Use Caution/Monitor.azithromycin and levoketoconazole both increase QTc interval. Monitor Closely (1)azithromycin and disopyramide both increase QTc interval. dofetilide increases toxicity of azithromycin by QTc interval. Serious - Use Alternative (1)lefamulin and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. Applies only to oral form of both agents. The best (first-line) antibiotics for tooth infection include: Amoxicillin, Penicillin, Cephalexin, Clindamycin, Azithromycin. Modify Therapy/Monitor Closely. Monitor Closely (1)quinidine and azithromycin both increase QTc interval. Monitor Closely (1)azithromycin and lumefantrine both increase QTc interval. Monitor Closely (1)azithromycin and artemether/lumefantrine both increase QTc interval. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: vision changes, eye pain.Use of this medication for prolonged or repeated periods may result in other types of eye infections, including fungal infections. Use Caution/Monitor. Modify Therapy/Monitor Closely. Atrial fibrillation: Avoid coadministering dabigatran with P-gp inhibitors if CrCl <30 mL/min. azithromycin will increase the level or effect of riociguat by decreasing metabolism. Do not start, stop, or change the dosage of any medicines without your doctor's approval. buprenorphine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Minor/Significance Unknown. Setting: Clinical pharmacology unit. Avoid or Use Alternate Drug. If it is near the time of the next dose, skip the missed dose. Serious - Use Alternative (1)amisulpride and azithromycin both increase QTc interval. Monitor Closely (1)azithromycin decreases effects of piperacillin by pharmacodynamic antagonism. azithromycin and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug. azithromycin and fostemsavir both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. The NIH COVID-19 Treatment Guidelines recommend against the use of chloroquine or hydroxychloroquine and/or azithromycin for the treatment of COVID-19 in hospitalized patients and in nonhospitalized patients. Monitor Closely (1)azithromycin and ibutilide both increase QTc interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended. Minor (1)azithromycin decreases effects of amoxicillin by pharmacodynamic antagonism. azithromycin increases levels of betrixaban by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Use Caution/Monitor. primaquine and azithromycin both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval. Avoid or Use Alternate Drug. Monitor Closely (1)azithromycin increases toxicity of lofexidine by QTc interval. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Monitor Closely (1)sodium bicarbonate decreases levels of azithromycin by inhibition of GI absorption. Monitor Closely (1)azithromycin increases toxicity of ribociclib by QTc interval. Use Caution/Monitor. pharmacodynamic antagonism. Low risk of contraceptive failure. Serious - Use Alternative (1)azithromycin increases effects of argatroban by decreasing metabolism. azithromycin and olodaterol inhaled both increase QTc interval. Adding 500 mg azithromycin, infused over 1 hour, 'may be considered' for women undergoing nonelective cesarean ; Obesity and postcesarean prophylaxis . Modify Therapy/Monitor Closely. Minor/Significance Unknown. Avoid or Use Alternate Drug. Applies only to oral forms of hormone. Minor (1)azithromycin and methadone both increase QTc interval. Monitor Closely (1)azithromycin increases levels of betrixaban by P-glycoprotein (MDR1) efflux transporter. Low risk of contraceptive failure. azithromycin will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increases risk of torsades de pointes. azithromycin will decrease the level or effect of pyridoxine by altering intestinal flora. Minor (1)azithromycin increases toxicity of tetrabenazine by QTc interval. It works by stopping the growth of . crizotinib and azithromycin both increase QTc interval. Increases risk of torsades de pointes. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Use Caution/Monitor.Minor (1)azithromycin increases toxicity of trimipramine by QTc interval. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Minor/Significance Unknown. liver problems--nausea, vomiting, loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); Call your doctor right away if a baby taking Zithromax IV becomes irritable or vomits while eating or nursing. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. 2010zithromax-zmax-azithromycin-342523Drugs, encoded search term (azithromycin (Zithromax)) and azithromycin (Zithromax), No Surprise: Highest Drug Prices Across the Board in the US, FDA: Don't Use Azithromycin for Lung Condition in Cancer Patients, No Major Azithromycin Arrhythmia Risk in Huge European Cohort, You Give Me Fever: Four Other Tickborne Illnesses. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated. Modify Therapy/Monitor Closely. Minor (1)azithromycin and pazopanib both increase QTc interval. Avoid or Use Alternate Drug. Minor (1)azithromycin and lapatinib both increase QTc interval. Serious - Use Alternative (1)efavirenz and azithromycin both increase QTc interval. Use Caution/Monitor. Maximum dose: 500 mg/dose. Monitor Closely (1)chlorpromazine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. Monitor Closely (1)azithromycin increases toxicity of clofazimine by QTc interval. Other drugs may affect Zithromax IV, including prescription and over-the-counter medicines, vitamins, and herbal products. Binds to 50S ribosomal subunit of susceptible microorganisms and blocks dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent protein synthesis to arrest; does not affect nucleic acid synthesis, Concentrates in phagocytes and fibroblasts, as demonstrated by in vitro incubation techniques; in vivo studies suggest that concentration in phagocytes may contribute to drug distribution to inflamed tissues, Absolute bioavailability: 38% (250-mg capsules), Protein bound: 51% (0.02 mcg/mL); 7% (2 mcg/mL), Clearance: 630 mL/min (single 500-mg oral and IV dose), Y-site: Amikacin, aztreonam, cefotaxime, ceftazidime, ceftriaxone, cefuroxime, ciprofloxacin, clindamycin, droperidol, famotidine, fentanyl, furosemide, gentamicin, imipenem, cilastatin, ketorolac, levofloxacin, morphine, piperacillin-tazobactam, ondansetron(? azithromycin and methadone both increase QTc interval. Separate by 2 hours. Minor/Significance Unknown. azithromycin and dofetilide both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. azithromycin and telavancin both increase QTc interval. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). rilpivirine increases toxicity of azithromycin by QTc interval. Monitor Closely (1)azithromycin decreases effects of cefuroxime by pharmacodynamic antagonism. Use Caution/Monitor. Serious - Use Alternative (1)buprenorphine transdermal and azithromycin both increase QTc interval. Minor (1)azithromycin increases toxicity of degarelix by QTc interval. chlorpromazine and azithromycin both increase QTc interval. Throw away any unused liquid medicine after 10 days. If you take an antacid that contains aluminum or magnesium, wait at least 2 hours before or after taking azithromycin. asenapine transdermal and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. azithromycin increases effects of enoxaparin by decreasing metabolism. azithromycin increases toxicity of asenapine by QTc interval. A: Generally acceptable. cobicistat, azithromycin. mifepristone, azithromycin. Use Caution/Monitor. Low risk of contraceptive failure. Monitor Closely (1)azithromycin and droperidol both increase QTc interval. Coadministration of riociguat (substrate of CYP isoenzymes 1A1, 2C8, 3A, 2J2) with strong CYP inhibitors may require a decreased initial dose of 0.5 mg PO TID; monitor for signs of hypotension and reduce dose if needed. Use Caution/Monitor. Either increases toxicity of the other by QTc interval. inotuzumab and azithromycin both increase QTc interval. Avoid use of colchicine with P-gp inhibitors. Minor/Significance Unknown. Use Caution/Monitor. osilodrostat and azithromycin both increase QTc interval. mobocertinib and azithromycin both increase QTc interval. Serious - Use Alternative (1)isoflurane and azithromycin both increase QTc interval. azithromycin and itraconazole both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor. Brand names: Azithromycin 3 Day Dose Pack, Azithromycin 5 Day Dose Pack, Zithromax, Zithromax IV, Zithromax TRI-PAK, Zithromax Z-Pak Panobinostat is known to significantly prolong QT interval. Monitor Closely (1)azithromycin increases toxicity of propafenone by QTc interval. Monitor Closely (1)azithromycin will decrease the level or effect of thiamine by altering intestinal flora. Avoid or Use Alternate Drug. Concomitant use of azithromycin and dronedarone may increase the risk of QT prolongation, cardiac arrhythmias. This single-dose form of the medication is used to treat certain infections, including genital infections. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval. Use Caution/Monitor. azithromycin increases toxicity of crizotinib by QTc interval. Use Caution/Monitor. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Minor/Significance Unknown. Avoid coadministration of cholera vaccine with systemic antibiotics since these agents may be active against the vaccine strain. azithromycin and dronedarone both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. Serious - Use Alternative (1)sevoflurane and azithromycin both increase QTc interval. azithromycin increases effects of argatroban by decreasing metabolism. azithromycin will increase the level or effect of cetirizine by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. However, this medicine will not work for colds, flu, or other virus infections. azithromycin decreases effects of microbiota oral by pharmacodynamic antagonism. Monitor Closely (1)rilpivirine increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Minor/Significance Unknown. azithromycin and venlafaxine both increase QTc interval. Use Caution/Monitor. azithromycin and paroxetine both increase QTc interval. DVT/PE treatment: Avoid coadministering dabigatran with P-gp inhibitors if CrCl <50 mL/min. Minor (1)azithromycin increases toxicity of solifenacin by QTc interval. Separate by 2 hours. Use Caution/Monitor. Indicated for treatment of community-acquired pneumonia due to Chlamydophila pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, or Streptococcus pneumoniae in patients appropriate for oral therapy, 500 mg PO x 1 dose on Day 1, followed by 250 mg PO qDay on Days 2-5, Indicated for treatment of pharyngitis/tonsillitis caused by Streptococcus pyogenes as an alternative therapy in individuals who cannot use first-line therapy, Indicated for treatment of uncomplicated skin and skin structure infections due to Staphylococcus aureus, Streptococcus pyogenes, or Streptococcus agalactiae, Indicated for treatment of acute bacterial exacerbations of chronic bronchitis due to Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae, Alternatively, 500 mg PO x 1 dose on Day 1, followed by 250 mg PO qDay on Days 2-5, Indicated for treatment of acute bacterial sinusitis due to Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae, Indicated for treatment of genital ulcer disease in men due to Haemophilus ducreyi (chancroid), Efficacy in treatment of chancroid in women has not been established, Indicated for treatment of urethritis and cervicitis due to Chlamydia trachomatis or Neisseria gonorrhoeae, Indicated for treatment of pelvic inflammatory disease due to Chlamydia trachomatis, Neisseria gonorrhoeae, or Mycoplasma hominis in patients who require initial IV therapy, If anaerobic microorganisms are suspected of contributing to the infection, administer an antimicrobial agent with anaerobic activity in combination with azithromycin. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Drug class: Macrolides. Use Caution/Monitor. Monitor Closely (1)amitriptyline and azithromycin both increase QTc interval. If this combination is used, closely monitor for evidence of atorvastatin toxicity (eg, muscle aches or pains, renal dysfunction). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Continue using it for the full time prescribed. azithromycin increases toxicity of cisapride by QTc interval. Use Caution/Monitor. Adding plans allows you to compare formulary status to other drugs in the same class. Uses. Applies only to oral forms of hormone. azithromycin and pasireotide both increase QTc interval. Reduced berotralstat dose to 110 mg/day when coadministered with P-gp inhibitors. Minor (1)azithromycin increases toxicity of vardenafil by QTc interval. Monitor Closely (1)amoxapine and azithromycin both increase QTc interval. 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