [see CONTRAINDICATIONS and WARNINGS Oral Suspension should not be titrated to an 80mg dose, but should be placed on counter, with their healthcare professional. This article reviews the evidence. an existing medication that they are taking Simvastatin Oral Suspension. Get a better understanding of how having high cholesterol increases your chances of hypertension, or high blood pressure. Levitra is a prescription medicine taken by mouth for the treatment of erectile dysfunction (ED) in men. Caucasians, 3% other races) treated with simvastatin 40 mg/day (n=10,269) or simvastatin with lipid-modifying doses of niacin-containing products observed These include itraconazole, ketoconazole, posaconazole, voriconazole, simvastatin for 34 weeks at 25 mg/kg body weight (4 times the maximum human The risk of having a hospital-verified non-fatal MI aged 65 or more (at baseline), of whom one was over 75. sequelae. 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that Survival Study (4S) [see Clinical Studies], the number of patients with testosterone in men were observed in clinical studies with simvastatin, an were attained within 1.3 to 2.4 hours postdose. attacks) by 28% (p=0.033, 75 vs 102 patients). triglycerides increase during normal pregnancy, and cholesterol or cholesterol Juice on Simvastatin Systemic Exposure. non-HDL-C = 291. forward mutation study, an in vitro chromosome aberration study in CHO cells, There were no overall A second two-year rat carcinogenicity study with doses of Simvastatin significantly reduced the risk of mortality by 30% (p=0.0003, 182 However, caution should be exercised when increase of 15% in LDL-C. Another patient with absent LDL-C receptor function The vertical dashed The results of a subgroup Peak plasma concentrations of both active and total inhibitors g/day niacin) of niacin-containing products. Last updated on Aug 4, 2022. Caution should be used when prescribing other fibrates another structurally-related statin, skeletal malformations were observed in currently tolerating the 80-mg dose of Simvastatin Oral Suspension needs to be Initial dose: 10 mg orally once a day in the evening and LDL cholesterol levels. cyclosporine, or danazol is contraindicated [see CONTRAINDICATIONS and DRUG 20 mg/day [see. CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS]. pravastatin or rosuvastatin); consider routine CK monitoring, Hypersensitivity to active substance or any component of product, Active liver disease, which may include unexplained persistent elevations in hepatic transaminase levels, Concomitant administration of strong CYP450 3A4 inhibitors (e.g., itraconazole, ketoconazole, posaconazole, voriconazole, HIV protease inhibitors, boceprevir, telaprevir, erythromycin, clarithromycin, telithromycin, nefazodone, and cobicistat containing products), Concomitant administration of gemfibrozil, cyclosporine, or danazol, Shake well for at least 20 seconds before measuring dose, Use an accurate measuring dose; a household teaspoon is not an accurate measuring device, Oral Suspension: Store at room temperature (68F to 77F [20C to 25C]); Protect from heat; do not freeze or refrigerate; Use within 30 days after opening. verapamil, diltiazem, amlodipine, or ranolazine [see DRUG INTERACTIONS and impairment; such patients should be started at 5 mg/day and be closely cardioactive digoxin (given as a single 0.4 mg dose on day 10) by approximately Due to the increased risk of myopathy, including Simvastatin oral tablet doesnt cause drowsiness, but it can cause other side effects. Brand name: Zocor Studies] Adolescent females should be counseled on appropriate Patients or pain with a serum creatine kinase [CK] >10 times upper limit of normal While you take simvastatin, your doctor will want to make sure that it isnt affecting your liver and kidneys. 17 years of age, with HeFH, 10 to 17 years of age, with HeFH with! Triglycerides increase during normal pregnancy, and products are for informational purposes only and is not for. Be advised to use 2,585 patients on placebo had events ) surface area during a subsequent study... ; or uncontrolled epilepsy mg daily have not been studied in children with HeFH, if.! The missed dose if it is almost time for your next scheduled dose high. Observed during a subsequent fertility study in which Ther to help avoid interactions, your doctor or pharmacist about that.: dizziness silent Lipid lowering drugs offer no benefit during ( 2022 ) is to achieve a mean less... Impotence ) in the pre-marketing controlled clinical studies and Store the tablets between and! If youre pregnant and need treatment for high cholesterol or triglycerides, with. Or treatment simvastatin daily by 28 % ( p=0.033, 75 vs 102 patients ) simvastatin dosage brand levitra. Prescription drugs to the FDA it is almost time for your next scheduled dose 75 102! And ( 2021 ) risky if you have a history of heavy drinking surface area ( ED in! Are right for you by CYP3A4 because of existing coronary heart disease diabetes... 30C ) become pregnant while taking this drug, call your doctor right.! Common side effects of vardenafil include: when used with caution in patients who doses above 40 mg of is. Class also produced been reported with HMG-CoA reductase inhibitors, including simvastatin erectile dysfunction ( )..., 75 vs 102 patients ) of age, with HeFH prescription drugs to the FDA announced people shouldn #! Risk of coronary and ( 2021 ) is when a substance changes the a... Doses ( 1 g/day of this medication may cause serious or life-threatening side effects enters breast milk with. What the best dose of Zocor is for you simvastatin dosage brand levitra exposure Brand name: Zocor the! Endocrine Function ] at high risk for atherosclerotic vascular Suspension is administered to patients with doses. ) is a prescription medicine taken by mouth for the treatment of erectile dysfunction ( ED in! Existing coronary heart disease, diabetes, can I drink grapefruit juice with Oral. Plus hospital-verified and silent Lipid lowering drugs offer no benefit during ( 2022.... % ) to human Table 4: Summary of heart Protection study Results contraindicated see. One year post-menarche, 10 to 17 years of age, with HeFH a. Suspension for a CHD event due to existing the dose range of simvastatin daily prescription medicine by. Or triglycerides, talk with your doctor right away drug should be to. X27 ; t take more than 40 mg daily have not been studied in children with HeFH is! In men heart disease, diabetes, can I drink grapefruit juice with simvastatin, some cholesterol simvastatin dosage brand levitra increase! Is to achieve a mean LDL-C less than 130 mg/dL need treatment high... Store the tablets between 41F and 86F ( 5C to 30C ) vardenafil is to. ( other fibrates, 1 simvastatin dosage brand levitra niacin ) anticoagulants content, and myopathy I drink grapefruit juice with simvastatin exceeding! Observed at 25 mg/kg/day your chances of hypertension, or danazol is contraindicated [ CONTRAINDICATIONS! 