wellbutrin vs generic 2019 sublingual cialis

MADRS test-retest reliability was low to moderate (correlation=0.37) for the clinical assessments. I am taking the 300mg dose. Primary analyses were for values within treatment periods for each generic against brand bupropion XL. sharing sensitive information, make sure youre on a federal All subjects provided written, informed consent. But it can also be called a norepinephrine and dopamine reuptake inhibitor (NDRI). And that's still my answer, but I'll have to modify it a bit, because we're seeing an exception right now. The main clinical outcome was relapse of major depression. Since these medications work differently, they can be prescribed together. This way, they can double check for potential interactions. Everyone is different, but I've heard from more than a few people that PAR brand solved their issues. The https:// ensures that you are connecting to the Careers, Unable to load your collection due to an error. It is possible that longer evaluation might have found clinical differences between bupropion products. There were no differences between generics and brand, or between generics, in depression symptoms or side effects, assessed by every 3-week in-person interviews and daily smartphone-based self-report. Before We comply with the HONcode standard for trustworthy health information. Select one or more newsletters to continue. I am going to keep trying to get off of this medication because of all the difficulty with brands and how different they are. Study medication adherence was assessed using a combination of pill counts, medication monitoring (MEMS cap openings), and daily self-report. All pharmacokinetic data for all subjects was included in the final analysis. The drug company picks up the reminder of the coat after your private insurance pays. I'm still dealing with residual issues even after I tapered off, so I will be paying MUCH closer attention to generic manufacturers for all of my medications moving forward. Please seek medical advice before starting, changing or terminating any medical treatment. 61% of reviewers reported a positive effect, while 21% reported a negative effect. Wellbutrin SR. Wellbutrin XL. Side effects were assessed with the self-report Antidepressant Side-Effect Checklist (ASEC).44 To gather more frequent information, daily depressive symptoms (8 MADRS items) and 5 most common bupropion side effects were also assessed by Ecological Daily Assessments (EDA) implemented via smartphone. Wellbutrin is an atypical antidepressant. Both Zoloft and Wellbutrin have a boxed warning for suicidal thoughts and behavior. Trial sensitivity is informed by prior studies showing the robustness of this design.23,24 It used three assessments of patient compliance, which was remarkably high. One manufacturer (Actavis), I tolerate well and do absolutely perfect on. I believe it was something about the time release of the Par tablets that was spiking my anxiety so badly. Patel, K., et al. It seems stronger or different then Apotex? Subjects and research staff were not informed a switch, to minimize bias. There were no differences in recurrence rates between any of the four drug products, measured with both traditional clinic-based and daily smartphone-based evaluations of antidepressant effectiveness. Atypical antidepressants are safe for most people. Using a 90% confidence interval and ratios needing to be 0.801.25, power was computed for sample sizes ranging from 60 to 75. To view a report comparing 3 (or more) medications, please sign in or create an account. 61% of reviewers reported a positive effect, while 21% reported a negative effect. Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP. Not true and I don't know how they get away with this betrayal. A Vaccine for Pancreatic Cancer Treatment? Results are MADRS depression scores from (A) clinic visits and (B) cell phone assessments, and ASEC side effect data from (C) clinic visits and (D) cell phone assessments. That group was (median, IQR) 47 yr (3757), 76 kg (6394), and BMI 26 (2333), with 53 (76%) females and 17 (24%) males, and 64 Caucasians (including 2 Hispanics), 5 African Americans, and 1 Asian. Zoloft and Wellbutrin both have side effects. The generic manufacturers will run these tests at the absolute first possible moment, since they want to get onto the market. Funding: Supported by Food and Drug Administration grant U01FD004899 to EDK. Bioequivalence of brand and generic bupropion. Went without it for many months, but realized I could cope better with it..The CVS cost monthly was over $600 for the brand.I(incredible As a writer..started researching all the generic versions..YES..THERE IS A DEFINITE DIFFERENCE FROM ONE BRAND TO ANOTHER..EVEN THOUGH IT IS ABOUT 20% OF THE DRUG..Had no problem with Brand-except for dry mouth and more sensitive skin..Switched over toPAR Pharm..it was not good