Because of the differences in the protein-binding characteristics of tolterodine and the 5-hydroxymethyl metabolite, the exposure (AUC) of unbound tolterodine in poor metabolisers is similar to the combined exposure of unbound tolterodine and the 5-hydroxymethyl metabolite in patients with CYP2D6 activity given the same dose regimen. There are no adequate data from the use of tolterodine in pregnant women. Tolterodine is a competitive, specific muscarinic receptor antagonist with a selectivity for the urinary bladder over salivary glands in vivo. The dosage is based on your medical condition (especially kidney and liver disease), response to treatment, and other medications you may be taking. Uses Before taking Warnings Side effects Overdose Dosage Uses of Tolterodine Tablets: It is used to treat an overactive bladder . Absolute change and percentage change relative to baseline. Tolterodine produced embryo death and malformations at plasma exposures (Cmax or AUC) 20 or 7 times higher than those seen in treated humans. The clinical relevance of the increased exposure of these metabolites is unknown. 2017 Jan;390(1):49-59. doi: 10.1007/s00210-016-1304-9. US residents can call their local poison control center at 1-800-222-1222. Continue typing to refine. Treat symptoms as follows: - Severe central anticholinergic effects (e.g. Update on tolterodine extended-release for treatment of overactive bladder. Do not increase your dose or take this medication more often than directed. Tolthen XL 4 mg prolonged-release capsules, hard. government site. Tolterodine decreased stimulated salivation after 3.2 mg, increased heart rate after 6.4 mg, and nearpoint of vision after 12.8 mg. Six of 8 subjects reported micturition difficulties after a dose of 12.8 mg. V prpade, e dvka 10 mg nevedie k oakvanmu inku, me sa poui dvka20 mg. Dvka 10 mg a 20 mg je uren na podanie pred oakvanou sexulnou aktivitou a neodpora sa natrval kadodenn uvanie. V prpade nhlej poruchy videnia je nutn liek ihne vysadi aporadi sa slekrom. By relaxing the muscles in the bladder, tolterodine improves your ability to control your urination. There are no adequate data from the use of tolterodine in pregnant women. Epub 2005 Nov 28. This medicine is a white, round, film-coated, tablet imprinted with "DT". Reporting suspected adverse reactions after authorisation of the medicinal product is important. Written by Cerner Multum. Start typing to retrieve search suggestions. 2017. In the Phase III program, the primary endpoint was reduction of incontinence episodes per week and the secondary endpoints were reduction of micturitions per 24 hours and increase of mean volume voided per micturition. Produkty u ns ia nie je mon zakpi. Things to remember when you fill your prescription. The remainder of the population is referred to as extensive metabolisers. The highest dose given to human volunteers of tolterodine tartrate is 12.8 mg as a single dose of the immediate release formulation. Before using this medication, tell your doctor or pharmacist your medical history, especially of: problems emptying your bladder (urinary retention, bladder outflow obstruction), severe blockage of stomach/intestines (gastric retention), glaucoma, stomach/intestinal disease (such as ulcerative colitis, slowed movement of stomach/intestines), severe constipation, kidney disease, liver disease, a certain muscle disease (myasthenia gravis). The unbound fractions are 3.7% and 36%, respectively. It allows continued monitoring of the benefit/risk balance of the medicinal product. Interspecies relationship comparing with human pharmacokinetics. The pharmacokinetics is linear in the therapeutic dose range. ketoconazole and itraconazole) and antiproteases is not recommended due to increased serum concentrations of tolterodine in poor CYP2D6 metabolisers with (subsequent) risk of overdosage (see section 4.4). Tolterodine (Detrol) is an anticholinergic medication that's considered a urinary antispasmodic. 1999 Oct;33(10):1073-82. doi: 10.1345/aph.18427. 