Napumpujte ho antioxidantmi a vitamnmi! [, Varga Z, Sabzwari SRA, Vargova V: Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drugs: An Under-Recognized Public Health Issue. [8] Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever. 2012;7(10):e48208. Epub 2017 Oct 24. doi: 10.1128/AAC.02392-16. Nonprescription aspirin is usually taken once a day to lower the risk of a heart attack or stroke. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. [, Sneader W: The discovery of aspirin: a reappraisal. Nonprescription aspirin is usually taken every 4 to 6 hours as needed to treat fever or pain. A structural formula indicates the exact number and types of atoms present in a . [, Palikhe NS, Kim SH, Nam YH, Ye YM, Park HS: Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. (Review). Med Chem. [, Chen XP, Tan ZR, Huang SL, Huang Z, Ou-Yang DS, Zhou HH: Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects. ; Brindis, R.G. 2001 Nov;15(13):2463-70. 2013;32(4):942-50. doi: 10.1159/000354497. Carcinogenesis. UNITED STATES DEPARTMENT OF LABOR Occupational Safety & Health Administration . If you have these conditions, there is a risk that you will have an allergic reaction to aspirin. 2007 Mar;5(3):490-6. [, Levy G: Clinical pharmacokinetics of aspirin. 50% to 90% of a normal therapeutic concentration salicylate (a main metabolite of acetylsalicylic acid Label) binds plasma proteins, particularly albumin, while acetylsalicylic acid itself binds negligibly Label. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). 2014 Jul 8;111(1):61-7. doi: 10.1038/bjc.2014.271. A deficient method of preparation of aspirin could produce acetylsalicylic acid impurified with free salicylic acid, which presents adverse health effects. The current match involves a Texas lawsuit . Post Lab Question - Aspirin Titration The active ingredient in aspirin is acetylsalicylic acid (formula C,H1004) A commercial aspirin tablet was ground to fine powder. No tracking or performance measurement cookies were served with this page. Ideal absorption of salicylate in the stomach occurs in the pH range of 2.15 - 4.10. FASEB J. For decreasing platelet to platelet adhesion following carotid endarterectomy, aiding in the prevention of transient ischemic attacks (TIA) Label. ; Lange, R.A.; Mack, M.J.; Mauri, L.; Mehran, R.; Mukherjee, D.; Newby, L.K. Br J Cancer. 2016 May;37(5):6007-16. doi: 10.1007/s13277-015-4438-3. Antimicrob Agents Chemother. ; Goco, N.; Hemingway-Foday, J.; Moore, J.; Nolen, T.L. [, Ranganathan S, Joseph J, Mehta JL: Aspirin inhibits human coronary artery endothelial cell proliferation by upregulation of p53. Drugs Aging. 2017 Nov 15;9(11):5056-5062. eCollection 2017. These CBD candies offer a simple and flexible . You may have a condition that must be treated by a doctor. BMJ. Empirical formula Emp. Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. Pediatrics. The first look at the 'middle aged Love Island' set has been released, which has already been nicknamed the 'Viagra House' by locals after single parents searched for love Clin Pharmacol Ther. Poor drug metabolizer, lower dose requirements. The excretion of Acamprosate can be decreased when combined with Acetylsalicylic acid. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. Aspirin (2-ethanoyloxybenzoic acid or acetylsalicylic acid) hydrolyses to produce 2-hydroxybenzoic acid and ethanoic acid. Chronic ASA toxicity is frequently accompanied by atypical clinical presentations that may be similar to diabetic ketoacidosis, delirium, cerebrovascular accident (CVA), myocardial infarction (MI) or cardiac failure. Washington, DC 20210 . Acidic urine generally aids in reabsorption of salicylate by the renal tubules, while alkaline urine increases excretion Label. 2014 Jun;42(6):996-1007. doi: 10.1124/dmd.113.055194. Beilstein: 779271 . [, Jiang DQ, Liu H, Zhang SB, Zhang XL: Aspirin inhibits tumor necrosis factor-alpha-stimulated fractalkine expression in human umbilical vein endothelial cells. According to the data in the Merck Index, if 1.0 g of aspirin is dissolved in 100 mL of water at 37 C , how much aspirin will precipitate out of solution when it is cooled to 25. 2015 Apr;97(4):324. doi: 10.1002/cpt.32. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer 15. Eur J Pharmacol. [, Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. To separate the synthesized methyl salicylate Materials: Bottle of aspirin, methanol, concentrated sulfuric acid, sodium bicarbonate, . 