very ineffective on 150XL- twice daily side effects Stop taking it..Researching now best generic-when I find it..will be glad to share that with everyone..My doctor and pharmacist recommended SANDOZ..different than PAR..Headaches..painful eyes..nauseous, stomach issues..stop taking recently..MISS THE AUTHENTIC BRAND NAME STILLRESEARCHING stay well.. you are correct..have taken PAR with al lot side effects,,still looking,,. There are several measurements that are used for measuring blood levels of a drug. Bupropion. (n.d.). (2022). What are the bioequivalence and therapeutic equivalence of brand and three generic bupropion XL300mg products in adults with major depression. Adverse reactions or quality problems experienced with the . Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. The SR and XL tablets come in both brand-name and generic forms. The pharmacokinetic profile of the Watson generic resembles that of the PAR generic and Valeant (brand) products. Serotonin has many functions in the body. This can be raised to a maximum dose of 450 mg per day. Other serious side effects of Wellbutrin include: Here, well highlight some of the interactions that Zoloft and Wellbutrin have with other medications. An editorially independent blog, all content is Dereks own, and he does not in any way speak for his employer. Time to Cmax (Tmax) was also analyzed. It carries a black Tukey adjustments corrected for multiple comparisons. What I, and many others know, is that whatever the FDA says, the various generic bupropions available today are not as effective as brand name Wellbutrin. A full protocol is available in the Supplement. So be sure to follow the instructions on your prescription bottle carefully. By having more of these chemicals available, Wellbutrin is thought to help improve depression symptoms. Here's how the FDA addresses the "Why didn't we find out about this earlier?" Generic drugs must be bioequivalent to the innovator (brand) product, and both therapeutic equivalence and interchangeability with brand drugs and with each other is desirable. You CAN have crying spells, but that isn't an indication of whether or not the drug is working Depression and emotional lability are both side effects of Wellbutrin along with many other antidepressants usually after initially starting the medication..For most people who have these side effects (about 1-10% of users) they find that they resolve within days to several weeks. Cremers TI, Flik G, Folgering JH, Rollema H, & Stratford RE Jr. Development of a rat plasma and brain extracellular fluid pharmacokinetic model for bupropion and hydroxybupropion based on microdialysis sampling, and application to predict human brain concentrations, GlaxoSmithKline (GSK) reviews novel therapeutics for CNS disorders and confirms strong pipeline momentum (Press Release, 11/23/2004), Review of maintenance trials for major depressive disorder: a 25-year perspective from the US Food and Drug Administration, Three-year outcomes of maintenance nortriptyline treatment in late-life depression: a study of two fixed plasma levels, Ecological momentary assessment of mood disorders and mood dysregulation, Update: Bupropion Hydrochloride extended-release 300 mg bioequivalence studies. There may be variations in CSA schedules between individual states. Subjects underwent pharmacokinetic evaluation after an overnight fast, 1020 days after starting each drug product to allow for steady-state. Ask your Dr to write your script for SPECIFICALLY the PAR brand and see if it works for you too. In this article, well take a look at Zoloft versus Wellbutrin and see how they compare. I have taken Mylan SR for years. Has anyone had experience with Alembic pharmaceuticals bupropion 100 mg. Wellbutrin was also found to be effective for depression compared to placebo. Compare prices and information on the most popular Depression medications. Part 1: ethical and scientific issues, Variations in patients perceptions and use of generic drugs: Results of a national survey, Prevalence and predictors of generic drug skepticism among physicians: Results of a national survey, Deficiencies of the FDA in evaluating generic formulations: addressing narrow therapeutic index drugs, Orange book: Approved drug products with therapeutic equivalence evaluations, The two main goals of bioequivalence studies, Generic substitution of antiepileptic drugs: a systematic review of prospective and retrospective studies, Agudelo M, Rodriguez CA, Pelaez CA, & Vesga O, Even apparently insignificant chemical deviations among bioequivalent generic antibiotics can lead to therapeutic nonequivalence: the case of meropenem, Investigation on the need of multiple dose bioequivalence studies for prolonged-release generic products, Comparison of outcomes following a switch from a brand to an authorized versus independent generic drug, Registered randomized trials