Vladutiu GD, Simmons Z, Isackson PJ, Tarnopolsky M, Peltier WL, Barboi AC, et al. trouble lifting your arms, trouble climbing or standing; liver problems --upper stomach pain, weakness, tired feeling, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes); or . Evidence from a nested case-control study has shown that exposure to statins and aspirin is associated with a reduced risk of de novo major depression.18. Results: Seventy-two studies were retrieved that investigated the effects of statins on the risk of developing depression or on depressive symptoms in both depressed and non-depressed populations. -, Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. official website and that any information you provide is encrypted There is a potential for drug-drug interactions between statins and psychotropic agents (Table 2). Atorvastatin oral tablet is a prescription drug. Global, regional, and national incidence, prevalence, and years lived with disability for 354 Diseases and Injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. 24. Second . 2nd ed. This medicine is available only with your doctor's prescription. Information on drug, drug dose, reported mood and behavioral effect, factors supporting a causal connection, other statin symptoms, family history of psychiatric problems associated with statin use, and presence of risk factors for statin adverse effects are listed in Table1. We know that cholesterol plays an important role in the serotonin system, so statins used to lower cholesterol may lead to the occurrence of depression. Lipitor leads the way in 2003. However, most involved atorvastatin and simvastatin, which have also historically been the most frequently prescribed statins. A comparison of adverse drug reaction reports from professionals and users, relating to risk of dependence and suicidal behavior. Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials. being able to get an erection sometimes, but not every time you want to have sex. Olweus D, Mattsson A, Schalling D, Low H. Circulating testosterone levels and aggression in adolescent males: a causal analysis. Front Psychiatry. Would you like email updates of new search results? Mitochondrial involvement in psychiatric disorders. Generic drugs usually cost less than the brand-name . But if you . Second, the fractional risk change itself may be greater in a behaviorally vulnerable subset (effect modification): illustrating this point, the odds ratios risk of psychiatric events with mefloquine use was reported to be 3.8 among those without a psychiatric history, versus apparently double that (8.0) in those with a psychiatric history [6]. Epub 2013 Sep 19. 10.1016/S2215-0366(17)30015-9 Irritability, detachment, joylessness, anxiety, impatience, reduced social activities, depressive mood, adjustment disorder, completed suicide, Depression, joylessness, loss of appetite, Depression, joylessness, hopelessness, aggression, irritability, Depression, aggression, impatience, irritability, paranoia, completed suicide, Depression, mania, suicide attempts, dyscontrol of bipolar episodes, Depression, nightmares, anxiety, attention/concentration problems, completed suicide, Depression, hopelessness, aggression, irritability, loss of interest in activities and socializing, completed suicide, Irritability, aggression, increased emotional response, Lovastatin, rosuvastatin, atorvastatin, simvastatin, pravastatin, Aggression, irritability, violent ideation, Case 2 is a female in her 50s with a history of autoimmune thyroid disorder, taking 100g of levothyroxine for treatment. verapamil, diltiazem or amlodipine, medicines for high blood pressure and heart problems amiodarone, a medicine that helps if you have an irregular heartbeat (atrial fibrillation) If you're taking atorvastatin and need to take one of these medicines, your doctor may: prescribe a lower dose of atorvastatin prescribe a different statin medicine A report about an ongoing trial of the drug from Raleigh-based Sprout Pharmaceuticals for treatment of low sexual desire in women finds in interim results that the so called 'female Viagra' can . Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. Partonen T, Haukka J, Virtamo J, Taylor PR, Lonnqvist J. Br J Psychiatry. Pharmacovigilance: when to report adverse reactions In: Thomsen HS, Webb JAW, editors. MeSH The lipophilic statins readily cross the blood-brain barrier. This study has the limitations inherent to all case series: data are observational, which constrains causal inference. Other mechanisms may be theorized. People with depression, bipolar disorder, and schizophrenia are substantially more vulnerable to metabolic syndrome and earlier age of mortality than the general population, predominantly from CVD. Statin-associated memory loss: analysis of 60 case reports and review of the literature. Further clinical studies are needed, especially in specific subgroups of patients identified by pre-treatment assessments of inflammatory and lipid profiles. J Affect Disord. Each of the patients in our report experienced problems while receiving at least one of simvastatin, atorvastatin, or lovastatin, which are lipophilic statins. Jarernsiripornkul N, Krska J, Richards RM, Capps PA. 2019;10:103. Dr. Cham takes final responsibility for the integrity of the data and the accuracy of the analysis. 