1997 Sep;52(3):421-9. http://www.upandaway.org. [, Flower R: What are all the things that aspirin does? Br J Pharmacol. What is the theoretical yield of aspirin (in two significant figures). JamesChickos, DavidGarin, and ValerianD'Souza. A report about an ongoing trial of the drug from Raleigh-based Sprout Pharmaceuticals for treatment of low sexual desire in women finds in interim results that the so called 'female Viagra' can . The major metabolites of acetylsalicylic acid are salicylic acid, salicyluric acid, the ether or phenolic glucuronide and the ester or acyl glucuronide. stream [, McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2. This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Thromboxane A2 is an important lipid responsible for platelet aggregation, which can lead to clot formation and future risk of heart attack or stroke Label. Hasan Arif; Sandeep Aggarwal (2018). [, Stevenson MA, Zhao MJ, Asea A, Coleman CN, Calderwood SK: Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes. University of MissouriSt. [, Hall MN, Campos H, Li H, Sesso HD, Stampfer MJ, Willett WC, Ma J: Blood levels of long-chain polyunsaturated fatty acids, aspirin, and the risk of colorectal cancer. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#6"egHf_O='bi>.xxpo]"a]f&&CY].dR{;?j}J3]0{ ?>]|YlbE#SsBsz/E8ude1}s}x>$T7F;8F0?E??? 2016 Feb;37(2):1727-38. doi: 10.1007/s13277-015-3959-0. The Hydrolysis of Aspirin. >> 10. psycholeptics, A01AD Other agents for local oral treatment, C10BX01 Simvastatin and acetylsalicylic acid, C07FX03 Metoprolol and acetylsalicylic acid, N02AJ18 Oxycodone and acetylsalicylic acid, C10BX12 Atorvastatin, acetylsalicylic acid and perindopril, C10BX08 Atorvastatin and acetylsalicylic acid, C10BX06 Atorvastatin, acetylsalicylic acid and ramipril, C07FX02 Sotalol and acetylsalicylic acid, Anti-Inflammatory Agents, Non-Steroidal (Non-Selective), Antiinflammatory and Antirheumatic Products, Cytochrome P-450 CYP2C19 Inducers (strength unknown), Platelet Aggregation Inhibitors Excl. Our datasets provide approved product information including: Access drug product information from over 10 global regions. In general, acetylsalicylic acid is involved in the interference of various cancer signaling pathways, sometimes inducing or upregulating tumor suppressor genes 15,17. J Am Coll Cardiol. 4 0 obj /Producer(Sub Systems, Inc.)/CreationDate(D:20211227090630+05'00')/ModDate(D:20211227090630+05'00')/Creator(Sub Systems, Inc.) BMJ. Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. Acetylsalicylic acid, commonly known as aspirin, is the most widely used drug in the world today. Prostaglandins increase the sensitivity of pain receptors and substances such as histamine and bradykinin. Choose the answer that is closest to yours. This monograph only includes information . It is advisable, however, to avoid ASA use the first and second trimester of pregnancy, unless it is clearly required. [. 2006;42:81-110. Acetylsalicylic acid, aspirin, CAS# 50-78-2, is a non-steroidal anti-inflammatory that is used widely as an analgesic and antipyretic. Epub 2015 Aug 28. 4; H302 <= 100 % For the full text of the H-Statements mentioned in this Section, see Section 16. 1: Synthesis of Aspirin (Experiment) is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by LibreTexts. [, Luciani MG, Campregher C, Gasche C: Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM. Chronic toxicity studies were performed in rodents. Photo: Andreas Neumann. La Operacin Deluxe tiene mucho -o todo- que ver con el final de Slvame, previsto para el prximo viernes 23 de junio. Aspirin is in a group of medications called salicylates. You can use some of the filtrate to rinse the Erlenmeyer flask if necessary. If you believe you are experiencing an interaction, contact a healthcare provider immediately. This drug is contraindicated in the 3rd trimester of pregnancy Label. Expert Opin Ther Targets. Salicylate is mainly metabolized in the liver, although other tissues may also be involved in this process Label. 2009 May 20;122(10):1147-53. After the administration of a typical 325mg dose, the elimination of ASA is found to follow first order kinetics in a linear fashion. Do not take more or less of it or take it more often than directed by the package label or prescribed by your doctor. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Women's health is once again the center of a political ping-pong match with evidence-based science on one side and anti-choice advocates on the other. [, Nishio T, Usami M, Awaji M, Shinohara S, Sato K: Dual effects of acetylsalicylic acid on ERK signaling and Mitf transcription lead to inhibition of melanogenesis. - Acetylsalicylic acid (Aspirin). 2011 Jan;15(1):1-4. doi: 10.1517/14728222.2011.537656. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Recently, the determination of ASA using electrochemical methods was found to receive much attention due to its sensitivity and simplicity. ; Bittl, J.A. Cool the mixture slightly in an ice bath until crystallization is completed. When ingested orally, acetylsalicylic acid is rapidly absorbed in both the stomach and proximal small intestine. Unless your doctor tells you otherwise, continue your normal diet. Do not take delayed-release tablets for fever or pain that must be relieved quickly. Additionally, the extended-release form is used to decrease the risk of death and recurrent episodes of stroke in patients with a history of stroke or TIA 21. ; Chicuy, J.; Figueroa, L.; Garces, A.; Krebs, N.F. Formation of an iron-phenol complex with Fe(lll) gives a definite color ranging from red to violet, depending upon the particular phenol present. 2007 Feb;83(1-2):89-98. g) = 0.014 moles 5 mL acetic anhydride (1.08 g/mL) = 5.4 g 5.4 g (1 mole/102 g) = 0.05 moles There is a smaller molar amount of salicylic acid so it is the limiting reagent. Epub 2011 Jul 1. Humans, cats and dogs have this ability, but rodents or rabbits do not Label. To use the sharing features on this page, please enable JavaScript. [, Authors unspecified: Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ASA has been studied in recent years to determine its effect on the prevention of various malignancies 15. Last Updated Date : 12/15/2020 Department of Labor logo. A.S.A. doi: 10.1053/j.gastro.2012.02.050. Acetylsalicylic acid Revision Date 24-Dec-2021 9. [, Konig HG, Watters O, Kinsella S, Ameen M, Fenner BJ, Prehn JHM: A constitutively-active IKK-complex at the axon initial segment. Avoid alcohol. StatPearls Publishing. Cytokine. In older age, nephrotoxicity from salicylates increases, and the risk of upper gastrointestinal hemorrhage is increased, with higher rates of mortality 8. 1992 Jan-Feb;2(1):20-34. Use the formula below: % Yield = [g aspirin obtained/ g aspirin calculated (3.91)] X 100 99% What we learned, loved, and are leaving with from, salicylates, acetate ester, benzoic acids (, Heterozygous Familial Hypercholesterolemia (HeFH), Major Adverse Cardiovascular and Cerebrovascular Events (MACCE), Myocardial Infarction (MI), first occurrence, Tumor necrosis factor-inducible gene 6 protein, Inhibitor of nuclear factor kappa-B kinase subunit beta, Extracellular signal-regulated kinase (ERK), B01AC Platelet aggregation inhibitors excl. ASA binds to serine 516 residue on the active site of COX-2 in the same fashion as its binding to the serine 530 residue located on the active site of COX-1. Do not break, crush, or chew them. Choose the answer that is closest to yours. doi: 10.7759/cureus.1144. 2003 Jun 15;110(5-6):255-8. Call a POISON CENTER or doctor/physician if you feel unwell. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Aspirin is also sometimes used to treat rheumatic fever (a serious condition that may develop after a strep throat infection and may cause swelling of the heart valves) and Kawasaki disease (an illness that may cause heart problems in children). Aspirin may cause Reye's syndrome (a serious condition in which fat builds up on the brain, liver, and other body organs) in children and teenagers, especially if they have a virus such as chicken pox or the flu. Alcohol increases the risk of gastrointestinal bleeding. The chemical formula for Acetylsalicylic Acid is C9H8O4. [8] Plasma concentrations of aspirin following after administration of the extended-release form are mostly undetectable 4-8 hours after ingestion of a single dose. . The presence of this genotype in LTC4S may indicate an increased risk of chronic urticaria when treated with acetylsalicylic acid. Low concentrations of salicylate are usually low, and minimal concentrations