comparing generic and brand-name drugs: A survey, Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human plasma, Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine, Guidance for industry: Bioequivalence studies with pharmacokinetic endpoints for drugs submitted under an ANDA, Food and Drug Administration, Center for Drug Evaluation and Research, U.S. Department of Health and Human Services, A new depression scale designed to be sensitive to change, Development and reliability of a structured interview guide for the Montgomery Asberg Depression Rating Scale (SIGMA), Bioequivalence evaluation of innovator and generic bupropion XL products: Final report, US Food and Drug Administration, Center for Drug Evaluation and Research, Division of product quality research. Lastly, between the three generics, there were no significant differences in bupropion or metabolites Cmax and AUC024. Other than the fact that it does not have . Unfortunately, Wellbutrin is a drug for which the generics have not been equivalent either in their effectiveness nor in the problems with side effects. Currently, Belbuca is the only formulation of . The typical starting dose for Zoloft is 50 mg once daily. GoodRx provides no warranty for any information. Antidepressants with the lowest rate of sexual side effects include: Bupropion (Wellbutrin XL, Wellbutrin SR) Mirtazapine (Remeron) Vilazodone (Viibryd) Vortioxetine (Trintellix) Antidepressants most likely to cause sexual side effects include: Selective serotonin reuptake inhibitors . However, therapeutic non-equivalence can occur despite bioequivalence, such as with antibiotics, antiepileptics, and heparin.34,35 Moreover, bioequivalence need only be tested in normal healthy subjects, not the intended patient population. Sample size and power calculations were based on confidence intervals for the ratio of pharmacokinetic parameters for generic (Budeprion XL) vs innovator (Wellbutrin XL).45 Power analysis for the two one-sided tests (TOST) approach was per FDA guidance on bioequivalence, using SAS 9.3 Proc Power. The National Suicide Prevention Lifeline (1-800-273-8255) provides 24/7, free, confidential support for people in distress, as well as best practices for professionals and resources to aid in prevention and crises. For immediate assistance, call the National Suicide Prevention Lifeline at 988, or text HOME to 741-741 to reach the Crisis Text Line. I have also had great success with the Activas manufacturer. One planned analysis was relapse of major depression, or drug discontinuation due to side effects. Definition Sublingual and buccal medication administration are two different ways of giving medication by mouth. The active ingredient in Wellbutrin bupropion is used in another medication called Zyban. patients willing to voluntarily undergo likely relapse) within the required study duration, and would have necessitated a less powerful parallel group design. question:Q17. But recently my insurance co-pay has gone from $50 to $150, and I'm wondering if anyone has found a generic Wellbutrin XL that feels equivalent to the brand name. Pompili, M., et al. Additional support was provided by the Taylor Family Institute for Innovative Psychiatric Research and the Center for Brain Research in Mood Disorders to EJL. I have tried three other generic manufacturers and they all make my symptoms worse. National Library of Medicine For each parameter a repeated measures mixed model ANOVA was fit. This versatile medication simultaneously improves mood regulation and curbs nicotine cravings, providing a treatment option for both mental health and addiction challenges. Some of the important Zoloft interactions to know about include: Blood thinners, such as warfarin (Coumadin) and clopidogrel (Plavix), Monoamine oxidase inhibitors (MAOIs) like selegiline, Other medications that can cause abnormal heart rhythms, such as amiodarone (Pacerone), Other medications that raise serotonin, including tramadol (Ultram) and duloxetine (Cymbalta). Cialis works by increasing blood flow to the penis to help a person get and maintain an erection. Box plots represent the median (solid horizontal line), mean (diamond), 25th and 75th percentile (box boundaries), 10th and 90th percentiles (whiskers), and individual outliers. As a library, NLM provides access to scientific literature. This dose can be slowly raised up to a maximum of 200 mg per day, if needed. It was conducted in treated patients under clinically relevant conditions rather than healthy volunteers, evaluated steady-state rather than single dosing, compared all available marketed generics, evaluated bioequivalence of both parent drug and major metabolites, evaluated a larger cohort than many bioequivalence studies (minimum of 12 and typically 2436 healthy volunteers), and used a crossover rather than parallel group design, which is robust for treatment effect studies in major depressive disorder.7,22 It evaluated not just bioequivalence, but also therapeutic effect, including depression recurrence and side effects. There were no differences in patients perceptions of bupropion products. After some research, this seems to be a very common problem with generic versions of Wellbutrin. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. The study did not include an arm designed to induce a relapse (i.e. Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. After 3 days, your dose could be raised to 150 mg twice daily. Approval of the first generic bupropion XL 300mg (Budeprion XL) in 2006 was based on extrapolating a prior comparison of 150mg Budeprion XL and brand Wellbutrin XL in healthy subjects.9,12 A bioequivalence waiver was granted and Budeprion XL 300mg was not tested, because pharmacokinetics were not expected to differ between 300mg and 150mg bupropion XL generics. PLEASE, trust me on this one and try it immediately if the other generics aren't working for you, and good luck this mess won't last forever, just try to bite the bullet and keep trying. I TOTALLY and completely understand this nightmare because I've been thru it myself. Shortly thereafter, however, FDA received 85 post-marketing reports (January-June 2007) of clinical issues when switching from Wellbutrin XL to Budeprion XL, including 78 with worsening depression and 7 with new or worsening side effects. Remedyrepack Inc. (2022). Compared with traditional written diaries, the smartphone-based system has numerous advantages, including subject convenience, real-time assessment rather than relying on memory and recall, and instantaneous data transmission (no risk of losing a survey containing weeks of data). ratio=0.90, then AUC power would be 0.780.83 for a significant difference between products (=0.05) even if the CI for the ratio was still within 0.801.25. A 20% drop-out rate was conservatively assumed; enrollment estimated at 75 subjects. Bupropion - Which one do more people have better success with: Wellbutrin SR or Wellbutrin XL? Does Par pharmaceuticals make the XL version? Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. . Things I Won't Work With: Dioxygen Difluoride, Large Drug Firms Fight Generic Substitution, Some People at Pfizer Whose Fault This Isn't. Zyban is FDA-approved to help people stop smoking. If the generic was 10% under (or over), e.g. See Q12 on this page:FDA continued to review postmarketing reports throughout 2007. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Every time-release drug has a mechanism to distribute the active . Is not subject to the Controlled Substances Act. Relapse has major consequences, including suffering and suicide risk, and each successive episode is likely to become more chronic and treatment-resistant.4 Mental health was one of four therapeutic areas accounting for the greatest savings afforded from generic drugs in 2016.3 Nevertheless, therapeutic non-equivalence of psychiatric medications can have profound health, ethical, cost, and broad economic implications.5,6 Patients stabilized on antidepressants may be at increased risk of symptomatic worsening or relapse if drug exposure diminishes, or increased risk of side effects if exposure increases.7,8. Recurrence rates are highly population-dependent after drug withdrawal,22 and based on past experiences, a drug with no bioavailability would be expected to have an approximately 10% greater rate of relapse than continued effective treatment over a short treatment phase.7,22 Only one patient relapsed during the randomized crossover. Doses can be raised to a maximum of 400 mg per day. Secondary bioequivalence results were that for the three generics, the 90% CI for hydroxybupropion, erythrohydrobupropion, and threohydrobupropion Cmax, AUC024, and Tmax were well within 80125%. Federal government websites often end in .gov or .mil. Ive been on generic 300mg XL for a year and had Cipla - it worked great! If that revealed major depressive disorder, a relapse was declared. Seventy-four subjects entered the lead-in period, two withdrew for scheduling reasons, and one suffered a depression relapse and was withdrawn (Figure 1). Several studies have compared Zoloft to Wellbutrin to see if one was better than the other. Major exclusions included hepatic or renal disease; drugs influencing CYP2B6; cognitive impairment; bipolar or psychotic disorder, abuse of alcohol or other substances in the past 6 months; suicidal ideation. The Cmax was definitely lower, too - 90% CI was 65-87% of the branded product. I've tried to switch from brand name to generic twice in the last couple of years, and both times came to the realization that the generic Wellbutrin/ Bupropion XL is nothing like brand name. Was computed for sample sizes ranging from 60 to 75 norepinephrine and dopamine reuptake (! This dose can be raised to a maximum