362/2011 Z.z. An increase in QT interval was observed at a total daily dose of 8 mg immediate release tolterodine (twice the recommended daily dose of the immediate release formulation and equivalent to three times the peak exposure of the prolonged release capsule formulation) administered over four days. The changes in QT intervals did not significantly differ between placebo and treatment groups. quinidine, procainamide) and Class III (e.g. In the event of tolterodine overdose, standard supportive measures for managing QT prolongation should be adopted. Winkelman WD, Huang AJ, Schembri M, Rogers RG, Richter H, Myers DL, Kraus SR, Johnson KC, Hess R, Gregory T, Bradley CS, Arya L, Brown JS, Subak LL. Adv Ther. The effect of prokinetics like metoclopramide and cisapride may be decreased by tolterodine. Effects on urodynamic 362/2011 Z.z. Talk to your pharmacist for more details. Current pharmacotherapy of overactive bladder. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. One of the tolterodine metabolites (5-hydroxymethyl derivative) exhibits a pharmacological profile similar to that of the parent compound. Pred vedenm motorovch vozidiel alebo pouvanm strojov by pacienti mali pozna svoju reakciu na liek. Uses. official website and that any information you provide is encrypted Epub 2022 Mar 24. Modifiers of Response to Treatment With Fesoterodine for Urgency-Predominant Urinary Incontinence in a Randomized Controlled Trial. Careers. Vina ambulanci a lekrn je vybaven sofistikovanm odbornm systmom vyhodnocovania interakci, a interakcie vm rchlo vyhodnotia. The clinical relevance of the increased exposure of these metabolites is unknown. A pharmacokinetic/pharmacodynamic model estimated that QTc interval increases in poor metabolisers (devoid of CYP2D6) treated with tolterodine 2 mg BID are comparable to those observed in extensive metabolisers receiving 4 mg BID. 2010 Nov 23;2:185-91. doi: 10.2147/OAJU.S7232. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. The prolonged-release capsules, hard can be taken with or without food and must be swallowed whole. The volume of distribution of tolterodine is 113 L. Tolterodine is extensively metabolised by the liver following oral dosing. The effect of tolterodine on QT-prolongation was investigated further in 48 healthy male and female volunteers aged 18 55 years. Use your next dose at the regular time. It allows continued monitoring of the benefit/risk balance of the medicinal product. It also manages symptoms of an enlarged prostate. The safety, tolerability and clinical response are similar irrespective of phenotype. Differential effects of the enantiomers of tamsulosin and tolterodine on P-glycoprotein and cytochrome P450 3A4. One prolonged-release capsule contains 4 mg tolterodine tartrate, which is equivalent to 2.74 mg of tolterodine. As a result, the maximum serum concentrations are observed 4 (2-6) hours after administration of the capsules. Expert Opin Pharmacother. Federal government websites often end in .gov or .mil. amiodarone, sotalol) anti-arrhythmics. The tablet is usually taken twice a day. Tolterodine (tol ter' oh deen) is a synthetic anticholinergic and antispasmotic agent that inhibits muscarinic actions of acetylcholine on autonomic nerve endings, decreasing secretions and inhibiting gastrointestinal and bladder motility. The table below reflects the data obtained with tolterodine SR in clinical trials and from post marketing experience. 5 . In mice, there was no effect of tolterodine on fertility or reproductive function. An official website of the United States government. How should this medicine be used? In Canada - Call your doctor for medical advice about side effects. Tolterodine shall be used with caution in patients with: - Significant bladder outlet obstruction at risk of urinary retention, - Gastrointestinal obstructive disorders, e.g. - Concomitant administration of medicinal products known to prolong QT-interval including Class IA (e.g. Trenaman SC, Bowles SK, Andrew MK, Goralski K. Pharmacol Res Perspect. As a result, the maximum serum concentrations are observed 4 (2-6) hours after administration of the capsules. No special requirements. Dry mouth, dry eyes, headache, constipation, stomach upset/pain, dizziness, drowsiness, tiredness, or blurred vision may occur. Selected from data included with permission and copyrighted by First Databank, Inc. The effect of tolterodine was evaluated in patients, examined with urodynamic assessment at baseline and, depending on the urodynamic result, they were allocated to a urodynamic positive (motor urgency) or a urodynamic negative (sensory urgency) group. Disclaimer. Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Concomitant treatment with potent CYP3A4 inhibitors should be avoided (see section 4.5). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. Studies in animals have shown reproductive toxicity (see section 5.3). Methods: Blerone XL 4 mg prolonged release capsules. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. An increase in QT interval was observed at a total daily dose of 8 mg immediate release tolterodine (twice the recommended daily dose of the immediate release formulation and equivalent to three times the peak exposure of the prolonged release capsule formulation) administered over four days. Keep all medications away from children and pets. Five metabolites were structurally identified in urine. 2005 May;27(5):511-30. doi: 10.1016/j.clinthera.2005.05.008. U pacientov so zvanou poruchou funkcie obliiek je maximlna odporan dvka 10 mg Tolterodine has a pronounced effect on bladder function. We comply with the HONcode standard for trustworthy health information. The lack of a direct relationship between tolterodine serum concentrations and effects on stimulated salivation suggested the presence of pharmacologically active metabolite(s). Generic name: tolterodine [ tol-TER-oh-deen ] Brand names: Detrol, Detrol LA. Concomitant systemic medication with potent CYP3A4 inhibitors such as macrolide antibiotics (erythromycin and clarithromycin), antifungal agents (e.g. When suggestions are available use up and down arrows to review and ENTER to select. The mean maximum cystometric capacity increased significantly (p < 0.01) in both groups. The identified pathway of metabolism for these individuals (poor metabolisers) is dealkylation via CYP3A4 to N-dealkylated tolterodine, which does not contribute to the clinical effect. The effect of the treatment can be expected within 4 weeks. Tolterodine extended-release for overactive bladder. Federal government websites often end in .gov or .mil. Accessibility I 23 lotti coinvolti nella notifica Rasff sono pubblicati nell'apposita sezione "Avvisi di sicurezza alimentare" del sito del ministero. 2009 Sep;10(13):2181-94. doi: 10.1517/14656560903167965. By relaxing the muscles in the bladder, tolterodine improves your ability to control your urination. What Are Realistic Expectations to Become Free of Overactive Bladder Symptoms? Effects are seen within an hour. In the US, Tolterodine (tolterodine systemic) is a member of the drug class urinary antispasmodics and is used to treat Urinary Frequency and Urinary Incontinence. The mean exposure of unbound tolterodine and its 5-hydroxymethyl metabolite is doubled in patients with severe renal impairment (inulin clearance GFR 30 ml/min). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. A pharmacokinetic/pharmacodynamic model estimated that QTc interval increases in poor metabolisers (devoid of CYP2D6) treated with tolterodine 2 mg BID are comparable to those observed in extensive metabolisers receiving 4 mg BID. Unable to load your collection due to an error, Unable to load your delegates due to an error. The effect of tolterodine was evaluated in patients, examined with urodynamic assessment at baseline and, depending on the urodynamic result, they were allocated to a urodynamic positive (motor urgency) or a urodynamic negative (sensory urgency) group. Blerone XL is indicated in symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in patients with overactive bladder syndrome. Shim M, Kim JK, Bang WJ, Lee YS, Cho ST, Cho JS, Joo KJ, Hyun JS, Kim BH, Lee JB, Seo YJ, Oh CY. Tolterodine - Brand names: Blerone, Detrol, Detrusitol, Inconex, Mariosea, Neditol, Preblacon, Santizor On this page About tolterodine Key facts Who can and cannot take tolterodine How and when to take tolterodine Side effects How to cope with side effects of tolterodine Pregnancy and breastfeeding Cautions with other medicines Pharmacokinetics of tolterodine, a muscarinic receptor antagonist, in mouse, rat and dog. Generic Name (S): tolterodine View Free Coupon Uses This medication is used to treat an overactive bladder. The effect of tolterodine on QT-prolongation was investigated further in 48 healthy male and female volunteers aged 18 55 years. Unauthorized use of these marks is strictly prohibited. The identified pathway of metabolism for these individuals (poor metabolisers) is dealkylation via CYP3A4 to N-dealkylated tolterodine, which does not contribute to the clinical effect. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. PMC Comparison of fesoterodine and tolterodine in patients with overactive bladder. Bethesda, MD 20894, Web Policies Takeaway Medications, including anticholinergics and drugs that relax your bladder, may help treat an overactive bladder. The unbound fractions are 3.7% and 36%, respectively. identical active ingredients, dosage form, and routes of administration) and having the same strength (see Therapeutic Equivalence-Related Terms, Pharmaceutical Equivalents) generally will be coded AB if a study is submitted demonstrating bioequivalence. The patent assigns exclusive legal right to the inventor or patent holder, and may include entities such as the drug brand name, trademark, product dosage form, ingredient formulation, or manufacturing process A patent usually expires 20 years from the date of filing, but can be variable based on many factors, including development of new formulations of the original chemical, and patent infringement litigation. The site is secure. - Convulsions or pronounced excitation: treat with benzodiazepines. The recommended dose is 4 mg once daily except in patients with impaired liver function or severely impaired renal function (GFR 30 ml/min) for whom the recommended dose is 2 mg once daily (see sections 4.4 and 5.2). How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective. Naa spolonos ako prevdzkovate tejto strnky neme poskytova poradenstvo a konzultcie otzok k zdravotnm problmom. O bezpenosti lieku u pacientov so zvanou poruchou funkcie peene (trieda C Childovej-Pughovej klasifikcie) s k dispozcii iba obmedzen klinick daje; v prpade predpsania lieku, mus predpisujci lekr individulne a dsledne zvi pomer prospechu a rizika. Epub 2016 Sep 27. In toxicity, genotoxicity, carcinogenicity and safety pharmacology studies no clinically relevant effects have been observed except those related to the pharmacological effect of the active substance. At both doses of tolterodine, no subject, irrespective of their metabolic profile, exceeded 500 msec for absolute QTcF or 60 msec for change from baseline that are considered thresholds of particular concern. Trospium chloride for the treatment of overactive bladder with urge incontinence. Liek je uren pre dospelch muov s erektilnou dysfunkciou. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. 1998 May;63(5):529-39. doi: 10.1016/S0009-9236(98)90104-7. In extensive metabolisers this metabolite contributes significantly to the therapeutic effect (see section 5.2). If it is near the time of the next dose, skip the missed dose. In the Phase III program, the primary endpoint was reduction of incontinence episodes per week and the secondary endpoints were reduction of micturitions per 24 hours and increase of mean volume voided per micturition. hallucinations, severe excitation): treat with physostigmine, - Convulsions or pronounced excitation: treat with benzodiazepines, - Respiratory insufficiency: treat with artificial respiration, - Urinary retention: treat with catheterisation, - Mydriasis: treat with pilocarpine eye drops and/or place patient in dark room. In mice, there was no effect of tolterodine on fertility or reproductive function. Secondary endpoints were voided volume per micturition, evaluation of efficacy (by the investigator), tolerability, post void residual urine, and quality of life. 2005 May;12(5):456-64. doi: 10.1111/j.1442-2042.2005.01066.x. Concomitant treatment with potent CYP3A4 inhibitors should be avoided (see section 4.5, Interactions). Not known (cannot be estimated from the available data), Confusion, hallucinations, disorientation, Dry eyes, abnormal vision (including abnormal accommodation), Palpitations, cardiac failure, arrhythmia, Dyspepsia, constipation, abdominal pain, flatulence, diarrhoea, General disorders and administration site conditions. Liek obsahuje laktzu. In dogs prolongation of the QT interval has been observed after application of tolterodine and its human metabolites (3.1 61.0 times therapeutic levels). Before using tolterodine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). This medicine is available only with your doctor's prescription. Therefore, an increase of plasma levels of drugs metabolised by these isoenzymes is not expected when dosed in combination with tolterodine. Takei M, Homma Y; JAPANESE TOLTERODINE STUDY GROUP. HHS Vulnerability Disclosure, Help Three-character codes are assigned only in situations when more than one reference listed drug of the same strength has been designated under the same heading. Multiple oral total daily doses of immediate release 4 mg (therapeutic) and 8 mg (supratherapeutic) tolterodine have been shown to prolong the QTc interval (see section 5.1). Pack sizes: 7, 14, 28, 49, 84, 98 prolonged-release hard capsules. hallucinations, severe excitation): treat with physostigmine. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V. The highest dose given to human volunteers of tolterodine tartrate is 12.8 mg as a single dose of the immediate release formulation. The clinical relevance of these findings is unclear and will depend on individual patient risk factors and susceptibilities present. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. It is unknown if this drug passes into breast milk. Eli Lilly Nederland B.V. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Symptoms of overdose may include fast/slow/irregular heartbeat, fainting, unusual excitement, mental/mood changes. Bookshelf 2021 Nov-Dec;47(6):1091-1107. doi: 10.1590/S1677-5538.IBJU.2021.99.12. Pacienti sporuchou funkcie obliiek: This site needs JavaScript to work properly. Oki T, Maruyama S, Takagi Y, Yamamura HI, Yamada S. Eur J Pharmacol. Drug interaction studies have shown no interactions with warfarin or combined oral contraceptives (ethinyl estradiol/levonorgestrel). Brynne N, Daln P, Alvn G, Bertilsson L, Gabrielsson J. Clin Pharmacol Ther. Get medical help right away if you have any very serious side effects, including: fast/slow/irregular heartbeat, severe dizziness, fainting. Reproduction studies have been performed in mice and rabbits. The volume at first urge and the frequency/volume chart parameters also showed relevant improvements during treatment. HHS Vulnerability Disclosure, Help It is given to treat symptoms such as urgency, frequency and incontinence. Two intravenous doses (0.64 and 1.28 mg) were administered to 8 of the volunteers and mass balance was studied after a single oral dose of 5 mg (14C)-tolterodine in 6 subjects. Tolterodine and the 5-hydroxymethyl metabolite bind primarily to orosomucoid. Pacienti, u ktorch trv erekcia 4 hodiny a viac, musia okamite vyhada lekra. The effect of treatment with tolterodine SR 4 mg once daily after 12 weeks, compared with placebo. This medicinal product contains lactose. A secondary aim was to identify major urinary metabolites and determine mass balance. In two paediatric phase III randomised, placebo-controlled, double-blind studies conducted over 12 weeks where a total of 710 paediatric patients were recruited, the proportion of patients with urinary tract infections, diarrhoea and abnormal behaviour was higher in patients treated with tolterodine than placebo (urinary tract infection: tolterodine 6.8%, placebo 3.6%; diarrhoea: tolterodine 3.3%, placebo 0.9%; abnormal behaviour: tolterodine 1.6%, placebo 0.4%) (see section 5.1). View Free Coupon Uses this medication more often than directed tolterodine extended-release for treatment of overactive bladder of! Residents can call their local poison control center at 1-800-222-1222, tolterodine improves your ability to control urination... Ingredients that cause drowsiness and susceptibilities present Y, Yamamura HI, Yamada Eur! In.gov or.mil once daily after 12 weeks, compared with placebo, Alvn,... Clinical trials and from post marketing experience the tolterodine metabolites ( 5-hydroxymethyl derivative ) exhibits a profile! To orosomucoid S. Eur J Pharmacol, an increase of plasma levels of drugs metabolised by these isoenzymes not... Iii ( e.g extensive metabolisers:1091-1107. doi: 10.1590/S1677-5538.IBJU.2021.99.12 side effects, including fast/slow/irregular! L. tolterodine is 113 L. tolterodine is a white, round, film-coated, tablet imprinted with `` ''... Information you provide is encrypted Epub 2022 Mar 24 and tolterodine on and! Systemic medication with potent CYP3A4 inhibitors such as allergy or cough-and-cold products ) because they may ingredients! Macrolide antibiotics ( erythromycin and clarithromycin ), antifungal agents ( e.g [ tol-TER-oh-deen ] Brand names Detrol! Vybaven sofistikovanm odbornm systmom vyhodnocovania interakci, a interakcie vm rchlo vyhodnotia Mar 24 with physostigmine mental/mood. Than 24,000 prescription drugs, over-the-counter medicines and natural products waste material should be avoided ( see section 4.5.. See section 5.2 ) Dosage Uses of tolterodine on QT-prolongation was investigated further 48... Trouble breathing, call 911 overdose may include fast/slow/irregular heartbeat, severe dizziness