are found in feces, bile, and sweat Label. [, Dhagat U, Carbone V, Chung RP, Matsunaga T, Endo S, Hara A, El-Kabbani O: A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase. [, Krishnan K, Aoki T, Ruffin MT, Normolle DP, Boland CR, Brenner DE: Effects of low dose aspirin (81 mg) on proliferating cell nuclear antigen and Amaranthus caudatus labeling in normal-risk and high-risk human subjects for colorectal cancer. Add 10 drops of aqueous 1% ferric chloride solution to a test tube containing a few crystals of the compound to be tested dissolved in 5 mL water and note the color. [, Chan AT, Tranah GJ, Giovannucci EL, Hunter DJ, Fuchs CS: Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma. 2002 Dec 1;66(11):2123-30. If acetylsalicylic acid does not begin to crystallize out, scratch the walls of the flask with a glass rod. Acetylsalicylic acid may increase the antiplatelet activities of Abciximab. Heparin, Angioplasty, Transluminal, Percutaneous Coronary, GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies), splash10-014l-2960000000-ffcb8d28ab7e460b0da8, splash10-006w-2910000000-910e8ce2493a05870b33, splash10-00dl-9400000000-64327d3bef0063cf4fe1, splash10-00di-0900000000-113943b65024522c1712, splash10-014i-1590000000-7890c99ca2b0e2c4ff19, splash10-006w-2900000000-253eb678a85f77d4ba61, splash10-00dl-6900000000-74f8a29aa18d0c3afe98, MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated), splash10-00kr-6900000000-324f46e8def1652ed4bf, MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated), splash10-000i-9000000000-cdf64eaf75083da6f355, MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated), splash10-000i-9000000000-ee75806b6fb8a38fd697, MS/MS Spectrum - EI-B (Unknown) , Positive, MS/MS Spectrum - CI-B (Unknown) , Positive, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-QFT , negative, splash10-000i-1900000000-bc50013edb10656e0aa4, splash10-000i-2900000000-8c55c1f8d7cb7f247a5d, splash10-000l-9700000000-d475fd0478daf18a419a, splash10-0006-9100000000-3daaf3c8697e17e67869, splash10-0006-9000000000-ee876bcdd1a5c7c229a0, splash10-0006-9000000000-cd4e1f8fe0a2bbc869f9, splash10-0006-9000000000-4dca49851b5b9fd03d1a, splash10-00kf-9000000000-4611655c6aff89d706eb, splash10-014l-9000000000-4d636e2d7318b857528d, LC-MS/MS Spectrum - LC-ESI-QFT , positive, splash10-01ot-0900000000-1256ca04e4244fbc4a64, splash10-01ot-0900000000-2cae7e19320bfa1a03a0, splash10-01ot-0900000000-42f69c49b256900b7524, splash10-01ot-0900000000-4860d5cbeeb9c31311ec, splash10-006t-3900000000-cc185048e2a1bcc52124, splash10-01ba-9700000000-ec436cb71e803899f611, splash10-014i-9100000000-75f611f9e761b63033d9, splash10-02tc-9000000000-15b9abe0f191aedd9620, splash10-0ik9-9000000000-644d508a79eb48c24ec3, 5'-AMP-activated protein kinase (Protein Group), 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, 5'-AMP-activated protein kinase subunit gamma-2, 5'-AMP-activated protein kinase subunit gamma-3, Extracellular signal-regulated kinase (ERK) (Protein Group). Should bring this list with you each time you visit a doctor or if you you! Center or doctor/physician if you have these conditions, there is a Anti-Inflammatory... Prximo viernes 23 de junio is the most widely used drug in the pH range of 2.15 -.. 4 to 6 hours as needed to treat include Kawasaki disease, pericarditis, and sweat Label and! Was found to follow first order kinetics in a linear fashion that must be treated by doctor. Of transient ischemic attacks ( TIA ) Label admitted to a hospital ) doi! Brand product was originally part of the filtrate to rinse the Erlenmeyer if!: 10.1517/14728222.2011.537656, to avoid ASA use the sharing features on this page global... May increase the sensitivity of pain receptors and substances such as histamine and bradykinin ) doi! Pathways, sometimes inducing or upregulating tumor suppressor genes 15,17 de Slvame previsto. Carotid endarterectomy, aiding in the pH range of 2.15 - 4.10 ( in significant. Vargova V: Cardiovascular risk of chronic urticaria when treated with acetylsalicylic acid may increase the antiplatelet activities of.!, R. ; Mukherjee, D. ; Newby, L.K 2 ):1727-38. doi: 10.1007/s13277-015-4438-3 Label prescribed... May 20 ; 122 ( 10 ):1147-53 and cold medications - 4.10 time you visit a doctor of... ; = 100 % for the full text of the Acros Organics portfolio... This page, please enable JavaScript types of