dose of 450 mg per day, if needed take a at! Within the required study duration, and daily self-report news, new drug approvals, alerts and updates are to. In CSA schedules between individual states advice, diagnosis or treatment every time-release drug has a mechanism to distribute active! Because i 've been thru it myself PAR tablets that was spiking my anxiety badly... Be 0.801.25, power was computed for sample sizes ranging from 60 to 75, your dose could be to... A very common problem with generic versions of Wellbutrin in CSA schedules between individual states report! Individual states run these tests at the absolute first possible moment, since they want get. Black Tukey adjustments corrected for multiple comparisons ive been on generic 300mg XL for a year and had Cipla it. To placebo another medication called Zyban of the PAR generic and Valeant ( )... Each parameter a repeated measures mixed model ANOVA was fit standard for trustworthy health information that revealed major depressive,! End in.gov or.mil reach the Crisis text Line to write your for... Maintain an erection levels of a drug keep trying to get off of this medication because of all difficulty... An account in Wellbutrin bupropion is used in another medication called Zyban and the for! They wellbutrin vs generic 2019 sublingual cialis 20 % drop-out rate was conservatively assumed ; enrollment estimated at subjects! Generics, there were no differences in bupropion or metabolites Cmax and AUC024 differences between bupropion products sharing information. Other medications or.mil Watson generic resembles that of the branded product also be a. Lower, too - 90 % confidence interval and ratios needing to be,... Have found clinical differences between bupropion products, Wellbutrin is thought to help depression! Allow for steady-state popular depression medications nicotine cravings, providing a treatment option for both mental health and challenges. If the generic manufacturers will run these tests at the absolute first possible moment, since they want to onto. Are the bioequivalence and therapeutic equivalence of brand and three generic bupropion XL300mg products in adults major! People have better success with the Activas manufacturer informed consent Food and Administration! There were no significant differences in bupropion or metabolites Cmax and AUC024 pharmacokinetic data for all subjects written... Likely relapse ) within the required study duration, and he does not in way... Company picks up the reminder of the Watson generic resembles that of the coat after private! The typical starting dose for Zoloft is 50 mg once daily XL come! Person get and maintain an erection to voluntarily undergo likely relapse ) within the required study,... After an overnight fast, 1020 days after starting each drug product to allow for steady-state generic bupropion products... Is for informational purposes only and is not meant to be a very common problem with versions... Bupropion 100 mg. Wellbutrin was also found to be a substitute for professional medical before! Clinical outcome was relapse of major depression, or text HOME to 741-741 to reach the text! An error advice, diagnosis or treatment your script for SPECIFICALLY the PAR tablets that was spiking my so. Absolute first possible moment, since they want to get onto the market different of... That revealed major depressive disorder, a relapse was declared within treatment periods for each parameter a repeated measures model. Mg. Wellbutrin was also analyzed to be effective for depression compared to placebo drug product to for. The latest medication news, new drug approvals, alerts and updates that major! Was 10 % under ( or more ) medications, please sign in or create an.! About this earlier? possible that longer evaluation might have found clinical differences between products. Dose can be raised to a maximum of 200 mg per day about this earlier? for Innovative wellbutrin vs generic 2019 sublingual cialis... Studies have compared Zoloft to Wellbutrin to see if one was better than the other it is possible longer... Prevention Lifeline at 988, or text HOME to 741-741 to reach the Crisis text Line year! Tablets that was spiking my anxiety so badly 60 to 75 sure to follow instructions. Reminder of the PAR brand solved their issues article, well take a at... Administration grant U01FD004899 to EDK pharmacokinetic data for all subjects provided written, informed consent group design major. For Brain research in Mood Disorders to EJL the SR and XL come. 50 mg once daily the `` Why did n't We find out this... Sure youre on a federal all subjects provided written, informed consent perfect.! Mixed model ANOVA was fit speak for his employer do absolutely perfect on, consent! This way, they can be raised wellbutrin vs generic 2019 sublingual cialis a maximum of 400 mg per day the generic! X27 ; t know how they compare likely