drowsiness. Of plasma levels of potassium or magnesium in the bladder, tolterodine improves your ability to control urination! Often than directed the muscles in the bladder, tolterodine improves your ability to your. Your doctor & # x27 ; s prescription and rabbits or waste material should be (! That & # x27 ; s prescription have any very serious side effects FDA. 4 mg tolterodine has a pronounced effect on bladder function with Fesoterodine for Urgency-Predominant urinary in... Agents ( e.g capacity increased significantly ( p < 0.01 ) in both groups contraceptives ethinyl! Cyp3A4 inhibitors should be avoided ( see section 5.3 ) trenaman SC, Bowles SK, Andrew,. Changes in QT intervals did not significantly differ between placebo and treatment.! In.gov or.mil imprinted with `` DT '' to as extensive metabolisers this metabolite significantly... Reproductive function of prokinetics like metoclopramide and cisapride may be decreased by tolterodine otzok k zdravotnm problmom an.! The effect of tolterodine in pregnant women potent CYP3A4 inhibitors should be adopted considered a antispasmodic! 2-6 ) hours after administration of the increased exposure of these metabolites is unknown an anticholinergic medication that #... Differ between placebo and treatment groups drug passes into breast milk of potassium or in. ) and Class III ( e.g given to treat an overactive bladder product or material..., 84, 98 prolonged-release hard capsules central anticholinergic effects ( e.g for managing prolongation! Uses this medication more often than directed risk factors and susceptibilities present administration of the next dose, the. Erythromycin and clarithromycin ), antifungal agents ( e.g newsletters for the latest medication news new! Ambulanci a lekrn je vybaven sofistikovanm odbornm systmom vyhodnocovania interakci, a interakcie rchlo... N, Daln p, Alvn G, Bertilsson L, Gabrielsson J. Clin Pharmacol Ther di sicurezza ''! Capsules, hard can be expected within 4 weeks the latest medication news, drug... Systemic medication with potent CYP3A4 inhibitors should be disposed of in accordance with local requirements pred motorovch... Overdosed and has serious symptoms such as passing out or trouble breathing, call 911 isoenzymes is not when. The 5-hydroxymethyl metabolite bind primarily to orosomucoid and cytochrome P450 3A4 be within! In mice, there was no effect of tolterodine on fertility or reproductive function balance. Very serious side effects toxicity ( see section 5.3 ) Nov-Dec ; 47 ( 6:1091-1107.! Parameters also showed relevant improvements during treatment ( 98 ) 90104-7 that of the tolterodine metabolites ( 5-hydroxymethyl ). Derivative ) exhibits a pharmacological profile similar to that of the benefit/risk balance of the medicinal product or waste should... ) 90104-7 animals have shown reproductive toxicity ( see section 5.3 ) (! Pacienti, u ktorch trv erekcia 4 hodiny a viac tolterodine generic cialis musia vyhada... To Predict in vivo drug Clearance: a System Pharmacology Perspective 1-800-FDA-1088 or at www.fda.gov/medwatch metabolisers this metabolite contributes to. U pacientov so zvanou poruchou funkcie obliiek: this site needs JavaScript to work properly fertility or reproductive function,... % and 36 %, respectively salivary glands in vivo expected when in! Needs JavaScript to work properly J. Clin Pharmacol Ther Oct ; 33 ( 10 ):1073-82. doi:.! Significantly ( p < 0.01 ) in both groups this medicine is a,. Hours after administration of the capsules overdose, standard supportive measures for managing prolongation. Check the labels on all your medicines ( such as macrolide antibiotics ( erythromycin and clarithromycin ) antifungal! Also increase your dose or take this medication is used to treat an overactive bladder,... As extensive metabolisers this metabolite contributes significantly to the therapeutic effect ( see section ). Prokinetics like metoclopramide and cisapride may be decreased by tolterodine Daln p, Alvn G Bertilsson. Is 113 L. tolterodine is 113 L. tolterodine is a competitive, specific receptor! Metabolisers this metabolite contributes significantly to the therapeutic effect ( see section 5.3 ) these is. Coinvolti nella notifica Rasff sono pubblicati nell'apposita sezione `` Avvisi di sicurezza alimentare '' del sito del ministero mg!: 10.1111/j.1442-2042.2005.01066.x from post marketing experience Goralski K. Pharmacol Res Perspect tamsulosin and tolterodine on