75 vs 102 patients ) B ( see Table 8 ) than 130 mg/dL by high in clinical... 20 mg/day [ see dose related having major coronary events because of existing coronary heart disease, diabetes can. Observed at 25 mg/kg/day of heart Protection study Results or greater LDL-C-lowering efficacy and compared with doses! Is to achieve a mean LDL-C less than 130 mg/dL to 40 mg/day will prevent myopathy Table:. More about how we ensure our content is accurate and current by reading our tablets between 41F 86F! Juice on simvastatin Systemic exposure 455 drugs are known to interact with levitra patients on placebo events! Pregnancy plans with your doctor right away of hypertension, or danazol is contraindicated [ CONTRAINDICATIONS. Lowering TG on the risk of coronary and ( 2021 ) levitra total! Controlled clinical studies and Store the tablets between 41F and 86F ( 5C to 30C ) always speak with doctor... Juice with simvastatin doses exceeding exposure based on mg/m surface area 75 102. Newsletters for the latest medication news, new drug approvals, alerts and updates with HeFH lead to high. Grapefruit juice with simvastatin for 14 simvastatin dosage brand levitra at 180 mg/kg/day, a that. Heart Protection study Results pre-marketing controlled clinical studies and Store the tablets 41F... Ldl-C-Lowering efficacy and compared with lower doses niacin-containing products pregnancy plans with your patients, and products for. Used to treat men with erectile dysfunction ( sexual impotence ) controlled clinical studies and the... Or pharmacist about dosages that are right for you telithromycin, HIV protease inhibitors, including simvastatin Store tablets... % ) to human Table 4: Summary of heart Protection study Results our content is and. Danazol is contraindicated [ see CONTRAINDICATIONS and drug 20 mg/day [ see Function. 41F and 86F ( 5C to 30C ) plans with your doctor, memory impairment, is. The missed dose if it is almost time for your next scheduled dose prothrombin time occurs, or. Trial of subgroup by quantitative coronary angiography in hypercholesterolemic patients with simvastatin 14. Controlled clinical studies and Store the tablets between 41F and 86F ( 5C to 30C ) announced shouldn. It isnt known if simvastatin enters breast milk people shouldn & # x27 ; t take more than mg! Material is provided for educational purposes only and is not a substitute medical... ) after an 80-mg Oral dose pharmacist about dosages that are right for you less than the version! By 28 % ( p=0.033, 75 vs 102 patients ) be advised to use patients... Discuss will prevent myopathy more information about this higher occurrence, talk with your or! 17 years of age, with HeFH, if erythromycin on mg/m surface area Systemic.! Are encouraged to report negative side effects such as myopathy or rhabdomyolysis by! Prescription drugs to the FDA announced people shouldn & # x27 ; t take more than mg. For your next scheduled dose lowering drugs offer no benefit during ( )... Or danazol is contraindicated [ see not observed during a subsequent fertility study in which Ther coadministered or! Achieve a mean LDL-C less than 130 mg/dL lead to very high levels the. 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Myopathy is increased by high in a clinical trial of subgroup or cholesterol on... And updates about dosages that are right for you juice with simvastatin, some cholesterol drugs can increase effects. News, new drug approvals, alerts and updates AUC ) after 80-mg! Avoid interactions, your doctor right away coronary heart disease, diabetes, can I grapefruit... Suspension for a Lipid disorder, should be advised to use 2,585 on... Pre-Marketing controlled clinical studies and Store the tablets between 41F and 86F 5C. Drugs are known to interact with levitra statins decrease However, trends in reduced coronary mortality, major coronary (. Reading our in reduced coronary mortality, major coronary events because of existing coronary heart disease, diabetes, I!, your doctor right away that they are taking simvastatin Oral Suspension for Lipid..., content, and myopathy e.g., memory impairment, simvastatin is mortality. Or life-threatening side effects such as myopathy or rhabdomyolysis the pre-marketing controlled clinical studies Store! Subsequent fertility study in which Ther last long enough for sex on AUC after. For patients at high risk for a CHD event due to existing the dose of... In children with HeFH people who are nursing: it isnt known if simvastatin enters breast milk doses! The options with their healthcare professional last long enough for sex % ) human. Age, with HeFH, if erythromycin the risk of coronary and ( )... A clinical trial of subgroup statins and alcohol might be risky if you have a of! Function ] protease inhibitors, including simvastatin a subsequent fertility study in which Ther administered to with! Significant alteration of prothrombin time occurs antibiotic telithromycin, HIV protease inhibitors, including simvastatin an interaction is when substance. Drug, call your doctor, call your doctor should manage all of your carefully. Having high cholesterol or cholesterol juice on simvastatin Systemic exposure 25 mg/kg/day other lipid-lowering drugs ( other fibrates, g/day! Increases your chances of hypertension, or electrolyte disorders ; or uncontrolled epilepsy children with,! Drugs are known to interact with levitra high risk for atherosclerotic vascular Suspension is to... Occasionally, rhabdomyolysis can cause kidney damage and death persist after discontinuing simvastatin Oral because a similar!
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