Share cases and questions with Physicians on Medscape consult. Adjust dosage of CYP3A4 substrates, if clinically indicated. Use Caution/Monitor. Recommended dose of rasagiline is 0.5mg daily in combination with CYP1A2 inhibitors. dicloxacillin will decrease the level or effect of ethinylestradiol by altering intestinal flora. Minor/Significance Unknown. ortho tri-cyclen (21) tablet On Label RX Reviews. Use Caution/Monitor. This medicine is available only with your doctor's prescription. Use Caution/Monitor. Use of a nonhormonal contraceptive is recommended. Use Caution/Monitor. Monitor Closely (1)ribociclib will increase the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Use Caution/Monitor. Use another non-oral contraceptive method for females of childbearing potential. Clinical significance of this interaction is unknown. amobarbital will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. Minor/Significance Unknown. Due to the potential for an indirect interaction between calaspargase pegol and oral contraceptives, concomitant use of these drugs is not recommended. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Contraindicated (1)tranexamic acid oral, ethinylestradiol. Use Caution/Monitor. Avoid or Use Alternate Drug. dexamethasone will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)fexinidazole will increase the level or effect of ethinylestradiol by affecting hepatic enzyme CYP2E1 metabolism. Use Caution/Monitor. Avoid or Use Alternate Drug. Minor (1)ethinylestradiol, dosulepin. Monitor for glycemic control in diabetic patients. Use Caution/Monitor. Other (see comment). Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Avoid coadministration unless benefit outweighs risk. Use Caution/Monitor. Monitor Closely (1)ethinylestradiol increases levels of selegiline transdermal by Other (see comment). Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug. health information, we will treat all of that information as protected health Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Ethinyl Estradiol And Norgestimate (Oral Route). Monitor Closely (1)penicillin VK will decrease the level or effect of ethinylestradiol by altering intestinal flora. Modify Therapy/Monitor Closely. Monitor Closely (1)ethinylestradiol decreases effects of insulin lispro by pharmacodynamic antagonism. This website also contains material copyrighted by 3rd parties. Use Caution/Monitor. Monitor for glycemic control in diabetic patients. Avoid or Use Alternate Drug. Use Caution/Monitor. The efficacy of hormonal contraceptives may be reduced. The efficacy of hormonal contraceptives may be reduced. Minor (1)ethinylestradiol will increase the level or effect of antipyrine by affecting hepatic enzyme CYP1A2 metabolism. Monitor for glycemic control in diabetic patients. Monitor Closely (1)lenacapavir will increase the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Low risk of contraceptive failure. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Comment: Increases norgestimate levels and may result in insulin resistance, dyslipidemia, acne, and venous thrombosis; decreases ethinyl estradiol levels that may result in decreased efficacy. If not feasible, avoid use of abametapir. cyclophosphamide will increase the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)ethinylestradiol will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Comment: Concomitant use may lead to additive hypercoagulability. Ethinyl estradiol and norgestimate combination is used to prevent pregnancy. Monitor Closely (1)darunavir will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Below is a list of common medications used to treat or reduce the symptoms of pregnancy contraception. Monitor Closely (1)ceritinib will increase the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. ethinylestradiol decreases effects of insulin NPH by pharmacodynamic antagonism. Minor (1)enasidenib, ethinylestradiol. Low risk of contraceptive failure. pill Drospirenone/Ethinyl Estradiol 3/0.03 mg, Ocella, Syeda, Zarah, Zumandimine (generic Yasmin) ring Eluryng, Etonogestrel/Ethinyl Estradiol 0.12/0.015 mg/24 hr (generic NuvaRing) pill Enpresse-28, Levonest, Levonorgestrel/Ethinyl Estradiol 6-5-10, Trivora-28 (generic Triphasil) pill Estarylla, Femynor, Mili, Mono-Linyah, Mononessa . The efficacy of hormonal contraceptives may be reduced. Minor/Significance Unknown. Monitor CYP3A substrates if coadministered. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Monitor Closely (1)itraconazole will increase the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ethinylestradiol, desipramine. Other (see comment). Low risk of contraceptive failure. Applies only to oral forms of hormone. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)atazanavir, norgestimate. Use Caution/Monitor. abametapir will increase the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Oral contraceptives may decrease hypoglycemic effects of antidiabetics by impairing glucose tolerance. Ethinyl estradiol and norgestimate is a combination birth control pill containing female hormones that prevent ovulation (the release of an egg from an ovary). Oral contraceptives may decrease hypoglycemic effects of antidiabetics by impairing glucose tolerance. Avoid or Use Alternate Drug. Minor/Significance Unknown. Low risk of contraceptive failure. Applies only to oral forms of hormone. Avoid or Use Alternate Drug. Applies only to oral forms of hormone. Modify Therapy/Monitor Closely. Low risk of contraceptive failure. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. amoxicillin will decrease the level or effect of ethinylestradiol by altering intestinal flora. Serious - Use Alternative (1)conivaptan will increase the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)tetracycline will decrease the level or effect of ethinylestradiol by altering intestinal flora. Oral contraceptives may decrease hypoglycemic effects of antidiabetics by impairing glucose tolerance. Potential for increased TCA adverse effects. Monitor Closely (1)levoketoconazole will increase the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Minor/Significance Unknown. Adjust dose according to prescribing information if needed. Use Caution/Monitor. Monitor Closely (1)cefprozil will decrease the level or effect of ethinylestradiol by altering intestinal flora. Minor/Significance Unknown. Minor (1)ethinylestradiol will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Monitor Closely (1)ethinylestradiol increases levels of green tea by decreasing elimination. Potential for increased TCA adverse effects. Antibiotics may decrease hormonal contraceptive efficacy. Avoid or Use Alternate Drug. Applies only to oral forms of hormone. Prescription only This product is available in the following dosage forms: There is a problem with Serious - Use Alternative (1)elvitegravir will decrease the level or effect of ethinylestradiol by unknown mechanism. Low risk of contraceptive failure. Estrogens may impair glucose tolerance. Modify Therapy/Monitor Closely. Monitor Closely (1)ethinylestradiol decreases effects of insulin degludec/insulin aspart by pharmacodynamic antagonism. Use Caution/Monitor. Minor/Significance Unknown. Potential for increased TCA adverse effects. WebMD does not provide medical advice, diagnosis or treatment. Additional non-hormonal forms of contraception are recommended. Ortho Tri-Cyclen Tri-Estarylla, Tri-Femynor, Tri-Linyah, Tri-Mili, TriNessa, Tri-Previfem, Tri-Sprintec, Tri-Vylibra Ortho Tri-Cyclen Lo Tri-Lo Estarylla, Tri-Lo Marzia, Tri-Lo-Mili, Tri-Lo-Sprintec, Tri-Vylibra Lo Ovcon-35 Balziva-28, Briellyn, Philith, Vyfemla Ovral Ogestrel 0.5/50 Quartette Fayosim, Rivelsa Safyral Tydemy Seasonale Introvale . Photo: Andreas Neumann. This effect was not observed with istradefylline 20 mg/day. Use of a nonhormonal contraceptive is recommended. Modify Therapy/Monitor Closely. Most Ortho Evra : Xulane . clindamycin will decrease the level or effect of ethinylestradiol by altering intestinal flora. Applies only to oral forms of hormone. ceftibuten will decrease the level or effect of ethinylestradiol by altering intestinal flora. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. ceftazidime will decrease the level or effect of ethinylestradiol by altering intestinal flora. Low risk of contraceptive failure. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Avoid or Use Alternate Drug. nafcillin will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.Minor (1)ethinylestradiol will increase the level or effect of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid or Use Alternate Drug. calaspargase pegol, ethinylestradiol. Coadministration may decrease amprenavir AUC, and may lead to loss of virologic response. Monitor Closely (1)dicloxacillin will decrease the level or effect of ethinylestradiol by altering intestinal flora. Avoid or Use Alternate Drug. ethinylestradiol will increase the level or effect of mexiletine by affecting hepatic enzyme CYP1A2 metabolism. If an oral contraceptive is taken on the same day of sugammadex, or the patient has a transdermal or implant hormonal contraceptive, the patient must use an additional, nonhormonal contraceptive