2005 Mar;11(2):81-4. doi: 10.1016/j.parkreldis.2004.07.012. It seems that if statins do cause nightmares, it's a rare side effect. Int Clin Psychopharmacol. Chaudhry IB, Husain N, Drake R, et al. These drugs are widely prescribed and most prominently include statins (3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors), which held the place of best-selling class of prescription drugs in the world and include the best-selling prescription drug in history [2124]. Lochhead JJ, McCaffrey G, Quigley CE, Finch J, DeMarco KM, Nametz N, et al. Below, check out the tour dates, as well as a weird tour . (8) Simvastatin 10mg was followed (time-course not recalled) by depression, aggression/irritability culminating in suicide in a man in his 60s (possible causality). Quinn AL, Dean OM, Davey CG, et al. Nomura et al identified 5 randomized controlled trials (N = 236) showing improvement of PANSS total score, but not of PANSS subscale scores.13 The meta-analysis included studies of atorvastatin, lovastatin, pravastatin, and simvastatin. Prevention of Cardiovascular Disease Rheumatoid Arthritis (off-label) Viagra A total of 323 drugs are known to interact with Viagra . Severe irritability associated with statin cholesterol-lowering drugs. The widely available and safe statins have several putative mechanisms of action, especially anti-inflammatory, which make them ideal candidates for repurposing in the treatment of depression. Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M; ASPREE Investigator Group. The site is secure. Am J Psychiatry. being able to get an erection, but not having it last long enough for sex. Shen et al identified 6 randomized controlled trials (N = 339) showing benefit for improvement of PANSS positive and negative subscales.14 The meta-analysis by Shen et al included all 5 trials from the Nomura et al meta-analysis plus an additional trial of simvastatin versus placebo. Atorvastatin belongs to the group of medicines called HMG-CoA reductase inhibitors, or statins. Here we present 12 cases of mood and behavioral change apparently associated with lipid-lowering agents. Careers. Definite causality assignments were limited to those who, in addition to recovery with discontinuation, were rechallenged with the drug, and experienced symptom recurrence. eCollection 2022. He had a family history of psychiatric illness and adverse behavioral reaction to statins. Kasliwal R, Wilton LV, Shakir SA. Peng P, Wang Q, Lang XE, Liu T, Zhang XY. We also hypothesize that effects on aggression, and perhaps mood problems on statins, may be linked to oxidative stress [80] and inter-related mitochondrial dysfunction (which has been linked to temper disorders) [81]. It belongs to a group of drugs . Furst BA, Champion KM, Pierre JM, et al. J Clin Pharm Ther. (9) Simvastatin 20mg then atorvastatin 10mg were followed (time-course not provided) by irritability/aggression in a man in his 60s (definite causality). Vladutiu GD. Int J Mol Sci. 11. These results measured the time period from baseline to week 8, using the Positive and Negative Syndrome Scale (PANSS).11 Simvastatin did not significantly differ from placebo for treating schizophrenia in an underpowered study (N = 36).12. FOIA These observations support the potential for adverse mood and behavioral change in some individuals with statin use, extend the limited literature on such effects, and provide impetus for further investigation into these presumptive ADRs. Improvement in sleep apnoea associated with switch from simvastatin to pravastatin. Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysis. Background: Depression is a leading cause of disability, burdened by high levels of non-response to conventional antidepressants. Laboratory studies have suggested that statins may be neuroprotective against a range of neurotoxic insults, but statins themselves may be neurotoxic at higher concentrations than those obtained at therapeutic doses.19 The best evidence that statins reduce markers of inflammation is derived from the JUPITER study of rosuvastatin.20 It is unclear whether brain penetrance or reduction in peripheral markers of inflammation is the more important mechanism in terms of potential therapeutic efficacy. BMJ Case Rep. 2011. doi:10.1136/bcr.09.2011.4758. Keywords: Typical effects in men (particularly in men who were both younger and less aggressive at baseline) were toward reduced aggression [69], with older age and female sex shifting the distribution. Lower testosterone in some settings is linked to lower aggression and violence [76, 77]. Effects of statins on energy and fatigue with exertion: results from a randomized controlled trial. Expert Opin Ther Pat. It works by blocking an enzyme that is needed by the body to make cholesterol, and this reduces the amount of cholesterol in the blood. Breggin P. Suicidality, violence and mania caused by selective serotonin reuptake inhibitors (SSRIs): a review and analysis. Ruano G, Thompson PD, Windemuth A, Seip RL, Dande A, Sorokin A, et al. Anxiety and new onset of cardiovascular disease: critical review and meta-analysis. . and transmitted securely. First, they stop the production of cholesterol in your body. 2023 Feb 1;24(3):2821. doi: 10.3390/ijms24032821. Genetic predisposition to statin myopathy. Nightmares and sleep disturbances have been reported in some people taking statins. 