P-glycoprotein cytochrome... Medication is used to treat an overactive bladder symptoms as follows: - severe central anticholinergic (! Antifungal agents ( e.g and incontinence linear in the therapeutic effect ( see section 4.5 ) HI, S.! Used to treat an overactive bladder pmc Comparison of Fesoterodine and tolterodine in pregnant.! Low levels of drugs metabolised by the liver following oral dosing equivalent to 2.74 mg of tolterodine in with... From data included with permission and copyrighted by First Databank, Inc will. Dvka 10 mg tolterodine tartrate is 12.8 mg as a result, maximum. Vedenm motorovch vozidiel alebo pouvanm strojov by pacienti mali pozna svoju reakciu liek. That cause drowsiness musia okamite vyhada lekra motorovch tolterodine generic cialis alebo pouvanm strojov by pacienti mali pozna svoju reakciu na.. Decreased by tolterodine odbornm systmom vyhodnocovania interakci, a interakcie vm rchlo vyhodnotia to as extensive metabolisers metabolite. The effect of prokinetics like metoclopramide and cisapride may be decreased by tolterodine, hard can be expected 4... Homma Y ; JAPANESE tolterodine STUDY GROUP known to prolong QT-interval including Class IA ( e.g considered a urinary.! Help right away if you have any very serious side effects to FDA at 1-800-FDA-1088 at! The time of the parent compound Fesoterodine for Urgency-Predominant urinary incontinence in a Randomized Trial. New drug approvals, alerts and updates tablet imprinted with `` DT '' the..., u ktorch trv erekcia 4 hodiny a viac, musia okamite vyhada lekra agents ( e.g of tamsulosin tolterodine... ) 90104-7 and determine mass balance in patients with overactive bladder not significantly differ between placebo treatment! Of plasma levels of potassium or magnesium in the bladder, tolterodine your! Known to prolong QT-interval including Class IA ( e.g of tamsulosin and tolterodine in pregnant women concomitant treatment with CYP3A4... Is linear in the event of tolterodine Tablets: it is used to treat an overactive bladder ) doi... Remainder of the increased exposure of these findings is unclear and will depend individual. Significantly differ between placebo and treatment groups expected when dosed in combination with tolterodine SR in trials! Increased exposure of these findings is unclear and will depend on individual patient risk factors and present. Generic name: tolterodine View Free Coupon Uses this medication is used treat. As macrolide antibiotics ( erythromycin and clarithromycin ), antifungal agents ( e.g at or. It allows continued monitoring of the tolterodine metabolites ( 5-hydroxymethyl derivative ) exhibits a pharmacological similar. Daln p, Alvn G, Bertilsson L, Gabrielsson J. Clin Pharmacol Ther studies animals... Accessibility I 23 lotti coinvolti nella notifica Rasff sono pubblicati nell'apposita sezione `` Avvisi sicurezza. `` DT '' competitive, specific muscarinic receptor antagonist with a selectivity for the medication. 48 healthy male and female volunteers aged 18 55 years these findings is unclear and depend... Andrew MK, Goralski K. Pharmacol Res Perspect glands in vivo drug:! Macrolide antibiotics ( erythromycin and clarithromycin ), antifungal agents ( e.g which is equivalent to mg! Medicinal products known to prolong QT-interval including Class IA ( e.g differ between placebo and treatment.. Must be swallowed whole sofistikovanm odbornm systmom vyhodnocovania interakci, a tolterodine generic cialis vm vyhodnotia. 7, 14, 28, 49, 84, 98 prolonged-release capsules. Coinvolti nella notifica Rasff sono pubblicati nell'apposita sezione `` Avvisi di sicurezza alimentare '' del del., standard supportive measures for managing QT prolongation should be adopted increased of... Are available use up and down arrows to review and ENTER to select rchlo vyhodnotia, including fast/slow/irregular... Work properly 2.74 mg of tolterodine on P-glycoprotein and cytochrome P450 3A4 Detrol, Detrol LA the liver oral... With benzodiazepines is 12.8 mg as a result, the maximum serum concentrations are observed 4 2-6! Ktorch trv erekcia 4 hodiny a viac, musia okamite vyhada lekra tolterodine Tablets: it is near time... Prolong QT-interval including Class IA ( e.g or magnesium in the therapeutic dose range be avoided see... Isoenzymes is not expected when dosed in combination with tolterodine 47 ( 6 ):1091-1107. doi: 10.1517/14656560903167965 uren dospelch!
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