method or back-up method of contraception (eg, condoms and spermicides) for the next 7 days. Oral contraceptives may decrease hypoglycemic effects of antidiabetics by impairing glucose tolerance. Potential for increased toxicity. Click here for an email preview. Ethinyl estradiol may inhibit the clearance of benzodiazepines that undergo oxidation, thereby increasing serum concentrations of concomitantly administered benzodiazepines. MonoNessa is a generic version of the brand-name drug Ortho-Cyclen. butabarbital will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: CYP450 activity in the liver is down regulated by infection and inflammation stimuli including cytokines (eg, IL-6); inhibition of IL-6 by siltuximab may restore CYP450 enzymatic activity; caution if coadministered with CYP substrates that have a narrow therapeutic index. Other (see comment). affecting hepatic/intestinal enzyme CYP3A4 metabolism. ethinylestradiol will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Concomitant use may increase incidence of menstruation associated adverse effects (amenorrhea, dysmenorrhea, menorrhagia). A Patient Handout is not currently available for this monograph. Birth control methods such as having surgery to become sterile or not having sex are more effective than birth control pills. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. Low risk of contraceptive failure. Applies only to oral forms of hormone. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)tigecycline will decrease the level or effect of ethinylestradiol by altering intestinal flora. Monitor Closely (1)ethinylestradiol, exenatide injectable solution. Adjust finererone dosage as needed. atorvastatin will increase the level or effect of ethinylestradiol by P-glycoprotein (MDR1) efflux transporter. CYP3A4 inhibitors such as ketoconazole may increase plasma hormone levels. . Use Caution/Monitor. Coadministration may increase risk for adverse effects of CYP3A4 substrates. Monitor Closely (1)ceftazidime will decrease the level or effect of ethinylestradiol by altering intestinal flora. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)ethinylestradiol will increase the level or effect of ramelteon by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Use Caution/Monitor. Increased antidepressant serum concentrations may occur. Use Caution/Monitor. Coadministration of enasidenib may increase or decrease the concentrations of combined hormonal contraceptives. Monitor for glycemic control in diabetic patients. Serious - Use Alternative (1)lumacaftor/ivacaftor will decrease the level or effect of ethinylestradiol by unspecified interaction mechanism. Low risk of contraceptive failure. Low risk of contraceptive failure. Coadministration of belzutifan with hormonal contraceptives may lead to contraceptive failure or increased breakthrough bleeding. Serious - Use Alternative (1)topiramate will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Oxidative metabolism of TCAs may be decreased by ethinyl estradiol. Use Caution/Monitor. Serious - Use Alternative (1)rifabutin will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. ethinylestradiol will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increased antidepressant serum concentrations may occur. Monitor Closely (1)ethinylestradiol will increase the level or effect of clonazepam by Mechanism: decreasing metabolism. Ortho Tri Cyclen Lo turned me into a hysterical bitch for 1-2 weeks out of the month. Low risk of contraceptive failure. tranexamic acid oral, ethinylestradiol. Low risk of contraceptive failure. Either increases toxicity of the other by unspecified interaction mechanism. Advise patients to take oral contraceptives at least 1 hr before exenatide. Serious - Use Alternative (1)fosamprenavir, ethinylestradiol. Women's health is once again the center of a political ping-pong match with evidence-based science on one side and anti-choice advocates on the other. Discontinue ethinyl estradiol-containing medications before initiating ombitasvir/paritaprevir/ritonavir, and/or dasabuvir. Use Caution/Monitor. Minor (1)ethinylestradiol, protriptyline. n/a : 1 injection Q3 mos (12 to 14 wks) Emergency . Fostemsavir inhibits BCRP transporters. Backup contraceptive method recommended. The efficacy of hormonal contraceptives may be reduced. Applies only to oral forms of hormone. Minor/Significance Unknown. By clicking send, you acknowledge that you have permission to email the recipient with this information. Coadministration of tranexamic acid oral and combination hormonal contraceptives increases thrombotic risk. Use Caution/Monitor. Serious - Use Alternative (1)armodafinil will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraceptives, Oral Print Dosing & Uses AdultPediatric Dosage Forms & Strengths norgestimate/ethinyl estradiol tablet, monophasic (Estarylla, Femynor, Mili, MonoNessa, Previfem, Sprintec). Minor (1)ethinylestradiol, imipramine. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use additional or alternative nonhormonal birth control. Fexinidazole inhibits CYP3A4. Queens of the Stone Age will bring Phantogram, Viagra Boys, the Armed, and Savages' Jehnny Beth on their fall North American tour. Use Caution/Monitor. Estrogens may impair glucose tolerance. Monitor Closely (1)nitrofurantoin will decrease the level or effect of ethinylestradiol by altering intestinal flora. Use Caution/Monitor. ethinylestradiol will increase the level or effect of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Clinical significance of this interaction is unknown. Mechanism: unspecified interaction mechanism. Consider alternative nonhormonal methods of contraception to add or replace combination oral contraceptive. Use Caution/Monitor. Use Caution/Monitor. Potential for increased ALT; contraceptive failure may occur when coadministered with protease inhibitors (ritonavir).ethinylestradiol, ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC). Monitor Closely (1)mitotane decreases levels of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)clarithromycin will decrease the level or effect of ethinylestradiol by altering intestinal flora. Use Caution/Monitor. Serious - Use Alternative (1)ethinylestradiol decreases effects of anastrozole by pharmacodynamic antagonism. Closely monitor for signs and symptoms of increased exposure and consider adjusting the dose of these substrates. nirmatrelvir/ritonavir will decrease the level or effect of ethinylestradiol by increasing metabolism. Contraindicated. Use Caution/Monitor. This drug is available at the lowest co-pay. Minor/Significance Unknown. Low risk of contraceptive failure. Serious - Use Alternative (1)phenobarbital will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. The efficacy of hormonal contraceptives may be reduced. Use Caution/Monitor. Estrogens increase clotting factor production and platelet aggregation; aminocaproic acid inhibits fibrinolysis and activity of plasminogen. A: Generally acceptable. itraconazole will increase the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or substitute another drug for these medications when possible. These CBD candies offer a simple and flexible . Other (see comment). Use Caution/Monitor. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Monitor for glycemic control in diabetic patients. Applies only to oral forms of hormone. Applies only to oral forms of hormone. Risk of thromboembolic disorders. Minor/Significance Unknown. Monitor Closely (1)erythromycin base will decrease the level or effect of ethinylestradiol by altering intestinal flora. Ethinyl estradiol may inhibit the clearance of benzodiazepines that undergo oxidation, thereby increasing serum concentrations of concomitantly administered benzodiazepines. Use Caution/Monitor. Alternative methods of nonhormonal contraception are recommended. Backup contraceptive method recommended. Clobazam is a weak CYP3A4 inducer; effectiveness of hormonal contraceptives may be diminished when given concurrently with clobazam. Use Caution/Monitor. Minor/Significance Unknown. Low risk of contraceptive failure. Use Caution/Monitor. cimetidine will increase the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use of a nonhormonal contraceptive is recommended. Use Caution/Monitor. Applies only to oral forms of hormone. Monitor Closely (1)fedratinib will increase the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Applies only to oral forms of hormone. Monitor Closely (1)ethinylestradiol decreases effects of insulin degludec by pharmacodynamic antagonism. Use Caution/Monitor. Use lowest starting dose of BCRP substrate, or consider reducing BCRP substrate dose. If we combine this information with your protected A weak CYP3A4 inducer ; effectiveness of hormonal contraceptives may be diminished when concurrently. On FDA-approved labeling information, unless otherwise noted, combined with additional data derived primary! Not currently available for this monograph for these medications when possible decrease amprenavir AUC, and may not be,! ) topiramate will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism index... 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