2023 Feb 28;14:1138233. doi: 10.3389/fendo.2023.1138233. The four cases designated possible are included because of factors not considered in Naranjo criteria that bear on likelihood of a causal connection. A woman has told how she feared she'd never become a mum but gave birth to a boy at age 45 after taking Viagra to get pregnant.. Carin Rockind, 48, welcomed a "miracle" baby after trying to have a . being unable to get an erection at any time. Unable to load your collection due to an error, Unable to load your delegates due to an error. He had no psychiatric history, and family members described him, pre-statin, as a strong-headed and lively personality, who was well known in his community for being social. yellowing of the skin or eyes. Int J Neuropsychopharmacol. Stewart JT. Statin treatment results in lower low-density lipoprotein cholesterol levels and in benefits to cardiovascular health. 2007;22(7):613-626. Kim SW, Kang HJ, Jhon M, et al. Beatrice A. Golomb, Hayley J. Koslik, and Stephanie Cham have no conflicts of interest that are directly relevant to the content of this study. JAMA. sharing sensitive information, make sure youre on a federal However, patient self-reports of ADRs can be a valuable and reliable tool [96100], andif heededmay hasten recognition of important ADRs [101]; such benefits have led to standardized implementation of patient reporting for EU-based pharmacovigilance databases [102]. Background: Depression is a leading cause of disability, burdened by high levels of non-response to conventional antidepressants. Dr Gimnez-Palomo is a psychiatrist inthe Hospital Clinic de Barcelona in Spainand a researcher at IMPACT, Univer-sityHospital Geelong, Australia. Raised levels of these cytokines appeared to predict depression after acute coronary syndrome.4, Many epidemiological studies have shown that treatment with statins is associated with a lower risk for depression (Table 1).5 A population cohort study (N = 4,607,990) using Swedish national registry data investigated the relationship between statin use and the development of depression. Statin use and risk of depression: a Swedish national cohort study. Demonstration of an association among dietary cholesterol, central serotonergic activity, and social behavior in monkeys. Though statins are widely tolerated, they may be among the growing list of prescription agents that, in some participants, may increase the risk of serious psychiatric events and/or behavioral changes. 2018;30(1):1-16. An expanded description of each case is provided (Table3). Patient reporting of adverse drug reactions: useful information for pain management? PMC Preliminary evidence, mainly from small studies, suggests that adjuvant treatment with a statin may be beneficial for individuals taking psychotropic drugs for depression and schizophrenia. Impact of carbamazepine, lamotrigine, and levetiracetam on vascular risk markers and lipid-lowering agents in the elderly. Bethesda, MD 20894, Web Policies Lipid-lowering medication use and aggression scores in women: a report from the NHLBI-sponsored WISE study. Fattal O, Link J, Quinn K, Cohen BH, Franco K. Psychiatric comorbidity in 36 adults with mitochondrial cytopathies. Paradoxical aggressive effect of propranolol in a patient with Huntingtons disease. Drug and food interactions Moderate atorvastatin food Applies to: atorvastatin The first look at the 'middle aged Love Island' set has been released, which has already been nicknamed the 'Viagra House' by locals after single parents searched for love Concentrations of pravastatin and lovastatin in cerebrospinal fluid in healthy subjects. government site. Lozano P, Henrikson NB, Dunn J, Morrison CC, Nguyen M, Blasi PR, Anderson ML, Whitlock E. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 Aug. Report No. Rather, this case series underscores that statins may in specific individuals promote adverse behavioral, mood, and personality changes, irrespective of whether behavioral (or mood) effects are on average favorable, adverse, or neutral. Not having it last long enough for sex aggression and violence [ 76, 77 ] also! Breggin P. Suicidality, violence and mania caused by selective serotonin reuptake inhibitors: systematic review of randomised controlled.! 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