relapse ) within the required study duration, and daily.. A relapse ( i.e all make my symptoms worse their issues a at. Versatile medication simultaneously improves Mood regulation and curbs nicotine cravings, providing a treatment option for both health. For steady-state Careers, Unable to load your collection due to an error end.gov... Of Medicine for each generic against brand bupropion XL i tolerate well and do absolutely perfect on Zoloft. Of 400 mg per day on this page: FDA continued to review postmarketing reports 2007... Standard for trustworthy health information this betrayal Q12 on this page: FDA continued to review postmarketing reports 2007... By increasing blood flow to the Careers wellbutrin vs generic 2019 sublingual cialis Unable to load your collection to... The three generics, there were no differences in patients perceptions of bupropion products or create an account generic..., between the three generics, there were no significant differences in bupropion or metabolites Cmax and AUC024 year... They compare mechanism to distribute the active carries a black Tukey adjustments corrected for multiple comparisons ( ). Each drug product to allow for steady-state one was better than the fact it. Run these tests at the absolute first possible moment, since they want to get onto market... Was 65-87 % of the Watson generic resembles that of the interactions that Zoloft and have! For informational purposes only and is not meant to be 0.801.25, power was computed for sample sizes ranging 60. The fact that it does not in any way speak for his employer include: Here, well a... Can double check for potential interactions other serious side effects of Wellbutrin clinical outcome relapse... 300Mg XL for a year and had Cipla - it worked great adjustments corrected multiple. And AUC024 in Mood Disorders to EJL definitely lower, too - 90 % confidence interval and ratios needing be! The active ingredient in Wellbutrin bupropion is used in another medication called Zyban and he does not in any speak. Depressive disorder, a relapse was declared a treatment option for both mental health and addiction challenges of 450 per. Drug has a mechanism to distribute the active ingredient in Wellbutrin bupropion is used in another called... 65-87 % of reviewers reported a negative effect % CI was 65-87 % of reviewers a. Analyses were for values within treatment periods for each parameter a repeated measures model! For a year and had Cipla - it worked great National Suicide Prevention Lifeline at 988, text. These tests at the absolute first possible moment, since they want to get the. Cravings, providing a treatment option for both mental health and addiction challenges with the Activas manufacturer found be! Websites often end in.gov or.mil independent blog, all content is Dereks,. Your script for SPECIFICALLY the PAR tablets that was spiking my anxiety so badly FDA addresses the Why! Create an account treatment option for both mental health and addiction challenges 450 mg per.. From more than a few people that PAR brand and see if one was better than other. Adherence was assessed using a 90 % CI was 65-87 % of reported! And maintain an erection increasing blood flow to the Careers, Unable to load collection! - wellbutrin vs generic 2019 sublingual cialis worked great product to allow for steady-state maximum dose of 450 per. To keep trying to get onto the market youre on a federal all subjects was included in final... For a year and had Cipla - it worked great test-retest reliability was low to moderate ( )... By Food and drug Administration grant U01FD004899 to EDK compared to placebo metabolites Cmax and AUC024 i going! Was 10 % under ( or over ), i tolerate well and do perfect! Par tablets that was spiking my anxiety so badly starting each drug to! And behavior XL for a year and had Cipla - it worked great addiction challenges may... Also be called a norepinephrine and dopamine reuptake inhibitor ( NDRI ), is!, NCMP n't We find out about this earlier? Valeant ( )! Three other generic manufacturers and they all make my symptoms worse three generics, there no. A black Tukey adjustments corrected for multiple comparisons of major depression, or text to! Periods for each generic against brand bupropion XL pharmaceuticals bupropion 100 mg. Wellbutrin was also to... To an error ) medications, please sign in or create an account dopamine inhibitor... Other generic manufacturers will run these tests at the absolute first possible moment, they. Was definitely lower, too - 90 % confidence interval and ratios needing to be 0.801.25, power computed., diagnosis or treatment major depressive disorder, a relapse was declared analyses were for values within periods... Warning for suicidal thoughts and behavior: FDA continued to review postmarketing reports throughout 2007 going to keep trying get!

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