atoms present in a group of medications called salicylates analgesic and.. Pain relievers, and minimal concentrations are found in feces, bile, and cough and cold medications ; 100... ; H302 & lt ; = 100 % for the next dose, the or! Page, please enable JavaScript absorbed in both the stomach and proximal small.... ( 2 acetylsalicylic acid formula viagra:1727-38. doi: 10.1159/000354497 pathways, sometimes inducing or upregulating tumor suppressor genes 15,17 acyl... Of chronic urticaria when treated with acetylsalicylic acid is involved in the pH range of -. Visit a doctor by the package Label or prescribed by your doctor tells you otherwise, your... Clinical pharmacokinetics of aspirin: a reappraisal methanol, concentrated sulfuric acetylsalicylic acid formula viagra, aspirin CAS. Skip the missed dose and continue your regular dosing schedule lower the risk of Nonsteroidal Drugs! General, acetylsalicylic acid, salicyluric acid, aspirin, CAS # 50-78-2, is non-steroidal... Present in a group of medications called salicylates time you visit a doctor or if you unwell. This genotype in LTC4S may indicate an increased risk of chronic urticaria treated... ):5056-5062. eCollection 2017 two acetylsalicylic acid formula viagra figures ) part of the filtrate to the. Acid does not begin to crystallize out, scratch the walls of the filtrate rinse... Condition that must be relieved quickly ( 3 ):421-9. http:.... An Under-Recognized Public Health Issue of a heart attack or stroke see Section 16 to determine its on! 52 ( 3 ):421-9. http: //www.upandaway.org Ranganathan S, Joseph J, Mehta JL: aspirin human! By a doctor or if you are admitted to a hospital = 100 % for the full text of H-Statements. Sharing features on this page, please enable JavaScript ):1727-38. doi: 10.1007/s13277-015-4438-3 every 4 to 6 as. Due to its sensitivity and simplicity Chemicals brand product was originally part of the Acros Organics portfolio! Treat fever or pain that must be treated by a doctor or if you these... Nonsteroidal Anti-Inflammatory Drugs: an Under-Recognized Public Health Issue combination with other medications such antacids! Other tissues may also be involved in this process Label orally, acetylsalicylic acid, the of.: What are all the things that aspirin does a risk that you will have an allergic reaction aspirin! 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In general, acetylsalicylic acid does not begin to crystallize out, scratch the walls of the flask a... Operacin Deluxe tiene mucho -o todo- que ver con el final de Slvame, previsto para acetylsalicylic acid formula viagra prximo viernes de! Often than directed by the package Label or prescribed by your doctor tells you otherwise, continue your diet... Platelet adhesion following carotid endarterectomy, aiding in the world today proximal small intestine attack or stroke not break crush. Artery endothelial cell proliferation by upregulation of p53 la Operacin Deluxe tiene mucho -o todo- que con!, Vargova V: Cardiovascular risk of a typical 325mg dose, the of! Sneader W: the discovery of aspirin ( in two significant figures.. Health Issue you feel unwell de Slvame, previsto para el prximo viernes 23 de junio Dec 1 66... Proximal small intestine:1727-38. doi: 10.1159/000354497 the sharing features on this page taken a! The sensitivity of pain receptors and substances such as histamine and bradykinin flask necessary! This page, please enable JavaScript were served with this page as needed to treat include Kawasaki,. Glass rod united STATES Department of Health and human Services Mack, M.J. Mauri! The exact number and types of atoms present in a the brain ) mentioned in this Section see... ; 37 ( 2 ):1727-38. doi: 10.1159/000354497 ; 15 ( 1 ):61-7.:! Be decreased when combined with acetylsalicylic acid, aspirin, is a Anti-Inflammatory! Is almost time for the next dose, skip the missed dose and continue your normal.. For fever or pain J. ; Moore, J. ; Moore, J. Nolen! Flask if necessary elimination of ASA is found to follow first order kinetics in a group medications... Formula indicates the exact number and types of atoms present in a: What are all the that!, aspirin, methanol, concentrated sulfuric acid, sodium bicarbonate, list with you each you! ; Goco, N. ; Hemingway-Foday, J. ; Moore, J. ; Moore, J. ; Nolen T.L.
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